Article
Engineering, Environmental
Wooseok Sim, Si Won Song, Subeen Park, Jin Il Jang, Jae Hun Kim, Yeo-Myoung Cho, Hyung Min Kim
Summary: The widespread use of plastic materials has led to an increase in plastic consumption, resulting in the production of primary and secondary microplastics. Current analytical methods lack insight into the size and shape of microplastics, and are time-consuming and susceptible to interference. In this study, a hyperspectral Raman method was developed to quickly quantify and characterize large volumes of plastics. The system successfully obtained Raman spectra of microplastics and effectively classified them, demonstrating its potential for real-world applications.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Chemistry, Analytical
Sebastian Wolf, Juergen Popp, Torsten Frosch
Summary: High-throughput screening requires efficient spectral imaging techniques, but current designs lack the ability to measure hyperspectral images or microscopy setups. This study presents a novel setup for parallelized hyperspectral Raman spectroscopy that allows simultaneous acquisition of 64 high-resolution Raman spectra from a multi-well plate. This setup offers a time-saving solution for high-throughput screening applications and allows real-time chemical comparison between different micro-well spots.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Optics
Cihang Kong, Christian Pilger, Manuel Kunisch, Christine Foerster, Jan Schulte am Esch, Thomas Huser
Summary: Coherent Raman scattering (CRS) microscopy is a label-free imaging method with high chemical sensitivity and sub-micron spatial resolution. A tunable two-color fiber laser with superior noise performance is demonstrated. Large-area multimodal imaging of human liver tissue sections is achieved and compared to commercial laser data.
LASER & PHOTONICS REVIEWS
(2023)
Article
Chemistry, Analytical
Hao He, Maofeng Cao, Xiaxia Yue, Mengxi Xu, Lei Wang, Bin Ren
Summary: A collaborative low-rank matrix approximation method was developed for fast hyperspectral Raman imaging and TERS imaging, demonstrating high signal-to-noise ratio and improved performance in signal extraction. The method significantly reduces noise, accelerates data acquisition, and provides a promising tool for fast TERS and conventional Raman imaging.
ANALYTICAL CHEMISTRY
(2021)
Article
Optics
Changben Yu, Jin Yang, Mingjia Wang, Ci Sun, Nan Song, Jicheng Cui, Shulong Feng
Summary: A snapshot microlens array microscopic hyperspectral imaging system is proposed to address the problem of inaccurate spectral calibration in existing systems. By using an accurate spectral image reconstruction model based on optical tracing, spatial dispersion equations, and an algorithm model for correspondence between microlens array's surface dispersion and imaging position, the system is able to achieve a spectral calibration error of better than 0.2 nm, meeting the image processing requirements of snapshot microlens array microscopic hyperspectral systems.
Article
Chemistry, Multidisciplinary
Kai-Qiang Lin, Johannes Holler, Jonas M. Bauer, Philipp Parzefall, Marten Scheuck, Bo Peng, Tobias Korn, Sebastian Bange, John M. Lupton, Christian Schueller
Summary: Low-frequency Raman scattering can detect atomic reconstruction and map out the inhomogeneity of moire lattice in twisted-bilayer transition-metal dichalcogenides. This method provides a way to study the emerging electrical and optical properties in moire superlattices.
ADVANCED MATERIALS
(2021)
Editorial Material
Optics
Shian Zhang
Summary: The article discusses a new approach to information acquisition in hyperspectral imaging.
ADVANCED PHOTONICS
(2023)
Article
Optics
Yujia Zhang, Minjian Lu, Jiaqi Hu, Yan Li, Perry Ping Shum, Jinna Chen, Haoyun Wei
Summary: Rapid coherent Raman hyperspectral imaging has potential applications in sensing, medical diagnostics, and dynamic metabolism monitoring. However, current multiplex coherent anti-Stokes Raman scattering (CARS) microscopy is limited by the spectrometer integration time, resulting in decreased signal-to-noise ratio (SNR) and poor imaging quality. This study presents a dual-comb coherent Raman hyperspectral microscopy system that combines a rapid delay-spectral focusing method and deep learning to achieve a spectral acquisition speed of 36 kHz, approximately 4 frames/s, with improved SNR and imaging quality.
Article
Engineering, Electrical & Electronic
Bingchen Wei, Zhuang Zhao, Jing Han, Jun Lu, Haocun Qi
Summary: This article proposes a rapid hyperspectral imaging system via subsampling coding, which demonstrates good adaptability and performance, and addresses the issue of low spatial resolution in hyperspectral images.
IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING
(2022)
Article
Optics
Yingchao Shi, Xingchen Xiao, Geng Tong, Luming Zhang, Fei Chen, Wei Zhang, Yiting Yu
Summary: In this study, we propose a flexible column coded scanning aperture hyperspectral imaging system using a spatial light modulator digital micromirror device. By introducing the concept of multiplex and constructing a multiplexing encoding matrix, we greatly improve scanning efficiency and achieve higher signal-to-noise ratio and equivalent spatial and spectral resolution in shorter sampling time compared to existing systems.
Article
Optics
David R. Smith, Siddarth Shivkumar, Jeff Field, Jesse W. Wilson, Herve Rigneault, Randy A. Bartels
Summary: Impulsive stimulated Raman scattering (ISRS) is a powerful technique for studying low-frequency Raman vibrational modes, and this study introduces a simple strategy for ISRS spectroscopy and hyperspectral imaging using spectral filters.
Article
Biochemical Research Methods
Yifei Wang, Qinming Zhang, Wang Yuan, Yixuan Wang, Hannah J. Loghry, Zijian Zhao, Michael J. Kimber, Liang Dong, Meng Lu
Summary: The study introduces a high-throughput, label-free EV microarray technology that can differentiate EVs by characterizing a panel of EV membrane proteins. This technology requires only a 2 mu L sample volume and a detection time of less than 2 hours.
Article
Chemistry, Multidisciplinary
Ewelina Lipiec, Janina Kaderli, Jan Kobierski, Roland Riek, Katarzyna Skirlinska-Nosek, Kamila Sofinska, Marek Szymonski, Renato Zenobi
Summary: Abnormal aggregation of amyloid-beta is a complex and heterogeneous process, and a new approach using TERS has provided detailed molecular structure information of single amyloid-beta aggregates, revealing a beta-sheet rearrangement. This study will contribute to a better understanding of the etiology of Alzheimer's disease.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Anastasiia Surkova, Andrey Bogomolov
Summary: By utilizing confocal Raman microscopy, this study investigates the chemical microstructure of milk samples of various compositions. The results show the spatial distribution of the main chemical components, such as fat, protein, and lactose, using intuitive graphical maps.
Article
Chemistry, Analytical
Xueqin Chen, Yan Gao, Jiayin Zhan, Qing Xia, Zixuan Chen, Jun-Jie Zhu
Summary: This paper proposes a spatiotemporal-resolved Raman spectroscopy (STRS) technology for fast and high spatial resolution hyperspectral Raman imaging of single nanostructures. By utilizing the outstanding electromagnetic field enhancement factor by surface plasmon resonance and the snapshot hyperspectral imaging strategy, the observation of stepwise Raman signals from single-particle plasmon-assisted reactions is demonstrated. The results reveal the impact of both surface plasmon-polariton generation and Raman molecule density on the reaction kinetics.
ANALYTICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Bonghwan Chon, Johnson Truong, Matthew Hansen, Jong-in Hahm, Young Jong Lee
Article
Optics
Young Jong Lee
Article
Biochemistry & Molecular Biology
Wei-Wen Chen, George A. Lemieux, Charles H. Camp, Ta-Chau Chang, Kaveh Ashrafi, Marcus T. Cicerone
NATURE CHEMICAL BIOLOGY
(2020)
Article
Optics
Charles H. Camp, John S. Bender, Young Jong Lee
Article
Optics
Xavier Audier, Wei-Wen Chen, Marcus T. Cicerone
Article
Chemistry, Analytical
Bonghwan Chon, Shuyu Xu, Young Jong Lee
Summary: In this study, a solvent absorption compensation (SAC) approach is proposed to enhance the concentration sensitivity and extend the available path length for protein analysis using infrared (IR) absorption spectroscopy in aqueous solutions. By applying this method, absorption spectra show good linearity and enhanced signal-to-noise ratio, allowing for more accurate investigation of protein structural conformations and reactions. The SAC method can also be applied to other absorption spectroscopies of analytes in strongly absorbing solvents for improved sensitivity without changing the detection system.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Daniel J. Lum, Michael D. Mazurek, Alexander Mikhaylov, Kristen M. Parzuchowski, Ryan N. Wilson, Ralph Jimenez, Thomas Gerrits, Martin J. Stevens, Marcus T. Cicerone, Charles H. Camp
Summary: This study demonstrates the preservation of time-energy entanglement of near-IR photons through thick biological media and tissue, supporting the use of nonclassical light in biological imaging and analyses. The entanglement characteristics of photons can be maintained even after propagation through thick, turbid biological samples.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Optics
Shuyu Xu, Jeremy Rowlette, Young Jong Lee
Summary: This article presents an algorithm that converts conventional polarization-controlled infrared hyperspectral data into images of the 3D angles of molecular orientations. The algorithm processes a pair of orthogonal IR transition-dipole modes concurrently and provides valuable information about the local alignments in continuously distributed molecules.
Article
Biochemical Research Methods
Jessica Zahn, Arno Germond, Alice Y. Lundgren, Marcus T. Cicerone
Summary: This study compared the performance of two machine learning models in discriminating between Raman spectra of different bacterial strains of Escherichia coli. Both models were found to accurately distinguish between the strains, but with different classification boundaries. By analyzing the strain-specific spectral features used by the models, it was observed that they mainly utilized a small subset of high intensity peaks, with only one model utilizing lower intensity peaks.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Polymer Science
Shuyu Xu, Chad R. Snyder, Jeremy Rowlette, Young Jong Lee
Summary: In this study, the 3D molecular orientations of polymer chains in both a quiescent spherulite region and a shear-deformed region of a semicrystalline poly(epsilon-caprolactone) film were imaged and compared. The results showed that the polymer chains in both regions were aligned in the azimuthal direction, but there was axial tilt. Additionally, there were differences in molecular orientation between different chain configurations.
Article
Chemistry, Physical
John P. Stoppleman, Jesse G. McDaniel, Marcus T. Cicerone
Summary: This study shows the role of structural excitations in liquid relaxation and their relationship with density scaling. The study also discovers the equivalence between Gru''neisen parameter and density scaling parameter in interbasin crossing modes.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Rajas Poorna, Wei-Wen Chen, Peng Qiu, Marcus T. Cicerone
Summary: Raman spectroscopy has the ability to distinguish different cell phenotypes based on their metabolic profiles that change with transcriptomic activity. However, associating Raman spectral changes with specific signaling pathways can be challenging due to weak signals and individual variations. In this study, broadband coherent anti-Stokes Raman scattering (BCARS) microscopy is used to map the C. elegans hermaphrodite gonad at subcellular resolution. The results show that the BCARS spatio-spectral signatures correlate with gene expression profiles, indicating the potential of BCARS as a spatially resolved omics surrogate.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Correction
Chemistry, Physical
Rajas Poorna, Wei-Wen Chen, Arno Germond, Peng Qiu, Marcus T. Cicerone
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Proceedings Paper
Engineering, Biomedical
Bonghwan Chon, Johnson Truong, Matthew Hansen, Jong-In Hahm, Young Jong Lee
LABEL-FREE BIOMEDICAL IMAGING AND SENSING (LBIS) 2020
(2020)
Article
Chemistry, Physical
John S. Bender, Miaochan Zhi, Marcus T. Cicerone