Article
Surgery
Mena Botros, Kenneth Jackson, Priyamvada Singh, Justin P. Rosenheck, Asvin M. Ganapathi, Matthew C. Henn, Molly M. Howsare, Nahush A. Mokadam, Todd Pesavento, Bryan A. Whitson, David R. Nunley, Brian C. Keller
Summary: This study retrospectively analyzed 153 lung transplant recipients and found a high incidence of postoperative acute kidney injury (AKI), which was associated with lower survival rates. Perioperative factors such as recipient race, transplant type, cardiopulmonary support, and red blood cell administration were associated with postoperative AKI.
CLINICAL TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Lei Jing, Wenhui Chen, Li Zhao, Lijuan Guo, Chaoyang Liang, Jingyu Chen, Chen Wang
Summary: Acute kidney injury (AKI) is a common and serious complication following lung transplantation (LTx), and it is associated with high mortality and morbidity. This study found that AKI is related to several perioperative factors and clinical outcomes, and persistent and severe AKI are associated with decreased kidney function and reduced survival in LTx patients.
CHINESE MEDICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Robert Greite, Li Wang, Lukas Gohlke, Sebastian Schott, Kirill Kreimann, Julian Doricic, Andreas Leffler, Igor Tudorache, Jawad Salman, Ruslan Natanov, Fabio Ius, Christine Fegbeutel, Axel Haverich, Ralf Lichtinghagen, Rongjun Chen, Song Rong, Hermann Haller, Vijith Vijayan, Magnus Gram, Irina Scheffner, Faikah Gueler, Wilfried Gwinner, Stephan Immenschuh
Summary: This study investigated the levels of CFH and CFH-binding hemoglobin in LuTx patients and found that CFH may be associated with postoperative AKI. Moreover, experimental studies on a mouse model of mild renal ischemia reperfusion injury confirmed the role of CFH in promoting AKI. Targeting CFH may be a therapeutic option to prevent AKI after LuTx.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Sayf A. Said, Toshihiro Okamoto, Amy S. Nowacki, Hiromichi Niikawa, Kamal S. Ayyat, Ichiro Sakanoue, James J. Yun, Kenneth R. McCurry
Summary: Blood transfusion from donors can increase recipient mortality, especially when more than 10 units are transfused.
ANNALS OF THORACIC SURGERY
(2021)
Article
Multidisciplinary Sciences
Sahar Alkhairy, Leo A. Celi, Mengling Feng, Andrew J. Zimolzak
Summary: AKI is common in ICU and has high mortality rates. Urine output and creatinine are used for AKI definition, with a study showing that a GEE model with static and time-varying features improves accuracy over current definitions.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew M. Vekstein, Babtunde A. Yerokun, Oliver K. Jawitz, Julie W. Doberne, Jatin Anand, Jorn Karhausen, David N. Ranney, Ehsan Benrashid, Hanghang Wang, Jeffrey E. Keenan, Jacob N. Schroder, Jeffrey G. Gaca, G. Chad Hughes
Summary: The study found that in patients undergoing proximal aortic surgery and requiring HCA, the degree of systemic hypothermia was not associated with the risk of AKI.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Medicine, General & Internal
Young Song, Hyo-Chae Paik, Namo Kim, Heejae Jung, Jin-Gu Lee, Young-Chul Yoo
Summary: This study compared the effects of sevoflurane and propofol anesthesia on acute kidney injury (AKI) following lung transplantation surgery. The results showed that propofol anesthesia reduced the incidence of AKI compared to sevoflurane anesthesia, and was associated with lower levels of NGAL and IL-6. AKI occurrence was also found to be related to a lower 5-year survival rate.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Isaac E. Hall, Peter Philip Reese, Sherry G. Mansour, Sumit Mohan, Yaqi Jia, Heather R. Thiessen-Philbrook, Daniel C. Brennan, Mona D. Doshi, Thangamani Muthukumar, Enver Akalin, Meera Nair Harhay, Bernd Schroeppel, Pooja Singh, Francis L. Weng, Jonathan S. Bromberg, Chirag R. Parikh
Summary: A study on kidney transplant recipients found that deceased-donor AKI was independently associated with lower risk for BKV infection, contrary to the initial hypothesis. Data from the OPTN database also showed that donor AKI was linked to lower risk for graft failure attributed to BKV.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Vittorio Scaravilli, Alessandra Merrino, Francesca Bichi, Fabiana Madotto, Letizia Corinna Morlacchi, Mario Nosotti, Alfredo Lissoni, Lorenzo Rosso, Francesco Blasi, Antonio Pesenti, Alberto Zanella, Giuseppe Castellano, Giacomo Grasselli
Summary: The occurrence of AKI is common in cystic fibrosis patients undergoing lung transplantation, often progressing to AKD and CKD, which significantly impacts both short-term and long-term outcomes.
JOURNAL OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Sangeeta Hingorani, Robert H. Schmicker, Patrick D. Brophy, Patrick J. Heagerty, Sandra E. Juul, Stuart L. Goldstein, David Askenazi
Summary: The study found that severe AKI is common in extremely low gestational age neonates. Stage 3 AKI is associated with mortality and this association can be observed 7 days before death.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Infectious Diseases
Michael Samarkos, Konstantinos Papanikolaou, Athena Sourdi, Nikolaos Paisios, Efstratios Mainas, Elisabeth Paramythiotou, Anastasia Antoniadou, Helen Sambatakou, Panayiotis Gargalianos-Kakolyris, Athanasios Skoutelis, George L. Daikos
Summary: This study examined the effects of once-daily versus twice- or thrice-daily dosing of colistin on renal function. The results showed that once-daily dosing of colistin is not more nephrotoxic than the standard dosing regimens. The only independent predictor of nephrotoxicity was diabetes mellitus, while eGFR > 80 mL/min had a protective effect.
Review
Biochemistry & Molecular Biology
Marco Fiorentino, Francesca Bagagli, Annamaria Deleonardis, Alessandra Stasi, Rossana Franzin, Francesca Conserva, Barbara Infante, Giovanni Stallone, Paola Pontrelli, Loreto Gesualdo
Summary: Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD). Kidney transplant recipients (KTRs) are at a higher risk of ICU admission, mainly in the late post-transplant period. Urosepsis and bloodstream infections are the main reasons for ICU admissions, and side effects of immunosuppressive treatment should also be accounted for. AKI incidence is common in KTRs during ICU stay, and in-hospital mortality can be high. The present review aims to explore the impact of AKI on outcomes in KTRs and provide insights into its diagnosis, management, and immunosuppression modulation.
Article
Multidisciplinary Sciences
Marcelo Augusto Duarte Silveira, Jose Manuel Condor Capcha, Talita Rojas Sanches, Roberto de Sousa Moreira, Margot S. Garnica, Maria Heloisa Shimizu, Andresa Berretta, Flavio Teles, Irene L. Noronha, Lucia Andrade
Summary: The study found that Brazilian green propolis has protective effects on the kidneys and lungs of rats with sepsis, improving survival rate, alleviating kidney injury, restoring renal tubular function, and reducing inflammation and cell infiltration. This discovery opens up new prospects for using Brazilian green propolis in clinical trials for treating sepsis.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Mekonnen Sisay, Bisrat Hagos, Dumessa Edessa, Yohannes Tadiwos, Abraham Nigussie Mekuria
Summary: This study investigated polymyxin-induced nephrotoxicity and its predictors, finding a high incidence of nephrotoxicity, especially in elderly patients, those receiving high daily doses, those with diabetes, and those using concomitant nephrotoxic drugs. Therefore, therapeutic drug monitoring should be implemented for these patients.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Toxicology
Dominique Vodovar, Hugo Peyre, Bruno Megarbane
Summary: Studies on the consensus definitions/classifications of acute kidney injury show that poisoned patients who develop acute kidney injury have a higher mortality rate compared to those who do not.
CLINICAL TOXICOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Joshua C. Grimm, Vicente Valero, Arman Kilic, Todd C. Crawford, John V. Conte, Christian A. Merlo, Pali D. Shah, Ashish S. Shah
ANNALS OF THORACIC SURGERY
(2015)
Article
Cardiac & Cardiovascular Systems
Joshua C. Grimm, Cecillia Lui, Arman Kilic, Vicente Valero, Christopher M. Sciortino, Glenn J. R. Whitman, Ashish S. Shah
ANNALS OF THORACIC SURGERY
(2015)
Editorial Material
Surgery
S. C. Sweet, A. S. Shah
AMERICAN JOURNAL OF TRANSPLANTATION
(2014)
Article
Anesthesiology
Charles H. Brown, Maura Grega, Ola A. Selnes, Guy M. McKhann, Ashish S. Shah, Andrew LaFlam, William J. Savage, Steven M. Frank, Charles W. Hogue, Rebecca F. Gottesman
ANESTHESIA AND ANALGESIA
(2014)
Article
Cardiac & Cardiovascular Systems
Arman Kilic, John V. Conte, William A. Baumgartner, Stuart D. Russell, Christian A. Merlo, Ashish S. Shah
ANNALS OF THORACIC SURGERY
(2014)
Letter
Cardiac & Cardiovascular Systems
R. Scott Stephens, Ashish S. Shah, Glenn J. R. Whitman
ANNALS OF THORACIC SURGERY
(2014)
Article
Cardiac & Cardiovascular Systems
Vasileios Karantalis, Darcy L. DiFede, Gary Gerstenblith, Si Pham, James Symes, Juan Pablo Zambrano, Joel Fishman, Pradip Pattany, Ian McNiece, John Conte, Steven Schulman, Katherine Wu, Ashish Shah, Elayne Breton, Janice Davis-Sproul, Richard Schwarz, Gary Feigenbaum, Muzammil Mushtaq, Viky Y. Suncion, Albert C. Lardo, Ivan Borrello, Adam Mendizabal, Tomer Z. Karas, John Byrnes, Maureen Lowery, Alan W. Heldman, Joshua M. Hare
CIRCULATION RESEARCH
(2014)
Article
Cardiac & Cardiovascular Systems
Claude A. Beaty, Timothy J. George, Arman Kilic, John V. Conte, Ashish S. Shah
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2013)
Article
Cardiac & Cardiovascular Systems
Josef Stehlik, Lynne W. Stevenson, Leah B. Edwards, Maria G. Crespo-Leiro, Juan F. Delgado, Richard Dorent, Maria Frigerio, Peter Macdonald, Guy A. MacGowan, Alessandro Nanni Costa, Joseph G. Rogers, Ashish S. Shah, Rhiannon Taylor, Rajaiyer V. Venkateswaran, Mandeep R. Mehra
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2014)
Article
Cardiac & Cardiovascular Systems
Jason O. Robertson, Maria V. Grau-Sepulveda, Shoichi Okada, Sean M. O'Brien, J. Matthew Brennan, Ashish S. Shah, Akinobu Itoh, Ralph J. Damiano, Sunil Prasad, Scott C. Silvestry
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2014)
Article
Cardiac & Cardiovascular Systems
Ryan J. Tedford, Claude A. Beaty, Stephen C. Mathai, Todd M. Kolb, Rachel Damico, Paul M. Hassoun, Peter J. Leary, David A. Kass, Ashish S. Shah
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2014)
Article
Cardiac & Cardiovascular Systems
Arman Kilic, Ashish S. Shah, John V. Conte, Kaushik Mandal, William A. Baumgartner, Duke E. Cameron, Glenn J. R. Whitman
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2014)
Article
Cardiac & Cardiovascular Systems
Arman Kilic, Joshua C. Grimm, Ashish S. Shah, John V. Conte, Glenn J. R. Whitman, Christopher M. Sciortino
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2014)
Article
Cardiac & Cardiovascular Systems
Arman Kilic, Ashish S. Shah, James H. Black, Glenn J. R. Whitman, David D. Yuh, Duke E. Cameron, John V. Conte
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2014)
Article
Surgery
George J. Arnaoutakis, Gregory J. Bittle, Jeremiah G. Allen, Eric S. Weiss, Jennifer Alejo, William A. Baumgartner, Ashish S. Shah, Christopher L. Wolfgang, David T. Efron, John V. Conte
WORLD JOURNAL OF SURGERY
(2014)