Article
Health Care Sciences & Services
Aleksandra Bodys-Pelka, Maciej Kusztal, Joanna Raszeja-Wyszomirska, Renata Glowczynska, Marcin Grabowski
Summary: The text discusses Cirrhotic cardiomyopathy (CCM) in terms of its definition, clinical manifestations, diagnosis, treatment, and the improvement of circulatory function associated with liver transplantation, while highlighting the importance of careful cardiac assessment in detecting CCM and the urgent need for an updated definition and diagnostic algorithm for early diagnosis and specific treatment of this condition.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Guangbo Wu, Min Chen, Qiang Fan, Hongjie Li, Zhifeng Zhao, Chihao Zhang, Meng Luo
Summary: This study investigated the changes in mesenteric arterioles in cirrhotic rats with portal hypertension (PHT). The cirrhotic rats showed mesenteric arteriole vasodilation, vascular remodeling, and hypocontractility. Transcriptome analysis revealed the potential molecular mechanisms of these vascular changes and identified promising candidate drugs for ameliorating PHT.
Article
Medicine, General & Internal
Hui-Chun Huang, Shao-Jung Hsu, Ching-Chih Chang, Yun-Chieh Kao, Chiao-Lin Chuang, Ming-Chih Hou, Fa-Yauh Lee
Summary: The study showed that lycopene can improve liver fibrosis, hyperdynamic circulation, and pathological angiogenesis in biliary cirrhotic rats, possibly through the modulation of intrahepatic Akt/PI3K/eNOS and VEGFR-2 pathways.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2022)
Article
Gastroenterology & Hepatology
Wilma Debernardi Venon, Sara Lo Pumo, Barbara Imperatrice, Mauro Giorgi, Dorico Righi, Paolo Fonio, Giorgio M. Saracco, Alfredo Marzano
Summary: The study found that cirrhotic patients with LVDD before undergoing TIPS for refractory ascites were more likely to have a lack of clinical response and higher mortality rates. NT-proBNP and careful investigation of LVDD can be useful in selecting patients and predicting clinical response and mortality after TIPS.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Alexander Isaak, Johannes Chang, Narine Mesropyan, Dmitrij Kravchenko, Christoph Endler, Leon Bischoff, Nina Boehling, Claus C. Pieper, Daniel Kuetting, Christian P. Strassburg, Ulrike Attenberger, Christian Jansen, Michael Praktiknjo, Julian A. Luetkens
Summary: This MRI study aimed to evaluate the presence of subclinical myocardial dysfunction, oedema, and fibrosis in non-cirrhotic portal hypertension (NCPH). The results showed that NCPH participants had similar levels of myocardial fibrosis and oedema as compensated cirrhosis, and these abnormalities were associated with splenic markers of portal hypertension.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Gastroenterology & Hepatology
Soren Moller, Karen V. Danielsen, Puria Nabliou, Nina Kimer, Flemming Bendtsen
Summary: Portal hypertension exacerbates cirrhosis and leads to major complications, but beta-blockers may cause adverse reactions in advanced cirrhosis patients.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Mohammed Hussien Ahmed, Mohammed Said Radwan, Ibrahim Fathi Amer, Hassan Elsayed Elbatea, Shimaa Mahmoud ElSharawy, Salwa Twafic
Summary: Cardiac changes were found in cirrhotic patients, and their relationship with the severity of liver impairment was investigated. Patients were divided into different groups based on clinical and cardiac evaluations. The study revealed significant cardiac abnormalities in cirrhotic patients.
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2023)
Article
Physiology
Nikolaj Worm Orntoft, Michel Ble, Anna Baiges, Jose Ferrusquia, Virginia Hernandez-Gea, Fanny Turon, Marta Magaz, Soren Moller, Holger Jon Moller, Juan Carlos Garcia-Pagan, Henning Gronbaek
Summary: The study found that soluble CD163 and soluble mannose receptor levels are elevated in patients with idiopathic portal hypertension and cirrhosis, but normal in patients with non-cirrhotic portal hypertension. This suggests that hepatic macrophage activation is more driven by the underlying liver disease such as cirrhosis, rather than portal hypertension.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Moritz Uhlig, Marc Hein, Moriz A. Habigt, Rene H. Tolba, Till Braunschweig, Marius J. Helmedag, Melissa Arici, Alexander Theissen, Axel Klinkenberg, Uwe Klinge, Mare Mechelinck
Summary: Cirrhotic patients often experience cirrhotic cardiomyopathy (CCM), which is studied in detail through animal models of bile duct ligation (BDL) and a second surgery. The study reveals delayed adaptability, impaired contractility at rest, reduced contractile reserve, increased creatine and transaminase levels, myocardial fibrosis, macrophage infiltration, systemic inflammation, altered expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1a), and increased expression of caspase-3. Structural changes in the myocardium are observed after 8 weeks. Transient myocardial insufficiency and secondary organ dysfunction occur after the second surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Soren Moller, Signe Wiese, Mads Barlose, Jens D. Hove
Summary: Liver diseases can impact the heart and vascular system, with cardiovascular complications being a leading cause of death in patients with non-alcoholic fatty liver disease (NAFLD) and cirrhosis. The extent of liver damage, ranging from steatosis to fibrosis to cirrhosis, can have varying effects on the cardiovascular system. Accurate assessment of symptoms is crucial in identifying at-risk patients, evaluating treatment candidates, and prior to invasive procedures.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Ieva Rinkunaite, Egidijus Simoliunas, Milda Alksne, Gabriele Bartkute, Siegfried Labeit, Virginija Bukelskiene, Julius Bogomolovas
Summary: Myocarditis is an inflammatory disease that can lead to sudden death and chronic heart failure. The molecular mechanisms during the post-myocarditis phase are not well understood. This study suggests that ANKRD1, a stress-responsive protein, may play a role in cardiac remodeling after myocarditis.
Review
Cardiac & Cardiovascular Systems
Kanza N. Qaiser, Sandeep Sahay, Adriano R. Tonelli
Summary: Pulmonary hypertension (PH) is usually associated with normal or decreased cardiac output. Less commonly, PH can occur in the context of a hyperdynamic circulation characterized by high cardiac output and/or decreased systemic vascular resistance. This distinct entity is often understudied and in this review article, we describe its pathophysiology, etiology, diagnosis, hemodynamic characteristics, and management. Recognizing this condition is important as treatment of the underlying etiology can improve PH and specific therapies for PH may worsen the hemodynamic state.
RESPIRATORY MEDICINE
(2023)
Article
Cell Biology
Anastasia Osokina, Viktoria Karetnikova, Olga Polikutina, Anna Ivanova, Olga Gruzdeva, Yulia Dyleva, Aleksandr Kokov, Natalia Brel, Tamara Pecherina, Olga Barbarash
Summary: This study revealed a direct correlation between serum PIIINP levels, severity of cardiac fibrosis, and indicators of diastolic function after 1 year of STEMI with preserved LVEF. Patients with PIIINP levels exceeding 381.4ng/ml on the 12th day post-STEMI had an increased risk of cardiac fibrosis. Monitoring PIIINP levels during the inpatient period may help identify high-risk patients for cardiac fibrosis 1 year after STEMI with preserved LVEF.
Review
Cell Biology
Ming-Yun Ho, Chao-Yung Wang
Summary: Irisin plays a vital role in regulating cardiovascular functions, with both protective and detrimental effects depending on the stage of myocardial infarction. Its functions include modulation of mitochondrial dysfunction, oxidative stress, metabolic imbalance, and energy expenditure in heart failure.
Article
Medicine, General & Internal
Michio Saeki, Hironao Okubo, Yusuke Takasaki, Eisuke Nakadera, Yuka Fukuo, Hiroo Fukada, Yuta Hotchi, Hitoshi Maruyama, Shigehiro Kokubu, Shuichiro Shiina, Akihito Nagahara, Kenichi Ikejima
Summary: This study aimed to investigate the impact of partial splenic embolization (PSE) on portal hypertensive gastropathy (PHG). Retrospective analysis of endoscopic findings and the portal venous system was performed on 31 cirrhotic patients with PHG. The results showed that PSE can be beneficial for PHG, especially in patients with Child-Pugh grade A, at least in the short term.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Gastroenterology & Hepatology
Marie-Louise Lindberg Pind, Soren Moller, Nasrin Faqir, Flemming Bendtsen
Article
Gastroenterology & Hepatology
Diana J. Leeming, Sanne S. Veidal, Morten A. Karsdal, Mette Juul Nielsen, Jonel Trebicka, Troels Busk, Flemming Bendtsen, Aleksander Krag, Soren Moller
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2015)
Review
Gastroenterology & Hepatology
Soren Moller, Flemming Bendtsen
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2015)
Review
Pharmacology & Pharmacy
Julie Steen Pedersen, Flemming Bendtsen, Soren Moller
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2015)
Review
Gastroenterology & Hepatology
Soren Moller, Flemming Bendtsen
LIVER INTERNATIONAL
(2018)
Article
Gastroenterology & Hepatology
Jonel Trebicka, Cyrus Wix, Matthias von Heydebrand, Kanishka Hittatiya, Thomas Reiberger, Sabine Klein, Robert Schierwagen, Glen Kristiansen, Markus Peck-Radosavljevic, Hans-Peter Fischer, Soren Moller, Flemming Bendtsen, Aleksander Krag, Tilman Sauerbruch
LIVER INTERNATIONAL
(2015)
Review
Gastroenterology & Hepatology
Nina Kimer, Martin Feineis, Soren Moller, Flemming Bendtsen
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2015)
Article
Gastroenterology & Hepatology
Jennifer Lehmann, Michael Praktiknjo, Mette Juul Nielsen, Robert Schierwagen, Carsten Meyer, Daniel Thomas, Francesco Violi, Christian P. Strassburg, Flemming Bendtsen, Soren Moller, Aleksander Krag, Morten Asser Karsdal, Diana Julie Leeming, Jonel Trebicka
LIVER INTERNATIONAL
(2019)
Article
Multidisciplinary Sciences
Emilie Garnaes, Christian Mortensen, Lise Hobolth, Ove Andersen, Jan Nehlin, Soren Moller
Review
Gastroenterology & Hepatology
Mads Barloese, Mohammadnavid Chitgar, Jens Hannibal, Soren Moller
LIVER INTERNATIONAL
(2020)
Article
Gastroenterology & Hepatology
Maja Thiele, Stine Johansen, Natasja S. Gudmann, Bjorn Madsen, Maria Kjaergaard, Mette Juul Nielsen, Diana J. Leeming, Suganya Jacobsen, Flemming Bendtsen, Soren Moller, Sonke Detlefsen, Morten Karsdal, Aleksander Krag
Summary: The study revealed an imbalance in extracellular matrix remodelling in patients with alcohol-related liver disease, with collagen formation and degradation becoming increasingly imbalanced with more severe disease. This has important implications for monitoring and early identification of patients at highest risk of progressing to cirrhosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Soren Moller, Jens H. Henriksen, Sannia Sjostedt, Flemming Bendtsen
Summary: This study compares single injection indocyanine green (ICG) clearances with steady-state ICG clearance (ICG(Cl)) in patients with cirrhosis in order to assess the most accurate estimate for ICG clearance and to relate it to established indicators of liver dysfunction. The results show that the single injection markers correlate closely with ICG(Cl) and established variables of portal hypertension and liver cell bile excretory dysfunction.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Soren Moller, Signe Wiese, Mads Barlose, Jens D. Hove
Summary: Liver diseases can impact the heart and vascular system, with cardiovascular complications being a leading cause of death in patients with non-alcoholic fatty liver disease (NAFLD) and cirrhosis. The extent of liver damage, ranging from steatosis to fibrosis to cirrhosis, can have varying effects on the cardiovascular system. Accurate assessment of symptoms is crucial in identifying at-risk patients, evaluating treatment candidates, and prior to invasive procedures.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Karen Vagner Danielsen, Puria Nabilou, Signe Skovgaard Wiese, Jens Dahlgaard Hove, Flemming Bendtsen, Soren Moller
Summary: This study aimed to assess the effects of non-selective beta-blockers (NSBB) on haemodynamics and determine if these changes were related to disease severity and hepatic venous pressure gradient (HVPG) response. The results showed that NSBB caused changes in cardiac output and blood flow, but there were no significant differences between NSBB responders and non-responders.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Michael Praktiknjo, Jennifer Lehmann, Mette J. Nielsen, Robert Schierwagen, Frank E. Uschner, Carsten Meyer, Daniel Thomas, Christian P. Strassburg, Flemming Bendtsen, Soren Moller, Aleksander Krag, Morten A. Karsdal, Diana J. Leeming, Jonel Trebicka
HEPATOLOGY COMMUNICATIONS
(2018)