Article
Biochemistry & Molecular Biology
Alice Della Valle, Azzurra Stefanucci, Giuseppe Scioli, Edina Szucs, Sandor Benyhe, Stefano Pieretti, Paola Minosi, Chiara Sturaro, Girolamo Calo, Gokhan Zengin, Adriano Mollica
Summary: The study investigated the influence of incorporating (R/S)-Agl in position 2 and 3 on the biological profile of EM-2 and DAPEA, revealing that peptide A2D selectively binds and activates MOR with a potent antinociceptive effect, outperforming the parent compounds in vivo.
BIOORGANIC CHEMISTRY
(2021)
Article
Immunology
Susana Lopez-Lopez, Maria Jose Romero de Avila, Natalia Carolina Hernandez de Leon, Francisco Ruiz-Marcos, Victoriano Baladron, Maria Luisa Nueda, Jorge Laborda, Jose Javier Garcia-Ramirez, Eva M. Monsalve, Maria Jose M. Diaz-Guerra
Summary: NOTCH4 acts as a negative regulator in macrophage activation by interfering with proinflammatory cytokine expression and signaling pathways such as IFN-gamma and STAT1. It also modulates the balance between STAT1 and STAT3 activation, impacting the transcriptional activity of macrophages. Moreover, NOTCH4 affects NF-kappa B and TLR signaling pathways, revealing new insights into the regulation of macrophage-specific effector functions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Linlin Fan, Hao Liu, Guofu Zhu, Shekhar Singh, Ze Yu, Shumin Wang, Hong Luo, Shiying Liu, Yawei Xu, Junbo Ge, Dongyang Jiang, Jinjiang Pang
Summary: This study reveals the critical role of CASP4/11 in adult angiogenesis and provides a promising therapeutic target for angiogenesis-related diseases in the future.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Spectroscopy
Na Huang, Dan Yang, Huanhuan Chen, Yu Xiao, Jiahui Wen, Yijuan Long, Huzhi Zheng
Summary: GTP not only plays a crucial role in cellular processes but also has the potential to mimic peroxidase activity. Based on its peroxidase-like activity, GTP can be used to develop a colorimetric method for detecting biomolecules. This method not only provides a platform for the detection of metal ions and biothiols, but also demonstrates the analytical potential of GTP.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Correction
Biochemistry & Molecular Biology
C. Kerr, H. Szmacinski, M. L. Fisher, B. Nance, J. R. Lakowicz, A. Akbar, J. W. Keillor, T. Lok Wong, R. Godoy-Ruiz, E. A. Toth, D. J. Weber, R. L. Eckert
Summary: The paper has been corrected.
Article
Hematology
Dongyang Jiang, Hao Liu, Guofu Zhu, Xiankai Li, Linlin Fan, Faxue Zhao, Chong Xu, Shumin Wang, Yara Rose, Jordan Rhen, Ze Yu, Yiheng Yin, Yuling Gu, Xiangbin Xu, Edward A. Fisher, Junbo Ge, Yawei Xu, Jinjiang Pang
Summary: In this study, researchers identified the proatherosclerotic effect of endothelial PHACTR1, contrary to macrophage PHACTR1. They demonstrated that global or endothelial cell specific Phactr1 deficiency can significantly inhibit atherosclerosis. Further research revealed that PHACTR1 functions as a PPARγ transcriptional corepressor by binding to PPARγ, which regulates endothelial activation and atherosclerosis. The findings suggest that endothelial PHACTR1 is a potential therapeutic target for atherosclerosis treatment.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biology
Audrey Antoine, Coraline De Sousa Do Outeiro, Coline Charnay, Corinne Belville, Fanny Henrioux, Denis Gallot, Loic Blanchon, Regine Minet-Quinard, Vincent Sapin
Summary: Phthalates, as reprotoxic pollutants, are found everywhere in the environment. They may disrupt the PPAR gamma pathway and lead to premature rupture of fetal membranes.
Article
Gastroenterology & Hepatology
Atsushi Takahashi, Hiromasa Ohira, Kazumichi Abe, Mikio Zeniya, Masanori Abe, Teruko Arinaga-Hino, Nobuhiro Nakamoto, Akinobu Takaki, Jong-Hon Kang, Satoru Joshita, Yoshiyuki Suzuki, Kazuhiko Koike, Ayano Inui, Atsushi Tanaka
Summary: The aim of this study was to identify the risk factors for relapse in recently diagnosed AIH patients. The results showed that elevated gamma-GTP levels and liver cirrhosis at diagnosis were significantly associated with relapse.
HEPATOLOGY RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Howard Ho-Wai Leung, Pavitratha Puspanathan, Anthony Wing-Hung Chan, Nik Raihan Nik Mustapha, Vincent Wai-Sun Wong, Wah-Kheong Chan
Summary: This study aimed to investigate the direct translation between the Non-alcoholic Steatohepatitis Clinical Research Network (NASH CRN) scoring system and the Steatosis Activity Fibrosis (SAF) scoring system, as well as the intra-observer and inter-observer agreement for each histological component and NASH diagnosis. The findings suggest that there is not a direct inter-translation between the two scoring systems and that the inter-observer agreement for lobular inflammation and NASH diagnosis needs improvement.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, Research & Experimental
Benedetta Perrone, Paola Ruffo, Giuseppina Augimeri, Diego Sisci, Maria Stefania Sinicropi, Giovanni Tripepi, Corrado Mammi, Daniela Bonofiglio, Francesca Luisa Conforti
Summary: This study aimed to explore the genetic factors related to the metabolic/inflammatory profile of adolescents, and identified significant associations between genetic polymorphisms and serum metabolic parameters. These findings provide evidence for the importance of genetic profiling in the prevention and management of chronic diseases.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Elettra Bianchi, Aurelie Najm, Sophie Vanbelle, Benoit Le Goff, Eugene Mutijima, Marie-Joelle Kaiser, Michel Malaise, Jean-Philippe Hauzeur
Summary: This study aimed to improve the reliability of quantitative scorings of synovial biopsies. The results showed that the diameter of arthroscopic forceps had some influence on the histological quality of synovial tissue and certain histological scores. There were variations in the inter-observer agreement among different scoring systems.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Szilvia Kisvarga, Dora Hamar-Farkas, Katalin Horotan, Adam Solti, Edina Simon, Mate Ordogh, Andras Nemenyi, Gabor Boronkay, Laszlo Orloci
Summary: The breeding of resistant, high-yield, decorative ornamental plant varieties may be impacted by climate change. Radiation-induced mutations can increase the genetic variability of plants. The study examined the effects of gamma mutation breeding on Rudbeckia hirta. Both morphological and physiological measurements showed that gamma radiation had positive effects on the Rudbeckia hirta strain, especially at higher doses.
Article
Biochemistry & Molecular Biology
Weiwei Han, Bee-Zen Peng, Chunyan Wang, Guy E. Townsend II, Natasha A. Barry, Frank Peske, Andrew L. Goodman, Jun Liu, Marina Rodnina, Eduardo A. Groisman
Summary: Protein synthesis is a vital cellular process that requires a significant amount of energy. However, cells can sustain protein synthesis under starvation conditions through the use of a bacterial elongation factor called EF-C2, which promotes translocation without hydrolyzing GTP. EF-G2, a variant of EF-C2, is crucial for bacterial gut colonization and can sustain protein synthesis at slower rates. EF-G2 is more abundant than canonical EF-C1 and specifically accumulates during carbon starvation. A unique 26-residue region in EF-G2 is essential for protein synthesis, dissociation from the ribosome, and the absence of GTPase activity. These findings provide insights into how cells minimize energy consumption while maintaining protein synthesis in fluctuating nutrient environments.
Article
Immunology
Nagarjuna Sivaraj, K. Rachel, Tarun Kumar Suvvari, Shilaja Prasad, Sri Harsha Boppana, Pradeep Kumar Vegi
Summary: The study revealed an association between the IL1R1rs2071374G allele and increased risk of preeclampsia, suggesting that IL1R1 genetic polymorphism may impact the pathogenesis of preeclampsia in Indian population. This provides new insights into the genetic factors underlying the disease.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Oncology
Ying Li, Li Zhu, Hongmin Yao, Ye Zhang, Xiangyu Kong, Liping Chen, Yingqiu Song, Anna Mu, Xia Li
Summary: Polymorphisms in AKT1 and PIGR genes are associated with the risk of HNSCC, while polymorphisms in IL-4RA gene, age <= 60 years, non-smoker status, and normal levels of SCC are significantly related to increased radiotherapy sensitivity in HNSCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Naruhiko Honmyo, Tsuyoshi Kobayashi, Shintaro Kuroda, Kentaro Ide, Masahiro Ohira, Hiroyuki Tahara, Hiroshi Morimoto, Naoki Tanimine, Michinori Hamaoka, Megumi Yamaguchi, Masateru Yamamoto, Daisuke Takei, Hiroshi Aikata, Kazuaki Chayama, Hideki Ohdan
Summary: This study identified risk factors for hepatocellular carcinoma (HCC) development after splenectomy for portal hypertension. The etiology of cirrhosis, presence of HCC history, and preoperative hemoglobin level were found to be associated with HCC development. The predictive model constructed in this study may assist in surveillance for HCC after splenectomy in patients with portal hypertension.
Review
Gastroenterology & Hepatology
C. Nelson Hayes, Michio Imamura, Junko Tanaka, Kazuaki Chayama
Summary: Since its discovery in 1989, the road to a cure for hepatitis C virus (HCV) has been slow, but most patients can now expect to achieve a sustained virological response (SVR). Adverse events are rare or mild, and patients with compensated cirrhosis and other co-morbidities are often eligible for treatment. However, a small number of patients fail to eradicate the virus even after retreatment.
LIVER INTERNATIONAL
(2022)
Article
Immunology
Yosuke Suehiro, Masataka Tsuge, Mio Kurihara, Takuro Uchida, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Grace Naswa Makokha, Takashi Nakahara, Eisuke Murakami, Hiromi Abe-Chayama, Tomokazu Kawaoka, Daiki Miki, Michio Imamura, Hiroshi Aikata, C. Nelson Hayes, Takashi Fujita, Kazuaki Chayama
Summary: HBV infection upregulates TRAIL-R3, which inhibits both TRAIL-dependent apoptosis and suppression of HBV replication. The upregulation of TRAIL-R3 is regulated by the TRAIL-R3 promoter and HBV signal pathway. The results suggest a mechanism by which HBV persists by escaping host immunity through upregulation of TRAIL-R3.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Osamu Yoshida, Sheikh Mohammad Fazle Akbar, Yusuke Imai, Takahiro Sanada, Kyoko Tsukiyama-Kohara, Takashi Miyazaki, Taizou Kamishita, Teruki Miyake, Yoshio Tokumoto, Hayato Hikita, Masataka Tsuge, Masahito Shimizu, Mamun Al Mahtab, Julio Cesar Aguilar, Gerardo Guillen, Michinori Kohara, Yoichi Hiasa
Summary: This study investigated the safety and efficacy of CVP-NASVAC in treating patients with chronic hepatitis B (CHB). The results showed that CVP-NASVAC induced anti-HBs antibodies and reduced HBsAg levels in some patients, leading to functional cure in 9.5% of the participants.
HEPATOLOGY RESEARCH
(2023)
Editorial Material
Gastroenterology & Hepatology
Masataka Tsuge, Tomokazu Kawaoka, Shiro Oka
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Yosuke Suehiro, Takuro Uchida, Masataka Tsuge, Eisuke Murakami, Daiki Miki, Tomokazu Kawaoka, Michio Imamura, Hiroshi Aikata, Koji Arihiro, Shiro Oka
Summary: We present the case of a rare occurrence of acute liver injury in a patient with non-alcoholic fatty liver disease (NAFLD) due to daily exposure to small amounts of chloroform. The patient had been regularly monitored and showed stable alanine aminotransferase (ALT) levels until a sudden increase in late August 2014. The liver injury was attributed to chloroform exposure and was successfully treated with the administration of 600 mg/day of ursodeoxycholic acid.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2023)
Correction
Gastroenterology & Hepatology
Serami Murakami, Michio Imamura, Takuro Uchida, Yosuke Suehiro, Maiko Namba, Yasutoshi Fujii, Shinsuke Uchikawa, Yuji Teraoka, Hatsue Fujino, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Wataru Okamoto, Masami Yamauchi, Tomokazu Kawaoka, Daiki Miki, Nelson C. Hayes, Masataka Tsuge, Hiroshi Aikata, Masahiro Ohira, Hideki Ohdan, Shiro Oka
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Serami Murakami, Michio Imamura, Takuro Uchida, Yosuke Suehiro, Maiko Namba, Yasutoshi Fujii, Shinsuke Uchikawa, Yuji Teraoka, Hatsue Fujino, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Wataru Masami Okamoto Yamauchi, Tomokazu Kawaoka, Daiki Miki, Nelson C. Hayes, Masataka Tsuge, Hiroshi Aikata, Masahiro Ohira, Hideki Ohdan, Shiro Oka
Summary: This study evaluated the prognosis and prognostic factors of patients with alcohol-related acute-on-chronic liver failure (ACLF). The cumulative survival rates of patients treated without liver transplantation were 69%, 48%, 41%, and 36% at 1, 3, 6, and 12 months, respectively. Serum IL-6 level and Day-4 MELD score were identified as prognostic factors for mortality within 6 months. Early liver transplantation may be a potential treatment option for patients with poor prognosis.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Oncology
Takahiro Kinami, Kei Amioka, Tomokazu Kawaoka, Shinsuke Uchikawa, Shintaro Yamasaki, Masanari Kosaka, Yusuke Johira, Shigeki Yano, Kensuke Naruto, Yuwa Ando, Kenji Yamaoka, Yasutoshi Fujii, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Wataru Okamoto, Masami Yamauchi, Daiki Miki, Masataka Tsuge, Michio Imamura, Hiroshi Aikata, Shiro Oka
Summary: This study investigated the relationship between radiological response and prognosis in HCC patients to determine whether to continue Atezo + Beva treatment. The results showed that a decrease in AFP level may reflect early efficacy and AFP trends can help decide the treatment strategy. It was found that a 25% or greater increase in AFP value was associated with disease progression and a decrease in AFP was related to improved progression-free survival.
Article
Gastroenterology & Hepatology
Yusuke Johira, Takashi Nakahara, Takahiro Kinami, Shintaro Yamasaki, Masanari Kosaka, Yuki Shirane, Ryoichi Miura, Serami Murakami, Shigeki Yano, Kei Amioka, Kensuke Naruto, Yuwa Ando, Yumi Kosaka, Kenichiro Kodama, Shinsuke Uchikawa, Hatsue Fujino, Atsushi Ono, Eisuke Murakami, Wataru Okamoto, Masami Yamauchi, Tomokazu Kawaoka, C. Nelson Hayes, Masataka Tsuge, Michio Imamura, Hiroshi Aikata, Shiro Oka
Summary: This study investigated the clinical characteristics of MAFLD-HCC patients compared with NAFLD-HCC patients and considered the validity and challenges of the new criteria. The majority of non-B, non-C HCC cases with hepatic steatosis were attributed to MAFLD. Further examination and revision of the criteria are needed to select fatty liver patients at high risk of developing HCC efficiently.
BMC GASTROENTEROLOGY
(2023)
Article
Oncology
Yosuke Tamura, Atsushi Ono, Hikaru Nakahara, Clair Nelson Hayes, Yasutoshi Fujii, Peiyi Zhang, Masami Yamauchi, Shinsuke Uchikawa, Yuji Teraoka, Takuro Uchida, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Masataka Tsuge, Masahiro Serikawa, Daiki Miki, Tomokazu Kawaoka, Wataru Okamoto, Michio Imamura, Yuko Nakamura, Kazuo Awai, Tsuyoshi Kobayashi, Hideki Ohdan, Masashi Fujita, Hidewaki Nakagawa, Kazuaki Chayama, Hiroshi Aikata, Shiro Oka
Summary: High-intensity Gd-EOB-DTPA-enhanced MRI imaging (EOB-MRI) in the hepatobiliary phase (HB) can predict the immune microenvironment and molecular subtype in hepatocellular carcinoma (HCC) patients but not the response to atezolizumab + bevacizumab therapy. The high-intensity group benefits from bevacizumab, while the low-intensity group benefits from atezolizumab.
Article
Oncology
Shigeki Yano, Tomokazu Kawaoka, Shintaro Yamasaki, Yusuke Johira, Masanari Kosaka, Yuki Shirane, Ryoichi Miura, Kei Amioka, Kensuke Naruto, Kenji Yamaoka, Yasutoshi Fujii, Shinsuke Uchikawa, Hatsue Fujino, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Daiki Miki, Masataka Tsuge, Yuji Teraoka, Hirotaka Kouno, Shintaro Takaki, Nami Mori, Keiji Tsuji, Shiro Oka
Summary: A total of 137 HCC patients treated with atezolizumab plus bevacizumab were enrolled in this study. The results showed that lenvatinib is an effective treatment option, as it can prolong the overall survival and progression-free survival of patients. Adverse events were relatively common, but none directly caused death.
Meeting Abstract
Gastroenterology & Hepatology
Kenji Yamaoka, Tomokazu Kawaoka, Masanari Kosaka, Yusuke Johira, Yuki Shirane, Ryoichi Miura, Shigeki Yano, Serami Murakami, Kei Amioka, Kensuke Naruto, Yuwa Ando, Yumi Kosaka, Shinsuke Uchikawa, Kenichiro Kodama, Takuro Uchida, Hatsue Fujino, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Wataru Okamoto, Masami Yamauchi, Daiki Miki, Michio Imamura, Kazuaki Chayama, Hiroshi Aikata