期刊
APPLIED CLAY SCIENCE
卷 118, 期 -, 页码 87-98出版社
ELSEVIER
DOI: 10.1016/j.clay.2015.09.007
关键词
Layered double hydroxides; Intercalation hybrids; Different synthesis methods; Bioassay explore
资金
- National Natural Science Foundation of China [21073093]
- Foundation of Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province [HPK201405]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Jiangsu Collaborative Innovation Center of Biomedical Functional Materials
A series of methotrexatum intercalated layered double hydroxides (MTX/LDHs) hybrids were synthesized by four different routes, i.e., typical coprecipitation method, reverse-microemulsion approach, ion-exchange and mechanochemical-hydrothermal procedures, at the same synthesis condition. The resulting hybrids were then characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), atomic force microscope (AFM) and thermogravimetry (TG) testing. From XRD and FTIR analysis, MTX anions were successfully intercalated into LDH interlayers for all hybrids. TEM images reveal that the monodispersity of samples from coprecipitation and reverse-microemulsion methods was much better than that of the others. Importantly, the biodegradation process of MTX/LDH hybrids is also examined in phosphate buffer solution (PBS). The results show that the biodegradation procedure can be divided into three stages: the release of drug by ion-exchange, the subsequent destruction of LDH structure and then the complete disintegration of LDHs. At last, bioassay results give the evidence that MTX/LDH hybrids synthesized from coprecipitation method present the highest tumor suppression effect. (C) 2015 Elsevier B.V. All rights reserved.
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