Article
Food Science & Technology
Kathryn Glass, Angus Mclure, Siobhan Bourke, Danielle M. Cribb, Martyn D. Kirk, Jason March, Ben Daughtry, Snezana Smiljanic, Emily Lancsar
Summary: Foodborne illnesses have a significant impact on both the health and economy of Australia, highlighting the need for interventions to improve food safety.
FOODBORNE PATHOGENS AND DISEASE
(2023)
Article
Health Care Sciences & Services
Jaime Espin, Zuzana Spacirova, Joan Rovira, David Epstein, Antonio Olry de Labry Lima, Leticia Garcia-Mochon
Summary: Costs are critical for the transferability of health technology assessment and economic evaluation results. This study aims to develop a cost database at the European level to facilitate cross-border cost comparisons and explain the differences in healthcare costs between different countries.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Valentina Ignatova, Kostadin Kostadinov, Evguenia Vassileva, Naira Muradyan, Georgi Stefanov, Georgi Iskrov, Rumen Stefanov
Summary: This study estimated the annual costs of MG patients in Bulgaria from a societal perspective and found that direct healthcare costs slightly outweighed indirect costs, with drug costs having the biggest impact. Severe generalized disease, disease crises, and recurrent infections were identified as significant cost drivers. The reliance on family members as informal caregivers among Bulgarian MG patients was common, likely due to the lack of access to appropriate social services. Further research and targeted health policies are needed to meet the needs of these patients.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Green & Sustainable Science & Technology
Elena Fregonara, Diego Giuseppe Ferrando
Summary: This study focuses on the limitations of the conventional Life Cycle Costing (LCC) in project economic sustainability evaluation and proposes two research topics to enhance LCC's capability in dealing with environmental components. The results show that environmental costs have a significant impact on the calculation of Global Cost, and the use of environmental hurdle rate can alter the final preferability ranking obtained using financial rates.
Article
Engineering, Chemical
Hamad H. Almutairi, Abdulrahman S. Almutairi, Suleiman M. Suleiman, Abdulrahman H. Alenezi, Khalid A. Alkhulaifi, Hamad M. Alhajeri
Summary: This paper presents an analysis of four different gas turbine engines with varying compressor configurations, focusing on economic, exergoeconomic, and exergoenvironmental aspects. Using specialized software, the performances of these engines were validated against manufacturer data. The economic analysis revealed that the gas turbine engine with a centrifugal-centrifugal compressor was the most economically feasible, followed by the axial and axial-centrifugal configurations. The axial-centrifugal configuration had the lowest CO2 emissions, confirming its environmental friendliness.
Article
Multidisciplinary Sciences
Xavier Sanchez, Gerardine Leal, Angel Padilla, Ruth Jimbo
Summary: The objective of this study was to estimate the direct medical cost per episode and the annual cost for acute diarrhea in children under five in Ambulatory Care Centers of the Ministry of Public Health of Ecuador. The study found that a high proportion of the direct medical cost of acute diarrhea in children under five in outpatient settings is due to unnecessary laboratory tests.
Review
Clinical Neurology
Irina Kinchin, Eileen Mitchell, Meera Agar, Dominic Trepel
Summary: This review systematically identified and appraised the methodological quality of claims on the cost of delirium, revealing significant variation among cost estimates and methodological quality. Limited attention has been paid to the economic implications of considering dementia as a sequel of delirium, but recent evidence suggests potential 52% increase in cost implications when dementia is included.
ALZHEIMERS & DEMENTIA
(2021)
Review
Immunology
Patricia Coelho de Soarez, Luciana Martins Rozmana, Taiane Siraisi Fonseca, Pietro Rodrigo Borsari, Jadher Percio, Lely Stella Guzman Barrera, Ana Marli Christovam Sartori
Summary: The objective of this study was to identify the main cost components of measles outbreaks and evaluate the quality of costing methodology. The study found that most studies did not report the costing methodology adopted or the method for the valuation of resource and cost components.
Article
Psychiatry
Naman Kochar, Sophie Ip, Vittoria Vardanega, Nick T. Sireau, Naomi A. Fineberg
Summary: This study evaluated the cost-of-illness (CoI) of obsessive-compulsive disorder (OCD) in the UK and found that it has a substantial economic burden, extending beyond direct treatment costs to include societal costs. Cognitive behavioral therapy was found to be the largest contributor to healthcare costs, while societal costs were driven by lost productivity due to absenteeism.
COMPREHENSIVE PSYCHIATRY
(2023)
Article
Construction & Building Technology
Evangelos I. Sakellariou, Petros J. Axaopoulos, Kosmas A. Kavadias, Antonios Nazos
Summary: In this study, the most prevalent space heating systems in Athens are assessed using a probabilistic economic method. The results show that the cost of all systems is higher than pre-crisis levels and not feasible in the current economic period. However, a solution to the volatility of the energy market can be achieved through energy cost subsidies and pairing heat pumps with PV systems.
JOURNAL OF BUILDING ENGINEERING
(2023)
Article
Agronomy
Emmanouil Tziolas, Stefanos Ispikoudis, Konstantinos Mantzanas, Dimitrios Koutsoulis, Anastasia Pantera
Summary: The preservation and promotion of agroforestry systems are important for ecosystem services, biodiversity benefits, and climate change mitigation. However, traditional agroforestry systems in the EU face adaptation problems. This study assesses the managerial framework of olive agroforestry practices in Northern Greece and analyzes the economic and environmental implications of four production plans. The results show significant deviations among the production plans and suggest the need for a decision support system for preserving current agroforestry systems.
Article
Health Care Sciences & Services
Thean Singh, Jawahar S. K. Pillai, Mukunda C. Sahoo
Summary: This study used the ABC technique to determine the cost of SICU beds per day, providing important information for hospital policy decisions.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Immunology
Daniel Olson, Diva M. Calvimontes, Molly M. Lamb, Gerber Guzman, Edgar Barrios, Andrea Chacon, Neudy Rojop, Kareen Arias, Melissa Gomez, Guillermo A. Bolanos, Jose Monzon, Anna N. Chard, Chelsea Iwamoto, Lindsey M. Duca, Nga Vuong, Melissa Fineman, Kelsey Lesteberg, David Beckham, Mario L. Santiago, Kendra Quicke, Gregory Ebel, Emily Zielinski Gutierrez, Eduardo Azziz-Baumgartner, Frederick G. Hayden, Hani Mansour, Kathryn Edwards, Lee S. Newman, Edwin J. Asturias
Summary: This study evaluated the clinical and socioeconomic burdens of respiratory diseases among banana farm workers in Guatemala, finding that workers with SARS-CoV-2 infections had more severe symptoms, higher absenteeism, and income loss compared to those without the infection, supporting the prioritization of COVID-19 vaccination for this group.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Engineering, Environmental
Jin Igarashi, Barbara Evans, Andrew Sleigh, Davies N. Tarkash, Ronoh Kennedy, Ruthie Rosenberg, Fiona Zakaria
Summary: This paper presents a global database that collects and aggregates reliable and comparable cost data for urban sanitation systems. The study shows that no specific mode of urban sanitation can be considered low cost compared to others. It also demonstrates that economies of scale exist for both sewerage systems and systems that transport waste from pits and sealed tanks by road. A case study example highlights the importance of comparing local costs to global benchmarks and identifies operational considerations as significant factors in determining overall cost liabilities for urban sanitation.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Bowei Xu, Hailing Wang, Junjun Li
Summary: Automatic container terminals (ACTs) are the direction for upgrading and transforming traditional manual container terminals. This study utilizes a Time-Driven Activity-Based Costing approach and a multi-agent based simulation model to compare different container terminal layouts in terms of operation cost and energy consumption. The results show that automated guided vehicles (AGVs) are crucial in improving the cost-effectiveness of ACTs, and ACTs with bilateral-cantilever ARMGs demonstrate better cost-effectiveness and energy consumption compared to ACTs with non-cantilever ARMGs. This study provides management insights for resource allocation, layout design, and sustainable development.
SIMULATION MODELLING PRACTICE AND THEORY
(2023)
Editorial Material
Clinical Neurology
Alberto Raggi, Matilde Leonardi, Simona Sacco, Paolo Martelletti
Summary: The diagnosis of chronic migraine should consider multiple factors, such as frequency, pain severity, associated symptoms, treatment response, and comorbidities. A paradigm change in the definition of chronic migraine is necessary, including the use of new diagnostic criteria, addressing issues related to treatment escalation towards MABs, and determining the endpoint for defining effectiveness.
Review
Pharmacology & Pharmacy
Enrico Bentivegna, Michelangelo Luciani, Valeria Ferrari, Silvia Galastri, Francesco Baldari, Francesco Scarso, Piera A. Lamberti, Paolo Martelletti
Summary: This article provides a narrative review of the scientific evidence on recently approved and emerging drugs for the prophylactic treatment of migraines. Monoclonal antibodies targeting the CGRP signaling pathway have brought innovation to prophylactic migraine therapy. New classes of molecules such as gepants and ditans show exceptional results. Additionally, new prophylactic drugs with various targets are emerging. These therapies will enhance migraine management and provide personalized medicine for each patient.
EXPERT OPINION ON PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Farzaneh Allahdinian Hesaruiyeh, Saeed Rajabi, Mohadeseh Motamed-Jahromi, Mohammad Sarhadi, Michelle L. Bell, Razieh Khaksefidi, Somayeh Sarhadi, Leili Mohammadi, Kamal Dua, Amin Mohammadpour, Paolo Martelletti
Summary: This study aimed to evaluate the levels of lead (Pb), 8-hydroxy di-guanine (8-oxo-Gua), and malondialdehyde (MDA) in the blood serum of opium addicts and non-addicts. The results showed that the amount of Pb in the blood serum of addicts was significantly higher than non-addicts, but there were no significant differences in the levels of 8-oxo-Gua and MDA between the two groups.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Editorial Material
Clinical Neurology
William David Wells-Gatnik, Fidel Dominique Festin Ambat, Paolo Martelletti
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2022)
Article
Clinical Neurology
Claudia Altamura, R. Ornello, F. Ahmed, A. Negro, A. M. Miscio, A. Santoro, A. Alpuente, A. Russo, M. Silvestro, S. Cevoli, N. Brunelli, L. Grazzi, C. Baraldi, S. Guerzoni, A. P. Andreou, G. Lambru, I Frattale, K. Kamm, R. Ruscheweyh, M. Russo, P. Torelli, E. Filatova, N. Latysheva, A. Gryglas-Dworak, M. Straburzynski, C. Butera, B. Colombo, M. Filippi, P. Pozo-Rosich, P. Martelletti, S. Sacco, F. Vernieri
Summary: This study aimed to investigate the outcome of OnabotulinumtoxinA (OBT-A) as preventative therapy in elderly chronic migraine (CM) patients. The results showed that there were no differences in the primary and secondary endpoints between elderly and non-elderly patients in the first three treatment cycles.
JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Dilara Onan, William David Wells-Gatnik, Enrico Bentivegna, Christian Lampl, Paolo Martelletti
Summary: Migraine is a prevalent and burdensome disease, affecting around 14% of the global population. Recent randomized controlled trials (RCTs) of new migraine drugs have included participants aged over 65 years, providing clinicians with safety and efficacy data for treating older patients. However, the inclusion criteria of RCTs often exclude patients with multiple comorbidities, reducing the clinical applicability of the new drugs for older patients.
Article
Clinical Neurology
Dilara Onan, Ozlem Ulger, Paolo Martelletti
Summary: This study aimed to compare the effects of telerehabilitation and face-to-face rehabilitation on patients with chronic nonspecific neck pain (CNNP). The results showed that both methods were equally effective in improving neck functional capacity, reducing pain and disability.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Claudio Tana, David Garcia Azorin, Francesco Cinetto, Cesare Mantini, Marco Tana, Massimo Caulo, Fabrizio Ricci, Paolo Martelletti, Francesco Cipollone, Maria Adele Giamberardino
Summary: Migraine and sarcoidosis may share some common biological and clinical pathways. Both conditions involve inflammation and immune system dysregulation. Migraine is a common comorbidity in sarcoidosis patients, and there have been reports of individuals with neurosarcoidosis experiencing migraines. The exact relationship between the two disorders is still unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Health Care Sciences & Services
Christina Deligianni, Paolo Martelletti, Dimos D. Mitsikostas
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
(2023)
Article
Clinical Neurology
Elena Gross, Elena Ruiz de la Torre, Paolo Martelletti
Summary: Despite the evidence on the epidemiology of migraine and its impact on patients in terms of disability, burden, and cost, the stigma of migraine has not been fully acknowledged as a key factor in the chronicity of the disease and social isolation of patients. In this commentary, a European advocacy body and a clinician specializing in migraine present different perspectives, highlighting the need for actions to improve community perception and propose treatment and rehabilitation paths for the reintegration of migraine sufferers into social contexts.
NEUROLOGY AND THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Tsubasa Takizawa, Keiko Ihara, Shunsuke Uno, Seiya Ohtani, Narumi Watanabe, Noboru Imai, Jin Nakahara, Satoko Hori, David Garcia-Azorin, Paolo Martelletti
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
William Wells-Gatnik, Paolo Martelletti
Summary: A recent study has found an increased risk of neurodevelopmental disorders in individuals exposed to valproate or topiramate. Regulatory bodies are reviewing the safety of topiramate during pregnancy. This review highlights the concerns regarding the use of valproate and topiramate in women of childbearing potential.
EXPERT OPINION ON DRUG SAFETY
(2023)
Review
Pharmacology & Pharmacy
William David Wells-Gatnik, Tiffany Yazmin Wences Chirino, Fatma Nur Onan, Dilara Onan, Paolo Martelletti
Summary: This article introduces new drugs for the treatment of migraine and discusses their clinical trial outcomes. As approximately 50% of patients do not respond to calcitonin gene-related peptide therapies, there is significant value in future drug innovation. Overall, these emerging drugs are largely developed based on important targets of migraine pathogenesis, but the clinical value of individual drugs needs further research to appropriately target the relevant pathways.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Medicine, General & Internal
Antonio Martocchia, Cinzia Piccoli, Michele Fortunato Notarangelo, Daniela Sergi, Beata Ostrowska, Paolo Martelletti, Carmine Savoia, Luciano De Biase, Giorgio Sesti
Summary: The use of point-of-care ultrasound for evaluating left ventricle systolic function (LV EF) has shown high accuracy in this study. It can support the diagnosis of heart failure in emergency situations without delays.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Clinical Neurology
Arife Cimen Atalar, Ayse Nur Ozdag Acarli, Betuel Baykan, Paolo Martelletti, Hayrunnisa Bolay, Mustafa Ertas, Esme Ekizoglu, Omer Karadas, Burcu Polat, Isil Yazici Gencdal, David Garcia Azorin, Dimos Mitsikostas, Loukia Apostolakopoulou, Hamit Genc, Pinar Yalinay Dikmen, Esra Aciman Demirel, Elif Ilgaz Aydinlar, Rabia Gokcen Gozubatik-Celik, Javid Shafiyev, Bahar Tasdelen, Aynur Ozge
Summary: This multinational observational study aimed to investigate prolonged or worsened headaches associated with COVID-19 vaccination. Questionnaires were used to assess the vaccination-related headaches at three time points. Repeated K-means cluster analysis identified patient profiles with prolonged or worsened headaches related to COVID-19 vaccination.
JOURNAL OF HEADACHE AND PAIN
(2023)