Article
Gastroenterology & Hepatology
Charlotte M. Heidsma, Diamantis Tsilimigras, Susan van Dieren, Flavio Rocha, Daniel E. Abbott, Ryan Fields, Paula M. Smith, George A. Poultsides, Cliff Cho, Mary Dillhoff, Alexandra G. Lopez-Aguiar, Zaheer Kanji, Alexander Fisher, Bradley A. Krasnick, Kamran Idrees, Eleftherios Makris, Megan Beems, Casper H. J. van Eijck, Elisabeth J. M. Nieveen van Dijkum, Shishir K. Maithel, Timothy M. Pawlik
Summary: This study found that long-term outcomes were comparable between patients who underwent EN and PD/DP for pNET. However, the incidence of clinically significant POPF was higher after EN.
Article
Medicine, General & Internal
Anna Caterina Milanetto, Anna-Lea Gais Zurcher, Alina David, Matteo Fassan, Claudio Pasquali
Summary: This retrospective study evaluated the possible prognostic role of clinic-pathological features and surgery in pancreatic neuroendocrine neoplasms (pNENs). The results showed that about 20% of pNENs had a size > 4 cm, 78% were nonfunctioning, and 55% had distant metastases at diagnosis. However, long-term survival of more than five years can be achieved after surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Senthil P. Kumar, Sakthivel Harikrishnan, Jeswanth Satyanesan
Summary: Central pancreatectomy is a safe and effective alternative for benign and low-grade lesions in the neck and body of the pancreas, preserving pancreatic function and reducing the risk of postoperative endocrine and exocrine insufficiency.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Gastroenterology & Hepatology
Rosa Klotz, Constanze Schilling, Charlotte Kuner, Ulf Hinz, Ulla Klaiber, Magdalena Holze, Christine Tjaden, Martin Loos, Markus W. Buechler, Thilo Hackert
Summary: This study compared the short- and long-term outcomes of central pancreatectomy (CP) versus distal pancreatectomy (DP) in the treatment of benign or low-grade malignant lesions located in the neck and body of the pancreas. The results showed that CP was associated with a higher risk of postpancreatectomy hemorrhage (PPH), but had better endocrine long-term outcomes and comparable perioperative mortality compared to DP.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Review
Oncology
Richard Zheng, Elie Ghabi, Jin He
Summary: Non-anatomic pancreatic resections can preserve more pancreatic parenchyma and reduce endocrine and exocrine insufficiency. Robotic parenchymal-sparing pancreatectomy has been increasingly used for technically challenging procedures. A systematic review found that postoperative pancreatic fistula is common but severe complications are rare, and the rates of endocrine and exocrine insufficiency are negligible.
Review
Oncology
Agata Mormul, Emilia Wloszek, Julia Nowoszewska, Marta Fudalej, Michal Budzik, Anna Badowska-Kozakiewicz, Andrzej Deptala
Summary: Pancreatic ductal adenocarcinoma is the most common pancreatic tumor, accounting for 85% of cases. The remaining 15% consists of various rare neoplasms. This study gathered the latest data on the epidemiology, diagnosis, biomarkers, and management of six rare pancreatic tumors to provide important insights for their proper classification and treatment.
Article
Surgery
Mohamad Mahseeri, Ahmad Alqaiseieh, Du'a Alkhader, Hala Halbony, Mutaz Albreazat, Saleh Abualhaj
Summary: Solid pseudopapillary neoplasm (SPN) is a rare pancreatic disorder that mainly affects young women with uncertain clinical manifestations. While most patients have a good prognosis after radical surgery, local recurrence or metastasis can still occur. Surgical options should consider tumor location, size, life expectancy, and potential complications.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2021)
Article
Gastroenterology & Hepatology
Fei Yu, Jingjing Fu, Chuan Zhang, Wenyu Wu, Shuyue Ai, Xiaochen Yao, Qingle Meng, Yue Huang, Guangming Lu, Feng Wang, Wei Qu
Summary: In this study, serum chromogranin A (CgA) levels were found to be associated with disease status and treatment response in patients with pancreatic neuroendocrine neoplasms (pNENs), providing a useful biomarker for monitoring and clinical management. The optimal cutoff values for CgA in diagnosing active and metastatic pNENs after treatment were identified, and optimal changes in CgA levels for predicting disease remission and progression were also determined based on patients with serial measurements.
Review
Endocrinology & Metabolism
Yi Wu, Guangbing Xiong, Hang Zhang, Min Wang, Feng Zhu, Renyi Qin
Summary: This study analyzed the clinical features, diagnosis, therapy, and prognosis of ACTHoma. It was found that ACTHoma is more common in women, tumors are generally large, and common clinical manifestations include hypokalemia, diabetes, and weakness. These tumors are commonly found in the tail of the pancreas, with the liver being the most frequent site of metastasis.
ENDOCRINE PRACTICE
(2021)
Article
Gastroenterology & Hepatology
Jennie J. Cao, Luyao Shen, Brendan C. Visser, Luke Yoon, Aya Kamaya, Justin R. Tse
Summary: The aims of this study were to describe the growth kinetics of pathologically proven, treatment-naive pancreatic neuroendocrine neoplasms (panNENs) at imaging surveillance and to determine their association with histopathologic grade and Ki-67. The results showed that low-grade panNENs grow slowly, while high-grade ones grow rapidly.
Article
Genetics & Heredity
Tincy Simon, Pamela Riemer, Armin Jarosch, Katharina Detjen, Annunziata Di Domenico, Felix Bormann, Andrea Menne, Slim Khouja, Nanna Monje, Liam H. Childs, Dido Lenze, Ulf Leser, Florian Rossner, Markus Morkel, Nils Bluethgen, Marianne Pavel, David Horst, David Capper, Ilaria Marinoni, Aurel Perren, Soulafa Mamlouk, Christine Sers
Summary: Pancreatic neuroendocrine neoplasms (PanNENs) can be classified into two subclasses: well-differentiated PanNETs and poorly-differentiated high-grade PanNECs. Recent studies have shown that high-grade PanNECs originate from exocrine cells, distinguishing them in cell lineage from other endocrine-origin PanNETs. This study provides a method to clearly distinguish PanNECs from G3 PanNETs, improving patient stratification.
Article
Radiology, Nuclear Medicine & Medical Imaging
Cong Liu, Yun Bian, Yinghao Meng, Fang Liu, Kai Cao, Hao Zhang, Xu Fang, Jing Li, Jieyu Yu, Xiaochen Feng, Chao Ma, Jianping Lu, Jun Xu, Chengwei Shao
Summary: The study developed and validated a multimodality radiomics model for predicting the grade of nonfunctional pancreatic neuroendocrine tumors before surgery. The model combined radiomic features from multidetector computed tomography and MRI to effectively differentiate different tumor grades.
ACADEMIC RADIOLOGY
(2022)
Article
Cell Biology
Rosa Lynn Schmitz, Julia Weissbach, Jan Kleilein, Jessica Bell, Stefan Huettelmaier, Fabrice Viol, Till Clauditz, Patricia Grabowski, Helmut Laumen, Jonas Rosendahl, Patrick Michl, Joerg Schrader, Sebastian Krug
Summary: Pancreatic neuroendocrine tumors (PanNET) are rare and heterogeneous compared to pancreatic adenocarcinoma (PDAC). Various therapeutic approaches, including surgical resection, targeted therapy, and biotherapy, are applicable, but resistance to current therapies remains challenging. Recent research suggests targeting epigenetic modulators in neuroendocrine cells as a new therapeutic avenue, with studies showing potential functional effects and pathways affected.
Article
Oncology
Hyun Jeong Jeon, Hye Jeong Jeong, Soo Yeun Lim, So Jeong Yoon, Hongbeom Kim, In Woong Han, Jin Seok Heo, Sang Hyun Shin
Summary: This study aimed to investigate the clinical course of patients with advanced pancreatic cancer who underwent resection following FOLIFIRNOX treatment. The results showed that patients with complete pathologic response (cPR) and nearly complete pathologic response (ncPR) had longer overall survival and disease-free survival. Additionally, adjuvant chemotherapy following neoadjuvant treatment might be beneficial for patient outcomes.
Article
Gastroenterology & Hepatology
Artem Boyev, Laura R. Prakash, Yi-Ju Chiang, Christopher P. Childers, Anish J. Jain, Timothy E. Newhook, Morgan L. Bruno, Elsa M. Arvide, Whitney L. Dewhurst, Michael P. Kim, Naruhiko Ikoma, Jeffrey E. Lee, Rebecca A. Snyder, Matthew H. G. Katz, Ching-Wei D. Tzeng, Jessica E. Maxwell
Summary: This study found an association between postoperative opioid use and the occurrence of clinically relevant postoperative pancreatic fistula (CR-POPF) after distal pancreatectomy. Decreasing perioperative opioid use through enhanced postoperative management may be an effective approach to reduce the rates of CR-POPF.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Letter
Surgery
Sebastien Gaujoux, Vinciane Rebours, Alain Sauvanet
Article
Gastroenterology & Hepatology
Charles Vanbrugghe, Maxime Ronot, Francois Cauchy, Christian Hobeika, Safi Dokmak, Beatrice Aussilhou, Emilia Ragot, Sebastien Gaujoux, Olivier Soubrane, Philippe Levy, Alain Sauvanet
JOURNAL OF GASTROINTESTINAL SURGERY
(2019)
Article
Oncology
Maxime Collard, Tiziana Marchese, Nathalie Guedj, Francois Cauchy, Caroline Chassaing, Maxime Ronot, Safi Dokmak, Olivier Soubrane, Alain Sauvanet
ANNALS OF SURGICAL ONCOLOGY
(2019)
Article
Oncology
Sjors Klompmaker, Niek A. Peters, Jony Van Hilst, Claudio Bassi, Ugo Boggi, Olivier R. Busch, Willem Niesen, Thomas M. Van Gulik, Ammar A. Javed, Jorg Kleeff, Manabu Kawai, Mickael Lesurtel, Carlo Lombardo, A. James Moser, Ken-ichi Okada, Irinel Popescu, Raj Prasad, Roberto Salvia, Alain Sauvanet, Christian Sturesson, Matthew J. Weiss, Herbert J. Zeh, Amer H. Zureikat, Hiroki Yamaue, Christopher L. Wolfgang, Melissa E. Hogg, Marc G. Besselink, Sarah L. Gerritsen, Mustapha Adham, M. Teresa Albiol, Frederik Berrevoet, Manuela Cesaretti, Raffaele Dalla Valle, Benjamin Darnis, Markus K. Diener, Marco Del Chiaro, Thilo H. Hackert, Robert Gruetzmann, Traian Dumitrascu, Helmut Friess, Seiko Hirono, Arpad Ivanecz, Anastasios Karayiannakis, Giuseppe K. Fusai, Knut J. Labori, Santiago Lopez-Ben, Jean-Yves Mabrut, Motoki Miyazawa, Fernando Pardo, Julie Perinel, Geert Roeyen
ANNALS OF SURGICAL ONCOLOGY
(2019)
Article
Oncology
Daniel Pietrasz, Olivier Turrini, Veronique Vendrely, Jean-Marc Simon, Olivia Hentic, Romain Coriat, Fabienne Portales, Bertrand Le Roy, Julien Taieb, Nicolas Regenet, Diane Goere, Pascal Artru, Jean-Christophe Vaillant, Florence Huguet, Christophe Laurent, Alain Sauvanet, Jean-Robert Delpero, Jean Baptiste Bachet, Antonio Sa Cunha
ANNALS OF SURGICAL ONCOLOGY
(2019)
Article
Gastroenterology & Hepatology
Julie Navez, Catherine Hubert, Safi Dokmak, Isadora Frick De La Maza, Nicolas Tabchouri, Olivier Benoit, Helene Hermand, Francis Zech, Jean-Francois Gigot, Alain Sauvanet
JOURNAL OF GASTROINTESTINAL SURGERY
(2020)
Article
Surgery
Maxime Palazzo, Alain Sauvanet, Rodica Gincul, Ivan Borbath, Goeffroy Vanbiervliet, Raphael Bourdariat, Anne-Isabelle Lemaistre, Bertrand Pujol, Fabrice Caillol, Laurent Palazzo, Alain Aubert, Frederique Maire, Louis Buscail, Marc Giovannini, Sebastien Marque, Bertrand Napoleon
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2020)
Correction
Gastroenterology & Hepatology
J. E. Dominguez-Munoz, A. M. Drewes, B. Lindkvist, N. Ewald, L. Czako, J. Rosendahl, J. M. Lohr
Article
Surgery
N. Regenet, A. Sauvanet, F. Muscari, B. Meunier, C. Mariette, M. Adham, V Moutardier, J-R Delpero, J-M Regimbeau, P. Pessaux, F. Paye, A. Sa Cunha, C. Ansquer
JOURNAL OF VISCERAL SURGERY
(2020)
Review
Oncology
Jean Robert Delpero, Alain Sauvanet
FRONTIERS IN ONCOLOGY
(2020)
Article
Gastroenterology & Hepatology
Nicolas Tabchouri, Morgane Bouquot, Helene Hermand, Olivier Benoit, Jean-Christophe Loiseau, Safi Dokmak, Beatrice Aussilhou, Sebastien Gaujoux, Olivier Turrini, Jean Robert Delpero, Alain Sauvanet
Summary: This study developed a predictive risk score for POPF following PD, which could more specifically identify low-risk patients compared to existing scores. Preoperative radiation therapy was identified as an independent protective factor.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Endocrinology & Metabolism
Marie-Louise F. Van Velthuysen, Anne Couvelard, Guido Rindi, Nicola Fazio, Dieter Hoersch, Els J. Nieveen van Dijkum, Gunter Kloeppel, Aurel Perren
Summary: In recent years, there have been changes in the WHO classification of neuroendocrine neoplasms (NEN), leading to the establishment of a working group by ENETS to develop standardized reporting templates. These templates allow for recording of essential information and help distinguish between different types of neuroendocrine tumors.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Review
Oncology
Maxime Barat, Anne-Segolene Cottereau, Sebastien Gaujoux, Florence Tenenbaum, Mathilde Sibony, Jerome Bertherat, Rossella Libe, Martin Gaillard, Anne Jouinot, Guillaume Assie, Christine Hoeffel, Philippe Soyer, Anthony Dohan
Summary: A rigorous approach is required for non-invasive characterization of adrenal lesions. While CT is the main method for adrenal lesion characterization, a multimodality multiparametric imaging method can improve confidence in diagnosis. The role of imaging is usually clear for adrenal lesions associated with hormonal secretion, but it may be challenging to characterize non-functioning adrenal lesions. Atypical lesions may be difficult to diagnose even with typical imaging features.
Review
Pathology
Anne Couvelard, Jerome Cros
Summary: This review examines the classification and recent advancements in molecular understanding of digestive neuroendocrine neoplasms (NENs), and discusses important issues in diagnosis and the use of biomarkers.
Meeting Abstract
Endocrinology & Metabolism
L. Maggino, A. Schmidt, A. Kaeding, S. Westermark, M. Sund, S. Gaujoux
NEUROENDOCRINOLOGY
(2019)