Article
Cardiac & Cardiovascular Systems
Maria Wideqvist, Annika Rosengren, Maria Schaufelberger, Aldina Pivodic, Michael Fu
Summary: This study aims to investigate the trends in incidence, prevalence, and co-morbidities of heart failure (HF) over a 10-year period in Region Vastra Gotaland, Sweden. The results showed an overall decrease in HF incidence, with higher rates in older age groups. Men had a higher incidence of HF compared to women. The prevalence of HF increased, especially in those aged over 85 years. Women had a lower risk of death compared to men.
Article
Cardiac & Cardiovascular Systems
Davide Stolfo, Lars H. Lund, Lina Benson, Camilla Hage, Gianfranco Sinagra, Ulf Dahlstrom, Gianluigi Savarese
Summary: This study compared HF patients in Sweden with a matched population without HF, finding that HF patients had more comorbidities and worse socioeconomic status, as well as a much higher risk of cardiovascular, all-cause, and noncardiovascular events. It highlights the substantial burden HF patients place on healthcare systems and the need for optimal resource allocation and trial design.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Geriatrics & Gerontology
Saaima Parveen, Bochra Zareini, Anojhaan Arulmurugananthavadivel, Caroline Kistorp, Jens Faber, Lars Kober, Christian Hassager, Tor Biering Sorensen, Charlotte Andersson, Deewa Zahir, Kasper Iversen, Emil Wolsk, Gunnar Gislason, Freja Gaborit, Morten Schou
Summary: The study explored the risk of cardiovascular and non-cardiovascular events in elderly patients at early stages of heart failure, finding that the risk of HFH, IHD, stroke and all-cause death increased with severity of HF stage. 10% of patients with undiagnosed HF stage C were admitted for HF within 3 years, but the risk of non-CV hospitalizations was greater compared to HFH.
Article
Cardiac & Cardiovascular Systems
Lara Aguilar-Iglesias, Ana Merino-Merino, Ester Sanchez-Corral, Maria-Jesus Garcia-Sanchez, Isabel Santos-Sanchez, Jesus Dominguez-Calvo, Ruth Saez-Maleta, Jose-Angel Perez-Rivera
Summary: The study aimed to investigate the differences in clinical baseline variables and geriatric scales between frail and non-frail patients admitted for acute heart failure. The results showed that 33.7% of acute heart failure patients were defined as frail, and they were older, had worse quality of life, higher comorbidity, and more dependence. However, despite these adverse characteristics, the treatment plans during admission and at hospital discharge were similar. Therefore, we believe that a geriatric assessment should be performed during the admission of acute heart failure patients to improve care and attention.
Article
Cardiac & Cardiovascular Systems
Louisa M. S. Gerhardt, Maren Kordsmeyer, Susanne Sehner, Guelmisal Gueder, Stefan Stoerk, Frank Edelmann, Rolf Wachter, Sabine Pankuweit, Christiane Prettin, Georg Ertl, Christoph Wanner, Christiane E. Angermann
Summary: This study compared asymptomatic patients at risk for heart failure and symptomatic heart failure patients, and found that the prevalence and severity of chronic kidney disease and anemia increased in both patient groups. These conditions were individually and additively associated with increased 5-year mortality risk.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Marco Canepa, Lucia Leporatti, Luca Persico, Pietro Ameri, Italo Porto, Filippo Ansaldi, Marcello Montefiori
Summary: This study used a large administrative database from Liguria to investigate hospital readmissions in elderly patients with heart failure. It found that a quarter of patients contributed to more than half of the readmissions, with a negative impact on prognosis. The study also identified male gender, lower educational level, and higher comorbidity index as predictors of increased readmissions and mortality.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Infectious Diseases
Marianne Ask Torvik, Stig Haugset Nymo, Stale Haugset Nymo, Lars Petter Bjornsen, Hanne Winge Kvarenes, Eirik Hugaas Ofstad
Summary: A retrospective chart review of deceased adults in a Norwegian hospital found a high prevalence of advanced frailty, comorbidity, and age among sepsis-related deaths. The findings are significant for understanding sepsis-related mortality in similar populations, applicability of study results to clinical work, and future research designs.
Article
Immunology
Ruoshu Duan, Kangli Ye, Yangni Li, Yujing Sun, Jiahong Zhu, Jingjing Ren
Summary: This study aimed to identify the core genes associated with heart failure (HF) and investigate their potential mechanisms in HF and lung cancer, including oxidative stress and immune responses. The signature genes ECM2, METTL7B, MNS1, and SFRP4 showed remarkable diagnostic performance in HF patients, and METTL7B may be involved in the co-occurrence of HF and lung cancer through affecting oxidative stress immune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Harriette G. C. Van Spall, Ersilia M. DeFilippis, Shun Fu Lee, Urun Erbas Oz, Richard Perez, Jeff S. Healey, Larry A. Allen, Adriaan A. Voors, Dennis T. Ko, Lehana Thabane, Stuart J. Connolly
Summary: The transitional care model reduced all-cause emergency department visits among females but not males following hospitalization for heart failure.
CIRCULATION-HEART FAILURE
(2021)
Article
Oncology
Edoardo Bertero, Fabio Robusto, Eliana Rulli, Antonio D'Ettorre, Lucia Bisceglia, Lidia Staszewsky, Christoph Maack, Vito Lepore, Roberto Latini, Pietro Ameri
Summary: This study assessed the association between heart failure (HF) and cancer incidence and mortality in a community-based cohort. The results showed that HF was associated with an increased risk of cancer and cancer-related mortality, especially among individuals under 70 years old.
JACC: CARDIOONCOLOGY
(2022)
Article
Medicine, General & Internal
Mony Shuvy, Donna R. Zwas, Andre Keren, Israel Gotsman
Summary: Cancer is common among patients with heart failure, and patients with both heart failure and malignancies have poor outcomes, especially among young patients. The presence of cancer is associated with reduced survival in heart failure patients, with the strongest impact on outcomes related to age.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Danielle J. Beetler, Katelyn A. Bruno, Damian N. Di Florio, Erika J. Douglass, Swikriti Shrestha, Carsten Tschoepe, Madeleine W. Cunningham, Jan Krejci, Julie Bienertova-Vasku, Sabine Pankuweit, Dennis M. McNamara, Eun-Seok Jeon, Sophie van Linthout, Lori A. Blauwet, Leslie T. Cooper, DeLisa Fairweather
Summary: This study aimed to investigate the sex and age differences in soluble ST2 (sST2) levels for various cardiovascular diseases (CVDs). Using ELISA kit, sST2 levels were measured in patients with myocarditis, cardiomyopathy, coronary artery disease (CAD), myocardial infarct (MI), and congestive heart failure (CHF) and compared to controls without CVDs. The results showed that myocarditis occurred in younger patients around the age of 40, while other CVDs were more common in individuals around the age of 60. There were significant differences in sST2 levels between sexes in myocarditis and cardiomyopathy, but not in other CVDs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Clara Saldarriaga, Dan Atar, Amanda Stebbins, Basil S. Lewis, Imran Zainal Abidin, Robert O. Blaustein, Javed Butler, Justin A. Ezekowitz, Adrian F. Hernandez, Carolyn S. P. Lam, Christopher M. O'Connor, Burkert Pieske, Piotr Ponikowski, Lothar Roessig, Adriaan A. Voors, Kevin J. Anstrom, Paul W. Armstrong
Summary: Coronary artery disease (CAD) is associated with higher cardiovascular events and heart failure hospitalizations in patients with Heart Failure with Reduced Ejection Fraction (HFrEF) and worsening HF. However, the treatment effect of vericiguat remains effective regardless of the presence of CAD. Patients with CAD are more likely to have other comorbidities compared to those without CAD.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Medicine, General & Internal
Mia Scholten, Patrik Midlov, Anders Halling
Summary: This study compared the prevalence of heart failure (HF) in relation to age, multimorbidity, and socioeconomic status in primary healthcare centers in southern Sweden. The results showed that the prevalence of HF increased with advancing age and multimorbidity level, and had a strong correlation with the socioeconomic status of the healthcare centers.
Article
Cardiac & Cardiovascular Systems
Anna Norhammar, Johan Bodegard, Marc Vanderheyden, Navdeep Tangri, Avraham Karasik, Aldo Pietro Maggioni, Kari Anne Sveen, Tiago Taveira-Gomes, Manuel Botana, Lukas Hunziker, Marcus Thuresson, Amitava Banerjee, Johan Sundstrom, Andreas Bollmann
Summary: The CaReMe HF study collected individual level data from digital healthcare systems in 11 countries to estimate the prevalence, clinical outcomes, and costs of HF. The study found that 1-2% of the contemporary adult population has HF, and these individuals are at significant risk of adverse outcomes and associated costs.
