期刊
JOURNAL OF GENERAL VIROLOGY
卷 93, 期 -, 页码 2431-2435出版社
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.045435-0
关键词
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资金
- European Union DG Research through the programmes EMPERIE [223498]
- EVA [228292]
- BonFor program of the University of Bonn [O-156-0006]
- ArboZooNet program of the European Commission [211757]
Drosophila X virus (DXV), the prototype Entomobirnavirus, is a well-studied RNA virus model. Its origin is unknown, and so is that of the only other entomobirnavirus, Espirito Santo virus (ESV). We isolated an entomobirnavirus tentatively named Culex Y virus (CYV) from hibernating Culex pipiens complex mosquitoes in Germany. CYV was detected in three pools consisting of 11 mosquitoes each. Full-genome sequencing and phylogenetic analyses suggested that CYV and ESV define one sister species to DXV within the genus Entomobirnavirus. In contrast to the laboratory-derived ESV, the ORF5 initiation codon AUG was mutated to (1927)GUG in all three wild-type CYV isolates. Also in contrast to ESV, replication of CYV was not dependent on other viruses in insect cell culture. CYV could provide a wild-type counterpart in research fields relying on DXV and other cell culture-adapted strains.
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