期刊
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
卷 22, 期 3, 页码 188-195出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0891988708327888
关键词
cognitive impairment; dementia; risk factors; vitamin D; serum 25-hydroxyvitamin D
资金
- UK Department of Health
- NIA [K08 AG019180, R01 AG027010]
- Paul Beeson Physician Faculty Scholars in Aging Research award
- NHS South-West Region Public Health Training Scheme
Vitamin D may be of interest in the prevention of cognitive impairment, though previous findings are inconclusive. Participants were 1766 adults aged 65 years and older from the Health Survey for England 2000, a nationally representative population-based study. Cognitive impairment was assessed using the Abbreviated Mental Test Score. The cross-sectional relation of serum 25-hydroxyvitamin D quartiles to cognitive impairment was modeled using logistic regression. In all, 212 participants (12%) were cognitively impaired. Odds ratios (95% confidence intervals) for cognitive impairment in the first (8-30 nmol/L), second (31-44 nmol/L), and third (45-65 nmol/L) quartiles of serum 25-hydroxyvitamin D compared with the fourth (66-170 nmol/L) were 2.3 (1.4-3.8), 1.4 (0.8-2.4), and 1.1 (0.6-1.9), after adjustment for age, sex, education, ethnicity, season of testing, and additional risk factors for cognitive impairment (P for linear trend = .001). Our data suggest low serum 25-hydroxyvitamin D is associated with increased odds of cognitive impairment.
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