Article
Oncology
Fan Yu, Yaozhong Zhang, Haidi Xu, Kuankuan Li, Jingge Gheng, Chenxi Lin, Lei Li, Na Wang, Lei Wang
Summary: This study evaluated and compared the therapeutic effects of Sweet esophagectomy and McKeown Minimally Invasive esophagectomy (McKeown MIE) for middle and lower third esophageal cancer patients receiving neoadjuvant chemotherapy combined with immunotherapy (NACI). The results showed that both Sweet esophagectomy and McKeown MIE were safe and effective for resectable esophageal squamous cell carcinoma (ESCC) patients after NACI therapy, with low operative mortality and morbidity rate. Sweet esophagectomy had a lower incidence of severe complications and shorter hospital stay for patients over 70 years old compared to McKeown MIE.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Fangfang Liu, Wenlei Yang, Wei Yang, Ruiping Xu, Lei Chen, Yu He, Zhen Liu, Fuyou Zhou, Bolin Hou, Liqun Zhang, Lixin Zhang, Fan Zhang, Fen Cai, Huawen Xu, Miaoping Lin, Mengfei Liu, Yaqi Pan, Ying Liu, Zhe Hu, Huanyu Chen, Zhonghu He, Yang Ke
Summary: The objective of this study was to evaluate the short-term and long-term outcomes of minimally invasive esophagectomy (MIE) compared with open esophagectomy (OE) in localized esophageal squamous cell carcinoma patients. The study found that MIE had a slightly higher 5-year overall survival rate compared to OE. Although MIE had longer surgery duration and higher treatment cost, it resulted in more lymph nodes harvested, lower intraoperative blood transfusion rate, and fewer postoperative complications. In conclusion, MIE can be considered as a safe and effective surgical approach for localized esophageal squamous cell carcinoma patients.
Article
Oncology
Qiuming Chen, Shaocong Mo, Rusidanmu Aizemaiti, Jun Cheng, Ziheng Wu, Peng Ye
Summary: This study compared short and mid-term outcomes in esophageal squamous cell carcinoma patients undergoing open or minimally invasive McKeown esophagectomy after neoadjuvant PD-1 inhibitor plus chemotherapy. The results showed that the minimally invasive approach had shorter operative times, but there was no significant difference in overall survival between the two surgical approaches.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Wei-an Song, Bo-shi Fan, Shou-yin Di, Jun-qiang Liu, Jia-hua Zhao, Si-yu Chen, Cai-ying Yue, Shao-hua Zhou, Tai-qian Gong
Summary: This study compared the efficacy of three-field lymphadenectomy (3-FL) with standard two-field lymphadenectomy (2-FL) in minimally invasive esophagectomy (MIE) for esophageal cancer. The results showed that 3-FL allowed for more lymph nodes harvest and accurate staging without increased surgical risks, despite longer operation time compared to 2-FL.
ANNALS OF THORACIC SURGERY
(2021)
Article
Immunology
Jiahan Cheng, Minzhang Guo, Yushang Yang, Yilin Liu, Weipeng Hu, Qixin Shang, Chuan Li, Liang Xia, Yun Wang, Wenping Wang, Dong Tian, Yong Yuan, Yang Hu, Longqi Chen
Summary: Neoadjuvant combination of chemotherapy and immunotherapy (NCI) may lead to better treatment outcomes and reduced complications for patients with locally advanced esophageal squamous cell carcinoma (ESCC).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jifeng Feng, Liang Wang, Xun Yang, Qixun Chen, Xiangdong Cheng
Summary: This study successfully predicted the therapeutic response and prognostic prediction in patients with esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant immunochemotherapy (NICT) by establishing a predictive score based on various peripheral hematological immune-nutritional indicators (BMI-LMR score, BLS).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Dongni Chen, Weidong Wang, Junxian Mo, Qiannan Ren, Huikai Miao, Youfang Chen, Zhesheng Wen
Summary: This study compared minimally invasive and open surgery approaches in treating ESCC patients who underwent neoadjuvant therapy. Results showed that MIE had shorter operative time, less intraoperative bleeding, and lower anastomotic leakage rate compared to open surgery. Overall survival and disease-free survival did not differ between the two approaches for patients receiving neoadjuvant chemotherapy, but for patients receiving neoadjuvant chemoradiotherapy, MIE showed significantly better overall survival rates.
Review
Oncology
Francisca dos S. Coelho, Diana E. Barros, Filipa A. Santos, Flavia C. Meireles, Francisca C. Maia, Rita A. Trovisco, Teresa M. Machado, Jose A. Barbosa
Summary: The paradigm of esophageal cancer treatment has shifted towards minimally invasive esophagectomy (MIE) over open esophagectomy (OE), with MIE showing trends towards decreased 30-day and 90-day postoperative mortality and fewer major cardiovascular and respiratory complications. Minor postoperative complications may also be reduced with MIE.
Article
Oncology
Zhenhua Li, Jingge Cheng, Yuefeng Zhang, Shiwang Wen, Huilai Lv, Yanzhao Xu, Yonggang Zhu, Zhen Zhang, Donghui Mu, Ziqiang Tian
Summary: The study demonstrates that minimally invasive esophagectomy offers a better short-term quality of life for patients with resectable esophageal cancer compared to open esophagectomy. The MIE group showed higher one-year survival rate, less intraoperative bleeding and lower incidence of postoperative pneumonia than the OE group. Additionally, the MIE group had significantly better Karnofshy performance scale (KPS), QLQC-30 score and OES-18 score at various time points after surgery compared to the OE group. Overall, the short-term quality of life was better in the MIE group.
Article
Surgery
Eivind Gottlieb-Vedi, Joonas H. H. Kauppila, Fredrik Mattsson, Mats Lindblad, Magnus Nilsson, Pernilla Lagergren, Ioannis Rouvelas, Jesper Lagergren, FINEGO Grp
Summary: This study suggests that minimally invasive esophagectomy (MIE) is associated with higher 5-year survival compared to open esophagectomy (OE) in patients with esophageal cancer, especially total MIE.
Article
Oncology
E. Tagkalos, P. C. van der Sluis, F. Berlth, A. Poplawski, E. Hadzijusufovic, H. Lang, M. I. van Berge Henegouwen, S. S. Gisbertz, B. P. Mueller-Stich, J. P. Ruurda, M. Schiesser, P. M. Schneider, R. van Hillegersberg, P. P. Grimminger
Summary: This study is a randomized controlled trial comparing RAMIE and MIE as surgical treatments for resectable esophageal adenocarcinoma or adenocarcinoma of the gastroesophageal junction in the Western World. The primary outcome is the total number of resected lymph nodes in the abdomen and mediastinum per lymph node station.
Article
Surgery
Ji-hong Lin, Shao-jun Xu, Chao Chen, Cheng-xiong You, Rui-qin Chen, Zhi-fan Zhang, Ming-qiang Kang, Shu-chen Chen
Summary: The study compared the failure patterns of minimally invasive total mesoesophageal excision (MITME) and minimally invasive esophagectomy (MIE) in locally advanced esophageal squamous cell carcinoma (ESCC) patients. MITME showed significant improvement in the postoperative failure pattern, with a lower 5-year cumulative failure rate compared to MIE. MIE was identified as an independent poor prognostic factor for a high cumulative failure rate at 5 years after surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Medicine, General & Internal
Halit Topal, Raymond Aerts, Annouschka Laenen, Andre Collignon, Joris Jaekers, Joachim Geers, Baki Topal
Summary: A comparative study of 396 patients with pancreatic adenocarcinoma found that minimally invasive pancreatic surgery (MIPS) was associated with better long-term overall survival (OS) and disease-free survival (DFS) compared to open pancreatic surgery (OPS).
Article
Oncology
Yu Kitamura, Taro Oshikiri, Gosuke Takiguchi, Naoki Urakawa, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Yasuhiro Fujino, Masahiro Tominaga, Tetsu Nakamura, Satoshi Suzuki, Yoshihiro Kakeji
Summary: The study shows that lymph node ratio (LNR) is an independent prognostic factor for patients with esophageal squamous cell cancer (ESCC) after minimally invasive esophagectomy (MIE). Particularly for patients with pN1 status, LNR is more useful than the number of metastatic lymph nodes for predicting survival outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
H. Tang, H. Wang, Y. Fang, J. Y. Zhu, J. Yin, Y. X. Shen, Z. C. Zeng, D. X. Xiang, Y. Y. Hou, M. Du, C. H. Lian, Q. Zhao, H. J. Jiang, L. Gong, Z. G. Li, J. Liu, D. Y. Xie, W. F. Li, C. Chen, B. Zheng, K. N. Chen, L. Dai, Y. D. Liao, K. Li, H. C. Li, N. Q. Zhao, L. J. Tan
Summary: This study aimed to evaluate the safety and efficacy of neoadjuvant chemoradiotherapy (nCRT) versus neoadjuvant chemotherapy (nCT) followed by minimally invasive esophagectomy (MIE) for locally advanced esophageal squamous cell carcinoma (ESCC). The results showed that nCRT did not significantly improve overall survival compared to nCT.
ANNALS OF ONCOLOGY
(2023)
Review
Gastroenterology & Hepatology
Hydar El Jamaly, Guy D. Eslick, Martin Weltman
Summary: This meta-analysis provides evidence showing a significant association between NAFLD and maternal diabetic and hypertensive complications, as well as multiple adverse fetal outcomes.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Ayesha Shah, Thomas Fairlie, Georgia Brown, Michael P. Jones, Guy D. Eslick, Kerith Duncanson, Nikhil Thapar, Simon Keely, Natasha Koloski, Mohit Shahi, Marjorie M. Walker, Nicholas J. Talley, Gerald Holtmann
Summary: This study investigated the association between duodenal eosinophils and mast cells in patients with functional dyspepsia (FD). The results showed that both duodenal eosinophils and mast cells were increased in FD patients compared with controls. However, the quality of evidence was very low due to substantial heterogeneity and publication bias, and the causality remains uncertain, requiring further studies.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Pediatrics
Marie Deverell, Amy Phu, Elizabeth J. Elliott, Suzy M. Teutsch, Guy D. Eslick, Clare Stuart, Sean Murray, Rebecca Davis, Troy Dalkeith, John Christodoulou, Yvonne A. Zurynski
Summary: The study aimed to describe health-related out-of-pocket expenses incurred by Australian families with children with chronic and complex diseases. Families reported high out-of-pocket costs, which impacted the family's financial situation and led to many mothers reducing or stopping work to care for their children. Prospective tracking revealed that out-of-pocket spending was associated with various healthcare costs and prescription medications.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2022)
Review
Gastroenterology & Hepatology
Hydar El Jamaly, Guy D Eslick, Martin Weltman
Summary: This meta-analysis provides pooled evidence that a PBC pregnancy is associated with fetal morbidity and maternal lifestyle associations that may influence pregnancy outcomes. More studies are needed to establish disease associations that may directly affect pregnancy outcomes. These data are essential for clinicians managing these patients before, during or after pregnancy.
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2022)
Review
Gastroenterology & Hepatology
Kening Fan, Guy D. Eslick, Prema M. Nair, Grace L. Burns, Marjorie M. Walker, Emily C. Hoedt, Simon Keely, Nicholas J. Talley
Summary: A systematic review and meta-analysis found that human colonic spirochetosis (CS) is significantly associated with diarrhea and irritable bowel syndrome (IBS), but not colonic polyps. CS may be underestimated and could be an overlooked risk factor for a subset of IBS patients with diarrhea.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Editorial Material
Pediatrics
Guy D. Eslick, Carlos Nunez, Elizabeth J. Elliott
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2022)
Review
Oncology
Gauri Mishra, Ammar Majeed, Anouk Dev, Guy D. Eslick, David J. Pinato, Hirofumi Izumoto, Atsushi Hiraoka, Teh-Ia Huo, Po-Hong Liu, Philip J. Johnson, Stuart K. Roberts
Summary: This study investigated the clinical utility of the emerging prognostic model, Albumin-Bilirubin (ALBI) grade, in patients with hepatocellular cancer (HCC) undergoing transarterial chemoembolization (TACE). The results showed that higher pre-treatment ALBI grade was associated with poorer prognosis in these patients.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Letter
Emergency Medicine
Guy D. Eslick, Carlos Nunez, Elizabeth J. Elliott
ACADEMIC EMERGENCY MEDICINE
(2023)
Article
Psychology, Clinical
Stephanie Baggio, Vladan Starcevic, Joel Billieux, Daniel L. King, Sally M. Gainsbury, Guy D. Eslick, David Berle
Summary: The present study tested the spectrum hypothesis of problematic online behaviors (POBs) using a network analysis approach. The findings suggest that different types of POBs are closely related, but with little overlap within each POB.
ADDICTIVE BEHAVIORS
(2022)
Review
Public, Environmental & Occupational Health
Carlos Nunez, Guy D. Eslick, Elizabeth J. Elliott
Summary: This study analyzed the injuries caused by toppling televisions in children and found that children under 6 years old are more likely to sustain head and neck injuries, require hospital treatment, and even die or be admitted to the intensive care unit. Strategies for injury prevention should include community education, promotion and use of tip restraint devices, mandatory safety standards, and manufacturers' commitment to improving TV stability.
Editorial Material
Medicine, General & Internal
Guy D. Eslick, Eloise G. Eslick
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Letter
Gastroenterology & Hepatology
Harry Crane, Guy D. D. Eslick, Jacob George
Summary: This article is connected to Fu et al's paper. Visit the paper to read this article.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pathology
Guy D. Eslick, Kening Fan, Prema M. Nair, Grace L. Burns, Emily C. Hoedt, Simon Keely, Nicholas J. Talley
Summary: This study aims to determine the distinguishing pathological and clinical factors of different Brachyspira species, which can be useful to clinicians and pathologists. Through a pooled analysis comparing each species, differences in the pathologic and clinical profiles of each Brachyspira species were identified. Patients infected with Brachyspira pilosicoli were more likely to have diarrhea, fever, HIV, and immunocompromised conditions. Patients infected with Brachyspira aalborgi were more likely to have lamina propria inflammation.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Gastroenterology & Hepatology
Raquel Cameron, Marjorie M. Walker, Michael Jones, Guy D. Eslick, Simon Keely, Peter Pockney, Carolina C. Cosentino, Nicholas J. Talley
Summary: This study examined the changes of eosinophils and other immune cells in the mucosa of colonic diverticula through quantitative histology. The results showed a significant increase in eosinophil counts at the base and neck of the diverticula. These findings provide new clues for understanding the role of eosinophils and chronic inflammation in the pathophysiology of colonic diverticulosis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Ayesha Shah, Parag Thite, Teressa J. Hansen, Thomas Fairlie, Michael P. Jones, Natasha A. Koloski, Mark Morrison, Gerald J. Holtmann