期刊
JOURNAL OF HEPATOLOGY
卷 50, 期 4, 页码 746-754出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jhep.2008.11.014
关键词
Markers; Hepatocellular carcinoma; Dysplastic nodules; Differential diagnosis; Liver biopsy
资金
- National R&D Program for Cancer Control, Ministry of Health Welfare [0620210]
- Korea Science and Engineering Foundation (KOSEF)
- Korea government (MOST) [R13-2002-054-03004-0]
- Republic of Korea
- Italian MURST
- Korea Health Promotion Institute [0620210] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2007-0056176, R13-2002-054-03004-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Background/Aims: Liver biopsy for hepatocellular carcinoma (HCC) detection is largely restricted to small hepatocellular lesions, which are often morphologically challenging, requiring careful distinction between dysplastic nodules (high-grade) and well-differentiated HCC. Methods: We investigated the diagnostic accuracy of a panel of markers (HSP70 G PC3 and GS), previously tested in resection specimens, in a series of liver biopsies of large regenerative nodules (n = 13), low-grade dysplastic nodules (n = 21), high-grade dysplastic nodules (n = 50), very well-differentiated (VWD) (n = 17), well-differentiated (WD-G1) (n = 40) and G2-3 (n = 35) HCC. Results: Almost all cases of large regenerative and low-grade dysplastic nodules did not stain while high-grade dysplastic nodules showed 1 marker (22%) but never 2 or 3. For HCC detection the overall accuracy of marker combination was 60.8% (3 markers) and 78.4% (2 markers) with 100% specificity. When restricted to VWD + WD-G1 HCC the accuracy was 57% (3 markers) and 72.9% (2 markers) with 100% specificity. Conclusions: This panel proved useful to detect well-differentiated HCC in biopsy. Two immunoreactive markers (out of 3) are recommended as the most valuable diagnostic combination for HCC detection. The diagnostic accuracy of the panel could be improved using additional markers, as suggested by studies of expression profiling in other human models. (c) 2009 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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