Article
Oncology
Christian Stephens, Dori Klemanski, Maryam B. Lustberg, Anne M. Noonan, Seuli Brill, Jessica L. Krok-Schoen
Summary: The study reveals that many primary care physicians lack confidence in providing survivorship care, which may be due to inadequate training, poor communication with oncologists, and underutilization of survivorship care plans.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Oncology
Abhishek Joshi, Sarah Larkins, Rebecca Evans, Nishila Moodley, Amy Brown, Sabe Sabesan
Summary: Existing research shows positive impact of SCPs on proximal outcomes like patient experience and care delivery, but results are mixed for health outcomes in breast cancer survivors. Future research should focus on better defining SCP content, ensuring follow-up recommendations are acted upon, including provider feedback, and using novel tools to empower stakeholders.
Review
Oncology
Lucy Rose, Maryam Lustberg, Kathryn J. Ruddy, Elizabeth Cathcart-Rake, Charles Loprinzi, Brittany Dulmage
Summary: This article provides a review on different types of alopecia, including chemotherapy-induced alopecia, telogen effluvium, and endocrine-induced alopecia, which are distressing side effects in breast cancer patients. The article aims to inform breast oncologists about the mechanisms, etiology, prevention strategies, and treatment options for hair loss related to cancer therapy, facilitating informative patient counseling.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Mya L. Roberson, Anna Henricks, Joshua Woods, Lesley Glenn, Julia Maues, Deltra James, Sonya Reid
Summary: There are substantial gaps in providing patient-centered supportive care for metastatic breast cancer. This study aims to assess how patients with metastatic breast cancer would re-imagine cancer care delivery.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Philip D. Poorvu, Shari I. Gelber, Yue Zheng, Kathryn J. Ruddy, Rulla M. Tamimi, Jeffrey Peppercorn, Lidia Schapira, Virginia F. Borges, Steven E. Come, Matteo Lambertini, Shoshana M. Rosenberg, Ann H. Partridge
Summary: Many young women with newly diagnosed breast cancer express interest in future pregnancies. Within 5 years of diagnosis, 36% reported interest in having children, with the majority successfully conceiving if they attempted to do so. Factors such as age at diagnosis and parity status were associated with likelihood of pregnancy, while endocrine therapy was inversely linked to pregnancy outcomes. Longitudinal fertility discussions are important for this population.
Article
Oncology
Naomi Y. Ko, Tsion G. Fikre, Anne K. Buck, Emily Restrepo, Erica T. Warner
Summary: Black breast cancer survivors have specific needs, challenges, and preferences. Supportive interventions that address their concerns are responsive and can help to ameliorate disparities.
Article
Psychology, Multidisciplinary
Emily C. Soriano, Christine Perndorfer, Amy K. Otto, Alyssa L. Fenech, Scott D. Siegel, Diana Dickson-Witmer, Lydia Clements, Jean-Philippe Laurenceau
Summary: The study reveals that the pandemic has mainly affected breast cancer survivors in terms of their fear of cancer progression risk and COVID-19. However, most survivors generally manage well psychosocially before or after delayed surgery due to the pandemic.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Oncology
Kain Phansuwon, Sim Yee (Cindy)Tan, Kim Kerin-Ayres, Ashanya Malalasekera, Janette L. Vardy
Summary: The study found that while most survivors found SCP useful, they did not share them with other healthcare providers, raising questions about their effectiveness in coordinating care. Additionally, there were challenges with SCP delivery. Survivors reported compliance with SCP lifestyle recommendations. Further research is needed to assess the utility of SCP among other stakeholders such as general practitioners.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Allen Mo, Julie Chung, Jeremy Eichler, Sarah Yukelis, Sheldon Feldman, Jana Fox, Madhur Garg, Shalom Kalnicki, Nitin Ohri, Joseph A. Sparano, Jonathan Klein
Summary: The study revealed a significant disruption in breast cancer survivorship follow-up during the COVID-19 pandemic, with younger patients, those receiving adjuvant radiation therapy, and those with lower household income more likely to continue follow-up during the pandemic.
Article
Oncology
Aisha Lofters, Ielaf Khalil, Nicolette Sopcak, Melissa Shea-Budgell, Christopher Meaney, Carolina Fernandes, Rahim Moineddin, Denise Campbell-Scherer, Kris Aubrey-Bassler, Donna Patricia Manca, Eva Grunfeld
Summary: The BETTER WISE intervention is an evidence-based approach to prevention and screening for cancers and chronic diseases in primary care, with a focus on breast, prostate, and colorectal cancer survivors. The study evaluates the impact of the intervention, taking into account the COVID-19 pandemic. The findings suggest that BETTER WISE has potential in providing comprehensive care for cancer survivors in primary care settings.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Kathryn E. Post, Donna L. Berry, Judith Shindul-Rothschild, Jane Flanagan
Summary: This study aimed to explore factors influencing patient engagement in breast cancer survivors, finding that survivors with higher health-related quality of life, greater social support, and higher education levels were more likely to be engaged.
Article
Oncology
Fernando A. Angarita, Nicole Jedrzejko, David Eisen, Maria Muraca, Marla Ash, Fahima Osman
Summary: This study investigated the perspective of primary care physicians (PCPs) in Toronto, Canada, regarding the barriers and needs associated with transitioning breast cancer follow-up care to their practices. The results revealed that PCPs require support in the form of follow-up care plans upon discharge, rapid re-referral to specialists, and regular updates of best practice changes. The majority of PCPs supported transitioning to a PCP-led model.
CLINICAL BREAST CANCER
(2022)
Review
Health Care Sciences & Services
Rahimeh Khajoei, Mahnaz Ilkhani, Payam Azadeh, Sima Zohari Anboohi, Fatemah Heshmati Nabavi
Summary: This study aimed to identify the supportive care needs of breast cancer survivors. The most frequently mentioned needs were psychological/emotional needs, health system/informational needs, physical and daily activities, and interpersonal/intimacy needs. Supportive programs should be designed to address all aspects of these needs, particularly psychological, emotional, and informational needs.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Oncology
Timiya S. Nolan, Elizabeth Arthur, Ogechi Nwodim, Amelia Spaulding, Jennifer Kue
Summary: The review of literature on preferences and utilization of survivorship care plans (SCPs) among Asian American breast cancer survivors reveals a lack of evidence in this area, with most studies focusing on survivors of Southeast Asian descent. Barriers to delivery of SCPs are primarily associated with socioeconomic factors. More research is needed to provide high-quality care to these survivors.
ONCOLOGY NURSING FORUM
(2021)
Article
Oncology
Kristin L. Szuhany, Matteo Malgaroli, Gabriella Riley, Carly D. Miron, Rebecca Suzuki, Jae Hyung Park, Jane Rosenthal, Abraham Chachoua, Marleen Meyers, Naomi M. Simon
Summary: Few survivors recalled receiving a formal SCP, and lack of information about wellness activities was a commonly reported barrier to participation. Interest in wellness activities was generally high and may indicate the need for more formal prescription or motivation enhancement techniques to promote SCP engagement.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Review
Ophthalmology
Tim R. Fricke, Padmaja Sankaridurg, Thomas Naduvilath, Serge Resnikoff, Nina Tahhan, Mingguang He, Kevin D. Frick
Summary: This study describes a methodology for estimating lifetime myopia costs and compares different management options in the context of Australia and China. The results suggest that investing in active myopia management can lead to economic balance or even better outcomes by reducing refractive progression, using simpler lenses, and minimizing the risk of pathology and vision loss.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Oncology
Julienne E. Bower, Ann H. Partridge, Antonio C. Wolff, Steve W. Cole, Michael R. Irwin, Elissa D. Thorner, Hadine Joffe, Laura Petersen, Catherine M. Crespi, Patricia A. Ganz
Summary: This study examined the effects of interventions on younger breast cancer survivors and found that mindful awareness practices (MAPs) had beneficial effects on psychological and immune outcomes, indicating its potential for enhancing biobehavioral health.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Adith Abraham, Carlos H. Barcenas, Richard J. Bleicher, Adam L. Cohen, Sara H. Javid, Ellis G. Levine, Nancy U. Lin, Beverly Moy, Joyce C. Niland, Antonio C. Wolff, Michael J. Hassett, Sarah Asad, Daniel G. Stover
Summary: We developed a risk prediction model for late relapse of triple negative breast cancer (lrTNBC) using clinicopathologic and sociodemographic features. Our study found that tumor stage at diagnosis and BMI were significantly associated with lrTNBC. This risk prediction model may help identify patients at risk of developing lrTNBC and should be further investigated.
Article
Oncology
Kala Visvanathan, Leslie Cope, Mary Jo Fackler, Michael Considine, Lori Sokoll, Lisa A. Carey, Andres Forero-Torres, James N. Ingle, Nancy U. Lin, Rita Nanda, Anna Maria Storniolo, Suzana Tulac, Neesha Venkatesan, Natalie C. Wu, Sudhakar Marla, Scott Campbell, Michael Bates, Christopher B. Umbricht, Antonio C. Wolff, Saraswati Sukumar
Summary: This study evaluated the clinical utility of a novel liquid biopsy-breast cancer methylation (LBx-BCM) prototype assay for early assessment of disease progression in women with metastatic breast cancer (MBC). The results showed that high levels of cumulative methylation (CM) were associated with shorter median progression-free survival (PFS) and overall survival (OS) at week 4. The CM levels at week 4 could be used to predict disease progression as early as 3 months after initiating a new treatment.
CLINICAL CANCER RESEARCH
(2023)
Editorial Material
Oncology
Cesar A. Santa-Maria, Antonio C. Wolff
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Zhengyi Deng, Miranda R. Jones, Mei-Cheng Wang, Antonio C. Wolff, Kala Visvanathan
Summary: Higher cancer mortality was observed among Non-Hispanic Black and Hispanic survivors, while higher cardiovascular mortality was observed among Non-Hispanic Black survivors among women who survive a first breast cancer to develop a second primary cancer.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Jennifer Y. Sheng, Claire F. Snyder, Katherine C. Smith, Jennifer DeSanto, Nancy Mayonado, Susan Rall, Sharon White, Amanda L. Blackford, Fabian M. Johnston, Robert L. Joyner, Joan Mischtschuk, Kimberly S. Peairs, Elissa Thorner, Phuoc T. Tran, Antonio C. Wolff, Youngjee Choi
Summary: Survivorship care plans (SCPs) are important for communicating cancer-related information. This study found that some tests conducted after SCP receipt were not consistent with guidelines, indicating overuse. This analysis identifies areas for improvement in guideline-concordant care.
Article
Oncology
Gabrielle B. Rocque, Courtney Andrews, Valerie M. Lawhon, Rachel Frazier, Stacey A. Ingram, Mary Lou Smith, Lynne I. Wagner, Lisa Zubkoff, Nadine Tung, Lauren P. Wallner, Antonio C. Wolff
Summary: As outcomes improve in early-stage breast cancer, clinical trials are shifting towards optimization trials, which aim to use less toxic therapy while maintaining survival outcomes. However, little is known about physician perspectives on the barriers and facilitators to enrollment in these trials and the generalizability of the results.
JCO ONCOLOGY PRACTICE
(2023)
Article
Oncology
Susana L. Garcia-Recio, Toshinori J. Hinoue, Gregory L. C. Wheeler, Benjamin J. Kelly, Ana C. A. Garrido-Castro, Tomas Pascual, Aguirre A. M. De Cubas, Youli B. Xia, Brooke M. Felsheim, Marni B. McClure, Andrei A. Rajkovic, Ezgi Karaesmen, Markia A. Smith, Cheng E. Fan, Paula I. Gonzalez J. Ericsson, Melinda E. Sanders, Chad J. Creighton, Jay T. Bowen, Kristen Leraas, Robyn T. Burns, Sara Coppens, Amy L. Wheless, Salma S. Rezk, Amy L. K. Garrett, Joel S. Parker, Kelly K. H. Foy, Hui Shen, Ben H. Park, Ian Krop, Carey F. Anders, Julie Gastier-Foster, Mothaffar F. U. Rimawi, Rita Nanda, Nancy U. Lin, Claudine Isaacs, P. Kelly J. Marcom, Anna Maria Storniolo, Fergus J. Couch, Uma Chandran, Michael Davis, Jonathan C. Silverstein, Alexander G. Ropelewski, Minetta C. Liu, Susan G. L. Hilsenbeck, Larry Norton, Andrea L. C. Richardson, W. Fraser E. Symmans, Antonio C. A. Wolff, Nancy E. V. Davidson, Lisa A. M. Carey, Adrian V. A. Lee, Justin M. W. Balko, Katherine A. R. Hoadley, Peter W. A. Laird, Elaine R. A. Mardis, Tari A. A. King, Charles M. AURORA US Network, Charles M. Perou
Summary: The AURORA US Metastasis Project aimed to identify molecular features associated with metastasis in breast cancer. By analyzing the samples from 55 females with metastatic breast cancer, changes in gene expression subtypes and DNA clonality shifts were observed. Downregulation of estrogen receptor (ER)-mediated cell-cell adhesion genes through DNA methylation mechanisms was observed in metastases. Differences in the tumor microenvironment and immune cell infiltrates were also found in different breast cancer subtypes, providing implications for targeted therapies.
Review
Oncology
Laura Pala, Tommaso De Pas, Eleonora Pagan, Isabella Sala, Chiara Catania, Emma Zattarin, Paolo Arnone, Massimo M. Grassi, Marco Colleoni, Antonio C. Wolff, Javier Cortes, Martine Piccart, Richard D. Gelber, Giuseppe Viale, Vincenzo Bagnardi, Fabio Conforti
Summary: This study conducted a systematic review and meta-analysis of randomized clinical trials to compare the efficacy of limited-extended adjuvant endocrine treatment (ET) and full-extended ET in patients with early-stage breast cancer. The results showed that full-extended ET significantly improved disease-free survival (DFS) in patients with nodal-positive disease, while no significant improvement was observed in other subgroups.
Article
Oncology
Antonio C. Wolff, Mark R. Somerfield, Mitchell Dowsett, M. Elizabeth H. Hammond, Daniel F. Hayes, Lisa M. McShane, Thomas J. Saphner, Patricia A. Spears, Kimberly H. Allison
Summary: This article is an update on the recommendations for HER2 testing in breast cancer, affirming the 2018 ASCO-CAP recommendations. The article emphasizes a new indication for trastuzumab deruxtecan when HER2 is not overexpressed or amplified, and provides best practice recommendations to distinguish IHC 0 and 1+.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Beverly Moy, Antonio C. Wolff, R. Bryan Rumble, Kimberly H. Allison, Lisa A. Carey
JCO ONCOLOGY PRACTICE
(2023)
Editorial Material
Oncology
Antonio C. Wolff
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Zhengyi Deng, Miranda R. Jones, Antonio C. Wolff, Kala Visvanathan
Summary: The UK National Health Service's Predict tool performs well in predicting breast cancer-specific mortality for first breast cancer, but underestimates it for second breast cancer, especially for estrogen receptor-positive breast cancer patients.
JNCI CANCER SPECTRUM
(2023)
Article
Oncology
Sara M. Tolaney, Paolo Tarantino, Noah Graham, Nabihah Tayob, Laia Pare, Guillermo Villacampa, Chau Dang, Denise A. Yardley, Beverly Moy, P. Kelly Marcom, Kathy S. Albain, Hope S. Rugo, Matthew J. Ellis, Iuliana Shapira, Antonio C. Wolff, Lisa A. Carey, Romualdo Barroso-Sousa, Patricia Villagrasa, Michelle DeMeo, Molly DiLullo, Jorge Gomez Tejeda Zanudo, Jakob Weiss, Nikhil Wagle, Ann H. Partridge, Adrienne G. Waks, Clifford A. Hudis, Ian E. Krop, Harold J. Burstein, Aleix Prat, Eric P. Winer
Summary: This study reports the long-term outcomes of patients with small, node-negative, HER2-positive breast cancer treated with adjuvant paclitaxel and trastuzumab, and establishes potential biomarkers to predict prognosis. The results indicate that adjuvant paclitaxel and trastuzumab is a reasonable treatment standard for this population, and the HER2DX genomic tool might help refine the prognosis.