Review
Biochemistry & Molecular Biology
Argen Mamazhakypov, Abdirashit Maripov, Akpay S. Sarybaev, Ralph Theo Schermuly, Akylbek Sydykov
Summary: Pulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure and vascular remodeling. Circulating osteopontin has been suggested as a biomarker of PH progression and right ventricular dysfunction. Preclinical studies have shown that osteopontin plays a role in PH pathogenesis by modulating various cellular processes. This article provides an overview of osteopontin regulation and its impact on pulmonary vascular remodeling, as well as the potential of targeting osteopontin for PH management.
Article
Cardiac & Cardiovascular Systems
Salaheldin Ahmed, Abdulla Ahmed, Goran Radegran
Summary: Plasma levels of AMBP, LPL, and glyoxalase I may serve as potential biomarkers to distinguish HFpEF-PH from PAH, with a combination of these proteins yielding the largest AUC in discriminating between the two conditions. Further large-scale clinical studies are recommended to validate these findings.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Miranda K. Culley, Stephen Y. Chan
Summary: This review discusses emerging concepts centered on endothelial senescence in pulmonary vascular disease. It proposes that endothelial senescence may serve as a unifying mechanism for pulmonary hypertension and highlights the link between aging and this disease. Additionally, it presents potential opportunities and barriers for targeting senescence in the diagnosis and treatment of pulmonary hypertension.
CIRCULATION RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Sunil Sharma, Robert Stansbury, Benjamin Hackett, Henrik Fox
Summary: Obstructive sleep apnea (OSA) and pulmonary hypertension (PH) are known to be associated, with limited understanding of the relationship which appears to be bidirectional. Limited data suggests that treatment with continuous positive pressure therapy may be beneficial and reduce pulmonary pressure. Further research on the mechanisms of this relationship is important.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Cardiac & Cardiovascular Systems
Yuta Suzuki, Hidehiro Kaneko, Yuichiro Yano, Akira Okada, Hidetaka Itoh, Satoshi Matsuoka, Katsuhito Fujiu, Satoko Yamaguchi, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Koichi Node, Hyeon-Chang Kim, Anthony J. Viera, Suzanne Oparil, Hideo Yasunaga, Issei Komuro
Summary: The age-dependent association of hypertension subtypes with incident heart failure suggests that preventive efforts for blood pressure control could provide a greater benefit in younger individuals.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Vivek Jani, M. Imran Aslam, Axel J. Fenwick, Weikang Ma, Henry Gong, Gregory Milburn, Devin Nissen, Ilton M. Cubero M. Salazar, Olivia Hanselman, Monica Mukherjee, Marc K. Halushka, Kenneth B. Margulies, Kenneth S. Campbell, Thomas C. Irving, David A. Kass, Steven Hsu
Summary: Right ventricular contractile dysfunction commonly occurs in patients with heart failure with reduced ejection fraction and pulmonary hypertension. Standard clinical indices may not reflect aspects of underlying myocyte dysfunction. This study investigates the mechanical properties of RV myocytes in HFrEF-PH patients and identifies potential underlying mechanisms.
Article
Cardiac & Cardiovascular Systems
Vineet Agrawal, Jonathan A. Kropski, Jason J. Gokey, Elizabeth Kobeck, Matthew B. Murphy, Katherine T. Murray, Niki L. Fortune, Christy S. Moore, David F. Meoli, Ken Monahan, Yan Ru Su, Thomas Blackwell, Deepak K. Gupta, Megha H. Talati, Santhi Gladson, Erica J. Carrier, James D. West, Anna R. Hemnes
Summary: This study investigates whether a well-accepted murine model of HFpEF displays features of PH, and identifies potential pathways driving early remodeling of the pulmonary vasculature in HFpEF.
CIRCULATION RESEARCH
(2023)
Review
Medicine, General & Internal
Marta Banaszkiewicz, Aleksandra Gasecka, Szymon Darocha, Michal Florczyk, Arkadiusz Pietrasik, Piotr Kedzierski, Michal Pilka, Adam Torbicki, Marcin Kurzyna
Summary: Pulmonary hypertension is a serious hemodynamic condition that can lead to right heart failure and death if not properly treated. The prognosis of pulmonary hypertension depends on various factors, and biomarkers provide information about disease severity, treatment response, and prognosis. However, due to the complexity of the condition, a single biomarker is not sufficient for evaluating different types of pulmonary hypertension patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Daniel Lemogoum, Felicite Kamdem, Hamadou Ba, William Ngatchou, Guillaume Hye Ndindjock, Anasthase Dzudie, Yves Monkam, Sidick Mouliom, Michel P. Hermans, Elysee Claude Bika Lele, Philippe van de Borne
Summary: This study investigated the epidemiology and prognostic factors of ADHF in Cameroonian patients, finding that hypertension, diabetes mellitus, tobacco use, and dyslipidaemia were the most common risk factors associated with HF. The major causes of HF in hospitalized patients were hypertensive heart disease, hypertrophic cardiomyopathy, and ischemic heart disease. Furthermore, factors such as hypotension, severe left ventricular dysfunction, and renal impairment were associated with worse outcomes, while the use of ACEIs/ARBs was linked to improved survival.
Article
Cardiac & Cardiovascular Systems
Javier Bermejo, Ana Gonzalez-Mansilla, Teresa Mombiela, Ana I. Fernandez, Pablo Martinez-Legazpi, Raquel Yotti, Rocio Garcia-Orta, Pedro L. Sanchez-Fernandez, Mario Castano, Javier Segovia-Cubero, Pilar Escribano-Subias, J. Alberto San Roman, Xavier Borras, Angel Alonso-Gomez, Javier Botas, Maria G. Crespo-Leiro, Sonia Velasco, Antoni Bayes-Genis, Amador Lopez, Roberto Munoz-Aguilera, Manuel Jimenez-Navarro, Jose R. Gonzalez-Juanatey, Arturo Evangelista, Jaime Elizaga, Javier Martin-Moreiras, Jose M. Gonzalez-Santos, Eduardo Moreno-Escobar, Francisco Fernandez-Aviles
Summary: The study reveals that the presence of pulmonary hypertension following successful correction of valvular heart disease is associated with a higher mortality rate, which is related to factors such as pulmonary vascular resistance, diabetes mellitus, and residual effective valve area. These findings have significant implications for individualizing valve correction procedures.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Endocrinology & Metabolism
Karl Swedberg
Summary: The diagnosis of heart failure is categorized into two main types based on left ventricular ejection fraction, which has significant implications for treatment. Type 2 diabetes is a common and important comorbidity in chronic heart failure, affecting prognosis and treatment decisions.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Cardiac & Cardiovascular Systems
Raffaele Maio, Maria Perticone, Edoardo Suraci, Angela Sciacqua, Giorgio Sesti, Francesco Perticone
Summary: Impaired endothelium-dependent vasodilation and high-sensitivity C-reactive protein (hs-CRP) predict the development of incident heart failure in hypertensive patients. Older age, female gender, higher baseline heart rate, glucose, insulin, creatinine, and hs-CRP mean values are associated with a higher risk of developing heart failure.
Review
Cardiac & Cardiovascular Systems
Jessica H. Huston, Sanjiv J. Shah
Summary: The development of pulmonary hypertension in patients with heart failure due to left heart disease is common and has adverse prognostic implications. However, there are currently no known specific treatments for this condition. Diagnostic criteria and clinical classification for pulmonary hypertension due to left heart disease are still evolving, posing challenges for researchers. The pathobiology of this condition is not well understood, but factors such as increased wall stress and endothelial dysfunction are believed to contribute to pulmonary vascular remodeling. Further investigation is needed to better understand the drivers of this condition and develop effective prevention and treatment strategies.
CIRCULATION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Leroy L. Cooper, Jian Rong, Niema M. Pahlevan, Derek G. Rinderknecht, Emelia J. Benjamin, Naomi M. Hamburg, Ramachandran S. Vasan, Martin G. Larson, Morteza Gharib, Gary F. Mitchell
Summary: Novel intrinsic frequencies may serve as valuable markers of heart failure risk in the community, with higher omega(1) and Delta omega being associated with increased risk of cardiovascular events and heart failure, while lower omega(2) is associated with reduced risk.
Article
Cardiac & Cardiovascular Systems
Kazunori Omote, Hidemi Sorimachi, Masaru Obokata, Yogesh N. Reddy, Frederik H. Verbrugge, Massar Omar, Hilary M. DuBrock, Margaret M. Redfield, Barry A. Borlaug
Summary: This study aimed to characterize the pathophysiology of pulmonary vascular disease in left heart disease (PH-LHD) and found that PH-LHD patients displayed distinct features, such as poorer left atrial function and more severe right ventricular dysfunction at rest, as well as more severe impairments in cardiac output and oxygen delivery during exercise. Further study is required to identify innovative treatments for the pulmonary vasculature in PH-LHD.
EUROPEAN HEART JOURNAL
(2022)
Article
Engineering, Biomedical
Eriberto Michel, Erik Orozco Hernandez, Daniel Enter, Michael Monge, Jota Nakano, Jonathan Rich, Allen Anderson, Carl Backer, Patrick McCarthy, Duc Pham
Article
Radiology, Nuclear Medicine & Medical Imaging
Ryan S. Dolan, Amir A. Rahsepar, Julie Blaisdell, Kai Lin, Kenichiro Suwa, Kambiz Ghafourian, Jane E. Wilcox, Sadiya S. Khan, Esther E. Vorovich, Jonathan D. Rich, Allen S. Anderson, Clyde W. Yancy, Jeremy D. Collins, Michael Markl, James C. Carr
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2019)
Article
Cardiac & Cardiovascular Systems
Abdul Rahman A. Abutaleb, Elizabeth M. McNally, Sadiya S. Khan, Allen S. Anderson, James C. Carr, Jane E. Wilcox
Article
Cardiac & Cardiovascular Systems
Ryan S. Dolan, Amir A. Rahsepar, Julie Blaisdell, Kenichiro Suwa, Kambiz Ghafourian, Jane E. Wilcox, Sadiya S. Khan, Esther E. Vorovich, Jonathan D. Rich, Allen S. Anderson, Clyde W. Yancy, Jeremy D. Collins, James C. Carr, Michael Markl
JACC-CARDIOVASCULAR IMAGING
(2019)
Article
Cardiac & Cardiovascular Systems
Kathleen L. Grady, Adin-Cristian Andrei, Tamara Shankel, Richard Chinnock, Shelley D. Miyamoto, Amrut V. Ambardekar, Allen Anderson, Linda Addonizio, Farhana Latif, Debra Lefkowitz, Lee R. Goldberg, Seth A. Hollander, Michael Pham, Kathleen Van't Hof, Jill Weissberg-Benchell, Clyde Yancy, Menghan Liu, Nichole Melody, Elfriede Pahl
JOURNAL OF CARDIAC FAILURE
(2019)
Article
Cardiac & Cardiovascular Systems
Randall C. Starling, Brian Armstrong, Nancy D. Bridges, Howard Eisen, Michael M. Givertz, Abdallah G. Kfoury, Jon Kobashigawa, David Ikle, Yvonne Morrison, Sean Pinney, Josef Stehlik, Sudipta Tripathi, Mohamed H. Sayegh, Anil Chandraker, Barbara Gus, Karen Keslar, Bill Magyar, John Petrich, Randall C. Starling, W. H. Wilson Tang, Kimberly Brooks, Michael Givertz, Charles Kelly, Katie Klein, Kerry Crisalli, Sandra DeBronkart, Joren Madsen, Marc Semigran, John Vetrano, Teresa DeMarco, Scott Fields, Carol Maguire, Robert Gordon, Allen Anderson, Jane Regalado, Anna Warzecha, Lee Goldberg, Caroline Olt, Kenneth Rockwell, Ashley Harris, Maryl Johnson, Susan Johnston, Chris Roginski, Rashid Ahmed, Ivy Cohen, Denise Peace, Sean Pinney, Tina Yao, Gloria Araujo, Arvind Bhimaraj, Eunice Karanga, Varsha Patel, Julie Chait, Mario Deng, Gregg Fonarow, Christina Shin, Charles Gibbs, Judson Hunt, Melissa Johnson, Tina Worley, Jeff Gibbs, John Kirk, Winter Redd, Josef Stehlik, Julia Bryan, Anna French, A. G. Kfoury, Kristin Konery, Erika Feller, Myounghee Lee, Richard Pierson, Cindi Young, Theodora Hollifield, Kimberley Porter, Mariann Schulz, Adrian VanBakel, Kiran Khush, Helen Luikart, Son Nguyen, Michael Pham, David DeNofrio, Ryan O'Kelly, Lucilla Garcia, Jon Kobashigawa, Sean Sana, Brandy Starks, Maria Thottam, Annie Yi, Barry Cabuay, Rachel Olson, Larry Tucker, Laura Uppgaard, Howard Eisen, Denise Lai, Colleen Poisker, Klaudija Dragicevic, Harrison Kelner, Darlette Luke, Jennifer Nelson, Ganesh Raveendran, Nick Kleissas, Srinivas Murali, Kenneth Rayl, Sarah Sherry, Michele Cosgrove
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Letter
Cardiac & Cardiovascular Systems
Ramsey M. Wehbe, Allen S. Anderson
JACC-HEART FAILURE
(2019)
Review
Cardiac & Cardiovascular Systems
Juan Simon Rico-Mesa, Averi White, Allen S. Anderson
CURRENT CARDIOLOGY REPORTS
(2020)
Review
Cardiac & Cardiovascular Systems
Anand Prasad, Siyab Panhwar, Robert C. Hendel, Omar Sheikh, Zunair Mushtaq, Fatima Dollar, Ariel Vinas, Chadi Alraies, Ahmed Almonani, Tung Huy Nguyen, Javier Amione-Guerra, Mark T. Foster, Craig Sisson, Allen Anderson, Jon C. George, Issa Kutkut, Jorge Armando Guarena Casillas, Auroa Badin
AMERICAN HEART JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
William F. Parker, Kevin Chung, Allen S. Anderson, Mark Siegler, Elbert S. Huang, Matthew M. Churpek
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Engineering, Biomedical
Jennifer A. Cowger, Jerry D. Estep, Debbie A. Rinde-Hoffman, Michael M. Givertz, Allen S. Anderson, Daniel Jacoby, Leway Chen, Andreas Brieke, Claudius Mahr, Shelley Hall, Gregory A. Ewald, Nick Dirckx, Andrew T. Baker, Sean P. Pinney
Summary: This study found a moderate correlation between noninvasive measurements and arterial line measurements of blood pressure in left ventricular assist device patients, and Doppler opening pressure may overestimate arterial blood pressure in some patients. These findings suggest the need for the simultaneous use of multiple measurement methods in blood pressure control.
Article
Cardiac & Cardiovascular Systems
K. C. Jackson, Q. R. Youmans, T. Wu, R. Harap, A. S. Anderson, A. Chicos, A. Ezema, E. Mandieka, R. Ohiomoba, A. Pawale, D. T. Pham, S. Russell, P. H. S. Sporn, C. W. Yancy, Ike S. Okwuosa
Summary: Patients with cardiac sarcoidosis (CS) and non-CS have similar survival rates, graft failure rates, hospitalizations for infection, and post-transplant malignancy rates after orthotopic heart transplantation (OHT). This study confirms the viability of heart transplantation as an option for CS patients.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Ike S. Okwuosa, Allen Anderson, Michael Petty, Tingqing Wu, Adin-Cristian Andrei, Andrew Kao, John A. Spertus, Duc T. Pham, Clyde W. Yancy, Mary Amanda Dew, Eileen Hsich, William Cotts, Justin Hartupee, Salpy Pamboukian, Francis Pagani, Brent Lampert, Maryl Johnson, Margaret Murray, Koji Tekeda, Melana Yuzefpolskaya, James K. Kirklin, Kathleen L. Grady
Summary: This study examined caregiver burden among three groups of older advanced heart failure patients, including those supported with mechanical circulatory support (MCS) before heart transplantation, those awaiting transplant without MCS, and those prior to long-term MCS. The results showed that caregivers of MCS patients reported spending more time and experiencing more difficulty in caregiving compared to caregivers of non-MCS patients.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
R. O. Ohiomoba, Q. R. Youmans, P. W. Akanyirige, A. U. Ezema, A. S. Anderson, A. Bryant, K. Jackson, E. Mandieka, D. T. Pham, Y. Raza, J. D. Rich, C. W. Yancy, I. S. Okwuosa
IJC HEART & VASCULATURE
(2020)
Letter
Cardiac & Cardiovascular Systems
William F. Parker, Matthew M. Churpek, Allen S. Anderson
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2020)