Article
Multidisciplinary Sciences
An Goto, Raul Rodriguez-Esteban, Sebastian H. Scharf, Garrett M. Morris
Summary: Drug resistance caused by mutations is a significant public health threat. This study provides a comprehensive perspective on Hepatitis B virus mutations by combining clinical research and genetic data from scientific literature, identifying mutational hotspots and a common mutation position related to anti-HBV drug binding.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Hao Wang, Fenfang Liao, Junmo Xie, Wenbo Gao, Min Wang, Jieting Huang, Ru Xu, Qiao Liao, Zhengang Shan, Yourong Zheng, Xia Rong, Chengyao Li, Yongshui Fu
Summary: The study revealed that E2G/A/V/D mutations significantly influence the detection of HBsAg, with different underlying mechanisms for OBI caused by E2 mutations in genotype B and genotype C. Additionally, E2G/A mutations may result in a N-terminal truncated S protein, contributing to HBsAg secretion impairment in OBI.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Oncology
Yonghuan Yu, Xinfeng Cui, Jingjing Zhao, Ting Jia, Baofeng Ren, Xiaoyan Zhang
Summary: The combination of entecavir and adefovir dipivoxil in the treatment of hepatitis B cirrhosis can significantly improve the therapeutic effect, reduce serum inflammatory factor levels, and has high safety, which is worthy of promotion and application.
JOURNAL OF ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Zhihong Liu, Qinglong Jin, Yuexin Zhang, Guozhong Gong, Guicheng Wu, Lvfeng Yao, Xiaofeng Wen, Zhiliang Gao, Yan Huang, Daokun Yang, Enqiang Chen, Qing Mao, Shide Lin, Jia Shang, Huanyu Gong, Lihua Zhong, Huafa Yin, Fengmei Wang, Peng Hu, Ling Xiao, Chuan Li, Qiong Wu, Chang'an Sun, Junqi Niu, Jinlin Hou
Summary: This study compared the efficacy and safety of TMF and TDF in patients with chronic hepatitis B for 48 weeks. Results showed that TMF was non-inferior to TDF in terms of anti-HBV efficacy and demonstrated better bone and renal safety after 48 weeks of treatment.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Man-Fung Yuen, Stephen Locarnini, Tien Huey Lim, Simone Strasser, William Sievert, Wendy Cheng, Alex J. Thompson, Bruce D. Given, Thomas Schluep, James Hamilton, Michael Biermer, Ronald Kalmeijer, Maria Beumont, Oliver Lenz, Filip De Ridder, Gavin Cloherty, Danny Ka-Ho Wong, Christian Schwabe, Kathy Jackson, Ching Lung Lai, Robert G. Gish, Edward Gane
Summary: This study assessed the safety and efficacy of JNJ-3989 in combination with nucleos(t)ide analogues for the treatment of patients with chronic hepatitis B. The results demonstrated that JNJ-3989 treatment reduced HBsAg levels in patients and sustained the reduction even 336 days after cessation of treatment.
JOURNAL OF HEPATOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Hui Dong, Yongqiang Zhu, Yan Shen, Shaoqing Xie, Yungang He, Lungen Lu
Summary: The study found a high prevalence of tryptophan-truncated S quasispecies and drug-resistant RT mutants in treatment-naive patients with chronic hepatitis B, providing new insights into the composition of the HBV population and potential optimization of treatment and management for these patients.
JOURNAL OF GENERAL VIROLOGY
(2021)
Article
Chemistry, Medicinal
Thane Jones, John E. Tavis, Qilan Li, Olga Riabova, Natalia Monakhova, Daniel P. Bradley, Thomas R. Lane, Vadim Makarov, Sean Ekins
Summary: Hepatitis B virus (HBV) is a hepatotropic DNA virus that chronically infects over 296 million people worldwide and causes a significant number of deaths annually. Current therapies for HBV are not able to eradicate the virus completely, so there is a need for additional antiviral drugs. In a preliminary screening, a compound called 11826096 showed promising antiviral activity against HBV. The mechanism of action is unknown, but it may be related to activities involved in RNA accumulation, translation, capsid assembly, and/or capsid stability. Machine learning models were not able to predict the activity of these compounds due to their novelty.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Thane Jones, John E. Tavis, Qilan Li, Olga Riabova, Natalia Monakhova, Daniel P. Bradley, Thomas R. Lane, Vadim Makarov, Sean Ekins
Summary: Hepatitis B virus (HBV) is a hepatotropic DNA virus that infects a large number of people worldwide and causes significant mortality. Current therapies are insufficient in eradicating the virus, and a new antiviral drug is needed. A preliminary screen of dispirotripiperazines identified a potential lead compound with potent activity against HBV. The mechanism of action is unclear, but preliminary assays suggest possible targets related to RNA accumulation, translation, capsid assembly, and/or capsid stability. Machine learning models were not able to predict the activity of these novel compounds due to their uniqueness outside of the model's applicability domain.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Hailing Liu, Yi Tian, Danjie Shen, Wei Chen
Summary: In patients with hepatitis B cirrhosis, entecavir has shown to be more effective compared to adefovir dipivoxil, with higher rates of HBV-DNA negative conversion and HBeAg negative conversion. Additionally, entecavir led to better improvements in life quality, hepatic fibrosis, and inflammation compared to adefovir dipivoxil.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Min Li, Qinghong Li, Jianhui Qu, Huiyin Yang, Tingting Lv, Yuanyuan Kong, Hongfei Zhang
Summary: Combination therapy with interferon (IFN) and nucleos(t)ide analogs (NAs) is more effective than IFN monotherapy for children with chronic hepatitis B (CHB), resulting in improved viral suppression and serological response. However, further studies are needed to evaluate the efficacy of this combination therapy compared to NAs monotherapy.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Machiko Umemura, Koji Ogawa, Kenichi Morikawa, Akinori Kubo, Yoshimasa Tokuchi, Ren Yamada, Takashi Kitagataya, Taku Shigesawa, Tomoe Shimazaki, Megumi Kimura, Kazuharu Suzuki, Akihisa Nakamura, Masatsugu Ohara, Naoki Kawagishi, Takaaki Izumi, Masato Nakai, Takuya Sho, Goki Suda, Mitsuteru Natsuizaka, Kota Ono, Kazumoto Murata, Masaya Sugiyama, Masashi Mizokami, Naoya Sakamoto
Summary: This study investigated the effects of nucleos(t)ide analogs (NAs) on hepatitis B surface antigen (HBsAg) reduction and interferon-lambda3 (IFN-lambda 3) induction in chronic hepatitis B (CHB) patients. The results showed that nucleotide analog (ADV/TDF) treatment reduced HBsAg levels greater compared with nucleoside analog (ETV) in parallel with IFN-lambda 3 induction.
HEPATOLOGY RESEARCH
(2022)
Article
Virology
Yandi Xie, Hui Ma, Bo Feng, Guangjun Song
Summary: By analyzing the follow-up data of chronic hepatitis B patients, this study found that changes in serum HBsAg and HBcrAg levels, as well as specific gene mutations, were associated with spontaneous HBeAg seroconversion.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Medicine, General & Internal
Quirino Lai, Gianluca Mennini, Francesco Giovanardi, Massimo Rossi, Edoardo G. Giannini
Summary: Prophylaxis with HBIG is effective in preventing post-LT HBV recurrence, and its combination with NUC provides the best protection. Further studies on high genetic barrier-to-recurrence NUC and protocols with definitive use of HBIG are needed to optimize prophylactic strategies.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Gastroenterology & Hepatology
Marc G. Ghany, Wendy C. King, Amanda S. Hinerman, Anna SF. Lok, Mauricio Lisker-Melman, Raymond T. Chung, Norah Terrault, Harry L. A. Janssen, Mandana Khalili, William M. Lee, Daryl T. Y. Lau, Gavin A. Cloherty, Richard K. Sterling
Summary: This study examined the predictive ability of HBV RNA and HBcrAg for patients with chronic hepatitis B (CHB) and found that they could predict key events such as not sustained inactive carrier phase, ALT flare, HBeAg loss, and HBsAg loss. However, their addition to readily available markers provided only small improvements in predictive ability.
Article
Pharmacology & Pharmacy
Hongcan Liu, Zemin Wan, Lanhui She, Yajuan Zhu, Zhiliang Cai, Bin Wu, Qizhen Zhuang, Peifeng Ke, Xinzhong Wu, Zhuo Li, Xianzhang Huang
Summary: The emergence of the tyrosine-methionine-aspartate-aspartate (YMDD) motif in reverse transcriptase is a serious problem in chronic hepatitis B (CHB) patients after Lamivudine (LAM) therapy. However, the relationship between inflammation pharmacological reaction and YMDD mutational patterns of CHB has not been well-characterized. The prevalence of different YMDD mutation patterns and their impact on biochemical and virological factors were investigated in this study, with implications for future therapy strategies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Martin C. S. Wong, Rungsun Rerknimitr, Khean Lee Goh, Takahisa Matsuda, Hyun-Soo Kim, Deng-Chyang Wu, Kai Chun Wu, Khay Guan Yeoh, Vui Heng Chong, Furqaan Ahmed, Jose D. Sollano, Jayaram Menon, Han-Mo Chiu, Jingnan Li, Jessica Y. L. Ching, Joseph J. Y. Sung
Summary: A scoring system was developed and validated to identify individuals at risk for APN. Participants with a score of 4 points or higher should undergo colonoscopy evaluation after undergoing flexible sigmoidoscopy screening.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Ouis H. S. Lau, Joseph J. Y. Sung
Summary: Advancements in endoscopic therapy, especially with the introduction of artificial intelligence-assisted machine learning models, have significantly improved the clinical outcomes of upper gastrointestinal bleeding. Novel endoscopic modalities not only enhance treatment success rates but also improve patient prognosis. Techniques such as over-the-scope clips and hemostatic powder are widely utilized in the management of refractory cases in clinical practice.
DIGESTIVE ENDOSCOPY
(2021)
Editorial Material
Gastroenterology & Hepatology
Joseph Sung
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Jessie Qiaoyi Liang, Sunny H. Wong, Chun Ho Szeto, Eagle S. H. Chu, Harry C. Lau, Yingxuan Chen, Jingyuan Fang, Jun Yu, Joseph J. Y. Sung
Summary: This study examined the application of microbial DNA markers in diagnosing colorectal cancer and adenoma compared to fecal immunochemical test (FIT). The results showed that microbial markers were more sensitive for detecting CRC and AA in asymptomatic subjects, but with lower specificity, while combining with FIT improved sensitivity for diagnosis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Immunology
Xuezhen Zeng, Jingying Zhou, Zhewen Xiong, Hanyong Sun, Weiqin Yang, Myth T. S. Mok, Jing Wang, Jingqing Li, Man Liu, Wenshu Tang, Yu Feng, Hector Kwong-Sang Wang, Shun-Wa Tsang, King-Lau Chow, Philip Chun Yeung, John Wong, Paul Bo-San Lai, Anthony Wing-Hung Chan, Ka Fai To, Stephen Lam Chan, Qiang Xia, Jing Xue, Xiao Chen, Jun Yu, Sui Peng, Joseph Jao-Yiu Sung, Ming Kuang, Alfred Sze-Lok Cheng
Summary: This study demonstrates that aberrantly activated CCRK signaling in chronic liver diseases can reprogram the immunosuppressive microenvironment to promote cancer metastasis to the liver. Overexpression of CCRK increases the metastasis of melanoma and colorectal cancer to the liver, while depletion of these signals reduces the risk of metastasis.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jingwan Zhang, Emily C. Hoedt, Qin Liu, Erwin Berendsen, Jing Jie Teh, Amy Hamilton, Amy Wilson O' Brien, Jessica Y. L. Ching, Hong Wei, Keli Yang, Zhilu Xu, Sunny H. Wong, Joyce W. Y. Mak, Joseph J. Y. Sung, Mark Morrison, Jun Yu, Michael A. Kamm, Siew C. Ng
Summary: Proteus spp, particularly Proteus mirabilis, is significantly more prevalent and abundant in fecal samples and colonic tissue of patients with Crohn's disease compared to healthy controls. The presence of P mirabilis is associated with an increase in pro-inflammatory pathways and cytokine production, leading to inflammation in cells and animal models of colitis. These findings suggest that P mirabilis may act as a pathobiont and play a crucial role in the pathogenesis of Crohn's disease.
Article
Gastroenterology & Hepatology
Yang Sun, Tao Zuo, Chun Pan Cheung, Wenxi Gu, Yating Wan, Fen Zhang, Nan Chen, Hui Zhan, Yun Kit Yeoh, Junkun Niu, Yan Du, Fengrui Zhang, Yunling Wen, Jun Yu, Joseph J. Y. Sung, Paul K. S. Chan, Francis K. L. Chan, Kunhua Wang, Siew C. Ng, Yinglei Miao
Summary: The study revealed significant variability in the human gut mycobiome across populations, with urbanization-related factors having the strongest impact on gut mycobiome variation, followed by geography, dietary habits, and ethnicity. Different fungal species showed differences in abundance and correlations in urban and rural populations.
Article
Gastroenterology & Hepatology
Jyh-Ming Liou, Peter Malfertheiner, Yi-Chia Lee, Bor-Shyang Sheu, Kentaro Sugano, Hsiu-Chi Cheng, Khay-Guan Yeoh, Ping- Hsu, Khean-Lee Goh, Varocha Mahachai, Takuji Gotoda, Wei-Lun Chang, Mei-Jyh Chen, Tsung-Hsien Chiang, Chieh-Chang Chen, Chun-Ying Wu, Alex Hwong-Ruey Leow, Jeng-Yih Wu, Deng-Chyang Wu, Tzu-Chan Hong, Hong Lu, Yoshio Yamaoka, Francis Megraud, Francis K. L. Chan, Joseph J. Y. Sung, Jaw-Town Lin, David Y. Graham, Ming-Shiang Wu, Emad M. El-Omar
Article
Gastroenterology & Hepatology
Thomas Y. T. Lam, Aric J. Hui, Felix Sia, Mei Y. Wong, Casper C. P. Lee, Ka W. Chung, James Y. W. Lau, Peter Wu, Joseph J. Y. Sung
Summary: In patients scheduled for outpatient colonoscopy, the use of SMS reminders was effective in reducing nonattendance rates and potentially improving bowel preparation quality.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Thomas Y. T. Lam, Peter I. Wu, Raymond S. Y. Tang, Arthur K. C. Luk, Simpson Ng, Joseph J. Y. Sung
Summary: Sending text reminders via mobile messengers like WhatsApp can significantly improve longitudinal adherence to FIT-based colorectal cancer screening programs. The routine use of this technology in CRC screening should be considered.
Review
Gastroenterology & Hepatology
Josef M. Penninger, Maria B. Grant, Joseph J. Y. Sung
Summary: Angiotensin converting enzyme 2 plays a role not only in regulating the renin angiotensin system, but also in maintaining amino acid balance in the intestine and stability of the gut microbiome. Research explores the role of angiotensin converting enzyme 2 as the receptor for severe acute respiratory syndrome coronavirus 2, and the impact of coronavirus disease 19 infection on the gut microbiome and gut epithelium.
Article
Gastroenterology & Hepatology
Hao Chen, Joseph J. Y. Sung
Summary: With the advancement of AI technology, AI-image analysis applications in gastroenterology and hepatology show great potential in improving the quality and consistency of patient care. Future research should focus on the promises and challenges of AI in medical image analysis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Rashid N. Lui, Moe H. Kyaw, Thomas Y. T. Lam, Jessica Y. L. Ching, Victor C. W. Chan, Martin C. S. Wong, Joseph J. Y. Sung
Summary: This study reported a prevalence of 1.4% for sessile serrated lesions (SSLs) in a Chinese population, with age ≥ 66 years, smoking, and diabetes mellitus identified as independent risk factors. These findings provide important new data for developing region-specific surveillance programs for SSLs to reduce the risk of colorectal cancer.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Xing Kang, Ru Zhang, Thomas Ny Kwong, Rashid Ns Lui, William Kk Wu, Joseph Jy Sung, Jun Yu, Sunny H. Wong
Summary: Colorectal cancer is a heterogeneous disease with different gene expression patterns, characterized by two major colorectal carcinogenesis pathways: conventional adenoma-carcinoma pathway and alternative serrated neoplasia pathway. Although serrated lesions have malignant potential and unique characteristics, they are often overlooked due to their anatomical location and histological features. Environmental factors, especially the gut microbial composition, play a crucial role in CRC pathogenesis, with potential interactions between microbiota composition and host genetic perturbations in the development of serrated lesions.
Meeting Abstract
Gastroenterology & Hepatology
Jia Yang, Chun Ho Setzo, Geicho Nakatsu, Chuangen Li, Yunfei Zhou, Yufeng Lin, Eagle S. Chu, Harry C. Lau, Olabisi O. Coker, Hong Wei, Joseph J. Sung, Jun Yu