Unfolded protein response in cancer: the Physician's perspective

Mitochondrial and endoplasmic reticulum stress pathways cooperate in zearalenone-induced apoptosis of human leukemic cells

(2011) Ratana Banjerdpongchai et al.   Journal of Hematology & Oncology

Mitochondria regulate the unfolded protein response leading to cancer cell survival under glucose deprivation conditions

(2010) Naomi Haga et al.   CANCER SCIENCE

Untangling the unfolded protein response

(2010) Emma L. Davenport et al.   CELL CYCLE

Unfolded protein response activation contributes to chemoresistance in hepatocellular carcinoma

(2010) Feras Y. Al-Rawashdeh et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans

(2010) Sachie Marubayashi et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase I Pharmacokinetic and Pharmacodynamic Study of 17-dimethylaminoethylamino-17-demethoxygeldanamycin, an Inhibitor of Heat-Shock Protein 90, in Patients With Advanced Solid Tumors

(2010) Ramesh K. Ramanathan et al.   JOURNAL OF CLINICAL ONCOLOGY

The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1

(2010) Saad Z Usmani et al.   Journal of Hematology & Oncology

Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia

(2010) J E Lancet et al.   LEUKEMIA

Biphasic, Bidirectional Regulation of NF-κB by Endoplasmic Reticulum Stress

(2009) Masanori Kitamura   ANTIOXIDANTS & REDOX SIGNALING

Implication of unfolded protein response in resveratrol-induced inhibition of K562 cell proliferation

(2009) Bao-Qin Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma

(2009) D. Chauhan et al.   BLOOD

Activation and clinical significance of the unfolded protein response in breast cancer

(2009) P Scriven et al.   BRITISH JOURNAL OF CANCER

Nitrosative Stress-Induced S-Glutathionylation of Protein Disulfide Isomerase Leads to Activation of the Unfolded Protein Response

(2009) D. M. Townsend et al.   CANCER RESEARCH

Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation

(2009) S. Saito et al.   CANCER RESEARCH

ATF4, an ER Stress and Hypoxia-Inducible Transcription Factor and its Potential Role in Hypoxia Tolerance and Tumorigenesis

(2009) Jiangbin Ye et al.   CURRENT MOLECULAR MEDICINE

The role of X-box binding protein-1 in tumorigenicity

(2009) A.N. Shajahan et al.   DRUG NEWS & PERSPECTIVES

Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies

(2009) Shivaani Kummar et al.   EUROPEAN JOURNAL OF CANCER

Retaspimycin hydrochloride (IPI-504): a novel heat shock protein inhibitor as an anticancer agent

(2009) Britt Erika Hanson et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Mechanism and components of endoplasmic reticulum-associated degradation

(2009) J. Hoseki et al.   JOURNAL OF BIOCHEMISTRY

Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum

(2009) B. C. S. Cross et al.   JOURNAL OF CELL SCIENCE

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

(2009) María Salazar et al.   JOURNAL OF CLINICAL INVESTIGATION

Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis

(2009) Mark G Goldstein et al.   Journal of Hematology & Oncology

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

(2009) E. Caldas-Lopes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and clinical significance of Glucose Regulated Proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus

(2008) Rupert Langer et al.   BMC CANCER

Critical Role of the Stress Chaperone GRP78/BiP in Tumor Proliferation, Survival, and Tumor Angiogenesis in Transgene-Induced Mammary Tumor Development

(2008) D. Dong et al.   CANCER RESEARCH

Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Metastatic Melanoma

(2008) D. B. Solit et al.   CLINICAL CANCER RESEARCH

A Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Hormone-Refractory Metastatic Prostate Cancer

(2008) E. I. Heath et al.   CLINICAL CANCER RESEARCH

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

(2008) D. Thomas Rutkowski et al.   DEVELOPMENTAL CELL

The potential of proteasome inhibitors in cancer therapy

(2008) Jan Sterz et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas

(2008) Hua-chuan Zheng et al.   HUMAN PATHOLOGY

Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer

(2008) Michael P.A. Davies et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of p97-dependent Protein Degradation by Eeyarestatin I

(2008) Qiuyan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic reticulum stress activates the expression of a sub-group of protein disulfide isomerase genes and AtbZIP60 modulates the response in Arabidopsis thaliana

(2008) Dong-Ping Lu et al.   MOLECULAR GENETICS AND GENOMICS

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bortezomib plus Melphalan and Prednisone for Initial Treatment of Multiple Myeloma

(2008) Jesús F. San Miguel et al.   NEW ENGLAND JOURNAL OF MEDICINE