Article
Clinical Neurology
Kasper Lolk, Julie W. Dreier, Jakob Christensen
Summary: The study found that the risk of epilepsy following traumatic brain injury increases with the repetition and severity of the injury, with females more likely to develop epilepsy after mild injuries and males more likely after severe injuries. These risks remain elevated for decades post-injury.
Article
Endocrinology & Metabolism
Matias Vaajala, Ilari Kuitunen, Rasmus Liukkonen, Ville Ponkilainen, Maiju Kekki, Ville M. M. Mattila
Summary: This study aims to investigate the association between traumatic brain injury (TBI) and the risk for the development of gestational diabetes (GDM). The results of a retrospective cohort study show that TBI is associated with an increased risk of GDM, with the highest risk observed at least 9 years after the injury.
ACTA DIABETOLOGICA
(2023)
Article
Orthopedics
Jessica M. Zendler, Ron Jadischke, Jared Frantz, Steve Hall, Grant C. Goulet
Summary: Among youth in the United States aged 6 to 18 years who were treated in the emergency department for injuries related to playing non-tackle football, the most common diagnosis for injuries to the head region was a laceration, followed by a concussion. Head region injuries associated with non-tackle football occurred at a notably lower rate than basketball, soccer, or tackle football.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2021)
Article
Sport Sciences
Christopher M. Fox, Jonathan G. Wu, Lucia Chen, Dena L. Florczyk
Summary: The study aimed to assess injury patterns in collegiate club quidditch athletes over three seasons. The overall injury incidence rate for quidditch injuries was 4.55 per 1000 athlete exposures. Male athletes had a higher injury rate compared to females, with the most common injuries being lower extremity injuries and sprains. The study identified areas for improvement in education, injury prevention, and athlete care, particularly in relation to concussions in quidditch.
SPORTS MEDICINE-OPEN
(2021)
Article
Sport Sciences
Landon C. Lempke, Elizabeth W. Teel, Robert A. Lynall, Nicole Hoffman, Thomas Buckley, James Eckner, Thomas McAllister, Michael McCrea, Steven R. Broglio, Julianne Schmidt
Summary: Early exercise after concussion is associated with higher probability and faster recovery of symptoms and clinical recovery, and lower prevalence of persisting post-concussion symptoms. Clinicians can consider implementing early exercise as a therapeutic intervention to improve student-athlete recovery.
Article
Orthopedics
Robert C. Lynall, Christopher D'Lauro, Zachary Y. Kerr, Kristen Knight, Emily Kroshus, Daniel D. Leeds, Johna K. Register-Mihalik, Michael McCrea, Steven P. Broglio, Thomas McAllister, Julianne D. Schmidt
Summary: The study aimed to investigate the association between previous concussion diagnosis status and outcomes on standard baseline concussion assessments. The results showed that individuals with a history of undiagnosed concussions performed worse on baseline clinical indicators.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Orthopedics
Julianne D. Schmidt, Steven P. R. Broglio, Kristen G. Knight, Daniel Leeds, Robert T. Lynall, Christopher P. D'Lauro, Johna Register-Mihalik, Emily Kroshus, Michael McCrea, Tom McAllister, Zachary Kerr
Summary: About half of concussions go undisclosed and delayed medical care is common. Delayed reporting of concussion symptoms leads to higher symptom burdens and longer recovery time.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Review
Public, Environmental & Occupational Health
Alexis Peterson, Barbara A. Gabella, Jewell Johnson, Beth Hume, Ann Liu, Julia F. Costich, Jeanne Hathaway, Svetla Slavova, Renee Johnson, Matt Breiding
Summary: This study assessed the evidence of TBI in ED medical records containing the S09.90 code, finding wide variation in the positive predictive value of S09.90 among sampled records, with 36%-52% showing medium to high evidence of TBI, while 48%-64% lacked evidence of TBI.
Review
Neurosciences
Emily L. Dennis, David Baron, Brenda Bartnik-Olson, Karen Caeyenberghs, Carrie Esopenko, Frank G. Hillary, Kimbra Kenney, Inga K. Koerte, Alexander P. Lin, Andrew R. Mayer, Stefania Mondello, Alexander Olsen, Paul M. Thompson, David F. Tate, Elisabeth A. Wilde
Summary: Traumatic brain injury (TBI) is a leading cause of global disability, but predicting patient outcomes is challenging due to the heterogeneous nature of TBI in terms of injury severity and other factors. Neuroimaging research has been limited by small sample sizes, and the development of reliable biomarkers for mild TBI or repeated subconcussive impacts has been slow.
HUMAN BRAIN MAPPING
(2022)
Article
Multidisciplinary Sciences
Alice Theadom, Natalie Hardaker, Charlotte Bray, Richard Siegert, Kevin Henshall, Katherine Forch, Kris Fernando, Doug King, Mark Fulcher, Sam Jewell, Nusratnaaz Shaikh, Renata Bastos Gottgtroy, Patria Hume
Summary: Currently, there is significant variability in health care pathways following mild traumatic brain injury, with clinicians lacking confidence in injury recognition and management. The Brain Injury Screening Tool (BIST) was developed by a clinical expert group to guide health care pathways and improve long-term prognosis. The tool shows high internal consistency, factor structure, and concurrent validity, suggesting its utility in clinical practice. Further research is needed to explore the tool's scoring criteria and responsiveness to changes in patients.
Article
Clinical Neurology
Nusratnaaz Shaikh, Alice Theadom, Richard Siegert, Natalie Hardaker, Doug King, Patria Hume
Summary: The psychometric properties of the Brain Injury Screening Tool (BIST) symptom scale were evaluated in a sample of people with a mild Traumatic Brain Injury (mTBI) through Rasch analysis, resulting in an interval level measurement score for potential clinical use. The 15-item symptom scale of the BIST tool was found to be a psychometrically sound measure of symptom burden following mTBI, supporting the use of both total and sub scale scores for clinical use.
Review
Nutrition & Dietetics
Hamilton Roschel, Bruno Gualano, Sergej M. Ostojic, Eric S. Rawson
Summary: There is strong evidence supporting the benefits of creatine supplementation on muscle function and health. Additionally, research suggests potential benefits for brain health, particularly in conditions with brain creatine deficits. More studies are needed to determine the optimal creatine protocol for increasing brain creatine levels and assessing cognitive function.
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Daniel A. Brown, Gary Grant, Kerrie Evans, Felix T. Leung, Julie A. Hides
Summary: The study aimed to compare the results of the vestibular/ocular motor screening (VOMS) in combat sport athletes with a healthy control group, explore differences between athletes with and without a history of concussion, and examine the relationship between VOMS and the Post-Concussion Symptom Scale (PCSS). The results showed that there were higher rates of abnormal scores and greater VOMS scores and NPC distance in the combat sport group compared to the control group. The VOMS scores were moderately positively correlated with the PCSS. However, there was no difference in VOMS between athletes with and without a history of concussion.
Article
Medicine, General & Internal
Aliyah Snyder, Christopher Sheridan, Alexandra Tanner, Kevin Bickart, Molly Sullan, Michelle Craske, Meeryo Choe, Talin Babikian, Christopher Giza, Robert Asarnow
Summary: The study suggests that cardiorespiratory functioning may be altered in youth with persistent post-concussive symptoms (PPCS) and could be related to neurobehavioral outcomes associated with poorer recovery from concussion. Participants with PPCS showed reduced end-tidal CO2 levels and an altered relationship between CO2 levels and respiration rate compared to controls. These findings highlight the potential importance of autonomic nervous system dysregulation in PPCS and its impact on recovery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Rune H. Karlsen, Justin E. Karr, Simen B. Saksvik, Astri J. Lundervold, Odin Hjemdal, Alexander Olsen, Grant L. Iverson, Toril Skandsen
Summary: The Cambridge Neuropsychological Test Automated Battery (CANTAB) is a commonly used computerized neuropsychological test battery in Europe. This study examined the test-retest reliability of CANTAB and developed reliable change indices and formulas for repeated measurements. The study found significant practice effects in certain aspects of cognitive function, but only a few tests showed adequate test-retest reliability. The findings suggest that large changes in performance are needed to interpret a change score as reliable.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Psychology, Clinical
Justin E. Karr, Grant L. Iverson
Summary: This study examined factor models for the Post-Concussion Symptom Scale (PCSS) and found support for a four-factor model, an alternative four-factor model, and an incomplete bifactor model. These models can be used to assess symptoms before and after concussion and demonstrate partial measurement invariance across different populations.
CLINICAL NEUROPSYCHOLOGIST
(2022)
Article
Psychology, Clinical
Rune Raudeberg, Justin E. Karr, Grant L. Iverson, Asa Hammar
Summary: This study examined the frequency of invalid scores on the RBANS in patients with schizophrenia spectrum disorders and its association with symptoms of apathy. The results showed that the rate of invalid scores was similar to previous studies, and invalid scores on the BRIEF-A were uncommon.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Clinical Neurology
Nea Nevalainen, Teemu M. Luoto, Grant L. Iverson, Ville M. Mattila, Tuomas T. Huttunen
Summary: This retrospective study assessed the national trends of acute craniotomies following traumatic brain injury (TBI) in the Finnish adult population. The results showed a gradual decrease in the number of trauma craniotomies, but the incidence of TBI-related craniotomies remains high among geriatric patients.
ACTA NEUROCHIRURGICA
(2022)
Article
Rehabilitation
Linda Fordal, Jonas Stenberg, Grant L. Iverson, Simen B. Saksvik, Migle Karaliute, Anne Vik, Alexander Olsen, Toril Skandsen
Summary: This study aimed to examine the trajectories of persistent postconcussion symptoms (PPCS) after mild traumatic brain injury (MTBI) and investigate the factors associated with symptom reporting. The results showed a similar prevalence of moderate to severe PPCS in the MTBI group at 3 and 12 months post-injury. Individual trajectory analysis revealed considerable change in both symptom severity and total scores over time in the MTBI group. In addition, the presence of intracranial lesions was associated with a higher likelihood of improvement. Female gender and personal factors such as reduced employment, pain, poor sleep, low resilience, high neuroticism and pessimism, and a psychiatric history were associated with persistent symptoms. In conclusion, personal factors play an important role in the presence of persistent symptoms during the first year after MTBI.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Psychology, Clinical
Ryan Van Patten, Grant L. Iverson
Summary: This study found that a history of multiple concussions is associated with subjective memory problems in older men, but to a lesser degree than fatigue, back or neck pain, and migraines.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Psychology, Developmental
Jessica Wallace, Justin E. Karr, Philip Schatz, Phillip Worts, Tracey Covassin, Grant L. Iverson
Summary: This study examined the relationship between the frequency of low scores on the ImPACT test and race and socioeconomic status (SES). The results showed that black student-athletes had higher rates of low scores, which was associated with lower SES. This study provides valuable information for clinicians in interpreting ImPACT test performances, taking race and SES into consideration.
DEVELOPMENTAL NEUROPSYCHOLOGY
(2022)
Article
Clinical Neurology
Zachary Weinstock, Sarah Morrow, Devon Conway, Tom Fuchs, Curtis Wojcik, Mahmut Unverdi, Robert Zivadinov, Bianca Weinstock-Guttman, Grant L. Iverson, Michael Dwyer, Ralph H. B. Benedict
Summary: The study suggests that an SDMT score change of 8 or more points offers the best balance of discriminatory power and external validity for estimating cognitive decline in individual patients. This methodology could be useful for identifying meaningful cognitive decline in both clinical management and clinical trial outcomes.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Pediatrics
Nathan E. Cook, Elizabeth Teel, Grant L. Iverson, Deborah Friedman, Lisa Grilli, Isabelle Gagnon
Summary: There was no significant difference in recovery time and duration of active rehabilitation following concussion between adolescents with and without ADHD.
PHYSICAL & OCCUPATIONAL THERAPY IN PEDIATRICS
(2022)
Review
Sport Sciences
Charles E. Gaudet, Grant L. Iverson, Alicia Kissinger-Knox, Ryan Van Patten, Nathan E. Cook
Summary: This systematic review examined the association between prior concussion history and clinical outcomes following subsequent sport-related concussions in college-age student athletes. The results showed mixed evidence for an association, with some studies reporting a worse clinical outcome for athletes with a history of prior concussions. The review also highlighted the need for larger, hypothesis-driven studies to further investigate this topic and consider the number of prior concussions as a factor.
SPORTS MEDICINE-OPEN
(2022)
Article
Clinical Neurology
Nathan E. Cook, Charles E. Gaudet, Ross Zafonte, Paul D. Berkner, Grant L. Iverson
Summary: Adolescents with ADHD may experience more severe acute effects following concussion, including cognitive impairment and worsened symptoms. However, there were no significant differences in the magnitudes of changes in overall symptom reporting compared to youth without ADHD. Further research is needed to determine whether these differences are associated with recovery time in youth with ADHD.
CHILD NEUROPSYCHOLOGY
(2023)
Editorial Material
Sport Sciences
Gavin A. Davis, Jon Patricios, Kathryn J. Schneider, Grant L. Iverson, Noah D. Silverberg
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Review
Sport Sciences
Grant L. Iverson, Rudolph J. Castellani, J. David Cassidy, Geoff M. Schneider, Kathryn J. Schneider, Ruben J. Echemendia, Julian E. Bailes, K. Alix Hayden, Inga K. Koerte, Geoffrey T. Manley, Michael McNamee, Jon S. Patricios, Charles H. Tator, Robert C. Cantu, Jiri Dvorak
Summary: There is concern about the potential adverse effects of sport-related concussion or repetitive head impacts on the later-in-life brain health of former athletes. A systematic review of the available studies suggests that exposure to repetitive head impacts is not associated with an increased risk of mental health problems or neurological diseases in former amateur athletes. However, some studies indicate a possible increased risk of neurological disorders, such as ALS and dementia, in former professional athletes, but these findings need to be confirmed in higher quality studies.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Clinical Neurology
Heather McCann, Anita Y. Bahar, Karim Burkhardt, Andrew J. Gardner, Glenda M. Halliday, Grant L. Iverson, Claire E. Shepherd
Summary: Recent studies indicate that chronic traumatic encephalopathy neuropathologic change is rare in the general population and can only be definitively diagnosed post-mortem.
BRAIN COMMUNICATIONS
(2022)
Article
Neurosciences
Justin E. Karr, Michael W. Williams, Grant L. Iverson, Sheng-Jean Huang, Chi-Cheng Yang
Summary: This study found that there was no significant difference in outcomes within 21 days of MTBI between patients with pre-injury headache and those with post-traumatic headache only, but they had worse physical and cognitive symptoms compared to patients with no headache. Future research should investigate whether differences in outcomes emerge later from the injury.
