Article
Engineering, Environmental
Xiaoming Zhao, Jun Gao, Hao Han, Xiaoxiao Lou, Hongyun Ma, Xiaochen Su, Liuyang Zhang, Jing Tian, Bo Len, Yingang Zhang
Summary: In this study, a multifunctional bioactive bone cement reinforced with poly(citrate-silicon) nanospheres was developed to overcome the limitations of traditional polymethyl methacrylate (PMMA) bone cement. The reinforced cement showed improved properties such as increased injectability, extended setting time, increased hydrophilicity, reduced polymerization heat, and good degradability. It also exhibited antioxidant, antibacterial, and biomineralization properties. Cellular experiments showed enhanced osteogenic differentiation, mineral deposition, anti-inflammatory, and pro-angiogenic properties. In a rat model, the reinforced bone cement significantly promoted new bone formation and bone ingrowth, through improved osteogenic proteins and angiogenesis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Ceramics
Manqi Yan, Yanan Zhao, Yue Dai, Xiaokang Yao, Honglian Dai
Summary: In this study, modified calcium magnesium phosphate bone cement (MCPC) composites were constructed by introducing gelatin solutions. The modified MCPC composites exhibited improved microenvironment, enhanced osteogenic differentiation and biomineralization. When incorporated with 1% and 5% of gelatin, the MCPC composites showed higher mechanical properties and osteogenic ability of BMSCs.
CERAMICS INTERNATIONAL
(2022)
Review
Engineering, Multidisciplinary
Muhammad Aqib, Aneela Anwar, Humayun Ajaz, Samina Akbar, Ahsan Manzoor, Maham Abid, Zohaib Waheed, Qudsia Kanwal
Summary: In recent years, calcium phosphate cement has been widely used in biomedical applications due to its excellent biocompatibility, bioactivity, self-setting qualities, minimal setting degree, suitable toughness, and versatility in shape. Brushite, a type of calcium phosphate, is particularly attractive for bone repair and can also potentially serve as a drug delivery device. The addition of metal ions, such as magnesium, zinc, and strontium, into the calcium phosphate structure has become a major research focus. This paper provides a comprehensive analysis of the advancements and prospects of metal-doped brushite cement, including its impact on physical and chemical properties, as well as its potential applications in regenerative medicine.
JOURNAL OF BIONIC ENGINEERING
(2023)
Article
Engineering, Mechanical
T. D. Campos, M. L. S. Barbosa, A. A. R. Olmos, M. Martins, F. A. M. Pereira, M. F. S. F. De Moura, A. Zille, N. Dourado
Summary: This study evaluates the strain energy release rate under mode I loading in a bone-cement bonded joint and measures cohesive zone laws using the finite element method and non-linear elastic fracture mechanics. The results show consistent fracture toughness in a cortical bone bonded joint with polymethylmethacrylate (PMMA).
THEORETICAL AND APPLIED FRACTURE MECHANICS
(2022)
Article
Materials Science, Ceramics
Ib Holzmeister, Jan Weichhold, Juergen Groll, Hala Zreiqat, Uwe Gbureck
Summary: The study investigated the hydraulic reactivity and cement formation of baghdadite (Ca3ZrSi2O9), revealing that the material exhibited reduced particle and crystallite size and partial amorphization after being mechanically activated. Cement formation resulted in high compressive strengths, with a preferred dissolution of calcium and marginal release of zirconium ions. Alkaline conditions were found to be crucial for cement formation.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2021)
Review
Biochemistry & Molecular Biology
Victoria Wall, Thi-Hiep Nguyen, Nghi Nguyen, Phong A. Tran
Summary: Bone cement is commonly used for bone implants and orthopaedic surgeries. Antibiotic-loaded bone cements are utilized to prevent and treat prosthetic joint infections, but controlling antibiotic release is crucial for infection control and tissue integration. More research is needed to improve the regulation of antibiotic release and enhance in vitro experiment designs for better prediction of in vivo antibiotic concentrations.
Article
Nanoscience & Nanotechnology
Hao Zhang, Yinglin Cui, Xianglong Zhuo, Jua Kim, Honglong Li, Shuaijie Li, Hongsheng Yang, Kun Su, Chunyu Liu, Pengfei Tian, Xian Li, Li Li, Deping Wang, Limin Zhao, Jianyun Wang, Bing Li, Xu Cui, Haobo Pan
Summary: PMMA bone cement used in vertebroplasty lacks proper biological response, resulting in a fragile interface with the host bone. This study modified PMMA by incorporating borosilicate glass, which provided an alkaline microenvironment and enhanced osteogenesis. Clinical case observation showed that the modified cement formed a biological interface, making it a promising biomaterial for vertebroplasty.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Ceramics
Min Wei, Yufei Tang, Lei Chen, Bo Zhang, Shitong Zhang, Kang Zhao, Zixiang Wu
Summary: This study successfully introduced montmorillonite (MMT) into calcium phosphate cement (CPC) to prepare CPC/MMT composite bone cement. The compressive strength of the composite cement was significantly enhanced, and the anti-washout ability was improved as well. The composite bone cement also exhibited outstanding cell adhesion and proliferation abilities.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Multidisciplinary
Jun Wu, Linjun Jiang, Lingpeng Ju, Yuan Zhang, Ming Li, Xing Liu, Xiangyang Qu
Summary: This study successfully combined bone morphogenetic protein-9 (BMP-9) with deproteinized osteoarticulation (DPOA) to achieve excellent osteogenic and angiogenic effects in a canine femoral condylar defect model, demonstrating outstanding osteoarticular repair outcomes.
MATERIALS & DESIGN
(2021)
Article
Medicine, General & Internal
Kui Sun, Fuli Huang, Biru Liang
Summary: This article describes a case of a 71-year-old female patient who developed chest tightness and decreased blood oxygen saturation following posterior decompression and cement-enhanced pedicle screw fixation. Diagnosis revealed the presence of foreign bodies in the heart, which were successfully removed during surgery and the patient recovered well.
Article
Materials Science, Multidisciplinary
Santuan Zhao, Kaili Zhang, Guangda Li, Zilin Zhang, Xiaofang Li, Bianyun Cai, Jinghua Li
Summary: This study reports a novel super-paramagnetic injectable radiopaque bone cement that can control hyperthermia temperature by itself. The cement shows good biocompatibility and mineralization ability, providing a new option for improving the thermal safety of magnetic hyperthermia treatment of bone tumors.
MATERIALS & DESIGN
(2022)
Article
Orthopedics
Zhihang Xiao, Dehao Fu, Li Zhang, Weiye Fan, Xiaoyu Shen, Xiangbei Qi
Summary: Enoxaparin sodium bone cement supplemented with alendronate was found to be effective in promoting bone repair in tibial bone defects in New Zealand rabbits, showing superior results compared to enoxaparin sodium bone cement and PMMA bone cement.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Engineering, Multidisciplinary
Wenjuan Liu, Zhiguang Huan, Chengtie Wu, Zhihua Zhou, Jiang Chang
Summary: This study developed a composite bone cement with high compressive strength and desirable bioactivity by incorporating calcium silicate bioceramic into magnesium phosphate bone cement. The composite bone cement showed significantly higher compressive strength compared to traditional bone cements and demonstrated apatite mineralization ability and moderate degradation behavior.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Chemistry, Physical
Yuwei Zhu, Jiaxin Guo, Yifeng Sheng, Jiankun Xu, Ling Qin, To Ngai
Summary: In this study, a hierarchical porous MOC foam (MOCF)-derived scaffold with favorable bio-resorption kinetic and superior bioactivity was fabricated through Pickering foaming technique. Compared with the traditional bone cement CDHA, the MOCF scaffold showed a higher biodegradation tendency and better cell recruitment ability. It is anticipated that the MOCF scaffold will be competitive for clinical therapies to augment osteoporotic bone regeneration.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Orthopedics
Xibing Zhang, Yanlin Chen, Jiaming Fu, Qiuhong Chen, Yang Li, Canliang Fang, Chenglong Li, Liang Wang, Dong Qiu, Zhongmin Zhang
Summary: An injectable pH neutral bioactive bone cement (PSC/CSC) was developed by mixing phosphosilicate bioactive glass and alpha-calcium sulfate hemihydrate, showing superior bone regeneration ability compared to traditional bone cements. The new composite cement has the potential to be used clinically for rapid bone repairs and reconstruction of critical sized bone defects.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)