Review
Medicine, General & Internal
Peter M. M. Stawinski, Karolina N. N. Dziadkowiec, Lily A. A. Kuo, Juan Echavarria, Shreyas Saligram
Summary: Barrett's esophagus (BE) is a premalignant mucosal transformation characterized by the replacement of esophageal squamous epithelium with metaplastic columnar epithelium. It is associated with an increased risk of esophageal adenocarcinoma and is often caused by gastroesophageal reflux disease. Screening for BE is selective based on risk factors and is not recommended for the general population. Diagnosis involves endoscopic recognition, targeted biopsies, and histologic confirmation of columnar metaplasia. This review provides a comprehensive overview of the epidemiology, pathogenesis, screening, and advanced techniques for detecting and eradicating Barrett's esophagus.
Review
Medicine, General & Internal
Maja Mejza, Ewa Malecka-Wojciesko
Summary: Barrett's esophagus is a precancerous condition of the esophagus, characterized by a salmon-colored lining and the presence of columnar epithelium with goblet cells. It is associated with esophageal adenocarcinoma, a tumor with poor survival rates and increasing incidence. The diagnosis and management of Barrett's esophagus remain a topic of ongoing debate. This article provides an overview of current recommendations and new discoveries in this field.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Vani Konda, Rhonda F. Souza, Kerry B. Dunbar, Jason C. Mills, Daniel S. Kim, Robert D. Odze, Stuart J. Spechler
Summary: This study aimed to characterize the early endoscopic and histologic features of radiofrequency ablation (RFA) wound healing in patients with Barrett's esophagus (BE). The results showed that squamous re-epithelialization of RFA wounds not only progressed through squamous cells extending from the proximal wound edge, but also through islands of squamous epithelium sprouting throughout the ablated segment. Additionally, subepithelial glandular structures associated with the squamous islands were found to increase post-RFA. Furthermore, subsquamous intestinal metaplasia (SSIM) was detected in biopsies of patients during the healing process. This study provides insights into the mechanisms of esophageal metaplasia and the healing of RFA wounds.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Oncology
Lu Zhang, Binyu Sun, Xi Zhou, QiongQiong Wei, Sicheng Liang, Gang Luo, Tao Li, Muhan Lu
Summary: This article briefly describes the etiology and clinical significance of intestinal metaplasia in Barrett's esophagus, as well as its impact on diagnosis, monitoring, and treatment according to different guidelines. The basis for endoscopic diagnosis and identification techniques of goblet cells in Barrett's esophagus are explored, along with current treatment methods related to the condition.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Nicholas J. Shaheen, Gary W. Falk, Prasad G. Iyer, Rhonda F. Souza, Rena H. Yadlapati, Bryan G. Sauer, Sachin Wani
Summary: Barrett's esophagus is a common condition associated with chronic gastroesophageal reflux disease and is a precursor to esophageal adenocarcinoma. The revised guidelines propose recommendations for the definition, diagnosis, screening, surveillance, and treatment of Barrett's esophagus, including important changes such as expanding acceptable screening methods and volume criteria for treatment centers.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Qiuyang Zhang, Ajay Bansal, Kerry B. Dunbar, Yan Chang, Jianning Zhang, Uthra Balaji, Jinghua Gu, Xi Zhang, Eitan Podgaetz, Zui Pan, Stuart Jon Spechler, Rhonda F. Souza
Summary: Reflux-induced epithelial-mesenchymal plasticity (EMP) may play a role in the development of subsquamous intestinal metaplasia (SSIM) in Barrett's esophagus (BE), potentially allowing Barrett's cells to migrate underneath squamous epithelium. This phenomenon could contribute to the formation of Barrett's cancers that escape detection by endoscopic surveillance and recurrences of Barrett's metaplasia following endoscopic eradication therapy.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Surgery
Colin P. Dunn, Justin C. Henning, Jason A. Sterris, Paul Won, Caitlin Houghton, Nikolai A. Bildzukewicz, John C. Lipham
Summary: This retrospective study evaluated the effectiveness of MSA for Barrett's esophagus patients, showing significant reduction in Barrett's length and prevention of progression to dysplasia or neoplasia. The results remained consistent after 2 years of follow-up.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Biochemistry & Molecular Biology
Ksenia Maslenkina, Liudmila Mikhaleva, Maxim Naumenko, Rositsa Vandysheva, Michail Gushchin, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann
Summary: Barrett's esophagus (BE) is a premalignant lesion that can develop into esophageal adenocarcinoma (EAC). The development of BE is caused by biliary reflux and involves various stem cell origins. The concept of healing has been replaced by the cytokine storm and inflammatory microenvironment, leading to intestinal metaplasia. This review discusses the roles of molecular pathways in the pathogenesis of BE and EAC, including NOTCH, hedgehog, NF-?B, and IL6/STAT3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Sathisha Upparahalli Venkateshaiah, Chandra Sekhar Yadavalli, Hemanth Kumar Kandikattu, Sandeep Kumar, Lokanatha Oruganti, Anil Mishra
Summary: This study aims to investigate the molecules involved in the development of Barrett's esophagus in patients with human eosinophilic esophagitis (EoE). The findings suggest that IL-9 plays an important role in the initiation and progression of BE characteristics in patients with chronic EoE.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Genetics & Heredity
Nandan P. Deshpande, Stephen M. Riordan, Claire J. Gorman, Shaun Nielsen, Tonia L. Russell, Carolina Correa-Ospina, Bentotage S. M. Fernando, Shafagh A. Waters, Natalia Castano-Rodriguez, Si Ming Man, Nicodemus Tedla, Marc R. Wilkins, Nadeem O. Kaakoush
Summary: This study comprehensively assessed the esophageal microenvironment in patients with gastro-esophageal reflux disease and metaplasia, identifying bacterial strain-specific signatures with high relevance to disease progression.
Article
Gastroenterology & Hepatology
Cary C. Cotton, Nicholas J. Shaheen, Aaron P. Thrift
Summary: Endoscopic surveillance after successful ablation of baseline high-grade dysplasia or intramucosal cancer is much more effective than surveillance after successful treatment of baseline low-grade dysplasia in preventing invasive adenocarcinoma.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Kentaro Ishikawa, Kenichiro Okimoto, Tomoaki Matsumura, Yosuke Hirotsu, Kenji Amemiya, Takashi Kishimoto, Naoki Akizue, Yuki Ohta, Keiko Saito, Daisuke Maruoka, Motoi Nishimura, Kazuyuki Matsushita, Hitoshi Mochizuki, Makoto Arai, Jun Kato, Osamu Yokosuka, Masao Omata, Naoya Kato
Summary: The study clarified the malignant potential of patients with CLE without intestinal metaplasia and/or less than 1 cm, suggesting the need for follow-up in these patients similar to those with BE.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Ana C. P. Correia, Danielle Straub, Matthew Read, Sanne J. M. Hoefnagel, Salvador Romero-Pinedo, Ana C. Abadia-Molina, Nicholas J. Clemons, Kenneth Wang, Silvia Calpe, Wayne Phillips, Kausilia K. Krishnadath
Summary: Targeting the BMP2 and BMP4 signaling pathways can effectively inhibit the development of Barrett's esophagus and promote the expansion of squamous cells, providing a novel potential strategy for the treatment of Barrett's esophagus.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Surgery
Ronan J. Kelly, Amir M. Ansari, Tomoharu Miyashita, Marianna Zahurak, Frank Lay, A. Karim Ahmed, Louis J. Born, Maryam K. Pezhouh, Kevan J. Salimian, Christopher Ng, Aerielle E. Matsangos, Anne-Heloise Stricker-Krongrad, Ken-ichi Mukaisho, Guy P. Marti, Christine H. Chung, Marcia I. Canto, Michelle A. Rudek, Stephen J. Meltzer, John W. Harmon
Summary: Itraconazole significantly reduces the development of esophageal adenocarcinoma and SHH expression in a preclinical animal model of Barrett's Metaplasia. In humans, BE tissue expresses higher levels of SHH, Indian Hedgehog, and bone morphogenic protein compared to normal squamous esophageal epithelium.
Editorial Material
Oncology
Matthew D. Stachler
Summary: The study characterizes and analyzes single-cell RNA-sequencing data of the tubal gastrointestinal system, including various inflammatory conditions and intestinal metaplasia of the stomach and esophagus. The findings reveal similarities in transcript and protein levels between gastric and esophageal intestinal metaplasia. Interestingly, the study shows that individual cells within metaplastic areas can coexpress transcriptional programs of both gastric and intestinal epithelia.
Article
Oncology
Maria Villamonte, Fernando Burdio, Eva Pueyo, Ana Andaluz, Xavier Moll, Enrique Berjano, Aleksander Radosevic, Luis Grande, Miguel Pera, Benedetto Ielpo, Patricia Sanchez-Velazquez
Summary: The study aimed to compare the impact of an additional application of RF energy on the top of the resection surface on local recurrence in liver surgery. The results showed that additional margin coagulation (AMC) was associated with lower local recurrence, and the use of RF applicator was significantly related to reduced local recurrence. The Control group had smaller coagulation widths compared to the AMC group.
Article
Oncology
Mariagiulia Dal Cero, Marta Roman, Luis Grande, Concepcion Yarnoz, Fernando Estremiana, Amaia Gantxegi, Clara Codony, Yanina Gobbini, Elisenda Garsot, Dulce Momblan, Marta Gonzalez-Duaigues, Alexis Luna, Noelia Perez, Aurora Aldeano, Sonia Fernandez, Carles Olona, Judit Hermoso, Laura Pulido, Juan Jose Sanchez-Cano, Merce Guell, David Salazar, Marta Gimeno, Manuel Pera
Summary: This study assessed the incidence of textbook outcome (TO) among patients undergoing curative gastric cancer resection and found an achievement rate of 41.1%. Age, comorbidity index, neoadjuvant treatment, multivisceral resection, and hospital type were associated with the achievement of TO. TO was associated with patient survival.
Article
Multidisciplinary Sciences
Aleksandar Radosevic, Rita Quesada, Clara Serlavos, Juan Sanchez, Ander Zugazaga, Ana Sierra, Susana Coll, Marcos Busto, Guadalupe Aguilar, Daniel Flores, Javier Arce, Jose Maria Maiques, Montserrat Garcia-Retortillo, Jose Antonio Carrion, Laura Visa, Maria Villamonte, Eva Pueyo, Enrique Berjano, Macarena Trujillo, Patricia Sanchez-Velazquez, Luis Grande, Fernando Burdio
Summary: This study compares the effectiveness and safety of MWA and RFA in hepatocellular carcinoma and colorectal liver metastasis. The results showed that there were no significant differences between MWA and RFA in terms of ablation zone size, SLR, effectiveness, and safety.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Benedetto Ielpo, Patricia Sanchez, Luis Grande, Fernando Burdio
Summary: Despite the technical challenges, the standardization of laparoscopic pancreatoduodenectomy can improve surgical outcomes and reduce postoperative complications.
UPDATES IN SURGERY
(2022)
Review
Surgery
Silvia Salvans, Luis Grande, Mariagiulia Dal Cero, Manuel Pera
Summary: Enhanced recovery after surgery (ERAS) programs provide a framework to standardize care processes and improve outcomes by reducing physiological surgical stress. Despite challenges in implementing ERAS in esophageal and gastric cancer resection procedures, systematic reviews have confirmed the benefits of reduced complications and hospital stay. However, there is heterogeneity and lack of standardization in the ERAS components. Despite the growing evidence of effectiveness, adherence to ERAS protocols remains low.
UPDATES IN SURGERY
(2023)
Article
Surgery
Carlos Manterola, Nataniel Claros, Luis Grande
Summary: This study describes the postoperative complications and recurrence in patients with abdominal echinococcal cyst ruptured (AECR) who underwent surgical treatment. The results show a high percentage of postoperative complications and recurrence in patients treated surgically for AECR.
INDIAN JOURNAL OF SURGERY
(2023)
Article
Pathology
Monica Gonzalez-Farre, Joan Gibert, Pablo Santiago-Diaz, Silvia Menendez, Xavier Monzonis, Francesc Olivares, Xenia Riera, David Lopez, Ariadna Torner, Beatriz Casado, Beatriz Bellosillo, Belen Lloveras, David Casadevall, Ana Rovira, Sonia Servitja, Joan Albanell, Ivonne Vazquez, Laura Comerma
Summary: Stromal tumor-infiltrating lymphocytes (sTILs) are a prognostic and predictive biomarker in triple-negative breast carcinoma. The distribution and association of T cells, B cells, and plasma cells with patient outcome were examined in this study, along with the expression of programmed death ligand 1 and the presence of tertiary lymphoid structures. Higher sTILs and T cell infiltration correlated with better progression-free survival, while B cell and plasma cell infiltration showed a positive trend. The study highlights the importance of characterizing immune cell infiltration and proposes a new classification for triple-negative breast carcinoma based on CD8+ T cell and plasma cell densities.
Review
Oncology
Mariagiulia Dal Cero, Maria Bencivenga, Drolaiz H. W. Liu, Michele Sacco, Mariella Alloggio, Kelly G. P. Kerckhoffs, Federica Filippini, Luca Saragoni, Mar Iglesias, Anna Tomezzoli, Fatima Carneiro, Heike I. Grabsch, Giuseppe Verlato, Lorena Torroni, Guillaume Piessen, Manuel Pera, Giovanni de Manzoni
Summary: The clinical behavior of signet ring cell histology in gastric cancer has been controversial due to the lack of a standardized definition. This meta-analysis aimed to gain a deeper understanding of the prognosis and clinicopathological features of signet ring cell gastric cancer compared to other histologies. The findings revealed that the prognosis of signet ring cell gastric cancer is closely linked to the disease stage and the specific comparison group employed. The lack of standardized classification may contribute to the variability in clinical behavior. Therefore, efforts should be made to establish a uniform classification system for gastric cancer to enhance clarity and coherence in research and clinical practice.
Article
Health Care Sciences & Services
Maria Bencivenga, Lorena Torroni, Mariagiulia Dal Cero, Alberto Quinzii, Camilla Zecchetto, Valeria Merz, Simona Casalino, Francesco Taus, Silvia Pietrobono, Domenico Mangiameli, Federica Filippini, Mariella Alloggio, Claudia Castelli, Mar Iglesias, Manuel Pera, Davide Melisi
Summary: This study found that the activation of the YAP pathway is associated with poor prognosis in poorly cohesive gastric cancer, suggesting its important role in the development of this type of cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Meeting Abstract
Surgery
Benedetto Lelpo, Patricia Sanchez-Velazquez, Luis Grande, Fernando Burdio
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Meeting Abstract
Surgery
Benedetto Ielpo, Marcello Di Martino, Fernando Burdio, Patricia Sanchez-Velazquez, Luis Grande
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Surgery
Aiysha Puri, Nikhil M. Patel, Viknesh Sounderajah, Lorenzo Ferri, Ewen A. Griffiths, Donald Low, Nick Maynard, Carmen Mueller, Manuel Pera, Mark I. van Berge Henegouwen, David Watson, Giovanni Zaninotto, George B. Hanna, Sheraz R. Markar
Summary: This study developed a symptom severity instrument (POST tool) specific to para-oesophageal hernia (POH). Through a systematic review and Delphi consensus process, the POST tool was created, which includes five symptoms that reached consensus among international experts.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Antoni Gelabert Mas, Luis Grande
Summary: A diagnostic reformulation of Pope Innocent XI's cause of death is made based on the reinterpretation of an autopsy report and drawing by Giovanni Maria Lancisi in 1769, as well as current knowledge. It is concluded that Pope Innocent XI died of end-stage renal failure caused by pyonephrosis due to bilateral coralliform lithiasis in a horseshoe kidney.
Article
Health Care Sciences & Services
Olga Morato, Maria Villamonte, Patricia Sanchez-Velazquez, Eva Pueyo-Periz, Luis Grande, Benedetto Ielpo, Edoardo Rosso, Alessandro Anselmo, Fernando Burdio
Summary: This study aims to evaluate the practical value of the KRAS gene in predicting oncological outcomes in patients with CRLM and to determine the necessity of KRAS testing in each situation. The results showed that patients could be classified into wild-type KRAS, mutated KRAS, and impractical KRAS groups based on their oncological variables. The impractical KRAS group had significantly longer survival periods. Multivariable analysis indicated that the KRAS mutational gene was the only variable associated with survival.
