期刊
JOURNAL OF GENERAL VIROLOGY
卷 94, 期 -, 页码 663-667出版社
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.048231-0
关键词
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资金
- National Natural Science Foundation of China [81222037, 81072250]
- China mega-Project on Major Drug Development [2011ZX09401-023]
- China mega-Project on Infectious Disease Prevention [2011ZX10004-001]
- State Key Laboratory of Pathogen and BioSecurity Program [SKLPBS1113]
Birnaviruses, including the genus Entomobirnavirus, are socio-economically important viruses. Currently, only Drosophila X virus has been formally assigned to the genus Entomobimavirus, but two more viruses were recently isolated, Espirito Santo virus (ESV) and Culex Y virus. The host mosquito has been reported to carry many viruses, but seldom entomobirnaviruses. To discover potential pathogens in mosquitoes, we exploited small-RNAs high-throughput sequencing of three mosquito species caught in South China. A virus that genetically likes entomobirnavirus, Mosquito X virus (MXV), was identified from Anopheles sinensis and was 97% identical to ESV, which co-infects with Dengue virus (DENV). However, the absence of DENV in the A. sinensis suggested the independence of MXV infection from dengue co-infection. Our discovery complements prior research on entomobirnaviruses and proved that MXV may be widespread in mosquitoes on different continents. This work also highlights the applying of high-throughput sequencing of small RNAs to survey viruses carried by insect vectors.
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