Review
Pharmacology & Pharmacy
Rashid Giniatullin
Summary: 5-hydroxytryptamine (5-HT) is considered a key mediator in migraine, but the role of 5-HT3 receptors in pain transmission remains controversial. The applicability of currently available 5-HT3 antagonists in migraine treatment is not clearly supported by clinical data.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Clinical Neurology
Tristan J. Philippe, Lexia Bao, Maya E. Koblanski, Victor Viau
Summary: This study found that male and female rats showed region-specific changes in 5-HT 1A receptor function after repeated restraint, which may be explained by changes in receptor availability.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Integrative & Complementary Medicine
Haoran Wang, Yanqiu Gu, Rahman Khalid, Xiaofei Chen, Ting Han
Summary: Insomnia is a common sleep disorder that lacks effective therapy and has a negative impact on a person's life. Understanding the targets related to insomnia is crucial in order to develop innovative treatments and compounds. Research on complementary and alternative medicines has shown their sedative and sleep-promoting properties through interaction with neurotransmitter systems in the brain, particularly the 5-hydroxytryptamine (5-HT) receptor. This review provides a summary of the role of 5-HT in insomnia development and analyzes the mechanisms of herbal medicines on different subtypes of 5-HT receptors for future reference.
CHINESE JOURNAL OF NATURAL MEDICINES
(2023)
Article
Clinical Neurology
Jacob C. A. Edvinsson, Aida Maddahi, Isabella M. Christiansen, Philip Reducha, Karin Warfvinge, Majid Sheykhzade, Lars Edvinsson, Kristian A. Haanes
Summary: This study reveals the presence of a subgroup of C-fibres that store 5-HT and shows high expression of 5-HT1B/1D receptors. The study suggests that the 5-HT1F receptor is a relatively unlikely target in the rat trigeminal system. Furthermore, Lasmiditan works as a partial agonist on 5-HT1B/1D receptors in clinically relevant dose regiments.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Pharmacology & Pharmacy
Ning Ding, Jiaxin Liu, Jianing Liu, Mengmeng Zhao, Lei Liu, Hanwen Liu, Jieke Yan, Wei Song, Jiliang Wen, Shulu Zu, Xiulin Zhang, Yang Xu
Summary: This study aimed to characterize the mediating receptors of 5-hydroxytryptamine (5-HT) in enhancing human ureteral contractions. The results showed that 5-HT2C and 5-HT2A receptors had the highest mRNA expression levels among the 13 5-HT receptors. Activation of 5-HT2C and 5-HT2A receptors increased the frequency of ureteral contractions, with partial involvement of sympathetic and sensory nerves.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Physical
Liping Fang, Shan He, Peng Yin, Ning Wang, Bin Zhang, Haixiao Jin
Summary: This study presents the design, synthesis, and evaluation of a series of novel tryptamine derivatives with 5-HT 1B R activation. Several compounds were identified as more potent 5-HT 1B R activators compared to the FDA-approved drug sumatriptan. The molecular docking results provided insights into the binding mode and interactions between the compounds and 5-HT 1B R.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Clinical Neurology
Raffaele Ornello, Carlo Baraldi, Simona Guerzoni, Giorgio Lambru, Matteo Fuccaro, Bianca Raffaelli, Astrid Gendolla, Piero Barbanti, Cinzia Aurilia, Sabina Cevoli, Valentina Favoni, Fabrizio Vernieri, Claudia Altamura, Antonio Russo, Marcello Silvestro, Elisabetta Dalla Valle, Andrea Mancioli, Angelo Ranieri, Gennaro Alfieri, Nina Latysheva, Elena Filatova, Jamie Talbot, Shuli Cheng, Dagny Holle, Armin Scheffler, Tomas Nezadal, Dana Ctrnacta, Jitka Sipkova, Zuzana Matousova, Lucia Sette, Alfonsina Casalena, Maurizio Maddestra, Stefano Viola, Giannapia Affaitati, Maria Adele Giamberardino, Francesca Pistoia, Uwe Reuter, Simona Sacco
Summary: The study found that erenumab is equally safe and effective in men compared with women after 12 weeks, without gender differences observed in the outcomes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Oleg Gafurov, Kseniia Koroleva, Rashid Giniatullin
Summary: The study revealed significant antidromic propagation of spontaneous spikes in meningeal nerves, which was weaker than orthodromic nociceptive traffic. There were differences in the expression of ATP, serotonin, and capsaicin receptors in different parts of the meningeal nerves. Disconnection of nerve from trigeminal ganglion reduced the tonic antidromic activity.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Endocrinology & Metabolism
Kai Sun, Yincang Wang, Jiazhe Du, Yujie Wang, Bo Liu, Xiaodong Li, Xiaofeng Zhang, Xilin Xu
Summary: This paper discusses the regulation of 5-HT by Traditional Chinese Medicine and its impact on bone metabolism, as well as the underlying mechanism of action. The results show that Traditional Chinese Medicine has the ability to regulate 5-HT, thereby improving bone loss and providing valuable insights for future osteoporosis treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pharmacology & Pharmacy
Farzin Zobdeh, Aziza Ben Kraiem, Misty M. Attwood, Vladimir N. Chubarev, Vadim V. Tarasov, Helgi B. Schioth, Jessica Mwinyi
Summary: Migraine is a prevalent disease globally and limited therapy response requires individually adjusted treatment. The pharmaceutical development for acute and chronic migraine has significantly intensified in recent years, with an expansion of drug targets and increased number of clinical trials.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Alex Sharp, Julia Focker, Louise O'Hare
Summary: Individuals with migraine may experience discomfort when viewing flickering stimuli. This study found that the response of migraine sufferers increases with exposure to 9-Hz stimulation, suggesting a possible build-up effect. Visual discomfort varies with spatial frequency, with higher spatial frequencies being less uncomfortable compared to low- and mid-range frequencies.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Giovanna Viticchi, Lorenzo Falsetti, Sergio Salvemini, Mauro Silvestrini, Alice Riva, Laura Buratti, Marco Bartolini
Summary: This study explored the OCD traits in patients with chronic migraine and medication overuse headaches, finding significantly high rates of OCD traits at baseline, particularly among men. Women showed more significant improvement in OCD traits after treatment. The study suggests that psychological attitudes in managing migraine should be further investigated.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Iris E. Verhagen, Britt W. H. van der Arend, Daphne S. van Casteren, Saskia le Cessie, Antoinette MaassenVanDenBrink, Gisela M. Terwindt
Summary: In this study, characteristics of migraine attacks were compared between men and women. The findings suggest that women experience longer migraine attacks with more accompanying symptoms than men, both during the perimenstrual and non-perimenstrual periods. A sex-specific approach to migraine treatment and research is necessary.
Article
Clinical Neurology
Carmen Fourier, Caroline Ran, Anna Steinberg, Christina Sjoestrand, Elisabet Waldenlind, Andrea Carmine Belin
Summary: This study on Swedish cluster headache patients found significant differences between male and female patients in clinical phenotype, attack patterns, treatment, and lifestyle. Female patients were more likely to have the chronic cluster headache subtype, longer attack durations, and higher usage of preventive treatment. They also had a higher prevalence of a family history of cluster headache and were more likely to have attacks triggered by lack of sleep.
Article
Anesthesiology
Nathan da Silva Xavier, Mariana Tedeschi Benatto, Lidiane Lima Florencio, Cesar Fernandez-de-las-Penas, Fabiola Dach, Debora Bevilaqua-Grossi
Summary: Women with migraine have a higher prevalence and severity of cutaneous allodynia and a higher risk of neck pain compared to men, but there were no significant gender differences in migraine-related disability, mobility of the upper cervical spine, and performance of the deep neck flexor muscles.
