Article
Neurosciences
Ying Lyu, Yiying Huang, Guiying Shi, Xuepei Lei, Keya Li, Ran Zhou, Lin Bai, Chuan Qin
Summary: This study revealed gene expression changes in the five brain regions following exposure to 6-hydroxydopamine in PD rats, identifying key pathways and cascade involved in synaptic damage. The dopaminergic synapse, retrograde endocannabinoid signaling, and Gi/o-GIRK were highlighted as potential key pathways. Potential candidate genes such as Ephx2, Fam111a, and Gng2 were identified for further studies on the pathogenesis of PD.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Victor Silva da Fonseca, Valeria de Cassia Goncalves, Mario Augusto Izidoro, Antonio-Carlos Guimaraes de Almeida, Fernando Luiz Affonso Fonseca, Fulvio Alexandre Scorza, Josef Finsterer, Carla Alessandra Scorza
Summary: Parkinson's disease is an incurable neurodegenerative disease with an increasing global disability and mortality rate. Non-motor symptoms are the main cause of disability and decreased quality of life. This study used metabolomics to assess changes in cardiac metabolism in a PD model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Camila G. Dantas, Ailma O. da Paixao, Tassia L. G. M. Nunes, Italo J. F. Silva, Bruno dos S. Lima, Adriano A. S. Araujo, Ricardo L. C. de Albuquerque-Junior, Katia P. Gramacho, Francine F. Padilha, Luiz P. da Costa, Patricia Severino, Juliana C. Cardoso, Eliana B. Souto, Margarete Z. Gomes
Summary: This study evaluated the neuroprotective effects of Africanized bee venom (BV) on a mice model of Parkinson's disease induced by 6-hydroxydopamine (6-OHDA). The results showed that BV could counteract the symptoms caused by 6-OHDA, reduce cell death, and protect the striatum from damage. These findings suggest that Africanized bee venom may have potential as a novel therapeutic approach for Parkinson's disease.
Article
Chemistry, Multidisciplinary
Emile F. van Vliet, Maarten J. Knol, Raymond M. Schiffelers, Massimiliano Caiazzo, Marcel H. A. M. Fens
Summary: Parkinson's disease is characterized by degeneration of dopaminergic neurons, causing dopamine deficiency and motor symptoms. Current treatment using L-DOPA has limitations and side effects. Encapsulation of L-DOPA into nanoparticles can protect it and improve delivery to the brain, reducing required dosages and side effects. Alternative delivery methods, such as intravenous administration and transdermal delivery, enhance therapeutic effects. This review discusses recent advances and future perspectives on NP-mediated L-DOPA delivery to the brain.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biotechnology & Applied Microbiology
Na Qi, Wenjuan Duan, Duan Gao, Ningzhu Ma, Jianguo Zhang, Jianfang Feng, Aimin Li
Summary: In this study, we developed dual-modified liposomes with lactoferrin and muscone to enhance the delivery and targeting of docetaxel to the brain. The results showed improved uptake and penetration in brain tumor cells and enhanced anti-tumor effects in vitro and in vivo.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Bira Arumndari Nurrahma, Tu-Hsueh Yeh, Rong-Hong Hsieh, Shu-Ping Tsao, Chia-Wen Chen, Yen-Peng Lee, Chun-Hsu Pan, Hui-Yu Huang
Summary: The study suggests that mangosteen pericarp extract may delay the progression of Parkinson's disease by counteracting oxidative stress and improving gut microbiota composition.
Article
Chemistry, Analytical
Yao Ma, Liping Zhao, Linsen Li, Chao Zhu, Feng Qu
Summary: A new type of aptamer-functionalized pH-responsive polymer-modified magnetic nanoparticles (ApMNPs) was developed for specific enrichment and sensitive determination of lactoferrin (Lf) in complex matrixes. The Lf-binding aptamers were conjugated onto pH-responsive polymer-modified magnetic nanoparticles (pMNPs) to prepare Lf-ApMNPs, which showed good selectivity and adsorption capacity for Lf. The introduction of pH-responsive monomer effectively regulated the adsorption-desorption process, making it a facile and efficient approach for the determination of targets in biological samples.
Article
Geriatrics & Gerontology
Jiewen Qiu, Guoyou Peng, Yuting Tang, Shiyin Li, Zengfu Liu, Jiayun Zheng, Yunxin Wang, Hanqun Liu, Lijian Wei, Yilin Su, Yuwan Lin, Wei Dai, Zhiling Zhang, Xiang Chen, Liuyan Ding, Wenyuan Guo, Xiaoqin Zhu, Pingyi Xu, Mingshu Mo
Summary: This study established a rat model of Parkinson's disease (PD) using 6-hydroxydopamine (6-OHDA) and analyzed the lipid profile in cerebrospinal fluid (CSF) using lipidomic approaches. The results showed significant effects of 6-OHDA on behavior, dopaminergic neurons, and lipid composition in CSF. Specific lipid families and species exhibited fluctuations during the progression of Parkinson's disease and were correlated with behavioral and pathological changes in the midbrain.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Jessica Burns, Amy Claire Buck, Sarah D'Souza, Admire Dube, Soraya Bardien
Summary: Nanoparticles can improve the efficacy of phytochemicals for treating Parkinson's disease by enabling targeted delivery to the brain and crossing the blood-brain barrier. Further research is warranted to explore nanophytomedicine as a therapeutic approach for Parkinson's disease.
Article
Medicine, Research & Experimental
Juzheng Zhang, Ronghao Fang, Yanping Li, Jiamin Jin, Feng Yang, Jian Chen
Summary: This study developed a novel metal-based drug that can cross the blood-brain barrier and target glioma. The drug induces apoptosis and autophagic death in glioma cells and selectively accumulates in tumor tissue, significantly reducing side effects.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Andrea Margari, Anna Grazia Monteduro, Silvia Rizzato, Loredana Capobianco, Alessio Crestini, Roberto Rivabene, Paola Piscopo, Mara D'Onofrio, Valeria Manzini, Giuseppe Trapani, Alessandra Quarta, Giuseppe Maruccio, Carmelo Ventra, Luigi Lieto, Adriana Trapani
Summary: The study developed CIT-Loaded Solid Lipid Nanoparticles for the treatment of Parkinson's disease, showing enhanced protection against neurotoxins and prompting further investigation of the underlying molecular mechanisms that explain this difference.
Article
Clinical Neurology
Jonathan Baskin, June Evelyn Jeon, Simon J. G. Lewis
Summary: Nanotechnology has opened up new possibilities for treating Parkinson's disease, improving drug delivery to the brain, and developing exciting treatment strategies that may offer more personalized approaches in the future.
JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nilufar Ali, Mukta S. Sane, Huiyuan Tang, Jadon Compher, Quinlan Mclaughlin, Christopher D. Jones, Shivani Kaushal Maffi
Summary: This study demonstrates that acute exposure to 6-hydroxydopamine (6-OHDA) activates multiple cell death pathways and has significant effects on the expression of mitochondrial complexes and apoptotic cell death cascade. The research provides a basis for further investigation into the impact of 6-OHDA on the ubiquitin proteasome system in PD therapies.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Ana Carolina D. Noseda, Lais S. Rodrigues, Adriano D. S. Targa, Jessica L. Ilkiw, Juliane Fagotti, Patricia D. dos Santos, Erika Cecon, Regina P. Markus, Michele Solimena, Ralf Jockers, Marcelo M. S. Lima
Summary: Melatonin MT2 receptors in the glomerular layer are implicated in depressive-like behaviors and olfactory function impairment associated with Parkinson's disease, as demonstrated in a rat model using 6-OHDA-induced lesions. The activation of these receptors by melatonin and specific drugs shows potential for treating non-motor symptoms in PD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Saeideh Nourmohammadi, Sanaz Yousefi, Mahboubeh Manouchehrabadi, Mona Farhadi, Zahra Azizi, Anahita Torkaman-Boutorabi
Summary: In this study, the potential neuroprotective effects of thymol were investigated in in vitro and in vivo models of Parkinson's disease. The results suggest that thymol exerts protective effects, possibly through its antioxidant properties.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Nanoscience & Nanotechnology
Aimeng Dong, Liang Han, Zhengbo Shao, Pan Fan, Xinrong Zhou, Huiping Yuan
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Chemistry, Multidisciplinary
Tongtong Miao, Xiufeng Ju, Qiuning Zhu, Yamei Wang, Qian Guo, Tao Sun, Chunzhu Lu, Liang Han
ADVANCED FUNCTIONAL MATERIALS
(2019)
Article
Chemistry, Multidisciplinary
Qian Guo, Qiuning Zhu, Tongtong Miao, Jing Tao, Xiufeng Ju, Zhenglong Sun, Hui Li, Guoqiang Xu, Huabing Chen, Liang Han
JOURNAL OF CONTROLLED RELEASE
(2019)
Article
Chemistry, Multidisciplinary
Jiang Ni, Tongtong Miao, Ma Su, Naveed Ullah Khan, Xiufeng Ju, Haiyan Chen, Feng Liu, Liang Han
Summary: Breast cancer brain metastases (BCBM) are a major cause of morbidity and mortality among breast cancer patients because systemic drug therapy is often ineffective due to poor penetration through the blood-brain tumor barrier (BTB). This study found a nanotechnology approach that can overcome the BTB and target BCBM effectively, showing promising results in preclinical studies.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Naveed Ullah Khan, Jiang Ni, Xiufeng Ju, Tongtong Miao, Haiyan Chen, Liang Han
Summary: Breast cancer brain metastases (BCBMs) are challenging due to their intracranial location and limited response to chemotherapy. Research has shown promising results with nanoparticles (NPs-K-s-A) targeting LRP1 and MMP1 to overcome the blood-brain barrier and enhance drug delivery, leading to improved therapeutic outcomes in mice with BCBMs. This fusion peptide-based drug delivery strategy shows potential for clinical management of BCBMs.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Pharmacology & Pharmacy
Liang Han, Chen Jiang
Summary: This review focuses on nanoscale brain-targeting drug delivery strategies designed based on blood-brain barrier (BBB) alterations and their applications in various brain diseases. However, advances on optimization of small molecules for BBB crossing and non-systemic administration routes such as intranasal treatment are not included in this review.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Engineering, Biomedical
Xiufeng Ju, Tongtong Miao, Haiyan Chen, Jiang Ni, Liang Han
Summary: Mfsd2a plays a crucial role in regulating the transcytosis and permeability of the blood-brain barrier. Strategies involving priming nanoparticles and drug-loaded nanoparticles have shown promising results in enhancing BBB crossing efficiency and brain accumulation of therapeutics for breast cancer brain metastases.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Medicine, Research & Experimental
Xiufeng Ju, Haiyan Chen, Tongtong Miao, Jiang Ni, Liang Han
Summary: Brain metastases from breast cancer are difficult to surgically remove and have limited drug treatment options due to their growth patterns and the blood-brain barrier. By assembling prodrug-loaded nanoparticles that target both the BBB and metastatic breast cancer, researchers were able to significantly extend the survival time of mice with intracranial metastatic breast cancer, suggesting a potential important direction for drug therapy against brain metastases.
MOLECULAR PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Liang Han
Summary: The blood-brain barrier tightly regulates substance transport into and out of the brain, but strategies to modulate the BBB have the potential to improve drug delivery and therapeutic efficacy against brain diseases. Various modulation strategies have been investigated, showing promising directions for future research.
Article
Chemistry, Multidisciplinary
Haiyan Chen, Mengyuan Zhou, Yuteng Zeng, Tongtong Miao, Haoyuan Luo, Yang Tong, Mei Zhao, Rui Mu, Jiang Gu, Shudi Yang, Liang Han
Summary: This study proposes a biomimetic nanoparticle that utilizes the BBB invasion ability of Escherichia coli K1 (EC-K1) outer membrane for brain-targeted drug delivery. The nanoparticles penetrate the BBB through the transcellular vesicle transport pathway, which is mediated by the interactions between outer membrane protein A and gp96 on BBB endothelial cells. This nanoengineering strategy provides the loaded drugs with prolonged circulation, intracranial interstitial distribution, and extremely high biocompatibility. The study also reveals the potential of delivering therapeutics to treat gp96-overexpressing intracranial malignancies.
Article
Chemistry, Multidisciplinary
Mengyuan Zhou, Haiyan Chen, Yuteng Zeng, Ziyan Lv, Xiaoxiao Hu, Yang Tong, Pan Wang, Mei Zhao, Rui Mu, Ju Yu, Yanming Chen, Lin Wei, Jiang Gu, Qing Lan, Xuechu Zhen, Liang Han
Summary: Receptor-mediated vesicular transport is a powerful brain-targeting delivery technology. However, commonly used BBB receptors can cause drug distribution in normal brain tissues. Researchers have found that GRP94 protein is upregulated and relocated in both BBB endothelial cells and brain metastatic breast cancer cells (BMBCCs). Inspired by this, nanocapsules coated with avirulent DH5 alpha outer membrane protein are developed to cross the BBB and target BMBCCs by recognizing GRP94. This platform shows potential in maximizing therapeutic effects on GRP94-positive brain diseases.
Review
Materials Science, Biomaterials
Haiyan Chen, Mengyuan Zhou, Yuteng Zeng, Ziyan Lv, Pan Wang, Liang Han
Summary: In this review, the extraction, characterization, and functionalization of outer membrane vesicles (OMVs) are described, with emphasis on the latest progress and prospects in biomedical applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Correction
Nanoscience & Nanotechnology
Duo Gao, Qiuning Zhu, Jianqing Ruan, Tao Sun, Liang Han
ACS APPLIED BIO MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Duo Gao, Qiuning Zhu, Jianqing Ruan, Tao Sun, Liang Han
ACS APPLIED BIO MATERIALS
(2020)
Article
Materials Science, Biomaterials
Qingbing Wang, Xiaoxia Guo, Yi Chen, Zhiyuan Wu, Yu Zhou, Saima Sadaf, Liang Han, Xiaoyi Ding, Tao Sun
JOURNAL OF MATERIALS CHEMISTRY B
(2020)