Review
Cell Biology
Dimitri Papukashvili, Nino Rcheulishvili, Cong Liu, Fengfei Xie, Deependra Tyagi, Yunjiao He, Peng George Wang
Summary: Androgenetic alopecia (AGA) is a challenging issue that requires the development of new treatment methods. The Wnt/β-catenin signaling pathway is crucial for hair growth and can be targeted for AGA therapy.
Review
Oncology
Kaiting Wang, Xinyao Qiu, Yan Zhao, Hongyang Wang, Lei Chen
Summary: The Wnt/beta-catenin signaling pathway plays a crucial role in regulating interactions among different components of the TME in hepatocellular carcinoma. Utilizing Wnt/beta-catenin mutations as a biomarker to predict resistance in immunotherapy holds significant clinical implications.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Cell & Tissue Engineering
Yuhui Xu, Jiali Hu, Qiaoying Lv, Chenyi Shi, Mengdi Qiu, Liying Xie, Wei Liu, Bingyi Yang, Weiwei Shan, Yali Cheng, Bing Zhao, Xiaojun Chen
Summary: This study aimed to investigate the potential therapeutic effects and underlying mechanisms of mesenchymal stem cells (MSCs) on well-differentiated endometrial cancer (EC). The results demonstrated that endometrium-derived MSCs (eMSCs) had the highest inhibitory effect on EC cell viability and xenograft tumor growth compared to adipose-derived MSCs (AD-MSCs) and umbilical-cord-derived MSCs (UC-MSCs). The study also revealed that eMSCs inhibited EC cell proliferation and stemness through the DKK1-Wnt/beta-catenin signaling pathway. Furthermore, the combination of eMSCs and medroxyprogesterone acetate (MPA) showed enhanced inhibition of EC growth. These findings suggest that eMSCs may be a promising therapeutic strategy for young EC patients desiring fertility preservation.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Oncology
Anja Kafka, Anja Bukovac, Emilija Brglez, Ana-Marija Jarmek, Karolina Poljak, Petar Brlek, Kamelija Zarkovic, Niko Njiric, Nives Pecina-Slaus
Summary: This study investigated genetic and epigenetic changes as well as protein expression levels of negative regulators of Wnt signaling in human astrocytomas. The results emphasize the importance of methylation in Wnt signaling regulation, and suggest that large deletions of the APC gene and effects of beta-catenin and GSK3 beta play key roles in astrocytoma evolution. Further studies are needed to understand the clinical and therapeutic relevance of these molecular alterations.
Article
Medicine, Research & Experimental
Wenjing Yang, Beili Wang, Qian Yu, Te Liu, Tong Li, Tongtong Tian, Anli Jin, Lin Ding, Wei Chen, Hao Wang, Jingrong Xian, Baishen Pan, Jian Zhou, Jia Fan, Xinrong Yang, Wei Guo
Summary: This study suggests that ARHGAP24 may serve as an independent prognostic indicator for HCC, inhibiting cell proliferation and invasion. It exerts its suppressive function by attenuating beta-catenin transactivation and blocking beta-catenin signaling.
Article
Gastroenterology & Hepatology
Mathilde Cadoux, Stefano Caruso, Sandrine Pham, Angelique Gougelet, Celine Pophillat, Rozenn Riou, Robin Loesch, Sabine Colnot, Cong Trung Nguyen, Julien Calderaro, Severine Celton-Morizur, Nadia Guerra, Jessica Zucman-Rossi, Chantal Desdouets, Jean-Pierre Couty
Summary: The expression of NKG2D ligands is associated with aggressive liver tumorigenesis, and downregulation of these ligands by beta-catenin signaling may contribute to the less aggressive phenotype of CTNNB1-mutated HCC tumors.
JOURNAL OF HEPATOLOGY
(2021)
Article
Environmental Sciences
Ahmed G. Abd Elhameed, Manar G. Helal, Eman Said, Hatem A. Salem
Summary: The study demonstrated that saxagliptin can delay experimentally-induced hepatocellular carcinoma progression by improving liver function biomarkers and acting through the suppression of specific signaling pathways, enhancing tumor apoptosis, and suppressing proliferation.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Cell Biology
Shi Wei, Miaomiao Dai, Chi Zhang, Kai Teng, Fengwei Wang, Hongbo Li, Weipeng Sun, Zihao Feng, Tiebang Kang, Xinyuan Guan, Ruihua Xu, Muyan Cai, Dan Xie
Summary: This study showed that KIF2C is significantly upregulated in HCC and associated with poor prognosis. Functional assays revealed that KIF2C promotes HCC cell proliferation, migration, invasion, and metastasis. Mechanistically, the study identified TBC1D7 as a binding partner of KIF2C, disrupting TSC complex formation and enhancing mTORC1 signaling.
Article
Cell Biology
Qingping Song, Hui Liu, Chengyan Li, Haifeng Liang
Summary: MiR-33a-5p and DKK1 play important roles in the development of EC, and their downregulation is negatively correlated with tumor progression, making them potential therapeutic targets for EC.
Article
Oncology
Anabel Zwick, Katrin Thieser, Viktoria Wagner, Nicole Ludwig, Oybek Khalmurzaev, Philine Loertzer, Alexey Pryalukhin, Arndt Hartmann, Carol-Immanuel Geppert, Hagen Loertzer, Heiko Wunderlich, Holger Kalthoff, Kerstin Junker, Sigrum Smola, Stefan Lohse, Isabelle Ariane Bley, Muriel Charlotte Hans, Vsevolod Borisovich Matveev, Carsten Maik Naumann
Summary: This study investigated the impact of high-risk HPV16 oncogenes on the Wnt pathway and found that HPV-positive PeCa cells express Wnt target and stemness-associated genes. However, the Wnt signaling is inhibited due to the endogenous expression of the antagonist DKK1. The study also revealed a potential link between DKK1, HPV-positivity, and metastatic disease progression in PeCa.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Liang-yun Li, Jun-fa Yang, Fan Rong, Zhi-pan Luo, Shuang Hu, Hui Fang, Ying Wu, Rui Yao, Wei-hao Kong, Xiao-wen Feng, Bang-jie Chen, Jun Li, Tao Xu
Summary: ZEB1 plays a crucial role in hepatocellular carcinoma (HCC) by promoting cell proliferation, migration, and invasion through activating the Wnt/β-catenin signaling pathway. Meanwhile, miR-708 inhibits the growth and metastasis of HCC cells by targeting ZEB1.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Oncology
Elisavet Lioulia, Panagiotis Mokos, Emmanuel Panteris, Dimitra Dafou
Summary: This study demonstrates the UBE2T/MAPK-ERK/beta-catenin axis as a critical regulator of cell state transition and EMT in HCC.
MOLECULAR ONCOLOGY
(2022)
Article
Environmental Sciences
Rong Li, Runze Shang, Shunle Li, Yifan Ren, Lin Shen, Longbao Yang, Shuo Chen, Xi Chen, Junhui Li, Meng Xu
Summary: The study found that high expression of LOXL3 in HCC was significantly correlated with tumor size and clinical stage, predicting a poor prognosis. Experimental results demonstrated that LOXL3 promoted HCC EMT process through the Snail1/USP4-mediated circulation loop and Wnt/β-catenin signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Oncology
Kosuke Iguchi, Ryota Sada, Shinji Matsumoto, Hirokazu Kimura, Yoh Zen, Masayuki Akita, Hidetoshi Gon, Takumi Fukumoto, Akira Kikuchi
Summary: This study comprehensively examined the relationship between cytoskeleton-associated membrane protein 4 (CKAP4) and Dickkopf-1 (DKK1) in hepatocellular carcinoma (HCC). The results showed that simultaneous expression of DKK1 and CKAP4 in HCC patients was associated with a poor prognosis, and deletion of either protein inhibited HCC cell growth. Anti-CKAP4 antibody showed inhibitory effects on HCC growth, and its effectiveness was enhanced when combined with lenvatinib, a multikinase inhibitor. Thus, the combination of anti-CKAP4 antibody and lenvatinib could be a promising strategy for treating advanced HCC.
Article
Biology
Marion Rosello, Juliette Vougny, Francois Czarny, Marina C. Mione, Jean-Paul Concordet, Shahad Albadri, Filippo Del Bene
Summary: Researchers have successfully generated precise point mutations in zebrafish models using gene editing technology, mimicking oncogenic mutations in human genes and creating new disease models.
Article
Oncology
Bo Hu, Hong Li, Wei Guo, Yun-Fan Sun, Xin Zhang, Wei-Guo Tang, Liu-Xiao Yang, Yang Xu, Xiao-Yan Tang, Guo-Hui Ding, Shuang-Jian Qiu, Jian Zhou, Yi-Xue Li, Jia Fan, Xin-Rong Yang
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Oncology
Yun-Fan Sun, Peng-Xiang Wang, Jian-Wen Cheng, Zi-Jun Gong, Ao Huang, Kai-Qian Zhou, Bo Hu, Ping-Ting Gao, Ya Cao, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Wei Guo, Xin-Rong Yang
CANCER CYTOPATHOLOGY
(2020)
Article
Cell Biology
Fei Song, Bo Hu, Jian-Wen Cheng, Yun-Fan Sun, Kai-Qian Zhou, Peng-Xiang Wang, Wei Guo, Jian Zhou, Jia Fan, Zhong Chen, Xin-Rong Yang
CELL DEATH & DISEASE
(2020)
Article
Oncology
Peng-Xiang Wang, Yun-Fan Sun, Kai-Qian Zhou, Jian-Wen Cheng, Bo Hu, Wei Guo, Yue Yin, Jun-Feng Huang, Jian Zhou, Jia Fan, Tan To Cheung, Xu-Dong Qu, Xin-Rong Yang
CLINICAL AND TRANSLATIONAL MEDICINE
(2020)
Article
Cell Biology
Wen-Jing Yang, Yun-Fan Sun, An-Li Jin, Li-Hua Lv, Jie Zhu, Bei-Li Wang, Yan Zhou, Chun-Yan Zhang, Hao Wang, Bo Hu, Peng-Xiang Wang, Liu Te, Bai-Shen Pan, Jian Zhou, Jia Fan, Xin-Rong Yang, Wei Guo
CELL DEATH & DISEASE
(2020)
Article
Medical Laboratory Technology
Xiao-Lu Ma, Xu-Dong Qu, Wen-Jing Yang, Bei-Li Wang, Min-Na Shen, Yan Zhou, Chun-Yan Zhang, Yun-Fan Sun, Jian-Wen Chen, Bo Hu, Zi-Jun Gong, Xin Zhang, Bai-Shen Pan, Jian Zhou, Jia Fan, Xin-Rong Yang, Wei Guo
CLINICA CHIMICA ACTA
(2020)
Article
Gastroenterology & Hepatology
Peng-Xiang Wang, Yang Xu, Yun-Fan Sun, Jian-Wen Cheng, Kai-Qian Zhou, Sui-Yi Wu, Bo Hu, Ze-Fan Zhang, Wei Guo, Ya Cao, Xiao-Wu Huang, Jian Zhou, Jia Fan, Xin-Rong Yang
Summary: This study investigated the value of circulating tumor cells (CTCs) as predictors of tumor recurrence following liver transplantation (LTx) in hepatocellular carcinoma (HCC) patients. Results showed that post-operative CTC count >= 1 per 5 mL blood could be a potential biomarker for predicting tumor recurrence, especially in patients with no detectable CTCs before LTx and negative tumor serological markers. Moreover, post-operative serial CTC detection may be useful in post-surgical surveillance for HCC recurrence.
LIVER INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Kai-Qian Zhou, Yun-Fan Sun, Jian-Wen Cheng, Min Du, Yuan Ji, Peng-Xiang Wang, Bo Hu, Wei Guo, Yang Gao, Yue Yin, Jun-Feng Huang, Jian Zhou, Jia Fan, Xin-Rong Yang
Article
Cell Biology
Xiaoxiu Tan, Linfeng Xu, Xingxing Jian, Jian Ouyang, Bo Hu, Xinrong Yang, Tao Wang, Lu Xie
Summary: The development of a neoantigen-based personalized vaccine shows potential in cancer immunotherapy. Researchers have developed a pipeline called PGNneo, which can accurately identify neoantigens derived from the noncoding region of the human genome. This tool provides additional immune targets for cancer types with a low tumor mutational burden in coding regions.
Review
Biotechnology & Applied Microbiology
Biaoyang Lin, Yingying Ma, ShengJun Wu
Summary: Chronic liver disease (CLD) is a global health burden, and there is a need for improved biomarkers, diagnostic methods, and the integration of multi-omics data with the help of artificial intelligence. This review summarizes the emerging frontiers and challenges in multi-omics data integration in liver pathology research, as well as the impact of digital transformation in this field.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Biaoyang Lin, Shengjun Wu
Summary: Digital transformation is revolutionizing personalized medicine and systems science by enabling real-time patient feedback and in-depth phenotypic analysis with advanced technologies like artificial intelligence and the Internet of Medical Things.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ao Huang, Xin-Rong Yang, Wen-Yuan Chung, Ashley R. Dennison, Jian Zhou
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2020)
Review
Biotechnology & Applied Microbiology
Biaoyang Lin, Yingying Ma, Shengjun Wu, Yunhua Liu, Longgen Liu, Lihua Wu
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Jie Liu, Ruifang Mao, Guoping Ren, Xiaoyan Liu, Yanling Zhang, Jili Wang, Yan Wang, Meiling Li, Qingchong Qiu, Lin Wang, Guanfeng Liu, Shanshan Jin, Liang Ma, Yingying Ma, Na Zhao, Jiajun Yan, Hongwei Zhang, Biaoyang Lin
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2019)
Letter
Biotechnology & Applied Microbiology
Biaoyang Lin
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2019)