Review
Biochemistry & Molecular Biology
Dalila Cavallaro, Marco Guerrieri, Stefano Cattelan, Gaia Fabbri, Sara Croce, Martina Armati, David Bennett, Antonella Fossi, Luca Voltolini, Luca Luzzi, Alberto Salvicchi, Piero Paladini, Adriano Peris, Miriana d'Alessandro, Paolo Cameli, Elena Bargagli, Tuscany Transplant Group, Laura Bergantini
Summary: Bronchiolitis obliterans syndrome is the most common form of CLAD, and its pathogenesis and markers play a crucial role in early diagnosis and treatment.
Article
Immunology
Juan Margallo Iribarnegaray, Alicia De Pablo Gafas, Rodrigo Alonso Moralejo, Carlos Andres Quezada Loaiza, Fernando Revuelta Salgado, Isabel Pina Maiquez, Virginia Luz Perez Gonzalez
Summary: Among 13 CLAD patients treated with ATG, half of them showed a favorable positive response, with most responders being in CLAD stage 1 to 2. Lung function improved after treatment. The study also found a trend toward better survival in early CLAD patients.
TRANSPLANTATION PROCEEDINGS
(2021)
Review
Medicine, General & Internal
Anna Astashchanka, Joseph Ryan, Erica Lin, Brandon Nokes, Catriona Jamieson, Seth Kligerman, Atul Malhotra, Jess Mandel, Jisha Joshua
Summary: This review discusses the pulmonary complications post-HSCT, providing essential knowledge for non-pulmonary healthcare providers and emphasizing the importance of early diagnosis, treatment, and prognosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Jarrod E. Dalton, Carli J. Lehr, Paul R. Gunsalus, Lyla Mourany, Maryam Valapour
Summary: This study examined the performance of models predicting waitlist and posttransplant survival in lung transplant allocation. The results showed that different models had similar performance in predicting waitlist and posttransplant survival, and using alternative modeling strategies and contemporary cohorts did not improve the models' performance in determining access to lung transplant.
Article
Infectious Diseases
Hugo Testaert, Margaux Bouet, Florent Valour, Anne Gigandon, Marie -Edith Lafon, Francois Philit, Agathe Senechal, Jean-Sebastien Casalegno, Elodie Blanchard, Jerome Le Pavec, Florence Ader
Summary: This study analysed the impact of antimicrobial treatments on functional outcomes in adult lung transplant recipients with RSV-confirmed infection. It was found that 28.8% of recipients developed new allograft dysfunction at 3 months post-infection. Ribavirin treatment and azithromycin prophylaxis did not prevent decline in lung function.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Respiratory System
Auke E. S. de Zwart, Annelies Riezebos-Brilman, Gerton A. Lunter, Ewald C. U. Neerken, Coretta C. van Leer-Buter, Jan-Willem C. Alffenaar, Anna P. van Gemert, Michiel E. Erasmus, Christiaan T. Gan, Huib A. M. Kerstjens, Judith M. Vonk, Erik A. M. Verschuuren
Summary: The social distancing measures during COVID-19 led to a reduction in respiratory virus infection rates, which correlated with less decline in lung function, fewer episodes of TDLF, and possibly lower incidence of CLAD in lung transplant recipients.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Review
Pediatrics
Frances Flanagan, Alicia Casey, Miguel Reyes-Mugica, Geoffrey Kurland
Summary: The article discusses the diagnosis, treatment options, and the importance of early diagnosis in PIBO.
PAEDIATRIC RESPIRATORY REVIEWS
(2022)
Review
Pediatrics
Die Liu, Jing Liu, Lipeng Zhang, Yuanmei Chen, Qi Zhang
Summary: This study conducted a systematic review and identified the strongest risk factors for PIBO, including hypoxemia, mechanical ventilation, tachypnea, and wheezing. The use of glucocorticoids, gamma-globulin, bacterial co-infection, a history of wheezing, and being male may also contribute to the development of PIBO. These factors can inform the generation of a clinical prediction model for PIBO in children.
FRONTIERS IN PEDIATRICS
(2022)
Article
Cardiac & Cardiovascular Systems
Siddhartha G. Kapnadak, Eric D. Morrell, Travis Hee Wai, Christopher H. Goss, Pali D. Shah, Christian A. Merlo, Ramsey R. Hachem, Kathleen J. Ramos
Summary: This study investigated the practices of azithromycin use among lung transplant providers internationally. The results showed significant variations in indications, timing, and dosing of azithromycin, with even inconsistencies within the same center. Most providers initiated azithromycin after the occurrence of risk factors and/or events related to chronic lung allograft dysfunction (CLAD).
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Review
Surgery
Rickey A. Evans, Krysta S. Walter, Leonard Jason Lobo, Raymond Coakley, Christina T. Doligalski
Summary: Chronic lung allograft dysfunction (CLAD) remains the leading cause of death in lung transplant recipients (LTRs) despite improvements in immunosuppression management. Treatments for CLAD are usually ineffective and there are currently no evidence-based guidelines.
CLINICAL TRANSPLANTATION
(2022)
Article
Biophysics
Jade L. Kutzke, Julianna A. Merten, Jodi L. Taraba, Kristin C. Mara, Mithun V. Shah, Shahrukh K. Hashmi, Mrinal M. Patnaik, Mark R. Litzow, William J. Hogan, Hassan B. Alkhateeb
Summary: This study examined whether the use of azithromycin at the time of BOS diagnosis in patients who received allogeneic HSCT would increase the risk of disease relapse. The results indicated that patients who used azithromycin were not associated with an increased risk of relapse compared to those who did not use azithromycin.
BONE MARROW TRANSPLANTATION
(2021)
Article
Immunology
Katelyn N. Rudzik, Cody A. Moore, Lauren M. Sacha, Ryan M. Rivosecchi, Melissa Saul, Joseph M. Pilewski, Silpa D. Kilaru, Mark E. Snyder, John F. McDyer, Carlo J. Iasella
Summary: This study evaluated the effectiveness of rabbit antithymocyte globulin (rATG) for corticosteroid refractory acute cellular rejection (ACR) in lung transplant recipients. The study found that rATG can effectively treat ACR, and nonresponders have a higher risk of early CLAD and death.
Article
Medicine, Research & Experimental
Aaditya Khatri, Jamie L. . Todd, Fran L. . Kelly, Andrew Nagler, Zhicheng Ji, Vaibhav Jain, Simon G. Gregory, Kent J. Weinhold, Scott M. Palmer
Summary: Chronic lung allograft dysfunction (CLAD), characterized by decline in pulmonary function and bronchiolitis obliterans, lacks approved therapies. Single-cell RNA-Seq and spatial transcriptomic analysis identified the important role of JAK-STAT signaling in airway epithelial cells in CLAD. Activation of JAK-STAT signaling leads to upregulation of MHC-I in airway basal cells, resulting in cytotoxic T cell-mediated basal cell death. This study provides mechanistic insight and potential therapeutic strategy for CLAD.
Article
Cell Biology
Sara Bozzini, Laura Pandolfi, Elena Rossi, Simona Inghilleri, Michele Zorzetto, Giuseppina Ferrario, Stefano Di Carlo, Gianfranco Politano, Annalisa De Silvestri, Vanessa Frangipane, Michele Porzio, Romain Kessler, Fiorella Calabrese, Federica Meloni, Patrizia Morbini
Summary: Epigenetic changes, in particular miRNA deregulation, have been shown to potentially contribute to obliterative bronchiolitis (OB) development. Specific over-expression of miR-21-5p in OB lesions and its potential regulation of STAT3 expression were identified in this study, although miR-21-5p is not the sole regulator of STAT3. This research adds to the understanding of the downstream pathways of miR-21-5p in the context of OB fibrogenesis.
Article
Multidisciplinary Sciences
Sudip Das, Eric Bernasconi, Angela Koutsokera, Daniel-Adrien Wurlod, Vishwachi Tripathi, German Bonilla-Rosso, John-David Aubert, Marie-France Derkenne, Louis Mercier, Celine Pattaroni, Alexis Rapin, Christophe von Garnier, Benjamin J. Marsland, Philipp Engel, Laurent P. Nicod
Summary: This study examined the viable bacterial community in bronchoalveolar lavage samples from 64 lung transplant recipients and identified four distinct compositional states, called "pneumotypes," which were associated with immune activity, lung function, and risks of infection and rejection. The findings highlight the link between the lung microbial ecosystem, human lung function, and clinical stability post-transplant.
NATURE COMMUNICATIONS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mathias Loft, Esben A. Carlsen, Camilla B. Johnbeck, Helle H. Johannesen, Tina Binderup, Andreas Pfeifer, Jann Mortensen, Peter Oturai, Annika Loft, Anne K. Berthelsen, Seppo W. Langer, Ulrich Knigge, Andreas Kjaer
Summary: Cu-64-DOTATATE PET/CT imaging 1-3 hours after injection showed no significant differences in lesion detection for patients with NENs, with high tumor-to-normal-tissue ratios in key organs.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marie Obro Fosbol, Sorel Kurbegovic, Helle Hjorth Johannesen, Martin Andreas Roder, Adam Espe Hansen, Jann Mortensen, Annika Loft, Peter Meidahl Petersen, Jacob Madsen, Klaus Brasso, Andreas Kjaer
Summary: The study aimed to evaluate the correlation between uptake of the PET ligand Ga-68-NOTA-AE105 and Gleason score in patients undergoing prostate biopsy. Results showed a significant positive correlation between SUVmax and Gleason score. SUVmax could discriminate between low-risk Gleason score profiles and intermediate risk Gleason score profiles accurately.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Pediatrics
Susanne Soendergaard Kappel, Per Torp Sangild, Thomas Scheike, Christel Renee Friborg, Magdalena Gormsen, Lise Aunsholt
Summary: The study investigates the effects of gestational age at birth, postnatal age, and milk diet on contrast passage rate in preterm piglets as a model for infants. The results indicate that these factors influence passage rate through different gut segments, highlighting the importance of understanding gut motility maturation, feeding tolerance, and gut health in preterm infants.
FRONTIERS IN PEDIATRICS
(2021)
Article
Mathematics, Interdisciplinary Applications
Julie K. Furberg, Christian B. Pipper, Thomas Scheike
Summary: This study discusses a testing approach for equivalence trials with survival outcomes, focusing on evaluating the equivalence of survival curves and proportional hazards assumption. Modification and non-parametric tests are proposed to address these issues, investigated through simulation and applied in a clinical trial on survival of gastric cancer patients.
LIFETIME DATA ANALYSIS
(2021)
Article
Nutrition & Dietetics
Sophie Maria Mathiesen, Kristian Asp Fuglsang, Giovanna Ranzato, Thomas Scheike, Palle Bekker Jeppesen
Summary: This study examined the changes in estimated glomerular filtration rate (eGFR) in patients with intestinal failure (IF) receiving home parenteral support (HPS) over a 5-year period. It was found that the most significant decline in eGFR occurred in the first year of HPS treatment, potentially due to factors such as dehydration, secondary hyperaldosteronism, and increased creatinine production. Patients with diabetes or high HPS volume needs may be more vulnerable to renal impairment and require special attention.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Article
Infectious Diseases
Dina Leth Moller, Soren Schwartz Sorensen, Michael Perch, Finn Gustafsson, Omid Rezahosseini, Andreas Dehlbaek Knudsen, Thomas Scheike, Jenny Dahl Knudsen, Jens Lundgren, Allan Rasmussen, Susanne Dam Nielsen
Summary: The incidence of bloodstream infections (BSI) varies among different solid organ transplantation (SOT) groups. Older age, comorbidity, current CMV infection, and leucopenia are all associated with increased risk of BSI in SOT recipients.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Obstetrics & Gynecology
George Mtove, Omari Abdul, Fanny Kullberg, Samwel Gesase, Thomas Scheike, Frederik Molkjaer Andersen, Mwayiwawo Madanitsa, Feiko O. Kuile, Michael Alifrangis, John P. A. Lusingu, Daniel T. R. Minja, Christentze Schmiegelow
Summary: This study aimed to generate sex-specific prediction maps and weight reference charts for the retrospective estimation of birthweight for exclusively breastfed newborns in a low-resource setting. The results showed the rapid decline in weight shortly after delivery, and the prediction maps and reference charts can be used to better assess the weight of newborns and estimate birthweight retrospectively.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Public, Environmental & Occupational Health
Jeppe Ekstrand Halkjaer Madsen, Jesper Hallas, Thomas Delvin, Thomas Scheike, Christian Pipper
Summary: The objective of this article is to advocate a new method of sampling controls in the case-time-control design in a cohort of drug users when the studied outcome prevents further treatment. The proposed sampling method removes the bias between treatment and outcome and makes it possible to use the case-time-control design in a cohort of subjects with registered use of a drug when outcome prevents further treatment.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Article
Mathematics, Interdisciplinary Applications
Thomas H. Scheike, Klaus Kahler Holst
Summary: Familial aggregation refers to the higher occurrence rate of a particular disease in certain families due to genetic or environmental factors. When studying this phenomenon, it is important to consider the age of disease onset and right-censored data, and apply polygenic modeling to quantify and separate the dependence. In addition, the modeling should account for both death and disease occurrence as competing risks, and it is closely related to the liability threshold model.
ANNUAL REVIEW OF STATISTICS AND ITS APPLICATION
(2022)
Article
Cell & Tissue Engineering
Charlotte Duch Lynggaard, Christian Gronhoj, Robin Christensen, Anne Fischer-Nielsen, Jacob Melchiors, Lena Specht, Elo Andersen, Jann Mortensen, Peter Oturai, Gry Hoffmann Barfod, Eva Kannik Haastrup, Michael Moller-Hansen, Mandana Haack-Sorensen, Annette Ekblond, Jens Kastrup, Siri Beier Jensen, Christian von Buchwald
Summary: This study aimed to evaluate the safety and efficacy of injecting allogeneic adipose tissue-derived mesenchymal stem/stromal cells (AT-MSCs) into the major salivary glands of patients with head and neck cancer who experienced radiation-induced salivary gland damage. The results showed that this treatment method was safe and effectively improved xerostomia symptoms in patients.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Mathematics, Interdisciplinary Applications
Paul Frederic Blanche, Anders Holt, Thomas Scheike
Summary: Simple logistic regression can be adapted for right-censoring using inverse probability of censoring weighting (IPCW). This study compares two IPCW approaches and examines their efficiency based on the censoring distribution. The authors demonstrate that the choice of weighting method depends on realistic settings and illustrate the application of these approaches in estimating causal treatment effects using logistic regression.
LIFETIME DATA ANALYSIS
(2023)
Article
Statistics & Probability
Giuliana Cortese, Thomas H. Scheike
Summary: This study investigates the estimation problem of recurrent events data, which has not been studied before. By transforming the standard estimator into an inverse probability of censoring weighted estimator and utilizing efficient estimation theory, an efficient augmented estimator is derived. The simulation results demonstrate that using the efficient augmented estimator based on dynamic predictions can greatly improve efficiency in settings with heterogeneity, without sacrificing robustness.
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS
(2022)
Article
Public, Environmental & Occupational Health
Y. Ladegaard, V. L. Dalgaard, P. M. Conway, N. H. Eller, J. Skakon, T. Maltesen, T. Scheike, B. Netterstrom
Summary: This study examines whether being notified with an occupational mental disorder in the Danish Labour Market Insurance is associated with changes in visits to the general practitioner, use of medicine, and annual income. The results suggest that notification status does not significantly affect health-related outcomes. However, both the notified and unnotified groups experienced a significant decrease in annual income over time.
OCCUPATIONAL MEDICINE-OXFORD
(2023)
Article
Otorhinolaryngology
Anders Christensen, Irene Wessel, Birgitte Wittenborg Charabi, Karina Juhl, Katalin Kiss, Giedrius Lelkaitis, Jann Mortensen, Andreas Kjaer, Christian von Buchwald, Jesper Filtenborg Tvedskov
Summary: The aim of this study was to investigate the diagnostic performance of bimodal optical and radio-guided sentinel node biopsy (SNB) for oral squamous cell carcinoma (OSCC) sub-sites in the anterior oral cavity. A total of 50 cN0 OSCC patients scheduled for SNB were prospectively studied and injected with the tracer complex Tc99m:ICG:Nacocoll. Optical imaging appeared to be an effective tool for real-time SN identification unaffected by possible interference from the injection.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Immunology
Dina Leth Moller, Soren Schwartz Sorensen, Omid Rezahosseini, Daniel Brauner Rasmussen, Nicoline Stender Arentoft, Josefine Amalie Loft, Michael Perch, Finn Gustafsson, Jens Lundgren, Thomas Scheike, Jenny Dahl Knudsen, Sisse Rye Ostrowski, Allan Rasmussen, Susanne Dam Nielsen
Summary: This study aimed to determine the incidence of positive herpes virus PCR tests during the first year post-transplantation and assess whether a model including immune function could predict subsequent positive tests. The cumulative incidence of positive tests was 36.6%, and the prediction model had an AUC of 77%. Risk scores based on the model allowed for identification of recipients with higher risk.
FRONTIERS IN IMMUNOLOGY
(2023)
