Article
Pharmacology & Pharmacy
Juan Pang, Huihui Xu, Xu Wang, Xu Chen, Qing Li, Qiannan Liu, Yiran You, Hanyue Zhang, Zhongliang Xu, Yimin Zhao, Yinghui Zhang, Yan Yang, Wenhua Ling
Summary: This study found that RSV can dose-dependently reduce blood cholesterol levels in mice fed with HFD or HCD, by enhancing trans-intestinal cholesterol excretion (TICE) and limiting cholesterol absorption through selective activation of intestinal LXR alpha.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Haksoo Lee, Eunguk Shin, Hyunkoo Kang, HyeSook Youn, BuHyun Youn
Summary: Soybean hydrolysate contains bioactive peptides that can reduce blood lipid concentrations by promoting trans-intestinal cholesterol excretion and inhibiting hepatic bile acid synthesis.
Article
Biochemistry & Molecular Biology
Maite M. Schroor, Fatma B. A. Mokhtar, Jogchum Plat, Ronald P. Mensink
Summary: This study found that certain SNPs are associated with cholesterol metabolism, including ABCG5 and ABCG8 genes with serum campesterol and/or sitosterol levels, NPC1L1 gene with serum lathosterol levels, and HMGCR and LBR genes with serum LDL-C concentrations. However, SNPs in cholesterol absorption genes were not associated with serum LDL-C concentrations.
Article
Cardiac & Cardiovascular Systems
Maite M. Schroor, Jogchum Plat, Maurice C. J. M. Konings, Ellen T. H. C. Smeets, Ronald P. Mensink
Summary: This study investigated the acute effect of a high-fat, high-carbohydrate, and high-protein meal on intestinal cholesterol absorption and synthesis in overweight and slightly obese males. The meal composition did not significantly affect cholesterol absorption, but several cholesterol synthesis intermediates decreased postprandially.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Multidisciplinary Sciences
Chiara Reggio, Erika Palmisano, Umberto Tecchiati, Alessandro Ravelli, Roberta F. F. Bergamaschi, Paola Salzani, Cristiano Putzolu, Sara Casati, Marica Orioli
Summary: The aim of this research is to identify mammalian species through faecal sediments in both modern and ancient environments, which is of interest to archaeologists, forensic scientists, and ecologists. The researchers have developed an optimized gas chromatography-mass spectrometry (GC-MS) method with a time-saving sample preparation protocol to analyze faecal biomarkers in soil samples from an archaeological site in Italy. By comparing these biomarker findings with new studies on faunal materials, the researchers can gain insights into the animal species farmed in the area and the management of breeding. This investigation, along with archaeozoological and archaeobotanical analyses, contributes to our understanding of how ancient communities utilized natural resources and their impact on the landscape.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Giancarlo Garofalo, Tyson Nielsen, Samuel Caito
Summary: This study found that the environmental toxicant methylmercury affects the expression of miRNA, leading to dysregulation of lipid metabolism. The changes in the affected miRNA sequences by MeHg may be a potential mechanism underlying lipid accumulation.
Article
Nutrition & Dietetics
Sultan Mashnafi, Jogchum Plat, Ronald P. Mensink, Peter J. Joris, Yvo H. A. M. Kusters, Alfons J. H. M. Houben, Coen D. A. Stehouwer, Casper G. Schalkwijk, Sabine Baumgartner
Summary: Obesity is associated with lower intestinal cholesterol absorption and higher endogenous cholesterol synthesis, which are also observed in other metabolic diseases. Weight loss can decrease cholesterol synthesis and increase cholesterol absorption, with changes in waist circumference, weight, BMI, and visceral fat volume related to changes in cholestanol levels.
Article
Biochemistry & Molecular Biology
Adrian Bouzas Munoz, Juan Antonio Gimenez-Bastida, Aurora Garcia Tejedor, Claudia Monika Haros, Marta Gomez de Cedron, Ana Ramirez de Molina, Jose Moises Laparra Llopis
Summary: The study showed that administration of SETIs improved survival and decreased tumor burden by modulating monocyte-derived macrophages, playing a key role in diet-induced HCC development. This suggests a potential therapeutic strategy to improve the hepatic innate immune response and create a better antitumoral environment in early stages of HCC development.
Review
Agriculture, Multidisciplinary
Fan Zhang, Junhua Li, Cuihua Chang, Luping Gu, Wen Xiong, Yujie Su, Yanjun Yang
Summary: This review discusses the contradictory conclusions about the relationship between egg consumption and cardiovascular disease (CVD) risk, as well as the effects of egg cholesterol intake on cholesterol homeostasis. The study finds that moderate egg consumption has no substantial overall impact on cholesterol homeostasis in healthy individuals. However, excessive cholesterol intake is not recommended for individuals with metabolic disorders. In the future, the impact of egg consumption on CVD risk should be considered from different perspectives.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Ecology
Marcel Lerch, Tobias Bromm, Clemens Geitner, Jean Nicolas Haas, Dieter Schaefer, Bruno Glaser, Michael Zech
Summary: The Ullafelsen is an important (geo)archeological reference site for the Mesolithic period, indicating the presence of hunter-gatherers. Livestock grazing has been a significant anthropozoological impact since the Bronze Age. The results suggest that the input of livestock feces is more significant than that of human feces.
Review
Biochemistry & Molecular Biology
Fatma B. A. Mokhtar, Jogchum Plat, Ronald P. Mensink
Summary: Intestinal cholesterol absorption varies widely between individuals and is associated with genetic variants. Seven genes were found to be associated with cholesterol absorption, and a network with fifteen additional genes was constructed. Further research is needed to validate and improve the network for a better understanding of inter-individual variability in cholesterol absorption and personalized interventions.
PROGRESS IN LIPID RESEARCH
(2022)
Article
Multidisciplinary Sciences
Emily J. Onufer, Rafael S. Czepielewski, Yong-Hyun Han, Cathleen M. Courtney, Stephanie Sutton, Anne Sescleifer, Gwendalyn J. Randolph, Brad W. Warner
Summary: This study found that functional transport of intestinal lipids significantly decreased after small bowel resection, with an increase in fecal fat content. Besides, significant morphological changes in the lymphatic vasculature were observed. Chronic short bowel syndrome leads to significant remodeling of the intestinal lymphatic vessels.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Emma L. Feeney, Aisling Daly, Simone Dunne, Victoria Dible, Rebecca Barron, Sanja Seratlic, J. C. Jacquier, Michael O'Sullivan, Tom Beresford, Soren Krogh Jensen, Eileen R. Gibney
Summary: The aim of this study was to test the effect of varying the calcium content within a cheese on faecal fat excretion and blood lipid markers. The results showed that the calcium content in cheese can significantly reduce fasting LDL-cholesterol (LDL-c), but it does not have a significant effect on faecal fat excretion.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Biology
Xiabing Gu, Kun Wang, Wenguo Li, Meiling He, Tiantian Zhou, Meng Liu, Qingyu Wu, Ningzheng Dong
Summary: Sodium homeostasis is critical for body fluid balance, and the kidney plays a central role in regulating sodium reabsorption and excretion. In this study, Corin and ANP were found to be expressed in the mouse intestine, where sodium excretion also occurs. This reveals a new function of Corin in promoting sodium excretion in the intestinal tract.
Article
Gastroenterology & Hepatology
Guilherme Piovezani Ramos, Adebowale O. Bamidele, Emily E. Klatt, Mary R. Sagstetter, Ahmed T. Kurdi, Feda H. Hamdan, Robyn Laura Kosinsky, Joseph M. Gaballa, Asha Nair, Zhifu Sun, Surendra Dasari, Ian R. Lanza, Cody N. Rozeveld, Micah B. Schott, Guillermo Urrutia, Maria S. Westphal, Benjamin D. Clarkson, Charles L. Howe, Eric V. Marietta, David H. Luckey, Joseph A. Murray, Michelle Gonzalez, Manuel B. Braga Neto, Hunter R. Gibbons, Thomas C. Smyrk, Steven Johnsen, Gwen Lomberk, William A. Faubion
Summary: Inhibition of G9a enzyme promotes the development of regulatory T cells (Tregs) in human CD4 T cells, suggesting the potential use of G9a inhibitors for the treatment of immune-mediated diseases.
Article
Biotechnology & Applied Microbiology
Anouk A. J. Hamers, Carmen Argmann, Perry D. Moerland, Duco S. Koenis, Goran Marinkovic, Milka Sokolovic, Alex F. de Vos, Carlie J. M. de Vries, Claudia M. van Tiel
Article
Multidisciplinary Sciences
Jing Zhao, Theodorus B. M. Hakvoort, A. Marcel Willemsen, Aldo Jongejan, Milka Sokolovic, Edward J. Bradley, Vincent C. J. de Boer, Frank Baas, Antoine H. C. van Kampen, Wouter H. Lamers
Article
Biochemistry & Molecular Biology
Aleksandar Sokolovic, Paula S. Montenegro-Miranda, Dirk Rudi de Waart, Radha M. N. Cappai, Suzanne Duijst, Milka Sokolovic, Piter J. Bosma
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2012)
Article
Biochemistry & Molecular Biology
Aleksandar Sokolovic, Cindy P. A. A. van Roomen, Roelof Ottenhoff, Saskia Scheij, Johan K. Hiralall, Nike Claessen, Jan Aten, Ronald P. J. Oude Elferink, Albert K. Groen, Milka Sokolovic
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2013)
Article
Biotechnology & Applied Microbiology
Milka Sokolovic, Aleksandar Sokolovic, Diederik Wehkamp, Emiel Ver Loren van Themaat, Dirk R. de Waart, Lisa A. Gilhuijs-Pederson, Yuri Nikolsky, Antoine H. C. van Kampen, Theodorus B. M. Hakvoort, Wouter H. Lamers
Article
Gastroenterology & Hepatology
Nora Bijl, Cindy P. A. A. van Roomen, Vassilis Triantis, Milka Sokolovic, Roelof Ottenhoff, Saskia Scheij, Marco van Eijk, Rolf G. Boot, Johannes M. Aerts, Albert K. Groen
Article
Gastroenterology & Hepatology
Nora Bijl, Milka Sokolovic, Carlos Vrins, Mirjam Langeveld, Perry D. Moerland, Roelof Ottenhoff, Cindy P. A. A. van Roomen, Nike Claessen, Rolf G. Boot, Jan Aten, Albert K. Groen, Johannes M. F. G. Aerts, Marco van Eijk
Article
Biochemistry & Molecular Biology
Youji He, Theodorus B. M. Hakvoort, S. Eleonore Kohler, Jacqueline L. M. Vermeulen, D. Rudi de Waart, Chiel de Theije, Gabrie A. M. ten Have, Hans M. H. van Eijk, Cindy Kunne, Wilhelmina T. Labruyere, Sander M. Houten, Milka Sokolovic, Jan M. Ruijter, Nicolaas E. P. Deutz, Wouter H. Lamers
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Article
Biochemistry & Molecular Biology
Theodorus B. M. Hakvoort, Perry D. Moerland, Raoul Frijters, Aleksandar Sokolovic, Wilhelmina T. Labruyere, Jacqueline L. M. Vermeulen, Emiel Ver Loren van Themaat, Timo M. Breit, Floyd R. A. Wittink, Antoine H. C. van Kampen, Arthur J. Verhoeven, Wouter H. Lamers, Milka Sokolovic
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
Kondababu Kurakula, Daniela Sommer, Milka Sokolovic, Perry D. Moerland, Saskia Scheij, Pieter B. van Loenen, Duco S. Koenis, Noam Zelcer, Claudia M. van Tiel, Carlie J. M. de Vries
MOLECULAR AND CELLULAR BIOLOGY
(2015)
Article
Nutrition & Dietetics
Inge Tetens, Christopher A. Birt, Elizabeth Brink, Stephanie Bodenbach, Susanne Bugel, Stefaan De Henauw, Trine Gronlund, Chantel Julia, Ase Bonde Konde, Daane Kromhout, Undine Lehmann, Quenia dos Santos, Milka Sokolovic, Stefan Storcksdieck Genannt Bonsmann, Caroline van Rossum, Heiner Boeing
BRITISH JOURNAL OF NUTRITION
(2020)
Article
Mathematical & Computational Biology
Martijn P. van Iersel, Milka Sokolovic, Kaatje Lenaerts, Martina Kutmon, Freek G. Bouwman, Wouter H. Lamers, Edwin C. M. Mariman, Chris T. Evelo
JOURNAL OF INTEGRATIVE BIOINFORMATICS
(2014)
Article
Nutrition & Dietetics
S. Lockyer, J. Cade, N. Darmon, M. Flynn, S. Gatenby, A. Govindji, B. Quick, M. Raats, M. Rayner, M. Sokolovic, A. Spiro, N. Sritharan, S. Stanner, J. L. Buttriss
NUTRITION BULLETIN
(2020)
Article
Cell Biology
Aleksandar Sokolovic, Milka Sokolovic, Willem Boers, Ronald P. J. Oude Elferink, Piter J. Bosma
FIBROGENESIS & TISSUE REPAIR
(2010)