Article
Microbiology
Qinting Dong, Xinyue Zhu, Leping Wang, Wenchao Zhang, Lifei Lu, Jun Li, Shuhong Zhong, Chunxia Ma, Kang Ouyang, Ying Chen, Zuzhang Wei, Yifeng Qin, Hao Peng, Weijian Huang
Summary: Porcine astrovirus type 1 (PAstV1) induces the production of IFN-beta through the IRF3 signaling pathway and inhibits viral replication. Knockdown of RIG-I and MDA5 results in decreased expression of IFN-beta and increased viral replication induced by PAstV1.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Yueyan Liao, Xiangyu Ke, Tianyi Deng, Qingsong Qin
Summary: Human cytomegalovirus (HCMV) is a common opportunistic pathogen with no available vaccine for prevention of associated diseases. Eltanexor effectively inhibits HCMV replication by suppressing viral gene expression and promoting proteasome-mediated degradation of XPO1, resulting in increased expression of type I interferon.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Paola S. Apaolaza, Diana Balcacean, Jose Zapardiel-Gonzalo, Grace Nelson, Nataliya Lenchik, Pouria Akhbari, Ivan Gerling, Sarah J. Richardson, Teresa Rodriguez-Calvo
Summary: The study reveals the presence of IFN response markers in the islets of T1D patients, which may lead to inflammation and impair beta cell function. Therapeutic interventions targeting the elimination of persistent infections and reduction of inflammation are crucial for individuals with T1D.
Article
Biochemistry & Molecular Biology
Jon B. Suzich, Sean R. Cuddy, Hiam Baidas, Sara Dochnal, Eugene Ke, Austin R. Schinlever, Aleksandra Babnis, Chris Boutell, Anna R. Cliffe
Summary: HSV establishes a restricted latent infection in primary murine neurons in the presence of type I interferon, with PML-NBs forming and persisting with IFN treatment. The viral genomes retain a memory of the IFN response during de novo infection, leading to differential subnuclear positioning and restricting their ability to reactivate.
Article
Biochemistry & Molecular Biology
Wenting Ke, Yanrong Zhou, Yinan Lai, Siwen Long, Liurong Fang, Shaobo Xiao
Summary: Cellular cholesterol synthesis is regulated by PRRSV to suppress the host's antiviral innate immune response. The viral protein nsp4 plays a significant role in this mechanism.
Article
Biochemistry & Molecular Biology
Yeon-Su Lee, Xiaoyong Bao, Hwi-Ho Lee, Jiyoung Joan Jang, Enkhjin Saruuldalai, Gaeul Park, Wonkyun Ronny Im, Jong-Lyul Park, Seon-Young Kim, Sooyong Shin, Sung Ho Jeon, Sangmin Kang, Hyun-Sung Lee, Ju-Seog Lee, Ke Zhang, Eun Jung Park, In-Hoo Kim, Yong Sun Lee
Summary: The noncoding RNA nc886 acts as a novel suppressor for the IFN-beta signaling and inflammation by inhibiting the activation of IRF3, NF-kappa B, and AP-1 through inhibiting PKR. This leads to decreased expression of IFN-beta and IFN-stimulated genes. Its role is to restrict the IFN-beta signaling from hyperactivation, which may explain the variability of innate immune responses to pathogens based on biological settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Sujie Dong, Ning Kong, Wenzhen Qin, Huanjie Zhai, Xueying Zhai, Xinyu Yang, Chenqian Ye, Manqing Ye, Changlong Liu, Lingxue Yu, Hao Zheng, Wu Tong, Hai Yu, Wen Zhang, Youwen Li, Guangzhi Tong, Tongling Shan
Summary: ATG4B plays a vital role in the replication of PEDV by activating type-I IFN signaling and inhibiting viral replication. The study found that ATG4B upregulated the TRAF3 protein to induce IFN expression, thereby restricting PEDV replication. These findings reveal a novel mechanism for ATG4B-mediated viral restriction and suggest new possibilities for preventing and controlling PEDV.
VETERINARY MICROBIOLOGY
(2022)
Article
Microbiology
Lei Xu, Mengyuan Li, Yadong Yang, Chen Zhang, Zhen Xie, Jingjing Tang, Zhenkun Shi, Shukun Chen, Guangzhe Li, Yanchao Gu, Xiao Wang, Fuhua Zhang, Yao Wang, Xihui Shen
Summary: This study reveals the important role of the cytosolic surveillance pathway cGAS-STING in the activation of the type I interferon response during S. Typhimurium infection, in addition to the TLR4-dependent response. The study also highlights the significance of mtDNA release triggered by S. Typhimurium infection in the induction of type I interferon.
Article
Biochemistry & Molecular Biology
Jorn E. Stok, Timo Oosenbrug, Laurens R. ter Haar, Dennis Gravekamp, Christian P. Bromley, Santiago Zelenay, Caetano Reis e Sousa, Annemarthe G. van der Veen
Summary: This study reveals the crucial role of LGP2 in inducing a type I interferon response in ADAR1-deficient cells. In addition, the sensitivity of tumor cells to ADAR1 loss is dependent on LGP2 expression.
Article
Immunology
Xin Zhao, Wenji Huang, Yanjie Shi, Jiahong Guo, Hehe Xiao, Ning Ji, Jianhua Feng, Huifeng Dang, Jun Zou
Summary: PLAAT1 plays important roles in tumor suppression, transglutaminase activation, and peroxisomal biogenesis. This study shows that PLAAT1 inhibits the production of type I interferon and promotes virus replication in zebrafish. Mechanistically, PLAAT1 interacts with IRF3 and IRF7 to degrade them.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Yang Wu, Hongling Zhang, Jianfei Chen, Zhaorong Shi, Mingwei Li, Ying Zhao, Hongyan Shi, Da Shi, Longjun Guo, Li Feng
Summary: In this study, the role of STAG2 in Porcine deltacoronavirus (PDCoV) infection was explored. It was found that STAG2 deficiency inhibits PDCoV replication through the activation of interferon expression and JAK-STAT signaling. These findings provide new insights into the mechanism of PDCoV replication.
Article
Cell Biology
Inessa Penner, Nicole Buescher, Mario Dejung, Anja Freiwald, Falk Butter, Bodo Plachter
Summary: This study investigated the impact of subviral particles produced during human cytomegalovirus (HCMV) infection on cellular gene expression. The results revealed that uptake of these subviral particles induced the upregulation of interferon-regulated genes (IRGs) through the type I interferon signaling pathway mediated by the pattern recognition receptor cGAS.
Review
Microbiology
Wenxiang Xue, Chan Ding, Kun Qian, Ying Liao
Summary: Coronaviruses pose a global threat to public health and animal breeding. Understanding the interaction between coronaviruses and the host immune system, particularly the evasion of the type I IFN response, is crucial for controlling and preventing coronavirus-related diseases. Studying how coronaviruses evade the IFN response provides insights for vaccine development and therapeutics.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Clinical Neurology
Sophie A. I. Sanford, Lauren V. C. Miller, Marina Vaysburd, Sophie Keeling, Benjamin J. Tuck, Jessica Clark, Michal Neumann, Victoria Syanda, Leo C. James, William A. Mcewan
Summary: This study demonstrates the critical role of IFN-I in promoting tau aggregation, suggesting IFN-I as a potential therapeutic target in Alzheimer's disease and other tauopathies.
ALZHEIMERS & DEMENTIA
(2023)
Article
Oncology
Hannah G. Abraham, Peter J. Ulintz, Laura Goo, Joel A. Yates, Andrew C. Little, Liwei Bao, Zhifen Wu, Sofia D. Merajver
Summary: RhoC, a member of the Rho GTPase family, plays a key role in the modulation of cell-cell junctions and the response to interferon, supporting its potential as a therapeutic target for anti-invasion strategies in aggressive breast cancers. Knockout of RhoC results in increased junctional integrity and cell-cell adhesion, as well as a dampened response to interferon-alpha stimulation in terms of adhesion and invasiveness. Our findings provide insights into the mechanism by which RhoC promotes metastasis and suggest a potential therapeutic approach for inhibiting invasion in breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Edward Emmott, Alexis de Rougemont, Myra Hosmillo, Jia Lu, Timothy Fitzmaurice, Juergen Haas, Ian Goodfellow
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Microbiology
Valeria Lulla, Adam M. Dinan, Myra Hosmillo, Yasmin Chaudhry, Lee Sherry, Nerea Irigoyen, Komal M. Nayak, Nicola J. Stonehouse, Matthias Zilbauer, Ian Goodfellow, Andrew E. Firth
NATURE MICROBIOLOGY
(2019)
Article
Microbiology
Sabastine E. Arthur, Frederic Sorgeloos, Myra Hosmillo, Ian G. Goodfellow
Article
Biology
Myra Hosmillo, Jia Lu, Michael R. McAllaster, James B. Eaglesham, Xinjie Wang, Edward Emmott, Patricia Domingues, Yasmin Chaudhry, Tim J. Fitzmaurice, Matthew K. H. Tung, Marc Dominik Panas, Gerald McInerney, Nicolas Locker, Craig B. Wilen, Ian G. Goodfellow
Article
Microbiology
Abimbola O. Kolawole, Carmen Mirabelli, David R. Hill, Sophia A. Svoboda, Andrew B. Janowski, Karla D. Passalacqua, Benancio N. Rodriguez, Michael K. Dame, Pamela Freiden, Ryan P. Berger, Diem-lan Vu, Myra Hosmillo, Mary X. D. O'Riordan, Stacey Schultz-Cherry, Susana Guix, Jason R. Spence, David Wang, Christiane E. Wobus
Article
Microbiology
Michele Brocard, Valentina Iadevaia, Philipp Klein, Belinda Hall, Glenys Lewis, Jia Lu, James Burke, Margaret M. Willcocks, Roy Parker, Ian G. Goodfellow, Alessia Ruggieri, Nicolas Locker
Article
Microbiology
Guido Papa, Donna L. Mallery, Anna Albecka, Lawrence G. Welch, Jerome Cattin-Ortola, Jakub Luptak, David Paul, Harvey T. McMahon, Ian G. Goodfellow, Andrew Carter, Sean Munro, Leo C. James
Summary: Research suggests that furin plays a promoting role in SARS-CoV-2 infectivity and cell-cell spread, but it is not essential, indicating that furin inhibitors may reduce but not completely prevent viral spread.
Article
Virology
Hazel Sutherland, Michaela J. Conley, Edward Emmott, James Streetley, Ian G. Goodfellow, David Bhella
Summary: Vesivirus 2117, an adventitious agent, has caused decreased productivity in biopharmaceutical production due to contamination of cell cultures. The structure of its capsid differs significantly from that of FCV, potentially affecting virus-host cell attachment mechanisms.
JOURNAL OF VIROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Constantina Borg, Aminu S. Jahun, Lucy Thorne, Frederic Sorgeloos, Dalan Bailey, Ian G. Goodfellow
Summary: The VF1 gene of murine norovirus is found to antagonize the innate immune response during persistent infection in mice, contributing to viral fitness in vivo. While not essential for viral persistence, VF1 plays an important role in the infection process and is just one component of noroviruses' multiple mechanisms to avoid and/or control host response to infection.
JOURNAL OF GENERAL VIROLOGY
(2021)
Article
Chemistry, Physical
Liron Issman, Brian Graves, Jeronimo Terrones, Myra Hosmillo, Rulan Qiao, Michael Glerum, Shuki Yeshurun, Martin Pick, Ian Goodfellow, James Elliott, Adam Boies
Summary: Carbon nanotube air filters demonstrated high filtration efficiency and active self-sanitization against viruses through resistive heating. These filters can achieve rapid air purification in a short period of time.
Review
Biotechnology & Applied Microbiology
Aminu S. Jahun, Ian G. Goodfellow
Summary: Human noroviruses are a major cause of transmissible gastroenteritis globally, with no effective treatment or vaccine available. Understanding host responses to infection and the importance of IFN responses in restricting noroviruses is critical for the development of vaccines or treatments. This review discusses the molecular mechanisms of IFN induction in norovirus-infected cells and the strategies used by noroviruses to evade host IFN responses.
JOURNAL OF GENERAL VIROLOGY
(2021)