Article
Surgery
Abraham Zavala, Johnny Chuieng-Yi Lu, Tommy Nai-Jen Chang, Bassem W. Daniel, David Chwei-Chin Chuang
Summary: This study investigates whether supercharge end-to-side (SETS) motor nerve transfers can enhance nerve regeneration and functional outcomes in long nerve grafts. The results show that long nerve grafts receiving SETS transfers demonstrate superior functional outcomes. Proximal SETS transfer has better electrodiagnostic outcomes compared to distal transfer, while double SETS transfer yields the highest axonal count and biceps compound muscle action potential amplitude.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Surgery
Gil Gontre, Michael Polmear, Jordan T. Carter, Christopher Castagno, Fernando A. Herrera
Summary: This study compared the outcomes of primary repair and primary repair plus anterior interosseous nerve (AIN) reverse end-to-side (RETS) coaptation in patients with proximal ulnar nerve injuries. The results showed that patients who underwent primary repair plus AIN RETS coaptation had better hand strength and upper extremity function.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Surgery
Matthew R. Zeiderman, Jeffrey Fine, Derek B. Asserson, Dattesh R. Dave, Corey M. Bascone, Andrew I. Li, Clifford T. Pereira
Summary: This study examines the effectiveness of end-to-side nerve transfer for peripheral nerve injuries in the upper extremity. The findings suggest that transfers performed within the brachial plexus have better outcomes. Age, sex, and time to surgery do not significantly affect meaningful recovery.
ANNALS OF PLASTIC SURGERY
(2022)
Article
Cell Biology
Chiung-Hui Liu, Yu-Chen Kuo, Che-Yu Wang, Chao-Chun Hsu, Ying-Jui Ho, Yun-Chi Chiang, Fu-Der Mai, Wei-Jhih Lin, Wen-Chieh Liao
Summary: The study suggests that syndecans may play a role in stabilizing Nav1.6 and modulating the distribution of sodium at nodal regions, leading to better functional repair of peripheral nerve injury. The re-clustering of sodium and Nav1.6 at nodal regions of regenerating nerves correlated with the recovery of muscle power after end-to-side neurorrhaphy.
HISTOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Neurosciences
Yijian Chen, Wanqiong Yuan, Xiaolong Zeng, Yuanchen Ma, Qiujian Zheng, Bofu Lin, Qingtian Li
Summary: The study shows that combining reverse end-to-side neurorrhaphy and rapamycin treatment can promote the recovery of muscle atrophy after peripheral nerve injury, demonstrating better nerve function and muscle protection effects.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Piotr Czarnecki, Juliusz Huber, Agnieszka Szymankiewicz-Szukala, Michal Gorecki, Leszek Romanowski
Summary: This study evaluated the regeneration, potential donor nerve damage, and the influence of epineural windows on regeneration efficiency after end-to-side neurorrhaphy (ETS). The results showed no statistically significant difference between the groups investigated in all parameters. Neurophysiological parameters indicated lower amplitudes in the tibial nerve of ETS groups, suggesting possible axonal impairment. The study concluded that regeneration after ETS was comparable to free graft reconstruction, and the technique of an epineural window did not affect the regeneration result of the peroneal nerve.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Surgery
Blair R. Peters, Lauren Jacobson, Stahs Pripotnev, Susan E. Mackinnon
Summary: Anterior interosseous nerve to ulnar motor nerve supercharged end-to-side (SETS) nerve transfer, known as a super turbocharged end-to-side (STETS) procedure, redirects axons from the abductor digiti minimi (ADM) muscle to enhance innervation of critical intrinsic muscles in severe ulnar neuropathy. The STETS technique may optimize outcomes without additional patient morbidity by directing the maximum number of nerve fibers to the most critical target.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Biochemical Research Methods
Laura Monza, Giulia Fumagalli, Alessia Chiorazzi, Paola Alberti
Summary: The study proposed a comprehensive neurophysiological assessment protocol for peripheral neuropathy treatment, comparing different experimental settings with control animals and animals treated with chemotherapy drugs. The results showed distinct patterns of sensory-motor polyneuropathy and distal sensory neuropathy, confirmed by neuropathological analysis. Compared to existing methods, the new protocol aims to fully reproduce clinical protocols and was validated by neuropathology as a translation outcome measure in a preclinical setting.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Review
Clinical Neurology
Rajesh Krishna Pathiyil, Saud Alzahrani, Rajiv Midha
Summary: The disappointing outcomes of conventional nerve repair or grafting procedures for proximal ulnar nerve injuries have led to the search for better alternatives. Transfer of the pronator quadratus branch of the anterior interosseous nerve to the distal ulnar motor branch in a reverse end-to-side fashion has shown promising results. This transfer is commonly used as an adjunct to cubital tunnel decompression in patients with compressive ulnar neuropathy, but the underlying mechanisms of recovery are not fully understood. This review aims to summarize the current understanding, define indications and best practices, and propose directions for future research.
Article
Clinical Neurology
Tak-Ho Chu, Saud Alzahrani, Amanda Mcconnachie, Nicolas Lasaleta, Amira Kalifa, Rajesh Pathiyil, Rajiv Midha
Summary: The study suggests that creating a perineurial window in the side of recipient nerves improves the efficiency of donor axonal regeneration in reverse end-to-side transfers (RETS). This finding provides guidance for nerve surgeons performing RETS procedures.
Article
Otorhinolaryngology
Jia-Qian Hu, Peng-Cheng Yu, Li-Cheng Tan, Wen-Jun Wei, Zhong-Wu Lu, Yu Wang, Qing-Hai Ji, Yu-Long Wang
Summary: This study demonstrates a novel method for reconstructing the right recurrent laryngeal nerve by transforming it into a nonrecurrent nerve. The procedure was successfully performed in a patient with advanced thyroid carcinoma, showing improved postoperative outcomes.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Orthopedics
Yi Zhang, Nianzong Hou, Jian Zhang, Bing Xie, Jiahui Liang, Xiaohu Chang, Kai Wang, Xin Tang
Summary: This study compared the outcomes of various finger nerve surgeries and identified factors such as age, gap size, and injury type that may affect recovery. No nerve repair method has absolute advantages, and comprehensive consideration of various factors is necessary when choosing a surgical approach for finger nerve injury repair.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Cell Biology
Yong-Bin Gao, Zhi-Gang Liu, Guo-Dong Lin, Yang Guo, Lei Chen, Bo-Tao Huang, Yao-Bin Yin, Chen Yang, Li-Ying Sun, Yan-Bo Rong, Shanlin Chen
Summary: A new nerve matrix membrane derived from decellularized porcine nerves has been shown to prevent adhesion between nerve anastomosis sites and surrounding tissues, enhancing nerve regeneration. Clinical trial results indicate that the safety and efficacy of the new membrane in repairing peripheral nerve injury are comparable to the commercially-available bovine-derived collagen membrane.
NEURAL REGENERATION RESEARCH
(2021)
Review
Clinical Neurology
Nicholas von Guionneau, Karim A. Sarhane, Gerald Brandacher, Shehan Hettiaratchy, Allan J. Belzberg, Sami Tuffaha
Summary: Proximal peripheral nerve injuries often lead to poor functional outcomes due to the long time period between injury and reinnervation of distal targets. The supercharged end-to-side (SETS) nerve transfer is a new technique that allows for rapid innervation and support of end organs, but its mechanisms and clinical applications are not well understood. This article comprehensively reviews the mechanisms and clinical use of SETS nerve transfer for peripheral nerve surgeons and their patients.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Matthew W. T. Curran, Jaret L. Olson, Michael J. Morhart, Simon S. Z. Wu, Raj Midha, Michael J. Berger, K. Ming Chan
Summary: This study evaluated the outcomes of anterior interosseous nerve RETS transfer compared to nerve decompression alone. Results showed that there was no crossover regeneration in the RETS group and the extent of reinnervation was no different from decompression surgery alone.
Article
Chemistry, Multidisciplinary
Mara Terzini, Andrea Di Pietro, Alessandro Aprato, Stefano Artiaco, Alessandro Masse, Cristina Bignardi
Summary: The study evaluated the biomechanical performance of non-conservative treatments for acetabular fractures through finite element analysis, finding that the SQBP plate offers lower bone stress and greater stability in transverse and T-shaped fractures, making it a promising option for treatment.
APPLIED SCIENCES-BASEL
(2021)
Article
Orthopedics
F. Toia, M. Romeo, M. Abate, E. Avarotti, B. Battiston, G. Bruno, F. F. Cannavo, C. Casamichele, M. Colonna, N. Catena, M. Cherubino, S. Coppolino, N. Galvano, G. Giuca, S. Gullo, G. Internullo, A. Lazzerini, I Marcoccio, M. Maruccia, C. Melloni, G. Pajardi, P. Pugliese, G. Risitano, G. Spata, M. Tripoli, L. Troisi, P. Tos, A. Cordova
Summary: The COVID-19 pandemic had a significant impact on emergency and elective hand surgery in four Italian regions, irrespective of high or low case loads. To improve treatment pathways, there is a need for a durable and flexible redesign of hand surgery activities, along with changes and increases in human resources and administrative support. Implementation of telematics, especially for delivering rehabilitation therapy, is also crucial.
HAND SURGERY & REHABILITATION
(2021)
Article
Biochemistry & Molecular Biology
Rui D. Alvites, Mariana V. Branquinho, Ana C. Sousa, Federica Zen, Monica Maurina, Stefania Raimondo, Carla Mendonca, Luis Atayde, Stefano Geuna, Artur S. P. Varejao, Ana C. Mauricio
Summary: This study established a sheep model for common peroneal nerve injuries, describing nerve anatomy, functional consequences, surgical protocol, and therapeutic options. Through morphological and stereological studies, optimal access methods and study periods were determined, providing foundational data for future research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Alfio Luca Costa, Nikolaos Papadopulos, Andrea Porzionato, Konstantinos Natsis, Franco Bassetto, Cesare Tiengo, Riccardo Giunta, Francisco Soldado, Jayme Augusto Bertelli, Alfonso Rodriguez Baeza, Bruno Battiston, Paolo Titolo, Pierluigi Tos, Christine Radtke, Oscar Aszmann, Francesco Moschella, Adriana Cordova, Francesca Toia, Rosario Emanuele Perrotta, Guilia Ronchi, Stefano Geuna, Michele Rosario Colonna
Summary: Axonal count is crucial for effective nerve transfer, but standard analysis methods are lacking. Different research groups have compared their experiences to reach a consensus on fiber count and develop a protocol for future studies to be comparable. Standardization of methodology aims to reduce variability in results.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Review
Medicine, General & Internal
Alessandro Crosio, Giulia Ronchi, Benedetta Elena Fornasari, Simonetta Odella, Stefania Raimondo, Pierluigi Tos
Summary: This review focuses on prevention of peripheral nerve scarring and highlights the importance of reliable animal models and standardized parameters for evaluating the efficacy of antiadhesion products. Currently, there are no standardized methods in experimental research for comparing results of different antiadhesion devices.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Andrea Marchesini, Francesco De Francesco, Pier Paolo Pangrazi, Letizia Senesi, Andrea Campodonico, Valentina Riccio, Stefano Geuna, Barbara Zavan, Michele Riccio
Summary: The local application of Hyaloglide(R) was found to be effective in preventing peritendinous adhesion formation and promoting normal healing with regeneration of the synovial sheath in a rabbit model of tenolysis.
APPLIED SCIENCES-BASEL
(2021)
Review
Cell Biology
Julia Murciano-Brea, Martin Garcia-Montes, Stefano Geuna, Celia Herrera-Rincon
Summary: The evidence connecting gut bacteria and brain neurons has led to a paradigm shift in neuroscience, highlighting the importance of bidirectional communication between intestinal bacteria and the brain. This interaction may have significant implications for brain function and behavior.
Article
Cell Biology
Giulia Ronchi, Pierluigi Tos, Elia Angelino, Luisa Muratori, Simone Reano, Nicoletta Filigheddu, Andrea Graziani, Stefano Geuna, Stefania Raimondo
Summary: Ghrelin plays a role in stimulating neurogenesis and may be beneficial in peripheral nerve regeneration, especially in cases of severe nerve injuries.
EUROPEAN JOURNAL OF HISTOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Giacomo Carta, Benedetta Elena Fornasari, Federica Fregnan, Giulia Ronchi, Stefano De Zanet, Luisa Muratori, Giulia Nato, Marco Fogli, Giovanna Gambarotta, Stefano Geuna, Stefania Raimondo
Summary: This study found that neurodynamic treatment (NDT) promotes nerve regeneration, accelerates sensory and motor recovery, and modulates mechanical pain by affecting the expression of TACAN in the DRG.
Article
Biochemistry & Molecular Biology
Rui D. Alvites, Mariana V. Branquinho, Ana C. Sousa, Bruna Lopes, Patricia Sousa, Justina Prada, Isabel Pires, Giulia Ronchi, Stefania Raimondo, Ana L. Luis, Stefano Geuna, Artur Severo P. Varejao, Ana Colette Mauricio
Summary: Cell secretome is of great interest in Regenerative Medicine. This study analyzed the secretome collected from Olfactory Mucosa Mesenchymal Stem Cells and Olfactory Ensheathing Cells and applied it to promote peripheral nerve regeneration. The results showed that this therapeutic combination had beneficial effects on nerve and muscle regeneration, but further research is needed to address irregularities in the outcomes.
Article
Biochemistry & Molecular Biology
David Munoz-Rodriguez, Marwane Bourqqia-Ramzi, Maria Teresa Garcia-Esteban, Antonio Murciano-Cespedosa, Alejandro Vian, Juan Lombardo-Hernandez, Pablo Garcia-Perez, Francisco Conejero, Alvaro Mateos Gonzalez, Stefano Geuna, Celia Herrera-Rincon
Summary: Inter-cellular communication involve biochemical, biophysical, and bioelectrical signals, which can occur between cells from the same tissue or animal species, as well as between cells that are evolutionarily distant. This paper presents a method for assessing the bioelectrical state of two bacterial strains and monitoring their bioelectrical profile during growth, revealing functional links between membrane potential and population growth. The study also demonstrates that bacteria respond to neural signals by changing their membrane potential, highlighting the potential for studying the relationship between bacteria and the brain in the context of the gut microbiota-brain axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Yuki Shirosaki, Federica Fregnan, Luisa Muratori, Saki Yasutomi, Stefano Geuna, Stefania Raimondo
Summary: In this study, porous chitosan-GPTMS hybrids with different amounts of GPTMS were prepared. The structures of the degradation products with Si from the hybrids were analyzed using mass spectrometry, and their potential use in nerve repair devices was evaluated through biological assessments. The results showed that lower-molecular-weight degradation products with Si improved motor cell line differentiation and neurite outgrowth of dorsal root ganglion explants.
Review
Biochemistry & Molecular Biology
Patricia Sousa, Bruna Lopes, Ana Catarina Sousa, Alicia Moreira, Andre Coelho, Rui Alvites, Nuno Alves, Stefano Geuna, Ana Colette Mauricio
Summary: This article presents a systematic review of studies on the use of exosomes for wound healing over the past five years. The review shows that exosome-based treatments can improve wound healing by promoting angiogenesis, reepithelization, collagen deposition, and reducing scar formation. However, further research is needed due to the variability in cell sources, biomaterials, and administration routes.
Review
Orthopedics
Simona Odella, Francesco Locatelli, Elia Creta, Jacopo Flore, Alessandro Crosio, Alessandra Fin, Michele D. Lombardo, Pierluigi Tos
Summary: Surgical treatment for wrist post-traumatic arthritis varies depending on the stage and location of degeneration, taking into account the functional needs of the patient. Different procedures, including arthrodesis and wrist prostheses, can be considered to alleviate pain and maintain range of motion.
MINERVA ORTHOPEDICS
(2021)
Letter
Surgery
Bruno Battiston, Stefano Artiaco, Davide Ciclamini
JOURNAL OF HAND AND MICROSURGERY
(2021)
