Article
Surgery
Yong-Gang He, Xiao-Min Yang, Xue-Hui Peng, Jing Li, Wen Huang, Gui-Cang Jian, Jing Wu, Yi-Chen Tang, Liang Wang, Xiao-Bing Huang
Summary: This study explores the association between a modified Blumgart anastomosis technique and operative time and surgical complications. The results show that the modified technique is associated with shorter operative time and lower incidence of postoperative pancreatic fistula.
FRONTIERS IN SURGERY
(2022)
Article
Surgery
Chuan-zhao Zhang, Zhong-Yan Zhang, Shan-zhou Huang, Bao-hua Hou
Summary: The study demonstrates that the simplified Blumgart method is an effective approach for laparoscopic pancreaticojejunostomy, with shorter operative time and lower rate of postoperative pancreatic fistula. Risk factors for POPF include soft pancreas, pancreatic ductal diameter, and intraoperative blood loss.
Article
Surgery
Wensheg Liu, Shunrong Ji, Wenyan Xu, Yihua Shi, Mengqi Liu, Li Zheng, Qifeng Zhuo, Xiaowu Xu, Xianjun Yu
Summary: This study retrospectively analyzed 100 patients who underwent 3D-LPD with modified Blumgart PJ. The results showed that the operative and PJ durations were relatively short, and the incidence of postoperative complications was low. The modified Blumgart technique in 3D-LPD was considered to be a novel, reliable, safe, and favorable method for pancreaticojejunostomy in pancreaticoduodenectomy.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Surgery
Yoon Hyung Kang, Jae Seung Kang, Mirang Lee, Hye-Sol Jung, Won-Gun Yun, Young Jae Cho, Youngmin Han, Wooil Kwon, Jin-Young Jang
Summary: This study compared the short-term outcomes of out-layer continuous suture anastomosis (OCA) and the modified Blumgart method (mBM) for duct-to-mucosa pancreaticojejunostomy (PJ). The results showed no significant differences in postoperative outcomes between the two methods, but mBM had a shorter operation time for PJ.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2022)
Article
Surgery
Yosuke Inoue, Takafumi Sato, Tomotaka Kato, Atsushi Oba, Yoshihiro Ono, Yoshihiro Mise, Hiromichi Ito, Yu Takahashi
Summary: This study details the technical tips for performing clipless modified Blumgart anastomosis (MBA) in a robotic environment. The results show that the robotic approach has acceptable short-term outcomes, with longer operation time but lower blood loss and shorter hospital stay compared to open surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Yasuyuki Fukami, Takuya Saito, Takaaki Osawa, Shunichiro Komatsu, Tsuyoshi Sano
Summary: This study aimed to investigate the practical significance of Blumgart anastomosis with PGA felt in preventing CR-POPF after PD. The results showed that Blumgart anastomosis with PGA felt significantly reduced the incidence of CR-POPF.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2022)
Article
Oncology
Rongqiang Ye, Wu Zhong, Xian Long, Lei Zhang
Summary: Modified Blumgart pancreaticojejunostomy can reduce pain level, expedite postoperative rehabilitation, improve intestinal mucosal barrier function and quality of life, while not significantly affecting nutritional status and pancreatic function.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Qu Liu, Zhiming Zhao, Yuanxing Gao, Guodong Zhao, Nan Jiang, Wan Yee Lau, Rong Liu
Summary: This study aimed to compare the impact of single-layer continuous suturing (SCS) and modified Blumgart anastomosis (MBA) during robotic pancreaticoduodenectomy (RPD) on the rate of clinically relevant postoperative pancreatic fistula (CR-POPF). The results showed that the CR-POPF rate in the SCS group was not inferior to that in the MBA group, with significantly shorter PJ duration in the SCS group.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Guo-Hua Liu, Xiao-Yu Tan, Jia-Xing Li, Guo-Hui Zhong, Jing-Wei Zhai, Ming-Yi Li
Summary: This study modified the Blumgart pancreaticojejunostomy technique and applied it to LPD surgery. After matching, the LPD group had significantly shorter postoperative hospital stays and no other severe postoperative complications.
Article
Surgery
Yu Zhou, Jiabin Yang, Lusheng Wei, Qing Lin, Shangyou Zheng, Guohua Liu, Quanbo Zhou, Xiaoyu Tan, Rufu Chen
Summary: The study included 149 patients who underwent LPD using the three sutures PJ technique at three hospitals. The results showed that the technique is a safe and reliable method with low risk of pancreatic fistula, short anastomosis time, and steep learning curve.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Article
Surgery
Kaushik Bhattacharya, Neela Bhattacharya, Utpal De
Summary: Leslie Harold Blumgart was a significant figure in the field of Hepatopancreaticobiliary surgery. He classified anatomical variations in the biliary tract and developed a special surgical technique to decrease the occurrence of postoperative pancreatic duct fistula after Whipple's pancreaticoduodenectomy. He also made significant contributions in managing hepatobiliary oncology cases with chemotherapy and radiotherapy, earning him the designation of living legend by the International Hepatopancreaticobiliary Association.
INDIAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Satyaprakash Ray Choudhury, Raja Kalayarasan, Senthil Gnanasekaran, Biju Pottakkat
Summary: During the learning curve of laparoscopic PD, modified binding PG reduces the occurrence of postoperative pancreatic fistula (POPF) but is associated with increased risk of intraluminal postpancreatectomy hemorrhage (PPH) compared to PJ using the modified Blumgart technique.
WORLD JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Surgery
Claudio Ricci, Carlo Ingaldi, Laura Alberici, Nico Pagano, Cristina Mosconi, Giovanni Marasco, Francesco Minni, Riccardo Casadei
Summary: Blumgart anastomosis appears to be superior to non-BA duct to mucosa in avoiding CR-POPF. Additionally, BA is also favored over DtoM in overall morbidity, PPH, and length of stay.
WORLD JOURNAL OF SURGERY
(2021)
Article
Medicine, General & Internal
Guo-Liang Yao, Meng-Jiao An, Yong-Gang Fan
Summary: This study compared customized D-M with invaginated D-M pancreaticojejunostomy procedures for pancreaticoduodenectomy. The results showed a significant reduction in pancreatic leakage with invaginated D-M, while no significant differences were observed in other complications.
Article
Gastroenterology & Hepatology
Riccardo Casadei, Claudio Ricci, Carlo Ingaldi, Laura Alberici, Emilio De Raffele, Francesco Minni
Summary: The Blumgart anastomosis has been shown to significantly reduce severe complications following pancreaticoduodenectomy, according to a retrospective study involving consecutive patients who underwent the procedure for pancreatic head cancer.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Oncology
Hayato Baba, Mitsuro Kanda, Koichi Sawaki, Shunsuke Nakamura, Sei Ueda, Dai Shimizu, Masahiko Koike, Yasuhiro Kodera, Tsutomu Fujii
Summary: The expression of SLC7A9 gene in esophageal squamous cell carcinoma influences cell proliferation, invasion, and migration. High SLC7A9 expression is associated with high levels of squamous cell carcinoma-related antigen and carcinoembryonic antigen, advanced disease stage, and lymph node metastasis. It can serve as a novel biomarker for predicting lymph node metastasis and recurrence in ESCC patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Osamu Maeda, Masahide Fukaya, Masahiko Koike, Kazushi Miyata, Mitsuro Kanda, Kazuki Nishida, Masahiko Ando, Yasuhiro Kodera, Yuichi Ando
Summary: The effectiveness and safety of DCF regimen with prophylactic pegfilgrastim for preoperative treatment of esophageal cancer were evaluated in this study. The histopathological response rate met the primary endpoint, indicating that DCF regimen was effective. However, the prophylactic use of pegfilgrastim was insufficient to prevent febrile neutropenia.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jinsei Miyoshi, Zhongxu Zhu, Aiping Luo, Shusuke Toden, Xuantong Zhou, Daisuke Izumi, Mitsuro Kanda, Tetsuji Takayama, Iqbal M. Parker, Minjie Wang, Feng Gao, Ali H. Zaidi, Hideo Baba, Yasuhiro Kodera, Yongping Cui, Xin Wang, Zhihua Liu, Ajay Goel
Summary: In this study, a circulating microRNA signature for early detection of esophageal squamous cell carcinoma (ESCC) was established and validated in multiple cohorts. The signature showed superior diagnostic performance compared to current clinical serological markers.
Article
Biochemistry & Molecular Biology
Souvick Roy, Mitsuro Kanda, Sachiyo Nomura, Zhongxu Zhu, Yuji Toiyama, Akinobu Taketomi, James Goldenring, Hideo Baba, Yasuhiro Kodera, Ajay Goel
Summary: This study developed a non-invasive liquid biopsy method for early detection of gastric cancer by using circular RNAs (circRNAs) as biomarkers. The researchers identified a panel of 8 circRNAs that could reliably distinguish gastric cancer patients from non-disease controls, even in early-stage patients. The decreased expression of circRNAs in serum samples suggested their tumor specificity.
Article
Surgery
Koki Nakanishi, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Daisuke Kobayashi, Dai Shimizu, Chie Tanaka, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera
Summary: The study evaluated the accuracy of the E-PASS scoring system in predicting short- and long-term outcomes in gastric cancer surgery. Higher E-PASS scores were associated with more postoperative complications and shorter overall survival time in stage II-III gastric cancer patients.
Article
Surgery
Koki Nakanishi, Mitsuro Kanda, Chie Tanaka, Shigeomi Takeda, Katsuhito Tanaka, Dai Shimizu, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Goro Nakayama, Michitaka Fujiwara, Yasuhiro Kodera
Summary: The combined measurement of D-AMYs on postoperative day 0 and postoperative day 1 enhances early prediction of peripancreatic inflammatory fluid collection after gastrectomy.
WORLD JOURNAL OF SURGERY
(2022)
Article
Oncology
Shinichi Yachida, Yasushi Totoki, Michael Noe, Yoichiro Nakatani, Masafumi Horie, Kenta Kawasaki, Hiromi Nakamura, Mihoko Saito-Adachi, Masami Suzuki, Erina Takai, Natsuko Hama, Ryota Higuchi, Seiko Hirono, Satoshi Shiba, Mamoru Kato, Eisaku Furukawa, Yasuhito Arai, Hirofumi Rokutan, Taiki Hashimoto, Shuichi Mitsunaga, Mitsuro Kanda, Hidenori Tanaka, So Takata, Ayaka Shimomura, Minoru Oshima, Wenzel M. Hackeng, Tomoyuki Okumura, Keiichi Okano, Masakazu Yamamoto, Hiroki Yamaue, Chigusa Morizane, Koji Arihiro, Toru Furukawa, Toshiro Sato, Tohru Kiyono, Lodewijk A. A. Brosens, Laura D. Wood, Ralph H. Hruban, Tatsuhiro Shibata
Summary: Gastrointestinal neuroendocrine carcinoma (GIS-NEC) is a rare but highly malignant tumor that is genetically distinct from gastrointestinal neuroendocrine tumors (GIS-NET). There are clear genomic differences between pancreatic NECs (Pant-NEC) and nonpancreatic GIS-NECs (Nonpanc-NEC). Panc-NECs can be classified into two subgroups based on genomic and epigenomic features.
Article
Oncology
Takahiro Shinozuka, Mitsuro Kanda, Dai Shimizu, Chie Tanaka, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Masahiko Koike, Yasuhiro Kodera
Summary: The study found that the preoperative ALBI score can serve as a prognostic marker for disease-specific survival in patients with esophageal squamous cell carcinoma after radical esophagectomy. mALBI Grade 2 was associated with a higher risk of disease-specific death.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Shinichi Umeda, Mitsuro Kanda, Dai Shimizu, Shunsuke Nakamura, Koichi Sawaki, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Chie Tanaka, Goro Nakayama, Yasuhiro Kodera
Summary: This study found that Lysosomal Associated Membrane Protein Family Member 5 (LAMP5) is upregulated in metastatic gastric cancer and knockout of LAMP5 can significantly suppress cancer cell proliferation, invasion, and migration, and increase apoptosis and cell cycle arrest. In addition, high levels of LAMP5 mRNA are significantly associated with worse prognosis.
Article
Surgery
Akira Nonogaki, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera
Summary: This study suggests that the preoperative neutrophil-to-platelet ratio (NPR) can serve as a prognostic factor in gastric cancer patients with positive peritoneal lavage cytology in the absence of other non-curative factors.
Article
Oncology
Keisuke Okuno, Shuichi Watanabe, Souvick Roy, Mitsuro Kanda, Masanori Tokunaga, Yasuhiro Kodera, Yusuke Kinugasa, Ajay Goel
Summary: We established a miRNA-based liquid biopsy signature that can reliably predict early recurrence in gastric cancer patients by analyzing miRNA expression profiling. Additionally, a model combining the miRNA signature, microsatellite instability (MSI) status, and tumor size exhibited better predictive performance and was successfully validated in another independent cohort. Finally, we translated the miRNA signature into a liquid biopsy assay and demonstrated its independence as a predictor for early recurrence.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Yuki Ito, Takashi Miwa, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera
Summary: This study aimed to build a risk score for predicting deaths from other causes after gastrectomy in gastric cancer patients. Nine characteristics were identified as risk factors for poor survival, and patients were classified into Low-, Intermediate-, and High-risk groups based on their risk scores. The 5-year survival rates were significantly different among the three risk groups, highlighting the usefulness of this risk score for predicting deaths from other causes after curative gastrectomy.
Article
Oncology
Mitsuro Kanda, Masanori Terashima, Takahiro Kinoshita, Hiroshi Yabusaki, Masanori Tokunaga, Yasuhiro Kodera
Summary: This study investigated the feasibility of using endoscopic biopsy samples for next-generation sequencing (NGS) and compared the results with those obtained from surgical samples. The results showed that NGS is applicable to analyzing biopsy samples of gastric cancer (GC) acquired through endoscopic biopsy and the data obtained were highly consistent with those from surgical samples.
Article
Oncology
Takahiro Shinozuka, Mitsuro Kanda, Yusuke Sato, Dai Shimizu, Chie Tanaka, Shinichi Umeda, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Goro Nakayama, Yasuhiro Kodera
Summary: The study reveals that high levels of STX3 mRNA and protein expression are significantly associated with lymph node involvement, pathological stage, and poor overall survival in patients with esophageal squamous cell carcinoma (ESCC), suggesting their potential use as prognostic biomarkers.
Article
Surgery
Koki Nakanishi, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Dai Shimizu, Chie Tanaka, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera
Summary: The study showed that patients with microscopic positive margins after curative gastrectomy for gastric cancer had worse survival outcomes compared to those with negative margins, with a higher overall recurrence rate.