Article
Chemistry, Multidisciplinary
Wanchuan Ding, Xuan Yang, Huoyue Lin, Zixing Xu, Jun Wang, Jie Dai, Can Xu, Feng Chen, Xiaowei Wen, Weiran Chai, Gang Ruan
Summary: Hard-to-transfect cells, such as BMSCs, present challenges in intracellular delivery due to vesicle trapping. We found that coating nanoparticles with PDS1 can effectively avoid vesicle trapping in BMSCs and significantly enhance transfection efficiency and osteoblastic differentiation. Mechanistic studies suggest that higher cholesterol content in BMSCs' plasma membranes may contribute to the difficulty of vesicle escape.
Article
Medicine, General & Internal
Daisuke Kato, Ichiro Kawachi, Junko Saito, Naoki Kondo
Summary: This study compared the prediction of mortality among older Japanese adults between complex multimorbidity (CMM) and conventional multimorbidity (MM), finding that both CMM and MM similarly predict mortality in older adults. Further replication studies with larger samples are needed to confirm these findings.
Article
Multidisciplinary Sciences
Jiayu Liu, Jiqi Zheng, Xintian Cai, Dongdong Wu, Chengliang Yin
Summary: This study investigates whether ChatGPT can respond in accordance with evidence-based medicine in neurosurgery. The results show that GPT-3.5's ability is comparable to neurosurgeons with low seniority, while GPT-4.0's ability is comparable to neurosurgeons with high seniority. Future upgrades could enhance ChatGPT's performance and abilities.
Article
Medicine, General & Internal
Jonathan Pearson-Stuttard, Sara Holloway, Rosie Polya, Rebecca Sloan, Linxuan Zhang, Edward W. Gregg, Katy Harrison, Jamie Elvidge, Pall Jonsson, Thomas Porter
Summary: Multimorbidity is common among people with T2DM, with the comorbidity profiles varying substantially. Two out of the top five comorbidities at diagnosis are traditional T2DM conditions, while the other three are not. The prevalence of each comorbidity increases over time, and patients with five or more comorbidities at diagnosis have a higher prevalence of each of the 35 comorbidities. People with obesity at diagnosis have significantly different comorbidity profiles, with the five commonest comorbidities being 50% more common in this group.
Article
Geriatrics & Gerontology
Clare Tazzeo, Debora Rizzuto, Amaia Calderon-Larranaga, Albert Roso-Llorach, Alessandra Marengoni, Anna-Karin Welmer, Graziano Onder, Caterina Trevisan, Davide Liborio Vetrano
Summary: The study found that older adults with multimorbidity characterized by cardiovascular and neuropsychiatric disease patterns are more susceptible to developing physical frailty.
Article
Medicine, General & Internal
M. Bernabeu-Wittel, O. Para, J. Voicehovska, R. Gomez-Huelgas, J. Vaclavik, E. Battegay, M. Holecki, B. C. van Munster
Summary: Patients with multimorbidity have a significant impact on healthcare systems, with higher mortality rates, polypharmacy, and development of various syndromes. Internists and Hospitalists are increasingly required to attend to these patients, but managing multimorbidity is complex and requires specific skills and experience. This paper proposes a set of emerging and re-emerging competences for internal medicine specialists to optimally address multimorbidity now and in the future.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Silvia Giovannini, Chiara Iacovelli, Claudia Loreti, Augusto Fusco, Vincenza Amoruso, Cristina Cuccagna, Lorenzo Biscotti, Luca Padua, Letizia Castelli
Summary: Frailty is a condition characterized by increased vulnerability and a risk factor for disability. With the increasing population of older adults, frailty and aging have become important social and health topics. Hospitalized elderly patients often have multiple comorbidities, leading to prolonged hospital stays and increased risks. Rehabilitation treatment plays a crucial role in improving disability, independence, and self-sufficiency among older inpatients.
APPLIED SCIENCES-BASEL
(2023)
Article
Geriatrics & Gerontology
Davide L. Vetrano, Cecilia Damiano, Clare Tazzeo, Alberto Zucchelli, Alessandra Marengoni, Hao Luo, Maria Beatrice Zazzara, Hein van Hout, Graziano Onder
Summary: The study aimed to analyze multimorbidity patterns among older individuals living in nursing homes and investigate their association with mortality, taking into account functional status. The results showed that different multimorbidity patterns were differently associated with mortality, with the heart diseases and dementia with sensory impairments patterns being associated with increased mortality risk. As the specific multimorbidity expression increased, the risk of mortality also increased.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Health Care Sciences & Services
Martijn Felder, Hester van de Bovenkamp, Willem Jan Meerding, Antoinette de Bont
Summary: The debate over evidence-based medicine (EBM) in healthcare governance involves the critique of EBM's reductionist epistemology and its uncritical use. Various actors in healthcare systems support contextualizing evidence, but do so in different ways. This debate actually reveals a political issue over who should contextualize evidence in a layered healthcare system.
Article
Public, Environmental & Occupational Health
Haofei Li, Enxue Chang, Wanji Zheng, Bo Liu, Juan Xu, Wen Gu, Lan Zhou, Jinmei Li, Chaojie Liu, Hongjuan Yu, Weidong Huang
Summary: This study investigated the incidence and determinants of catastrophic health expenditure in households with elderly people with multimorbidity in China. The results showed that multimorbidity is a significant risk factor for CHE, and there are socioeconomic and regional disparities in CHE incidence.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Eman Alefishat, Anan S. Jarab, Suhaib Muflih, Abdel Wahab Aqeel
Summary: The attitudes of community pharmacists towards practice-based research (PBR) have an impact on their utilization of current best evidence in pharmacy practice. This study highlights the importance of supporting and promoting PBR among community pharmacists to enhance their utilization of the best evidence in their everyday practice.
Article
Humanities, Multidisciplinary
Kristin Margrethe Heggen, Henrik Berg
Summary: Patients suffering from fibromyalgia often feel their testimonies are not taken seriously by healthcare professionals, resulting in epistemic injustice. This injustice is attributed to a gap between patients' lived experience of illness and professionals' conceptualization of illness, potentially harming patients' capacity as knowers. The dominant model of evidence-based practice in medicine may further devalue patients' stories, highlighting the need for more inclusive and patient-centered care approaches.
HUMANITIES & SOCIAL SCIENCES COMMUNICATIONS
(2021)
Article
Geriatrics & Gerontology
Minjun Zhao, Xu He, Tianrong Li, Heng Shao, Qian Huo, Yan Li
Summary: There is a connection between early-life factors and multimorbidity in later years. Health status, family socioeconomic status, and experience of violence in childhood are all related to multimorbidity.
Article
Geriatrics & Gerontology
Mengli Liu, Shuqin Liu, Shuqin Sun, Huimin Tian, Suyun Li, Yili Wu
Summary: The study found sex-specific associations between handgrip strength and asymmetry with incident multimorbidity, particularly in women.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Geriatrics & Gerontology
Priyanka Patel, T. Muhammad, Harihar Sahoo
Summary: Advances in public health and clinical interventions have increased life expectancy worldwide. This study aimed to determine the prevalence of multimorbidity and disease-specific multimorbidity among older adults in India and examine its association with demographic and socioeconomic characteristics.
