期刊
JOURNAL OF GASTROINTESTINAL SURGERY
卷 17, 期 9, 页码 1618-1626出版社
SPRINGER
DOI: 10.1007/s11605-013-2242-1
关键词
Intraductal papillary mucinous neoplasm; IPMN; Pancreatectomy; Survival; Recurrence; Clinical outcomes; Surveillance
资金
- I.W. Foundation
We examined long-term outcomes in patients with surgically treated intraductal papillary mucinous neoplasm (IPMN) to determine if any clinical or histologic features could predict risk of recurrent disease. We reviewed 183 margin-negative surgical resections performed for IPMN between 1994 and 2011 with documented postoperative abdominal imaging. We calculated time to recurrent disease as indicated by radiographic change and created a multivariable Cox proportional hazards model to assess the relationship between patient characteristics and histopathologic tumor features and disease recurrence. Among patients with margin-negative resections and adequate imaging follow-up, we observed a recurrence rate of 13 % over a median follow-up of 32.0 months. Individuals with invasive tumors on original pathology were more likely to recur (HR 5.2, 95 % CI 2.2-12.2); however, original pathology did not predict disease severity on recurrence. Controlling for invasive pathology, no other histologic feature of the original tumor, including dysplasia at the surgical margin, predicted recurrence. Among non-invasive IPMN, pancreatitis was associated with disease recurrence (HR 3.6, 95 % CI 1.2-10.7). The frequency of recurrent disease in this population and the inability to predict recurrence argues for universal and continuous surveillance after resection for IPMN. The relationship between pancreatitis and disease recurrence should be investigated further.
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