Article
Cell Biology
Fan Deng, Jing-Juan Hu, Ze-Bin Lin, Qi-Shun Sun, Yue Min, Bing-Cheng Zhao, Zhi-Bin Huang, Wen-Juan Zhang, Wen-Kao Huang, Wei-Feng Liu, Cai Li, Ke-Xuan Liu
Summary: This study found significant differences in susceptibility to enterogenic sepsis induced by intestinal ischemia/reperfusion (I/R) in mice, while the underlying mechanisms remain unclear. Further investigations revealed that enterogenic-sepsis-tolerant mice had significantly higher levels of milnacipran (MC) in their intestines. Additionally, the pre-operative fecal MC content in cardiopulmonary bypass patients, including those with intestinal I/R injury, was found to be associated with susceptibility to post-operative gastrointestinal injury. Moreover, MC was shown to attenuate I/R injury in wild-type mice but not in intestinal epithelial aryl hydrocarbon receptor (AHR) gene conditional knockout mice or IL-22 gene deletion mice. Overall, these findings suggest that gut microbiota influences susceptibility to I/R-induced enterogenic sepsis and gut microbiota-derived MC plays a crucial role in tolerance to intestinal I/R in an AHR/ILC3/IL-22 signaling-dependent manner, providing insights into the pathological mechanism, potential prevention and treatment drugs, and treatment strategies for intestinal I/R.
CELL REPORTS MEDICINE
(2023)
Article
Immunology
Jiro Kusakabe, Koichiro Hata, Tetsuya Tajima, Hidetaka Miyauchi, Xiangdong Zhao, Shoichi Kageyama, Tatsuaki Tsuruyama, Etsuro Hatano
Summary: This study found that Properdin inhibition significantly improves hepatic ischemia/reperfusion injury by reducing serum transaminases and histopathological damages, decreasing platelet aggregation and apoptosis, maintaining macrophage population, suppressing HMGB-1 release and infiltration of macrophages and neutrophils, without affecting liver regeneration.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Kuei-Yi Hung, Shu-Yu Wu, Hsin-Ping Pao, Wen- Liao, Shi-Jye Chu
Summary: Recent data suggests that acetate, a type of short-chain fatty acid, shows protective effects against acute lung injury induced by ischemia-reperfusion. Acetate works by inhibiting inflammation and reducing cellular damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tianfei Lu, Qing Li, Weiwei Lin, Xianzhe Zhao, Fu Li, Jianmei Ji, Yu Zhang, Ning Xu
Summary: This study reveals that gut microbiota and its metabolites play critical roles in liver ischemia/reperfusion (I/R) injury by modulating macrophage metabolic reprogramming. The depletion of gut microbiota can alleviate the severity of I/R-induced hepatic injury. The gut microbiota-derived metabolite a-ketoglutarate (aKG) promotes M2 macrophage activation through oxidative phosphorylation, which is associated with the protective effect in liver I/R injury.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Marc Mico-Carnero, Carlos Rojano-Alfonso, Ana Isabel alvarez-Mercado, Jordi Gracia-Sancho, Arani Casillas-Ramirez, Carmen Peralta
Summary: Microbiota in the gut plays a crucial role in the development of liver diseases and post-operative outcomes. Imbalance in the microbiota can lead to liver diseases. Changes in the microbiota after surgery have significant effects on post-operative outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Zenan Chang, Yinan Zhang, Ming Lin, Shihong Wen, Hanjin Lai, Yaqing Zhan, Xiufen Zhu, Zhikun Huang, Xuyu Zhang, Zimeng Liu
Summary: This study investigates the role of terlipressin in reducing gut-vascular barrier and organ damage in gut-derived sepsis. The results demonstrate that terlipressin improves gut-vascular barrier damage and reduces bacterial translocation by activating the PI3K signaling pathway. This leads to a decrease in distant organ injuries.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Surgery
Petros Ypsilantis, Maria Lambropoulou, Konstantinos Anagnostopoulos, Konstantinos Kiroplastis, Georgios Tepelopoulos, Petros Bangeas, Ifigenia Ypsilantou, Michael Pitiakoudis
Summary: This experimental study compared the effects of laparoscopic and open techniques for major liver resection on the integrity, inflammatory and immune responses of the gut barrier. The results showed that the laparoscopic technique attenuated disruption of the gut barrier and reduced inflammatory and immune responses of the intestinal mucosa.
Article
Biochemistry & Molecular Biology
Lu-Yuan Peng, Hai-Tao Shi, Yue-Rong Tan, Si-Yang Shen, Peng-Fei Yi, Hai-Qing Shen, Ben-Dong Fu
Summary: The study found that baicalin protected against APEC infection by modulating gut microbiota, increasing short chain fatty acid (SCFA) production, especially acetate. Acetate may circulate to the lungs to activate FFAR2 to defend against APEC infection.
Review
Biology
Valeria Maccauro, Carlo Airola, Francesco Santopaolo, Antonio Gasbarrini, Francesca Romana Ponziani, Maurizio Pompili
Summary: Liver cirrhosis is a chronic disease that often leads to complications such as variceal bleeding, hepatic encephalopathy, ascites, and jaundice, with increased mortality. Infections, particularly spontaneous bacterial peritonitis (SBP), are common in cirrhotic patients due to impaired immunity and altered intestinal microbiota. SBP is primarily caused by Gram-negative bacteria translocating through the defective intestinal barrier. The first-line treatment is antibiotic therapy, but it may worsen dysbiosis. Future therapies aim to selectively modulate the gut microbiota or reduce intestinal permeability.
Article
Oncology
Zhiyong Guo, Jinghong Xu, Shanzhou Huang, Meixian Yin, Qiang Zhao, Weiqiang Ju, Dongping Wang, Ningxin Gao, Changjun Huang, Lu Yang, Maogen Chen, Zhiheng Zhang, Zebin Zhu, Linhe Wang, Caihui Zhu, Yixi Zhang, Yunhua Tang, Haitian Chen, Kunpeng Liu, Yuting Lu, Yi Ma, Anbin Hu, Yinghua Chen, Xiaofeng Zhu, Xiaoshun He
Summary: Ischemia-free liver transplantation can avoid graft ischemia-reperfusion injury and has the potential to improve transplant outcomes and organ utilization.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Surgery
Shintaro Kuroda, Tsuyoshi Kobayashi, Hirotaka Tashiro, Takashi Onoe, Akihiko Oshita, Tomoyuki Abe, Toshihiko Kohashi, Koichi Oishi, Ichiro Ohmori, Yasuhiro Imaoka, Junko Tanaka, Hideki Ohdan
Summary: This study investigated the role of antithrombin III in preventing posthepatectomy liver failure and found that its administration did not significantly prevent liver failure. Treatment for postoperative coagulopathy was performed safely without adverse events, and the incidence of liver failure did not differ significantly between the administration and non-administration groups.
Review
Pharmacology & Pharmacy
Ya-Qun Huang, Rui-Ting Wen, Xiao-Tong Li, Jiao Zhang, Zhi-Ying Yu, Yu-Fei Feng
Summary: Perioperative administration of dexmedetomidine can protect against liver ischemia-reperfusion injury after hepatectomy by reducing serum markers, decreasing oxidative damage, and alleviating liver injury. Further studies are needed to explore the impact of dexmedetomidine on postoperative recovery outcomes with different dosing regimens.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Junya Kawasoe, Yoichiro Uchida, Hiroshi Kawamoto, Tomoyuki Miyauchi, Takeshi Watanabe, Kenichi Saga, Kosuke Tanaka, Shugo Ueda, Hiroaki Terajima, Kojiro Taura, Etsuro Hatano
Summary: Liver ischemia and reperfusion injury (IRI) is a common problem in liver surgery, and this study found that feeding mice with inulin can prevent liver IRI. It is suggested that the inulin-induced increase of short-chain fatty acid propionic acid (PA) may play a key role in the prevention of liver IRI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Noemi Daradics, Gergo Horvath, Laszlo Tretter, Agnes Paal, Andras Fulop, Andras Budai, Attila Szijarto
Summary: Depletion of CypD improves mitochondrial function following ALPPS and enhances liver growth.
Article
Biochemistry & Molecular Biology
Asa Noren, Mihai Oltean, Styrbjorn Friman, Antonio Molinaro, Johan Molne, Carina Sihlbom, Gustaf Herlenius, Annika Thorsell
Summary: Acute kidney injury (AKI) is common after liver transplantation (LT) and is related to the later development of chronic kidney disease. This study found that grafts from LT recipients who develop early AKI have distinct proteomic alterations, primarily dominated by an early yet prominent activation of innate immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Yiannis Kotsis, Anastasia Mikellidi, Cleopatra Aresti, Eleni Persia, Aristomenis Sotiropoulos, Demosthenes B. Panagiotakos, Smaragdi Antonopoulou, Tzortzis Nomikos
EUROPEAN JOURNAL OF NUTRITION
(2018)
Review
Medical Laboratory Technology
Tzortzis Nomikos, Elizabeth Fragopoulou, Smaragdi Antonopoulou, Demosthenes B. Panagiotakos
CLINICAL BIOCHEMISTRY
(2018)
Editorial Material
Cardiac & Cardiovascular Systems
Nikolaos Papoutsidakis, Stephen B. Heitner, Meghan C. Mannello, Anna Rodonski, William Campbell, Kylie McElheran, Daniel L. Jacoby
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2018)
Review
Nutrition & Dietetics
Agathi Ntzouvani, Smaragdi Antonopoulou, Tzortzis Nomikos
BRITISH JOURNAL OF NUTRITION
(2019)
Article
Biochemistry & Molecular Biology
Agathi Ntzouvani, Efstathia Giannopoulou, Elizabeth Fragopoulou, Tzortzis Nomikos, Smaragdi Antonopoulou
Article
Microbiology
E. K. Mitsou, M. Detopoulou, A. Kakali, E. Fragopoulou, T. Nomikos, S. Antonopoulou, D. B. Panagiotakos, A. Kyriacou
BENEFICIAL MICROBES
(2019)
Article
Engineering, Biomedical
Yiannis Kotsis, Spyridon Methenitis, Anastasia Mikellidi, Cleopatra Aresti, Eleni Persia, Smaragdi Antonopoulou, Tzortzis Nomikos
ISOKINETICS AND EXERCISE SCIENCE
(2020)
Article
Nutrition & Dietetics
Spyridon Methenitis, Thomas Mpampoulis, Polyxeni Spiliopoulou, George Papadimas, Constantinos Papadopoulos, Eleanna Chalari, Eftychia Evangelidou, Angeliki-Nikoletta Stasinaki, Tzortzis Nomikos, Gerasimos Terzis
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2020)
Review
Nutrition & Dietetics
Fotios Barkas, Tzortzis Nomikos, Evangelos Liberopoulos, Demosthenes Panagiotakos
Article
Nutrition & Dietetics
Hajara Aslam, Felice N. Jacka, Wolfgang Marx, Kalliopi Karatzi, Christina Mavrogianni, Eva Karaglani, Mohammadreza Mohebbi, Julie A. Pasco, Adrienne O'Neil, Michael Berk, Tzortzis Nomikos, Spyridon Kanellakis, Odysseas Androutsos, Yannis Manios, George Moschonis
Article
Clinical Neurology
Dimitrios Sagris, George Ntaios, Georgios Georgiopoulos, Nikolaos Kakaletsis, Moses Elisaf, Niki Katsiki, Eleni Korompoki, Kyriakos E. Kypreos, Chrysoula Boutari, Helen Bilianou, Konstantinos Makaritsis, Tzortzis Nomikos, Vasileios Papavasileiou, Christos Pitsavos, Androniki Plomaritoglou, Konstantinos Spengos, Konstantinos Tziomalos, Alexandros Tselepis, Konstantinos Vemmos, Evangelos Liberopoulos, Haralampos Milionis
Summary: This document provides consensus recommendations from the Hellenic Stroke Organization and the Hellenic Atherosclerosis Society on lipid modification in patients with ischemic stroke or transient ischemic attack. The clinical guide summarizes the current literature on lipid management and aims to assist physicians in treating stroke patients in clinical practice.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Biochemistry & Molecular Biology
E. Fragopoulou, P. Detopoulou, E. Alepoudea, T. Nomikos, N. Kalogeropoulos, S. Antonopoulou
Summary: The study found that SFA were related to increased PAF biosynthesis and decreased Lp-PLA2 only in women, while MUFA were inversely associated with PAF biosynthesis and positively with Lp-PLA2. The pattern of high MUFA and low n6 was associated with reduced PAF biosynthesis and/or increased catabolism, suggesting that fatty acids play a role in amplifying or reducing inflammation.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2021)
Article
Nutrition & Dietetics
Agathi Ntzouvani, Smaragdi Antonopoulou, Elizabeth Fragopoulou, Meropi D. Kontogianni, Tzortzis Nomikos, Anastasia Mikellidi, Marianna Xanthopoulou, Nick Kalogeropoulos, Demosthenes Panagiotakos
Summary: This study found that consumption of enriched farmed gilthead sea bream did not have a greater effect on coagulation markers in adults compared to conventionally fed fish.
Review
Biochemistry & Molecular Biology
Spyridon Methenitis, Ioanna Stergiou, Smaragdi Antonopoulou, Tzortzis Nomikos
Summary: Subclinical, low-grade inflammation is a key factor in many chronic diseases, and understanding the anti-inflammatory properties of diet is challenging. Exercise-induced muscle damage may serve as a useful model for evaluating the effects of diet on inflammation in humans.
Article
Biochemistry & Molecular Biology
Elizabeth Fragopoulou, Filio Petsini, Maria Choleva, Maria Detopoulou, Olga S. Arvaniti, Eftyhia Kallinikou, Eleni Sakantani, Ageliki Tsolou, Tzortzis Nomikos, Yiannis Samaras