Article
Immunology
Vanessa M. Beutgen, Norbert Pfeiffer, Franz H. Grus
Summary: This study revealed alterations in autoantibody levels in glaucoma patients and identified important subgroup predictors, enhancing prospective glaucoma subtype prediction. Furthermore, it provided insights into the characteristics of glaucoma-related antigens and their role in glaucoma pathogenesis, proposing new diagnostic approaches for glaucoma.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Jean-Baptiste Vulsteke, Rita Derua, Sylvain Dubucquoi, Frederic Coutant, Sebastien Sanges, David Goncalves, Greet Wuyts, Petra De Haes, Daniel Blockmans, Wim A. Wuyts, Kristl G. Claeys, Ellen De Langhe, Nicole Fabien, Xavier Bossuyt
Summary: New and known antisynthetase autoantibodies (ASAs) were discovered and detected through protein immunoprecipitation combined with gel-free liquid chromatography-tandem mass spectrometry (IP-MS). The dominant cognate ARS autoantigen of the newly discovered anti-Ly ASA specificity was identified. Unbiased and targeted IP-MS are promising methods for discovery and detection of autoantibodies.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Bettina Hohberger, Max Worn, Robert Laemmer, Aparna Mahajan, Christian Mardin, Ursula Schoetzer-Schrehardt, Rudolph Kunze, Martin Herrmann, Gerd Wallukat
Summary: The presence of beta 2-agAAb was detected in 92.3% of OAG patients' sera and 87.2% of AH samples. The seropositivity for beta 2-agAAb in patients with POAG and SOAG was 95% and 89% respectively, with 86% (POAG) and 78% (SOAG) positive in AH samples. The adrenergic activity of beta 2-agAAb in the AH was higher in patients with POAG compared to those with SOAG.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Ake Lernmark, Beena Akolkar, William Hagopian, Jeffrey Krischer, Richard McIndoe, Marian Rewers, Jorma Toppari, Kendra Vehik, Anette-G. Ziegler, TEDDY Study Grp
Summary: The etiology of type 1 diabetes involves pancreatic islet beta-cell autoimmune pathogenesis that leads to the clinical onset of the disease. By testing autoantibodies against insulin, glutamic acid decarboxylase, islet antigen-2, and ZnT8 transporter, children can be monitored from birth until the appearance of the first islet autoantibody. The incidence rate of the first-appearing autoantibody follows two different patterns, and an innate immune reaction may precede the adaptive response.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Tomislav Bulum, Marijana Vucic Lovrencic, Jadranka Knezevic Cuca, Martina Tomic, Sandra Vuckovic-Rebrina, Lea Duvnjak
Summary: This study aimed to investigate the relationship between three autoantibodies and their combination with anthropometric and metabolic components and microvascular complications in patients with latent autoimmune diabetes in adults (LADA). The results showed that ZnT8 and IA-2 autoantibodies were present in a significant number of LADA patients and associated with clinical and metabolic characteristics resembling classic type 1 diabetes.
Review
Biochemistry & Molecular Biology
Claudia Sirbe, Gelu Simu, Iulia Szabo, Alina Grama, Tudor Lucian Pop
Summary: Pediatric autoimmune liver disorders encompass autoimmune hepatitis, autoimmune sclerosing cholangitis, and de novo AIH after liver transplantation. The pathogenesis involves genetic variations, environmental factors, and epigenetic modifications. Current first-line therapy includes prednisolone plus azathioprine for clinical and biochemical remission induction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jolene Su Yi Tan, Bernett Lee, Jackwee Lim, Dong Rui Ma, Jia Xin Goh, Suh Yee Goh, Muhammad Yaaseen Gulam, Ser Mei Koh, Weiling Wendy Lee, Lei Feng, Qing Wang, Yinxia Chao, Olaf Rotzschke, Eng King Tan
Summary: This study identified stress-inducible phosphoprotein 1 (STIP1) as a potential neuroprotective factor targeted by PD-specific autoantibodies. Clinical and neuro-immunological studies revealed high levels of STIP1 autoantibodies in PD patients and identified four PD-specific B cell epitopes. This suggests the possible involvement of autoimmune mechanisms in PD and highlights the potential of STIP1 as an endogenous neuroprotective agent.
Article
Rheumatology
Michelle L. Joachims, Bhuwan Khatri, Chuang Li, Kandice L. Tessneer, John A. Ice, Anna M. Stolarczyk, Nicolas Means, Kiely M. Grundahl, Stuart B. Glenn, Jennifer A. Kelly, David M. Lewis, Lida Radfar, Donald U. Stone, Joel M. Guthridge, Judith A. James, R. Hal Scofield, Graham B. Wiley, Jonathan D. Wren, Patrick M. Gaffney, Courtney G. Montgomery, Kathy L. Sivils, Astrid Rasmussen, A. Darise Farris, Indra Adrianto, Christopher J. Lessard
Summary: The study identified specific transcription profiles in Sjögren's disease (SjD) cases, with downregulation of differentially expressed (DE) transcripts compared to healthy controls. Certain lncRNAs exhibited correlated expression with interferon (IFN)-regulated genes in SjD patients.
Article
Endocrinology & Metabolism
Christian Lundtoft, Daniel Eriksson, Matteo Bianchi, Maribel Aranda-Guillen, Nils Landegren, Solbritt Rantapaa-Dahlqvist, Peter Soderkvist, Jeniffer R. S. Meadows, DISSECT Consortium, Immunoarray Consortium, Swedish Addison Registry Study Grp, Gerli Rosengren Pielberg, Sophie Bensing, Gerli Rosengren Pielberg, Kerstin Lindblad-Toh, Lars Ronnblom, Olle Kampe
Summary: Autoantibodies against the adrenal enzyme 21-hydroxylase are a hallmark manifestation in autoimmune Addison's disease (AAD). This study identified strong associations between copy number variants in the CYP21 region and the risk of AAD, most likely due to linkage disequilibrium with disease-associated HLA class II alleles.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Maria Correa-Rodriguez, Gabriela Pocovi-Gerardino, Jose Luis Callejas-Rubio, Raquel Rios-Fernandez, Maria Martin-Amada, Maria-Gracia Cruz-Caparros, Blanca Rueda-Medina, Norberto Ortego-Centeno
Summary: Research on autoantibodies such as nucleosome and double-stranded DNA (dsDNA) showed their associations with disease activity and damage accrual in patients with systemic lupus erythematosus (SLE). Higher Systemic Lupus Erythematosus Disease Activity Index and SDI scores were observed in patients with these antibodies, indicating their relevance to SLE clinical manifestations.
JOURNAL OF INVESTIGATIVE MEDICINE
(2021)
Article
Rheumatology
Warren A. James, Elizabeth Ogunrinde, Zhuang Wan, Diane L. Kamen, Jim Oates, Gary S. Gilkeson, Wei Jiang
Summary: This study analyzed the blood and stool samples from patients with systemic lupus erythematosus (SLE) and healthy controls (HCs) to investigate the microbial community composition. It was found that the plasma microbiome had distinct community and greater heterogeneity compared to the gut microbiome. The decreased plasma alpha diversity in patients with SLE suggests an altered plasma microbiome, which may play a role in the immune perturbations and pathogenesis of SLE.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Robert M. Clancy, Miranda C. Marion, Hannah C. Ainsworth, Miao Chang, Timothy D. Howard, Peter M. Izmirly, Mala Masson, Jill P. Buyon, Carl D. Langefeld
Summary: This study investigates the relationship between the microbiome and anti-SSA/Ro antibodies, and how it affects disease state. Comparing the gut microbiome of healthy controls and anti-SSA/Ro positive women, differences in microbial relative abundances were found to be associated with clinical severity.
Article
Medicine, Research & Experimental
Si-Yu Zhou, Chi Zhang, Wen-Jing Shu, Li-Ye Chong, Jun He, Zhiwei Xu, Hai-Feng Pan
Summary: This review focuses on the association between coronavirus and autoimmunity, suggesting that coronavirus may be implicated in the development and pathogenesis of autoimmune diseases. Additionally, it briefly introduces the role of coronavirus in several autoimmune diseases.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Savino Sciascia, Chelsea Bentow, Massimo Radin, Alice Barinotti, Irene Cecchi, Silvia Foddai, Dario Roccatello, Michael Mahler
Summary: This study aimed to explore the use of saliva as an alternative matrix for the detection of autoantibodies. By using a novel and highly sensitive method, the study found a high level of correlation between saliva and serum results, and participants clearly preferred saliva sampling.
Review
Immunology
Jana Sophia Buhre, Mareike Becker, Marc Ehlers
Summary: The development of inflammatory autoimmune diseases involves two steps, from harmless self-directed antibody responses to more inflammatory responses. Identifying biomarkers that signal the transition from the pre-disease to the disease stage can help determine the optimal time to initiate treatment and develop therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
