Article
Chemistry, Multidisciplinary
Julian Matthias Metzler, Daniel Fink, Patrick Imesch
Summary: Ibrutinib, a small-molecule inhibitor of Bruton's tyrosine kinase, is used to treat hematological diseases like chronic lymphocytic leukemia. The hypothesis that it may suppress the tumor marker CA-125 in ovarian cancer is based on an observation in a patient with low-grade serous ovarian cancer who received ibrutinib for CLL. A mechanistic model explaining this potential drug effect is proposed for further research.
APPLIED SCIENCES-BASEL
(2021)
Article
Oncology
Christopher Walker, Tuan-Minh Nguyen, Shlomit Jessel, Ayesha B. Alvero, Dan-Arin Silasi, Thomas Rutherford, Sorin Draghici, Gil Mor
Summary: Ovarian cancer patients' survival is largely dependent on the disease extent at diagnosis, with early detection being crucial. A newly developed blood test measuring four proteins shows promise in distinguishing ovarian cancer samples, including early-stage disease, from healthy samples. Combining these proteins with the commonly used CA-125 biomarker improves accuracy and specificity in detecting ovarian cancer.
Article
Cardiac & Cardiovascular Systems
Patricia Lourenco, Filipe M. Cunha, Catarina Elias, Catarina Fernandes, Isaac Barroso, Joao T. Guimaraes, Paulo Bettencourt
Summary: A decrease in CA-125 levels in patients with acute heart failure, especially those with a hospital stay of more than 10 days, predicts a lower risk of death within one year, suggesting that re-evaluation with CA-125 measurement after hospitalization may be beneficial for patient management.
Article
Oncology
Thomas J. Herzog, Sandro Pignata, Sharad A. Ghamande, Maria-Jesus Rubio, Keiichi Fujiwara, Christof Vulsteke, Deborah K. Armstrong, Jalid Sehouli, Robert L. Coleman, Hani Gabra, Giovanni Scambia, Bradley J. Monk, Jose A. Arranz, Kimio Ushijima, Rabbie Hanna, Claudio Zamagni, Robert M. Wenham, Antionio Gonzalez-Martin, Brian Slomovitz, Yan Jia, Lisa Ramsay, Krishnansu S. Tewari, Susan C. Weil, Ignace B. Vergote
Summary: The study aimed to determine the efficacy of farletuzumab, an antifolate receptor-alpha monoclonal antibody, in improving progression-free survival (PFS) in patients with platinum-sensitive recurrent ovarian cancer. The results showed that adding farletuzumab did not improve PFS, and the expression of the folate receptor-alpha was not measured in this study.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Roli Purwar, Kishan Soni, Ragini Tilak, Ashish Verma, Manoj Pandey
Summary: Peritonitis associated with Curvularia lunata is rare, with only five cases reported in the literature, all in middle-aged patients with comorbidities undergoing dialysis. This case report presents a 21-year-old female patient who was diagnosed with ovarian malignancy based on raised CA 125 and suspected tubo-ovarian mass on MRI, but was later found to have a pelvic collection with Curvularia lunata infection.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biophysics
G. Wijffels, M. L. Sullivan, S. Stockwell, S. Briscoe, S. T. Anderson, Y. Li, C. C. de Melo Costa, R. McCulloch, J. C. W. Olm, J. Cawdell-Smith, J. B. Gaughan
Summary: The impact of moderate heat load on plasma hormone concentrations in cattle was studied, comparing thermally challenged (TC) feedlot steers to feed restricted thermoneutral (FRTN) steers. Differences in plasma leptin, adiponectin, and T4 between the two groups were observed during the challenge and recovery periods, as well as occasionally during the outdoor pen period. Relationships between plasma hormone concentrations, rumen temperature, and dry matter intake were also investigated.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2023)
Article
Oncology
Er Yue, Guangchao Yang, Yuanfei Yao, Guangyu Wang, Atish Mohanty, Fang Fan, Ling Zhao, Yanqiao Zhang, Tamara Mirzapoiazova, Tonya C. Walser, Lorna Rodriguez-Rodriguez, Yuman Fong, Ravi Salgia, Edward Wenge Wang
Summary: Ovarian cancer is a deadly disease with urgent need for new treatments. The development of a conditionally replicative oncolytic adenovirus (CRAd) that targets MUC16/CA-125 in cancer cells shows promising anti-cancer effects. This approach represents a unique and practical direction for further investigation in ovarian cancer treatment.
Article
Neurosciences
Rodrigo S. Carraro, Guilherme A. Nogueira, Davi Sidarta-Oliveira, Rodrigo S. Gaspar, Nathalia R. Dragano, Joseane Morari, Vanessa C. D. Bobbo, Eliana P. Araujo, Natalia F. Mendes, Ariane M. Zanesco, Natalia Tobar, Celso D. Ramos, Jessica M. Toscaro, Marcio C. Bajgelman, Licio A. Velloso
Summary: NHLH2 is a hypothalamic transcription factor that plays a role in energy homeostasis and obesity. Overexpression of NHLH2 in mice can prevent and reduce obesity by affecting caloric intake.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemical Research Methods
Jin Song, Lori J. J. Sokoll, Zhen Zhang, Daniel W. W. Chan
Summary: Close to 75% of ovarian cancer cases are diagnosed at an advanced stage, with a high rate of relapse after primary therapy. Therefore, it is crucial to identify strategies for early detection of ovarian cancer recurrence to improve outcomes.
CLINICAL PROTEOMICS
(2023)
Article
Immunology
Lingeng Lu, Wenxue Ma, Caroline H. Johnson, Sajid A. Khan, Melinda L. Irwin, Lajos Pusztai
Summary: Somatic mutation-derived neoantigens are used to develop an mRNA vaccine targeting CA-125 neoantigen for breast and ovarian cancer. Immuno-bioinformatics tools were used to predict CD8' T cell epitopes and a self-adjuvant mRNA vaccine was constructed to enhance cross-presentation by dendritic cells. Immune responses post-immunization were estimated using an in silico algorithm, showing IFN-c and CD8' T cell response. The strategy described in this study can be used to design precision multi-epitope mRNA vaccines targeting multiple neoantigens.
Article
Oncology
Christoph Wohlmuth, Vladimir Djedovic, Susanne K. Kjaer, Allan Jensen, Rosalind Glasspool, Patricia Roxburgh, Anna DeFazio, Sharon E. Johnatty, Penelope M. Webb, Francesmary Modugno, Diether Lambrechts, Joellen M. Schildkraut, Andrew Berchuck, Liv Cecilie Vestrheim Thomsen, Line Bjorge, Estrid Hogdall, Claus K. Hogdall, Ellen L. Goode, Stacey J. Winham, Keitaro Matsuo, Beth Y. Karlan, Jenny Lester, Marc T. Goodman, Pamela J. Thompson, Tanja Pejovic, Marjorie J. Riggan, Katherine Lajkosz, Alicia Tone, Taymaa May
Summary: This study analyzed data from 176 women with low-grade serous ovarian cancer through a multi-center collaborative effort, revealing that elevated post-treatment CA-125 levels are significantly associated with poor survival, while FIGO staging and residual disease also impact patient outcomes.
Review
Oncology
Qingyi Wang, Xiaoling Feng, Xiaofang Liu, Siyu Zhu
Summary: According to the meta-analysis, higher pretreatment serum CA-125 levels are associated with poor prognosis in epithelial ovarian cancer (EOC) patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Analytical
Omer Faruk Er, Hilal Kivrak, Omruye Ozok, Sebahattin Celik, Arif Kivrak
Summary: The COVID-19 crisis has a serious impact on ovarian cancer patients, highlighting the importance of early detection. In this study, a PTTC-based sensor was designed to detect CA-125, a common marker for ovarian cancer, with higher precision and speed using electrochemical methods. The PTTC-based GCE electrode showed promising sensitivity and reliability for CA-125 detection, with optimum conditions determined as 3 μL PTTC loading, 5000 ng/mL CA125 antigen concentration, and 30 min incubation time. The linear range of this electrode was found to be 1-100 ng/mL, with a limit of detection of 0.0096 ng/mL and a limit of quantification of 0.0288 ng/mL. These findings suggest that PTTC is a novel and promising material for the detection of ovarian cancer antigen CA-125.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Jessica de Souza Magalhaes, Millena Prata Jammal, Paula Carolina Arvelos Crispim, Eddie Fernando Candido Murta, Rosekeila Simoes Nomelini
Summary: The study found that CA-19.9 is useful in distinguishing between endometriomas and ovarian cancers, with a higher diagnostic value in endometriomas. Furthermore, the combination analysis of CA-125 and CA-19.9 can aid in differentiating endometriomas from other ovarian lesions.
Article
Multidisciplinary Sciences
Szymon Piatek, Grzegorz Panek, Zbigniew Lewandowski, Dominika Piatek, Przemyslaw Kosinski, Mariusz Bidzinski
Summary: The nadir CA-125 level in patients with epithelial ovarian cancer is associated with progression-free survival but not overall survival. Patients with nadir CA-125 levels between 11-35 U/ml after first-line treatment have a higher risk of recurrence compared to patients with levels <= 10 U/ml.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Mira Park, Seok-Ho Hong, So Hee Park, Yeon Sun Kim, Seung Chel Yang, Hye-Ryun Kim, Songmi Noh, Sunghun Na, Hyung Keun Lee, Hyunjung J. Lim, Sang Woo Lyu, Haengseok Song
Article
Obstetrics & Gynecology
S-J Choi, D. W. Kwak, K. Kil, S-C Kim, J-Y Kwon, Y. H. Kim, S. Na, J-G Bae, H-H Cha, J-Y Shim, K. Y. Oh, K. A. Lee, S. M. Kim, I. A. Cho, S. M. Lee, G. J. Cho, Y. S. Jo, G. Y. Choi, S. K. Choi, S. E. Hur, H. S. Hwang, Y. J. Kim
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Roya Rasaei, Eunbi Kim, Ji-Young Kim, Sunghun Na, Jung-Hyun Kim, Jinbeom Heo, Dong-Myung Shin, Sun Shim Choi, Seok-Ho Hong
Article
Pharmacology & Pharmacy
Mi Seon Seo, Jin Ryeol An, Hee Seok Jung, Minji Kang, Ryeon Heo, Eun-Taek Han, Se-Ran Yang, Hongzoo Park, Won-Kyo Jung, Il-Whan Choi, Young Min Bae, Sung Hun Na, Won Sun Park
Summary: Darifenacin inhibits Kv currents in rabbit coronary arteries, leading to vasocontraction and decreased coronary blood flow. This inhibition is concentration- and use-dependent and associated with the Kv1.5 subtype.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Obstetrics & Gynecology
Se Jin Lee, Hyun Sun Ko, Sunghun Na, Jin Young, Won Joon Seong, Jong Woon Kim, Jaeeun Shin, Hae Joong Cho, Gyu Yeon Choi, Jinsil Kim, Geum Joon Cho, In Yang Park
BMC PREGNANCY AND CHILDBIRTH
(2020)
Article
Obstetrics & Gynecology
Kwang-Sig Lee, Ho Yeon Kim, Se Jin Lee, Sung Ok Kwon, Sunghun Na, Han Sung Hwang, Mi Hye Park, Ki Hoon Ahn
Summary: This study used machine learning to predict newborn's BMI based on ultrasound measures and maternal/delivery information. The most important predictors were AC and EFW among the ultrasound measures, and linear regression and random forest models outperformed artificial neural networks in predicting newborn's BMI.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Pharmacology & Pharmacy
Hee Seok Jung, Mi Seon Seo, Jin Ryeol An, Ryeon Heo, Minji Kang, Eun-Taek Han, Hongzoo Park, Geehyun Song, Youn Kyoung Son, Won-Kyo Jung, Il-Whan Choi, Sung Hun Na, Won Sun Park
Summary: In this study, alogliptin induced vasorelaxation in rabbit aortic smooth muscle by activating Kv channels and SERCA pump independently of other K+ channels, cGMP/PKG-related or cAMP/PKA-related signaling pathways, and the endothelium. No significant changes were observed with inhibitors targeting different channels or signaling pathways, suggesting a unique mechanism for the vasorelaxant effect of alogliptin.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Parasitology
Egy Rahman Firdaus, Ji-Hoon Park, Fauzi Muh, Seong-Kyun Lee, Jin-Hee Han, Chae-Seung Lim, Sung-Hun Na, Won Sun Park, Jeong-Hyun Park, Eun-Taek Han
Summary: The computer vision diagnostic approach has developed several malaria diagnostic tools for clinical and health center use, with the malaria scanner showing high precision and ease of use. Strong correlation was observed between measured parasitemia levels from different diagnostic methods.
KOREAN JOURNAL OF PARASITOLOGY
(2021)
Article
Oncology
Se Jin Lee, Young-Han Kim, Mi-Young Lee, Hyun Sun Ko, Soo-young Oh, Hyun-Joo Seol, Jong Woon Kim, Ki Hoon Ahn, Sunghun Na, Won Joon Seong, Hee Seung Kim, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Hye-Sung Won, Moon Young Kim, Han Sung Hwang, Seung Mi Lee
Summary: The study compared ultrasonographic ovarian mass scoring systems in pregnant women, finding that the Sassone scoring system had the highest accuracy in predicting malignant ovarian tumors.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Medicine, General & Internal
Ki Hoon Ahn, Kwang-Sig Lee, Se Jin Lee, Sung Ok Kwon, Sunghun Na, Kyongjin Kim, Hye Sim Kang, Kyung A. Lee, Hye-Sung Won, Moon Young Kim, Han Sung Hwang, Mi Hye Park
Summary: This study compared the performance measures of various newborn weight-for-height indicators using machine learning, ultrasonographic data, and maternal/delivery information. The top predictors for newborn weight were identified, and it was concluded that ultrasonographic fetal biometry is more suitable for newborn weight, weight/height, and weight/height(2) indicators. Machine learning with ultrasonographic data is highlighted as an effective noninvasive approach for predicting newborn weight and related indicators.
Article
Medicine, Research & Experimental
Hongliang Li, Jin Ryeol An, Mi Seon Seo, Minji Kang, Ryeon Heo, Seojin Park, Seo-Yeong Mun, Young Min Bae, Eun-Taek Han, Jin-Hee Han, Wanjoo Chun, Sung Hun Na, Won Sun Park
Summary: The study found that BKCa channel function in umbilical arterial smooth muscle cells of GDM patients was impaired, leading to reduced vasorelaxation activity, primarily due to decreased expression levels of BKCa channels rather than the influence of protein kinases.
Article
Immunology
Mohammad Rafiul Hoque, Myat Htut Nyunt, Jin-Hee Han, Fauzi Muh, Seong-Kyun Lee, Ji-Hoon Park, Feng Lu, Won Sun Park, Eun-Taek Han, Sunghun Na
Summary: The study revealed that PocDBP may play an important role in the reticulocyte invasion process of P. ovale curtisi, with significantly higher reticulocyte binding activity than erythrocyte binding activity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Seung-Ah Choe, Hyun-Joo Seol, Ji Young Kwon, Chan-Wook Park, Minhyoung Kim, Ji Yeon Lee, Min-A Kim, Han-Sung Hwang, Sunghun Na, Jae-Yoon Shim, Kunwoo Kim, Hyun Mee Ryu
Summary: The Korean Society of Maternal-Fetal Medicine developed the first Korean clinical practice guidelines for prenatal aneuploidy screening and diagnostic testing in 2019, which were adapted from established guidelines in other countries. The guidelines focus on maternal serum screening for fetal aneuploidy and cell-free DNA screening, with recommendations including informing pregnant women of common fetal aneuploidy, providing counseling early in pregnancy, and not recommending cfDNA screening for multiple gestations. The guidelines were reviewed and approved by the Korean Academy of Medical Sciences.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Ji Yeon Lee, Ji Young Kwon, Sunghun Na, Seung Ah Choe, Hyun Joo Seol, Minhyoung Kim, Min A. Kim, Chan Wook Park, Kunwoo Kim, Hyun Mee Ryu, Han Sung Hwang, Jae Yoon Shim
Summary: The first Korean guideline on prenatal aneuploidy screening and diagnostic testing was proposed by the Korean Society of Maternal Fetal Medicine in April 2019. The guideline includes specific recommendations for invasive diagnostic testing, aiming to improve accuracy of detection and reduce risks associated with the procedures.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Shinyoung Kim, Hyun Soo Park, Hayan Kwon, Hyun-Joo Seol, Jin Gon Bae, Ki Hoon Ahn, Sunghun Na, Se Jin Lee, Mi-Young Lee, Seung Mi Lee, Dong Wook Kwak, Jung Yoon Park, In Yang Park, Hye-Sung Won, Moon Young Kim, Hyun Sun Ko, Han Sung Hwang
JOURNAL OF KOREAN MEDICAL SCIENCE
(2020)
