Article
Biochemistry & Molecular Biology
Hayden Waller, Thomas Blankers, Mingzi Xu, Kerry L. Shaw
Summary: Sexual signalling traits and their associated genetic components are crucial for the speciation process. However, our understanding of the genetic basis of variable sexual signalling traits linked to speciation is limited. This study provides new genetic evidence of Quantitative Trait Loci (QTL) underlying divergent sexual signalling behaviour in Hawaiian crickets. By sequencing RNA in the brain and central nervous system, candidate genes associated with pulse rate are identified, shedding light on the genetic processes driving reproductive isolation and species diversity.
INSECT MOLECULAR BIOLOGY
(2023)
Article
Plant Sciences
Qing Meng, Zhiyuan Liu, Chunda Feng, Helong Zhang, Zhaosheng Xu, Xiaowu Wang, Jian Wu, Hongbing She, Wei Qian
Summary: In this study, a major quantitative trait locus (QTL) related to early bolting in spinach was identified, and two candidate genes associated with flowering regulatory pathways were proposed. This research provides a basis for understanding the molecular mechanisms of bolting in spinach.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Elham Kharazmi, Dominique Scherer, Felix Boekstegers, Qunfeng Liang, Kristina Sundquist, Jan Sundquist, Mahdi Fallah, Justo Lorenzo Bermejo
Summary: This study found an association between gallstones and an increased risk of kidney cancer after cholecystectomy. The risk of cancer was highest within 6 months after the surgery. The study emphasizes the importance of screening for kidney cancer before and after gallbladder removal.
Article
Genetics & Heredity
Juying Han, Brian Ritchey, Emmanuel Opoku, Jonathan D. Smith
Summary: Through the study of congenic strains, three atherosclerosis modifier gene regions named Ath28.1, Ath28.2, and Ath28.3 were successfully identified at the distal end of chromosome 2 in mice. The research suggests that even within a relatively small region of the mouse genome, there are multiple genes that influence susceptibility to atherosclerosis.
Article
Agronomy
Cheolwoo Park, Dequan Liu, Qingyu Wang, Donghe Xu
Summary: A RIL population was cultivated in field conditions for 3 years to identify QTLs and their candidate genes controlling the tocopherol synthesis pathway using a genetic map with 1624 DNA markers. 22 QTLs for seed tocopherol contents and their ratios were identified, with two QTL clusters on Chr 9 and 14 having consistent large effects on tocopherol composition across the 3 years. The QTL cluster on Chr 9 might correspond to gamma-TMT3, which controls the conversion of gamma-Toc into alpha-Toc, while the QTL cluster on Chr 14 could regulate the conversion of MPBQ into DMPBQ.
Article
Biochemical Research Methods
Chen Lyu, Manyan Huang, Nianjun Liu, Zhongxue Chen, Philip J. Lupo, Benjamin Tycko, John S. Witte, Charlotte A. Hobbs, Ming Li
Summary: The proposed Methylation Random Field (MRF) method offers advantages in detecting Methylation Quantitative Trait Loci (mQTLs) by utilizing a beta distribution and considering multiple common and rare genetic variants. Through simulations and application to a study on congenital heart defects, the MRF demonstrated improved power in detecting rare variants, especially with small sample sizes. This tool is useful for identifying novel mQTLs, particularly in studies with limited sample sizes.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Plant Sciences
Sanjeev Kumar Dhungana, Ji-Hee Park, Jae-Hyeon Oh, Beom-Kyu Kang, Jeong-Hyun Seo, Jung-Sook Sung, Hong-Sik Kim, Sang-Ouk Shin, In-Youl Baek, Chan-Sik Jung
Summary: This study identified 10 QTLs for drought tolerance in soybean using a recombinant inbred line population developed from a cross between a drought-tolerant and a susceptible cultivar. The QTLs were found on seven chromosomes, with some overlapping or located close to previously reported related QTLs and/or potential candidate genes. These QTLs and closely linked markers could be used in marker-assisted selection to accelerate breeding for drought tolerance in soybean.
Article
Genetics & Heredity
Chaeyoung Lee
Summary: This paper discusses the importance and challenges of discovering expression quantitative trait loci (eQTLs), focusing on the complexity of eTraits and the voluminous work required for eQTL profiles. It presents the properties and prospects of statistical methods, including the mixed model method, Bayesian inference, deep learning, and integration methods, as future directions for eQTL discovery.
Article
Plant Sciences
Bin Yang, Nan Chen, Yifei Dang, Yuzhi Wang, Hongwei Wen, Jun Zheng, Xingwei Zheng, Jiajia Zhao, Jinxiu Lu, Ling Qiao
Summary: This study investigated the changes in chlorophyll content in wheat flag leaves under different phosphorus conditions and identified 157 QTLs associated with this trait. Six major QTLs were detected under multiple phosphorus conditions, and two novel major QTLs were discovered. Additionally, SNP markers closely linked to these QTLs were validated.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Fisheries
Lei Wang, Lan Zhang, Yuhan Chen, Junping Chen, Meng Zhang, Miao Yu, Hongxia Jiang, Zhigang Qiao, Xuejun Li
Summary: This study explores the genetic regulation mechanism of overwintering growth in Yellow River carp, identifying growth-related QTLs and candidate genes associated with biological activities. These findings provide valuable references for breeding and genetic selection of Yellow River carp.
Article
Plant Sciences
Ling Qiao, Justin Wheeler, Rui Wang, Kyle Isham, Natalie Klassen, Weidong Zhao, Meng Su, Junli Zhang, Jun Zheng, Jianli Chen
Summary: This study conducted multiple field trials in Southeast Idaho, United States, to identify three major QTL regions associated with Cd content in wheat grain and proposed TaHMA2 gene as a candidate gene for grain Cd content in wheat.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Agronomy
Toshiyuki Takai, Mitsukazu Sakata, Njato M. Rakotoarisoa, Ny Toky Razafinarivo, Tomohiro Nishigaki, Hidetoshi Asai, Takuma Ishizaki, Yasuhiro Tsujimoto
Summary: The study demonstrates that the MP3 genetic locus can increase the number of panicles, spikelets, and grain yield in nutrient-poor soils, offering a potential genetic resource for improving rice yields in the SSA region.
Article
Plant Sciences
Pao Xue, Yu-yu Chen, Xiao-xia Wen, Bei-fang Wang, Qin-qin Yang, Ke Gong, Yi-wei Kang, Lian-ping Sun, Ping Yu, Li-yong Cao, Ying-xin Zhang, Xiao-deng Zhan, Shi-hua Cheng
Summary: This study focused on small-effect quantitative trait loci (QTLs) related to grain size in rice. By developing residual heterozygous populations and conducting genotyping and phenotyping, two genetically linked small-effect QTLs (qGS7.1 and qTGW7.2b) were mapped and candidate genes were identified. The study also revealed the impact of these QTLs on cell expansion, leading to changes in grain width. In addition, a QTL (qTGW7.2b) was identified to significantly affect grain length and width, but had little effect on grain weight.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Xiaolei Wang, Lingfeng Li, Xiaotang Sun, Jie Xu, Linjuan Ouyang, Jianmin Bian, Xiaorong Chen, Weixing Li, Xiaosong Peng, Lifang Hu, Yicong Cai, Dahu Zhou, Xiaopeng He, Junru Fu, Haihui Fu, Haohua He, Changlan Zhu
Summary: The study detected quantitative trait loci (QTLs) for panicle apical abortion (PAA) in rice using chromosome segment substitution lines (CSSLs), identifying a novel major effector QTL, qPAA7. The research provides a foundation for further cloning and functional characterization of the target gene from this locus.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kunjiang Yu, Yuqi He, Yuanhong Li, Zhenhua Li, Jiefu Zhang, Xiaodong Wang, Entang Tian
Summary: This study used a population of recombined inbred lines of Brassica napus to investigate the genetics of seed germination, uncovering a novel major QTL regulating germination. Transcriptome analysis revealed differences in metabolic pathways such as sugar, protein, lipid, and amino acid metabolism between the high germination rate variety 'Holly' and other varieties.
Article
Biochemistry & Molecular Biology
Cornelia Then, Christian Herder, Barbara Thorand, Chaterina Sujana, Margit Heier, Christa Meisinger, Annette Peters, Wolfgang Koenig, Wolfgang Rathmann, Michael Roden, Michael Stumvoll, Haifa Maalmi, Holger Then, Uta Ferrari, Juergen Scherberich, Jochen Seissler
Summary: This study found that serum uromodulin is inversely associated with pro-inflammatory adipokines chemerin and retinol-binding protein-4. The association is stronger in participants with type 2 diabetes, but the association of uromodulin with type 2 diabetes is independent of chemerin and retinol-binding protein-4.
Editorial Material
Endocrinology & Metabolism
Haiko Schloegl, Michael Stumvoll
Review
Endocrinology & Metabolism
Rima Chakaroun, Lucas Massier, Niculina Musat, Peter Kovacs
Summary: Despite the ongoing debate, recent studies have shown that under strict contamination-free conditions, various methods combined with advanced bioinformatics tools can detect and quantify bacteria and bacterial DNA in human tissues. Changes in bacterial load and composition in the blood have been associated with several disease states, potentially contributing to systemic inflammation in cardiometabolic disease. This review explores the clinical relevance of a blood bacterial signature to cardiometabolic diseases and proposes strategies for future research and application, considering the challenges posed by low bacterial biomass.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2022)
Article
Medicine, General & Internal
Hila Zelicha, Nora Kloting, Alon Kaplan, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Yoash Chassidim, Matthias Bluher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Rita Nana Quayson, Martin von Bergen, Beatrice Engelmann, Ulrike E. Rolle-Kampczyk, Sven-Bastiaan Haange, Kieran M. Tuohy, Camilla Diotallevi, Ilan Shelef, Frank B. Hu, Meir J. Stampfer, Iris Shai
Summary: Through an 18-month study, it was found that a green-MED diet, enriched with plant-based polyphenols and lower in red meat intake, may be a potent intervention to promote visceral adipose tissue regression.
Article
Biochemistry & Molecular Biology
Anja Saalbach, Ulf Anderegg, Ralph Wendt, Joachim Beige, Anette Bachmann, Nora Kloeting, Matthias Blueher, Ming-Zhi Zhang, Raymond C. Harris, Michael Stumvoll, Anke Toenjes, Thomas Ebert
Summary: Kidney fibrosis, a major factor in chronic kidney disease (CKD), leads to irreversible organ function loss. This study investigated the association of the soluble form of Thymocyte differentiation antigen-1 (sThy-1) with clinical parameters in CKD patients receiving hemodialysis. The study also examined Thy-1 tissue expression in a mouse model of diabetic CKD. The results showed that sThy-1 levels increased with worsening renal function, regardless of the presence of diabetes. Serum creatinine was found to be a major predictor of sThy-1 levels. Additionally, sThy-1 was found to be an independent predictor of markers of renal function. The study suggests that Thy-1 may have a role in controlling kidney fibrosis and could potentially be used as a renal antifibrotic factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Janine Molder, Esther Guiu-Jurado, Yusef Moulla, Christine Stroh, Arne Dietrich, Michael R. Schoen, Daniel Gaertner, Tobias Lohmann, Miriam Dressler, Michael Stumvoll, Peter Kovacs, Matthias Blueher, Nora Kloeting
Summary: This study aimed to investigate the influence of SNP rs10487505 on leptin mRNA expression and obesity-related parameters. The researchers found that rs10487505 is associated with lower leptin levels in women and a lower mean BMI in women carrying the C allele. However, no association was found between rs10487505 and leptin mRNA expression in adipose tissue.
Article
Endocrinology & Metabolism
Noa Ofir, Yuval Mizrakli, Yariv Greenshpan, Yftach Gepner, Omri Sharabi, Gal Tsaban, Hila Zelicha, Anat Yaskolka Meir, Uta Ceglarek, Michael Stumvoll, Matthias Blueher, Yoash Chassidim, Assaf Rudich, Anat Reiner-Benaim, Iris Shai, Ilan Shelef, Roi Gazit
Summary: In this study, the researchers found that long-term weight loss can temporarily reduce bone marrow adipose tissue (BMAT) in adults, with more prominent effects in younger adults. The storage and dynamics of BMAT are largely independent of other fat depots or cardio-metabolic risk markers, highlighting its unique functions.
Review
Medicine, General & Internal
Lara Heuft, Jenny Voigt, Lars Selig, Michael Stumvoll, Haiko Schloegl, Thorsten Kaiser
Summary: This study investigates the role of clinical decision support systems (CDSS) in the diagnosis of refeeding syndrome (RFS) and highlights the importance of identifying high-risk patients. The literature review reveals that malnourished patients with RFS have higher mortality rates and an increased risk of ICU admission compared to those without RFS. The use of CDSS significantly improves the detection and diagnosis of RFS.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Inka Rapoehn, Ivet Elias, Juliane Weiner, Anna Pujol, Stephanie Kehr, Alexandra Chadt, Hadi Al-Hasani, Ralph Burkhardt, Nora Kloeting, Michael Stumvoll, Fatima Bosch, Peter Kovacs, John T. Heiker, Jana Breitfeld
Summary: Adipose tissue inflammation and insulin resistance are important factors in the development of metabolic diseases resulting from overweight and obesity. The serpin vaspin has compensatory roles in inflammation and insulin resistance. A new transgenic mouse line with human vaspin expression in adipose tissue has been developed, which showed improved metabolic parameters and increased energy expenditure under high-fat diet conditions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Marleen Wuerfel, Matthias Blueher, Michael Stumvoll, Thomas Ebert, Peter Kovacs, Anke Toenjes, Jana Breitfeld
Summary: Adipokines play a crucial role in the development of obesity and its associated metabolic and cardiovascular complications. While some adipokines have been identified and studied, many regulatory mechanisms remain unclear, hindering their clinical application. However, due to their complex metabolic properties, adipokines hold great potential as biomarkers and treatment strategies for obesity and related disorders. This review summarizes current clinical studies on adipokines and their potential diagnostic and therapeutic use in obesity and metabolic disorders, highlighting the promising clinical application of fibroblast growth factors (FGF)-19, FGF-21, and leptin.
Article
Health Care Sciences & Services
Maximiliane Chiara Hammel, Robert Stein, Juergen Kratzsch, Mandy Vogel, Alexander J. Eckert, Rima Destya Triatin, Marco Colombo, Christof Meigen, Ronny Baber, Juraj Stanik, Ulrike Spielau, Anette Stoltze, Kerstin Wirkner, Anke Toenjes, Harold Snieder, Reinhard W. Holl, Michael Stumvoll, Matthias Blueher, Wieland Kiess, Antje Koerner
Summary: The study aimed to establish reference ranges for fasting insulin indices across all age ranges and evaluate their clinical application in predicting glycemic deterioration in children. The results showed that insulin resistance in children with obesity doubled the risk for future glycemic deterioration, and insulin-based indices were better predictors of dysglycemia than fasting glucose alone.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Medicine, General & Internal
Anat Yaskolka Meir, Maria Keller, Anne Hoffmann, Ehud Rinott, Gal Tsaban, Alon Kaplan, Hila Zelicha, Tobias Hagemann, Uta Ceglarek, Berend Isermann, Ilan Shelef, Matthias Blueher, Michael Stumvoll, Jun Li, Sven-Bastian Haange, Beatrice Engelmann, Ulrike Rolle-Kampczyk, Martin von Bergen, Frank B. Hu, Meir J. Stampfer, Peter Kovacs, Liming Liang, Iris Shai
Summary: This study found that Mediterranean and green-MED diets with increased polyphenols intake are inversely associated with biological aging. To the best of our knowledge, this is the first clinical trial to indicate a potential link between polyphenol intake, urine polyphenols, and biological aging.
Article
Gastroenterology & Hepatology
Evelyn Medawar, Frauke Beyer, Ronja Thieleking, Sven-Bastiaan Haange, Ulrike Rolle-Kampczyk, Madlen Reinicke, Rima Chakaroun, Martin von Bergen, Michael Stumvoll, Arno Villringer, A. Veronica Witte
Summary: This study investigated the effects of high-dosed prebiotic fiber on reward-related food decision-making in overweight young adults. The results showed that prebiotic intake decreased brain activation towards high-caloric food stimuli and caused shifts in gut microbiota.
Article
Endocrinology & Metabolism
Jana Breitfeld, Katrin Horn, Diana Le Duc, Akhil Velluva, Carola Marzi, Harald Grallert, Nele Friedrich, Maik Pietzner, Uwe Voelker, Henry Voelzke, Emma Ahlqvist, Dina Mansour Aly, Tiinamaija Tuomi, Ronny Baber, Juergen Kratzsch, Joachim Thiery, Berend Isermann, Markus Loeffler, Nora Kloeting, Matthias Blueher, Michael Stumvoll, John T. Heiker, Anke Toenjes, Markus Scholz, Peter Kovacs
Summary: This study found a correlation between genetic variants of the Vaspin gene and serum Vaspin levels, and further revealed the causal role of Vaspin in lipid metabolism.
Meeting Abstract
Ophthalmology
Yan Luo, Franziska G. Rauscher, Tobias Elze, Yu Tian, Min Shi, Saber Kazeminasab Hashemabad, Mohammad Eslami, Kerstin Wirkner, Thomas Peschel, Michael Stumvoll, Berend Isermann, Matthias Blueher, Markus Loeffler, Toralf Kirsten, Thomas Ebert, Mengyu Wang
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)