Article
Multidisciplinary Sciences
Asuka Tanaka, Kentaro Ide, Yuka Tanaka, Masahiro Ohira, Hiroyuki Tahara, Hideki Ohdan
Summary: Pretransplant desensitization with rituximab was found to enhance anti-donor CD4(+) T cell responses in DSA-positive transplant recipients, while IL-10(+) CD5(+) B cells were shown to suppress excessive responses of anti-donor CD4(+) T cells.
SCIENTIFIC REPORTS
(2021)
Article
Respiratory System
Francois Parquin, Benjamin Zuber, Alexandre Vallee, Jean-Luc Taupin, Elise Cuquemelle, Stephanie Malard, Mathilde Neuville, Jerome Devaquet, Morgan Le Guen, Julien Fessler, Laurence Beaumont, Clement Picard, Abdulmonem Hamid, Sylvie Colin de Verdiere, Dominique Grenet, Sandra De Miranda, Matthieu Glorion, Edouard Sage, Ciprian Pricopi, Julien De Wolf, Anne-Laure Brun, Elisabeth Longchampt, Charles Cerf, Antoine Roux, Olivier Brugiere
Summary: The study compared outcomes of desensitised LTx patients with high DSAs and those with low or no DSAs. It found that the desensitisation protocol reduced the level of immunodominant DSAs and cleared high DSAs were identified as an independent predictor of graft survival.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Nutrition & Dietetics
Marijana Vuckovic, Josipa Radic, Andrea Gelemanovic, Hrvoje Raos, Dora Bucan Nenadic, Ela Kolak, Mislav Radic
Summary: The study aimed to evaluate adherence to Mediterranean diet (MeDi) and its correlation with nutritional status parameters in Dalmatian kidney transplant recipients (KTRs). Results showed low adherence to MeDi in Dalmatian KTRs, but it was associated with certain nutritional status parameters. MeDi may have beneficial effects on nutritional status in KTRs, but a structured nutritional approach is needed to enhance adherence and prevent potential adverse effects.
Article
Nursing
Ching-Hwa Hsu, Heng-Hsin Tung, Yi-Chen Wu, Jeng Wei, Shiow-Luan Tsay
Summary: The study investigated the characteristics and prevalence of demoralisation syndrome among heart transplantation patients in Taiwan. Findings showed that 35.8% of patients experienced demoralisation syndrome, with stress and poor renal function being predictors of the syndrome. Further research on demoralisation in cardiac transplant recipients is warranted.
JOURNAL OF CLINICAL NURSING
(2022)
Article
Cardiac & Cardiovascular Systems
Kyle Freischlag, Thomas J. Lynch, Vitaly Ievlev, Caitlyn Gries, John C. Keech, Evgeny Arshava, Tahuanty Pena, Julia A. Klesney-Tait, Kalpaj R. Parekh
Summary: This study found that recipients of lung transplantation for COVID-19-related lung disease have comparable outcomes to other recipients with similar levels of lung dysfunction, including survival rate, mechanical ventilation, and postoperative complications.
ANNALS OF THORACIC SURGERY
(2023)
Article
Medicine, General & Internal
Hsun-Yi Fu, Yi-Chia Wang, Chuan- Tsao, Sz-Han Yu, Yih-Sharng Chen, Heng -Wen Chou, Nai-Hsin Chi, Chih-Hsien Wang, Ron -Bin Hsu, Shu-Chien Huang, Hsi-Yu Yu, Nai-Kuan Chou
Summary: This study analyzed the perioperative desensitization in 25 consecutive sensitized heart transplant recipients. The results showed a 76% patient survival rate within the first year post-transplant, with infection being the major cause of death. The cumulative incidence of rejection was 8% for antibody-mediated rejection and 16% for acute cellular rejection, with no significant difference in 1-year survival or rejection rate between sensitized and nonsensitized recipients.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Medicine, General & Internal
Dorota Sikorska, Dorota Kaminska, Rusan Catar, Miroslaw Banasik, Harald Heidecke, Kai Schulze-Forster, Katarzyna Korybalska, Rafal Rutkowski, Joanna Luczak, Jerzy Jablecki, Andrzej Oko, Przemyslaw Daroszewski, Mariusz Kusztal, Wlodzimierz Samborski
Summary: The role of non-HLA antibodies in hand allograft rejection was investigated in this study. Six patients after hand transplantation were studied, compared with kidney transplant recipients and healthy volunteers. Non-HLA antibodies and proinflammatory cytokines were tested, and markers of endothelial activation were used to assess potential vasculopathy. The study found that the patient with the most acute rejections had multiple positive non-HLA antibodies. All patients after hand transplantation showed high levels of markers of endothelial activation. Therefore, further research is needed to explore the potential role of non-HLA antibodies in humoral injury in vascular composite allotransplantation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Marta Crespo, Laura Llinas-Mallol, Dolores Redondo-Pachon, Carrie Butler, Javier Gimeno, Maria Jose Perez-Saez, Carla Burballa, Anna Buxeda, Carlos Arias-Cabrales, Montserrat Folgueiras, Sara Sanz-Urena, Nicole M. Valenzuela, Elaine F. Reed, Julio Pascual
Summary: The relationship between HLA-DSA and ABMR in kidney transplant recipients is strong but imperfect. Pre-transplant HLA-DSA and AT(1)R-Ab are more common in ABMR, indicating their potential role in ABMR(h)DSA(pos) cases. HLA epitope mismatches are associated with ABMR(h)DSA(pos) cases, suggesting non-HLA factors may contribute to the development of ABMR.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Martin Tepel, Subagini Nagarajah, Qais Saleh, Olivier Thaunat, Stephan J. L. Bakker, Jacob van den Born, Morten A. Karsdal, Federica Genovese, Daniel G. K. Rasmussen
Summary: The characterization of potential kidney transplant recipients using novel biomarkers can lead to improved outcomes after transplantation. This mini-review focuses on the current understanding of pretransplant recipients' characteristics, biomarkers, and immunology. Clinical characteristics and immunological risk assessment, such as histocompatibility leukocyte antigens (HLAs) and non-HLA antibodies, have been used to predict recipient and allograft survival. Recent studies have shown that pretransplant markers, such as plasma endotrophin levels and non-synonymous single-nucleotide polymorphism mismatch, are associated with posttransplant complications and allograft loss. Integrating clinical characteristics and novel markers is important for making better diagnostic decisions tailored to individual patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Matthaios Papadimitriou-Olivgeris, Ana Cipriano, Nicolas Guggisberg, Marie Kroemer, Jonathan Tschopp, Oriol Manuel, Dela Golshayan
Summary: Kidney transplant recipients are at higher risk for COVID-19 complications. This study examines the epidemiology and outcome of PCR-documented SARS-CoV-2 infection in KTR patients from March 2020 to May 2022. Early administration of monoclonal antibodies and a lower Charlson Comorbidity Index are associated with better outcomes.
TRANSPLANT INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Yael Peled, Eilon Ram, Jacob Lavee, Amit Segev, Shlomi Matezki, Anat Wieder-Finesod, Rebecca Halperin, Michal Mandelboim, Victoria Indenbaum, Itzchak Levy, Leonid Sternik, Ehud Raanani, Arnon Afek, Yitshak Kreiss, Yaniv Lustig, Galia Rahav
Summary: This study investigated the safety and immunogenicity of a third dose of the Pfizer BNT162b2 vaccine in heart transplant patients. The results showed that the third dose had a low rate of adverse events and elicited a strong immune response.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Multidisciplinary Sciences
Ye Eun Shim, Youngmin Ko, Jung Pyo Lee, Jin Seok Jeon, Heungman Jun, Jaeseok Yang, Myoung Soo Kim, Seong Jun Lim, Hye Eun Kwon, Joo Hee Jung, Hyunwook Kwon, Young Hoon Kim, Jungbok Lee, Sung Shin
Summary: Anti-thymocyte globulin (ATG) is commonly used as an induction regimen to prevent acute rejection after solid organ transplantation, but the optimal dose for Asian kidney recipients is unclear. A retrospective cohort study in South Korea compared different induction regimens in 4579 adult renal transplantation patients. The study found that high-dose ATG induction (>4.5 mg/kg) showed better graft and patient survival outcomes compared to basiliximab and low-dose ATG induction in Asian kidney transplant patients.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Sunjae Bae, JiYoon B. Ahn, Corey Joseph, Ryan Whisler, Mark A. Schnitzler, Krista L. Lentine, Bernard S. Kadosh, Dorry L. Segev, Mara A. McAdams-DeMarco
Summary: Statins appear to be well tolerated in kidney transplant recipients, but their use may be associated with a slightly higher risk of post-transplant diabetes mellitus, cataract, and rhabdomyolysis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Microbiology
Zheng Wu, Jinhua Lan, Xipei Wang, Yijin Wu, Fen Yao, Yifan Wang, Bo-Xin Zhao, Yirong Wang, Jingchun Chen, Chunbo Chen
Summary: This study investigated the population pharmacokinetics of caspofungin in heart transplant (HTx) and non-HTx patients. The findings showed that HTx did not affect the pharmacokinetics of caspofungin, but dosing adjustments should be made in patients with decreased albumin levels.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Oncology
Yan Liu, Billy C. Wang, Craig W. Zuppan, Peter Chau, James Fitts, Richard Chinnock, Jun Wang
Summary: Post-transplant lymphoproliferative disorders (PTLD) are heterogenous lymphoproliferative disorders that develop as a consequence of immunosuppression in transplant recipients. We sought to determine if subtypes of PTLD correlated with different outcomes. Our retrospective review of PTLD occurring in pediatric heart transplant recipients found that infant recipients were less likely to develop PTLD compared to older children. Infants who developed PTLD were diagnosed later and had a lower rate of more aggressive PTLD. Patients with more aggressive PTLD had significantly lower overall survival than patients with low-grade PTLD.
