Article
Engineering, Biomedical
Sijie Wu, Gaodan Liu, Ping Shao, Xingyu Lin, Jiahao Yu, Hanchi Chen, Huiliang Li, Simin Feng
Summary: This study developed a carboxymethyl-modified chitosan/hyaluronic acid thermosensitive hydrogel for sustained transdermal delivery of liposomes. The hydrogel exhibited suitable gel properties and structure, resulting in delayed liposomes release and improved skin retention. The liposome-hydrogel system more efficiently promoted the effects of anti-aging agents on the skin.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Chang Ni, Zijun Zhang, Yuling Wang, Zhenhai Zhang, Xueping Guo, Huixia Lv
Summary: Hyaluronic acid (HA) is widely used in cosmetics due to its moisturizing property. This study investigated the factors and mechanism of HA on skin penetration and designed HA-modified liposomes for transdermal drug delivery. The results showed that low molecular weight HA could penetrate the skin barrier and enhance skin hydration, while the high molecular weight HA was trapped on the skin surface. The HA-modified liposomes exhibited increased skin penetration and retention compared to conventional liposomes.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Nanoscience & Nanotechnology
Huaiji Wang, Zihan Zhao, Chenghao Wu, Xiaowen Tong, Yuling Shi, Shunjie Chen
Summary: Transdermal drug delivery provides an alternative method for psoriasis treatment by dampening immune cell activation and inflammation. The developed MN patch showed excellent skin penetration and inhibited the progression of psoriasis. This study also provided new insights into the mechanism of the transdermal drug delivery system.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Pharmacology & Pharmacy
S. L. Jyothi, K. L. Krishna, V. K. Ameena Shirin, Renu Sankar, K. Pramod, H. Gangadharappa
Summary: Psoriasis is an autoimmune disorder with genetic and environmental factors as its causes. Various drug targets and targeted therapies, including nano-carriers, have been identified for psoriasis treatment. In addition to traditional treatments, novel drug delivery systems show promising efficacy for psoriasis therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Medicine, General & Internal
Tory R. Spindle, Dennis J. Sholler, Edward J. Cone, Timothy P. Murphy, Mahmoud ElSohly, Ruth E. Winecker, Ronald R. Flegel, Marcel O. Bonn-Miller, Ryan Vandrey
Summary: This study evaluated the accuracy of CBD and THC labeling in topical cannabinoid products and found that they are often inaccurately labeled and many contain THC. These findings suggest the need for clinical studies to determine whether topical cannabinoid products with THC can produce psychoactive effects or positive drug tests for cannabis.
Review
Pharmacology & Pharmacy
Nakamwi Akombaetwa, Ange B. B. Ilangala, Lorraine Thom, Patrick B. B. Memvanga, Bwalya Angel Witika, Aristote B. B. Buya
Summary: Skin delivery is a promising approach for effective drug delivery, but low skin permeability is a major challenge. Advances in skin delivery depend on overcoming the challenges associated with drug molecule permeation and skin irritation. Lipid nanosystems offer potential solutions, but their formulation requires careful consideration of factors such as particle size and surface charge.
Article
Chemistry, Multidisciplinary
Jushan Gao, Shanbo Ma, Xinxin Zhao, Jinpeng Wen, Datao Hu, Xiaoye Zhao, Xiaopeng Shi, Ke Wang
Summary: The study explored the potential mechanisms of a dual-labeled nano drug delivery system for transdermal absorption, revealing that the nanoparticles can impact cell functions through various pathways to promote transdermal absorption. Visual demonstrations confirmed the penetration of the nanoparticle delivery system into the dermis, suggesting a new method for future investigations into transdermal drug delivery mechanisms.
CHINESE CHEMICAL LETTERS
(2021)
Article
Biophysics
Jing Liu, Xiang Li, Lina Liu, Qiang Bai, Ning Sui, Zhiling Zhu
Summary: The synthesis of a core-shell structured silver nanocluster based nanocomposite showed high antimicrobial efficacy and wide pH tolerance, making it suitable for in vivo wound disinfection. This innovative design could potentially lead to the development of silver nanoclusters in portable bandages and implantable devices for localized antimicrobial delivery.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biophysics
Bruna G. Carvalho, Bianca B. M. Garcia, Antonio A. Malfatti-Gasperini, Sang W. Han, Lucimara G. de la Torre
Summary: The association between chondroitin sulfate (CS) and cationic liposomes (CLs)/lipoplex (CL-pDNA) was analyzed in this study. The results showed that the electrostatic interaction between CS and CL/CL-pDNA could reorganize the lipid bilayers and form nanoscale vesicles. These findings have implications for the development of novel carriers for drug and gene delivery applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Instruments & Instrumentation
Michele Schlich, Umberto M. Musazzi, Virginia Campani, Marco Biondi, Silvia Franze, Francesco Lai, Giuseppe De Rosa, Chiara Sinico, Francesco Cilurzo
Summary: The skin is an important site for drug absorption, and recent research has supported the design of innovative nanosystems to improve the absorption of poorly skin-permeable drugs. However, topically applied liposomal systems face several challenges, making their clinical application difficult.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Boyang Sun, Georgios Paraskevopoulos, Jiwei Min, Robert Rossdeutcher, Sanjana Ghosh, Breandan Quinn, Meng-Hsuan Lin, Debanjan Sarkar, Dinesh Sukumaran, Yuefei Wang, Katerina Vavrova, Jonathan F. Lovell, Yumiao Zhang
Summary: This study finds that cabazitaxel (CTX) can be dissolved in alpha-tocopherol at high concentrations exceeding 100 mg mL(-1). The addition of 30% dimethyl sulfoxide (DMSO) to the alpha-tocopherol/CTX solution improves its permeation through human skin. Topical application of CTX using a DMSO and alpha-tocopherol solvent shows significant suppression of tumor growth in nude mice bearing skin cancer xenografts.
Article
Chemistry, Multidisciplinary
Ming Yuan, Jiangxiu Niu, Fei Li, Huiyuan Ya, Xianghui Liu, Keying Li, Yanli Fan, Qiuyan Zhang
Summary: This study proposes a hydrogel containing CUR-encapsulated nanostructured lipid carriers (CUR-DP-NLCs gel) to enhance topical drug delivery and improve the therapeutic effect. The gel showed increased skin retention of CUR and better anti-inflammatory and analgesic activities after topical administration.
Article
Pharmacology & Pharmacy
Chi Zhang, Jiwen Duan, Yongxiang Huang, Ming Chen
Summary: This study demonstrates the successful transdermal or dermal administration of therapeutic peptides such as insulin and cyclosporine A using spicule-based delivery systems derived from marine sponges. The results show that these spicules significantly enhance skin permeability and offer promising strategies for delivering therapeutic peptides effectively.
Article
Pharmacology & Pharmacy
Zhe Lv, Han Bao, Ming Zhu, Yizhuo Xie, Huan Tang, Dongfanghui Miao, Xin Guo, Xinhui Zhai, Shanshan Wang, Hongli Chen, Dengli Cong, Xin Liu, Jin Pei
Summary: Excessive sebum is the main cause of seborrheic diseases. Chemical medicines often have side effects, so polypeptides with fewer side effects are considered ideal for reducing sebum production. An inhibiting polypeptide (SREi) was developed to suppress the activation of sterol regulatory element-binding proteins-1 (SREBP-1). Anionic deformable liposomes containing SREi were prepared and showed high entrapment efficiency, small particle size, and negative surface charge. When formulated into a hydrogel, the SREi liposomes exhibited sustained release and improved cellular uptake and transdermal absorption. In vivo studies confirmed that the SREi hydrogel had the strongest inhibitory effect on sebum synthesis and gland growth. Histological analysis showed reduced sebaceous gland lobes in the SREi hydrogel group. Overall, this study suggests that the SREi hydrogel has potential applications in diseases related to excessive sebum production.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Xiang Wang, Xuefeng Hou, Yihan Wu, Jingwen Guo, Haichuan Tai, Yongtai Zhang, Nianping Feng
Summary: In this study, a new preparation of CHR-loaded liposomal gel (CHR-LipGel) with good physicochemical stability and efficient antiphotoaging properties was described. The CHR-loaded liposomes were hybridized with D-a-tocopherol polyethylene glycol succinate and Poloxamer 188, and dispersed in sodium hyaluronate-formed hydrogel to obtain CHR-Lip-Gel. The CHR-Lip-Gel significantly increased skin permeability and skin retention of chrysin, and showed superior cellular uptake and anti-photoaging effects compared to free CHR. The newly developed CHR-Lip-Gel is a superior anti-photoaging system. Rating: 8/10.
ARABIAN JOURNAL OF CHEMISTRY
(2023)