Article
Chemistry, Multidisciplinary
Tanja Seibold, Jonathan Schoenfelder, Florian Weeber, Andre Lechel, Milena Armacki, Mareike Waldenmaier, Christoph Wille, Annette Palmer, Rebecca Halbgebauer, Ebru Karasu, Markus Huber-Lang, Miriam Kalbitz, Peter Radermacher, Stephan Paschke, Thomas Seufferlein, Tim Eiseler
Summary: Trauma is the leading cause of death in individuals under 44 years of age, with thorax trauma strongly associated with trauma-related death, an unbalanced immune response, sepsis, respiratory distress syndrome, and organ dysfunction. Research shows that small extracellular nanovesicles (sEVs) released from endothelial cells in response to trauma trigger systemic inflammation, neutrophil infiltration, and organ damage, suggesting a fundamental pathophysiological mechanism.
Review
Biochemistry & Molecular Biology
Janusz P. Sikora, Jakub Karawani, Jaroslaw Sobczak
Summary: This study aims to determine the role of neutrophils in individual phenomena occurring during an inflammatory and anti-inflammatory reaction, considering their cidal, immunoregulatory, and reparative abilities. The study also highlights the pro- and anticoagulatory properties of endothelium in systemic inflammatory response syndrome (SIRS) and their clinical implications. Additionally, it presents clinically useful biomarkers related to neutrophils and emphasizes their role in the diagnosis and forecasting of sepsis, burn disease, and COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Manoj Arra, Gaurav Swarnkar, Naga Suresh Adapala, Syeda Kanwal Naqvi, Lei Cai, Muhammad Farooq Rai, Srikanth Singamaneni, Gabriel Mbalaviele, Robert Brophy, Yousef Abu-Amer
Summary: Osteoarthritis is a common joint disease with a prominent inflammatory component, while the role of glutamine metabolism in chondrocytes, especially in the context of inflammation, remains poorly understood. Studies show that mouse chondrocytes utilize glutamine for energy production and anabolic processes, and glutamine deprivation can lead to metabolic reprogramming and decreased inflammatory response.
Article
Environmental Sciences
Lei Qi, Yan-Mei Dong, Hong Chao, Peng Zhao, Shu-Li Ma, Gang Li
Summary: This study investigated the effects of glyphosate-based herbicides (GBH) on liver toxicity in mice. The results showed that GBH caused structural changes, inflammation, oxidative stress, and altered metabolic pathways in the liver. This study provides new insights into the systematic mechanism underlying hepatotoxicity caused by GBH.
Article
Medicine, General & Internal
Maria Dulfary Sanchez-Pino, William S. Richardson, Jovanny Zabaleta, Ramesh Thylur Puttalingaiah, Andrew G. Chapple, Jiao Liu, Yonghyan Kim, Michelle Ponder, Randi DeArmitt, Lyndsey Buckner Baiamonte, Dorota Wyczechowska, Liqin Zheng, Amir A. Al-Khami, Jone Garai, Rachel Martini, Melissa Davis, Jessica Koller Gorham, James B. Wooldridge, Paulo C. Rodriguez, Lucio Miele, Augusto C. Ochoa
Summary: The number of LDN in the circulation is increased in obese patients and is associated with an inflammatory gene signature. Bariatric surgery significantly reduces LDN levels and improves metabolic parameters.
Review
Cell Biology
Christof Kaltenmeier, Ronghua Wang, Brandon Popp, David Geller, Samer Tohme, Hamza O. Yazdani
Summary: Ischemia reperfusion injury (IRI) is a common complication in liver surgery and transplantation, involving the activation of various cytokines and chemokines, as well as the release of damage-associated molecular patterns. The injury leads to cell death and a cytokine/chemokine storm, which attracts immune cells to the site and worsens the damage.
Review
Cell Biology
Yang Wang, Jing Wang
Summary: Proper crosstalk between immune and nonimmune cells is crucial for maintaining a healthy liver, allowing it to cope with daily stressors. Dysregulation of the inflammatory process can lead to severe liver diseases. Intravital imaging is a powerful tool for studying the complex interactions of immune cells in the liver during inflammatory responses.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Surgery
Jaqueline Velkoski, Franco Grimaldi, Laura Di Meo, Francesca Mion, Riccardo Pravisani, Marco Marino, Sergio Calandra, Vittorio Cherchi, Giovanni Terrosu
Summary: Immunonutrition plays a role in affecting granulocytopoiesis and neutrophil recruitment in damaged tissues, leading to better tissue healing and reduced postoperative complications; Patients receiving immunonutrition required less postoperative antibiotic treatment, reflecting reduced susceptibility to postoperative infections.
Article
Allergy
Ankit Sharma, Matija Rijavec, Sunil Tomar, Amnah Yamani, Varsha Ganesan, James Krempski, Charles F. Schuler, Supinda Bunyavanich, Peter Korosec, Simon P. Hogan
Summary: This study aimed to identify dysregulated immunological processes associated with severe food allergic reactions by integrating bulk RNA-sequencing data from human and mouse samples. The results showed that genes related to innate and inflammatory immune responses, MAPK and NFkB signaling, as well as 429 genes correlated with reaction severity in mice. By comparing the mouse transcriptome with two independent human cohorts, 11 significantly dysregulated genes correlated with severity were identified. Additionally, during IgE-mediated reactions, rapid changes in blood leukocytes, particularly inflammatory monocytes and neutrophils, were observed along with changes in surface expression of CLEC4E, CD218A, and GPR27.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Medicine, Research & Experimental
Jing Ma, Adrien Guillot, Zhihong Yang, Bryan Mackowiak, Seonghwan Hwang, Ogyi Park, Brandon J. Peiffer, Ali Reza Ahmadi, Luma Melo, Praveen Kusumanchi, Nazmul Huda, Romil Saxena, Yong He, Yukun Guan, Dechun Feng, Pau Sancho-Bru, Mengwei Zang, Andrew MacGregor Cameron, Ramon Bataller, Frank Tacke, Zhaoli Sun, Suthat Liangpunsakul, Bin Gao
Summary: Two distinct patterns of intrahepatic neutrophil infiltration are observed in severe alcoholic hepatitis (SAH) patients, suggesting separate mechanisms driving liver injury.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Immunology
Qiongqiong Zhou, Bingfang Yan, Wanying Sun, Qi Chen, Qiling Xiao, Yuncai Xiao, Xiliang Wang, Deshi Shi
Summary: The study demonstrated that carboxylesterases PLE1 and PLE6 can hydrolyze endocannabinoids 2-AG and AEA, leading to increased inflammatory response. Exogenous addition or transfection of PLE6 enhanced the expression and secretion of proinflammatory cytokines, while BNPP reduced inflammation triggered by LPS and inhibited the formation of AA and proinflammatory mediators. This innovative connection between PLE-endocannabinoid-inflammation highlights the critical roles of carboxylesterases in pathophysiological processes related to endocannabinoid metabolism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Patrick P. G. Mulder, Marcel Vlig, Esther Fasse, Matthea M. Stoop, Anouk Pijpe, Paul P. M. van Zuijlen, Irma Joosten, Bouke K. H. L. Boekema, Hans J. P. M. Koenen
Summary: The immune response in burn patients is often extreme and abnormal. Understanding the immune effects of thermal injury is necessary to improve patient outcomes. This study shows that after burn injury, immune cells persistently increase in number, unlike in normal wound healing. The study also reveals high levels of chemokines and pro-inflammatory cytokines in burn tissue. The local immune response in burns is similar to the systemic immune reaction, but differs in neutrophil maturity and lymphocyte composition.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Shu Zhang, Wen Fang, Siqi Zhou, Dongming Zhu, Ruidong Chen, Xin Gao, Zhuojin Li, Yao Fu, Yixuan Zhang, Fa Yang, Jing Zhao, Hao Wu, Pin Wang, Yonghua Shen, Shanshan Shen, Guifang Xu, Lei Wang, Chao Yan, Xiaoping Zou, Dijun Chen, Ying Lv
Summary: In this study, the single-cell transcriptomic landscape of pancreatic ductal adenocarcinoma (PDAC) primary tumors and matched liver metastases was comprehensively characterized. The results showed distinct transcriptomic profiles in liver metastasis compared to primary tumors, with clearly defined evolutionary routes. Specific subtypes of stromal and immune cells critical to the formation of the pro-tumor microenvironment in metastatic lesions were also identified.
NATURE COMMUNICATIONS
(2023)
Article
Developmental Biology
Kanako Gondo, Fumio Yamasaki, Makoto Nomiyama, Nami Hisamoto, Natsumi Yamashita, Takuya Nakagawa, Masazumi Ikeda, Satoko Tsuda, Masato Ishimatsu, Yuko Oshima, Takeshi Ono, Yutaka Kozuma, Yukiko Nakura, Itaru Yanagihara, Keisuke Tsumura
Summary: We aimed to determine the frequencies of maternal inflammatory response (MIR) and fetal inflammatory response (FIR) in patients with intra-amniotic infection and inflammation (IAI) using amniotic fluid interleukin-6 (IL-6) concentration at diagnosis and diagnosis-to-delivery interval. The amniotic fluid IL-6 concentration at diagnosis was 15.8 ng/mL, and the diagnosis-to-delivery interval was 12 hours. MIR was positive in 98% of cases with intra-amniotic infection, and there were no significant differences between the frequencies of MIR and FIR.
Article
Immunology
Aiten Ismailova, Reyhaneh Salehi-Tabar, Vassil Dimitrov, Babak Memari, Camille Barbier, John H. White
Summary: This study identified a transcription network in neutrophils that is induced in response to inflammatory stimuli, which is regulated by FOXP4 transcription factor. The network consists of genes encoding proinflammatory cytokines and transcription factors involved in stress, survival, and inflammation responses. The findings highlight the importance of the FOXP4 transcription network in neutrophil response to inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Anesthesiology
Antonio Ojeda, Andrea Calvo, Tomas Cunat, Ricard Mellado-Artigas, Oscar Comino-Trinidad, Jorge Aliaga, Marilyn Arias, Carlos Ferrando, Graciela Martinez-Palli, Christian Dursteler
Summary: This study examined the occurrence of new-onset pain in COVID-19 survivors after hospital discharge and its impact on Health-Related Quality of Life (HRQoL), revealing a negative correlation between pain and HRQoL.
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Anesthesiology
Edward Yap, Julia Wei, Christopher Webb, Kevin Ng, Matthias Behrends
Summary: Compared with general anesthesia, neuraxial anesthesia improves outcomes following outpatient hip and knee arthroplasty, including reduced pain, less opioid use, and lower incidence of postoperative nausea and vomiting.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Review
Surgery
Carmen Vinaixa, Graciela Martinez Palli, Donald Milliken, Daniel Sellers, Sebastien Dharancy, Michael Spiro, Dimitri Aristotle Raptis, Didier Samuel, Claus Niemann, Joerg-Matthias Pollok, Marina Berenguer, Shahi Abdul Ghani, Ka Siu Fan
Summary: Prehabilitation programs prior to liver transplantation are likely to have short-term benefits on functional status and are unlikely to cause harm.
CLINICAL TRANSPLANTATION
(2022)
Article
Oncology
Raquel Sebio-Garcia, Fernando Dana, Elena Gimeno-Santos, Manuel Lopez-Baamonde, Marta Ubre, Mar Montane-Muntane, Raquel Risco, Monique Messagi-Sartor, Josep Roca, Graciela Martinez-Palli
Summary: The study aimed to assess the repeatability and learning effect of the 6-minute walk test (6MWT) in preoperative cancer patients. The results showed excellent repeatability of the 6MWT distance, but a significant learning effect was observed in the second test. No clinical factors were associated with improvement in the second test. Therefore, it is recommended to encourage two attempts of the 6MWT in this population.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Anesthesiology
G. Munoz-Rojas, B. Garcia-Lorenzo, D. Esteve, S. Trias, D. Caellas, M. Sanz, R. Mellado, T. Peix, L. Sampietro-Colom, N. Pou, G. Martinez-Palli, Carlos Ferrando
Summary: Rapid response systems (RRS) have shown to be more effective in preventing adverse events (AE), reducing risks and lowering healthcare costs.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2022)
Article
Oncology
Berta Diaz-Feijoo, Nuria Agusti-Garcia, Raquel Sebio, Antonio Lopez-Hernandez, Marina Siso, Ariel Glickman, Nuria Carreras-Dieguez, Pere Fuste, Tiermes Marina, Judit Martinez-Egea, Laura Aguilera, Juan Perdomo, Amaia Pelaez, Manuel Lopez-Baamonde, Ricard Navarro-Ripoll, Elena Gimeno, Betina Campero, Aureli Torne, Graciela Martinez-Palli, Maria J. Arguis
Summary: Multimodal prehabilitation programmes before surgery are feasible and safe in patients with advanced ovarian cancer, and result in shorter hospital stays and time to starting chemotherapy.
Article
Anesthesiology
A. Lopez-Hernandez, M. J. Arguis, E. Gimeno-Santos, R. Navarro, M. Coca-Martinez, G. Martinez-Palli
Summary: Multimodal prehabilitation program is feasible in candidates for elective cardiac surgery and improves preoperative functional capacity without complications.
REVISTA ESPANOLA DE ANESTESIOLOGIA Y REANIMACION
(2023)
Article
Surgery
Raquel Risco, Ruben Gonzalez-Colom, Mar Montane-Muntane, Isaac Cano, Emili Vela, Raquel Sebio, Fernando Dana, Joan Faner, Miquel Coca, Sara Laxe, Josep Roca, Graciela Martinez-Palli
Summary: Prehabilitation has potential for improving surgical outcomes, but its scalability is limited by an efficacy-effectiveness gap. This study found that completion of the prehabilitation program can reduce hospital and intensive care unit stays, and also save costs.
Article
Medicine, General & Internal
Marc Alan Buren, Alekos Theologis, Ariadne Zuraek, Matthias Behrends, Aaron J. Clark, Jacqueline M. Leung
Summary: Postoperative delirium is a common adverse event after non-cardiac surgery, which increases the risk of functional impairment, placement to facilities other than home, cognitive impairment, as well as in-hospital and possibly long-term mortality. Currently, there is a lack of effective strategies to minimize the risk of postoperative delirium, including postoperative pain control and analgesic regimen. The use of lidocaine infusions during the intraoperative period has been shown to decrease postoperative opioid requirements, but whether postoperative lidocaine infusions can lead to lower opioid requirements and a reduction in postoperative delirium remains to be investigated.
Article
Gastroenterology & Hepatology
Antonio Giordano, Gherzon Casanova, Miriam Escapa, Gloria Fernandez-Esparrach, Angels Gines, Oriol Sendino, Isis K. Araujo, Andres Cardenas, Henry Cordova, Julia Martinez-Ocon, Graciela Martinez-Palli, Francesc Balaguer, Josep Llach, Elena Ricart, Begona Gonzalez-Suarez
Summary: Motorized Spiral Enteroscopy (MSE) is an effective and safe examination method for patients with prior major abdominal surgery. Although longer procedure times were observed in these patients, the diagnostic yield was similar. Patients with gastrointestinal surgery showed a lower depth of insertion compared to those with other abdominal surgeries.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Surgery
Roger Pujol, Eva Rivas, Isabel Gracia, Angel Caballero, Purificacion Matute, Tomas Cunat, Misericordia Basora, Neus Fabregas, Maria Jose Arguis, Daniel Luis Forne, Jose Maria Balibrea, Anais Besa, Guillermo Laguna, Concepcion Monsalve, Antonio M. Lacy, Graciela Martinez-Palli
Summary: This study aims to determine the impact of the COVID-19 outbreak on hospital surgical activity and the occurrence of perioperative COVID-19 in two screening pathways for elective and non-elective surgery. The elective pathway involved surveys and RT-PCR tests for asymptomatic and low-risk patients, while the non-elective pathway conducted preoperative screening during hospital admission. Results showed a significant reduction in surgical activity during the outbreak, with a higher incidence of COVID-19 and mortality in non-elective surgery patients.
Article
Health Care Sciences & Services
Erik Baltaxe, Isaac Cano, Raquel Risco, Raquel Sebio, Fernando Dana, Sara Laxe, Ramon Martinez, Fernando Ozores, Josep Roca, Graciela Martinez-Palli
Summary: This report describes the co-creation process undertaken to deploy a prehabilitation service, aiming to achieve sustainable adoption and facilitate site transferability. Personalization and modularity of the intervention were identified as key traits to enhance patients' adherence and value generation.
INTERNATIONAL JOURNAL OF INTEGRATED CARE
(2022)
Review
Oncology
Fernando Dana, Raquel Sebio-Garcia, Beatriz Tena, Marina Siso, Francisco Vega, Amaia Pelaez, David Capitan, Marta Ubre, Ana Costas-Carrera, Graciela Martinez-Palli
Summary: This article describes the process of establishing a prehabilitation unit in our center and the evolution of perioperative nursing. The unit has developed multimodal prehabilitation programs that have been shown to improve functional capacity, reduce complications, and decrease hospital and ICU stay for cancer patients. The availability of a specialized unit facilitates the development of comprehensive and patient-centered prehabilitation programs.
Article
Surgery
Charlotte Johanna Laura Molenaar, Enrico Maria Minnella, Miquel Coca-Martinez, David Wouter Gerard ten Cate, Marta Regis, Rashami Awasthi, Graciela Martinez-Palli, Manuel Lopez-Baamonde, Raquel Sebio-Garcia, Carlo Vittorio Feo, Stefanus Johannes van Rooijen, Jennifer Marijke Janneke Schreinemakers, Rasmus Dahlin Bojesen, Ismail Gogenur, Edwin R. van den Heuvel, Francesco Carli, Gerrit Dirk Slooter
Summary: Colorectal surgery is associated with significant morbidity rates and decreased functional capacity. A multimodal prehabilitation program before colorectal cancer surgery can reduce postoperative complications and enhance functional recovery, as demonstrated by the PREHAB trial.
Article
Medicine, General & Internal
Manuel Lopez-Baamonde, Maria Jose Arguis, Ricard Navarro-Ripoll, Elena Gimeno-Santos, Barbara Romano-Andrioni, Marina Siso, Silvia Teres-Belles, Antonio Lopez-Hernandez, Adria Burniol-Garcia, Marta Farrero, Raquel Sebio-Garcia, Elena Sandoval, Maria Sanz-de la Garza, Julian Librero, Ana Garcia-Alvarez, Maria Angeles Castel, Graciela Martinez-Palli
Summary: This study aimed to investigate the impact of prehabilitation on the postoperative outcomes of heart transplantation and its cost-effectiveness. The results showed that prehabilitation significantly improved patients' preoperative functional capacity and quality of life, while reducing the rate and severity of postoperative complications, mechanical ventilation time, ICU stay, total hospitalization stay, and the need for transfer to nursing/rehabilitation facilities after discharge. Cost-consequence analysis demonstrated that prehabilitation did not increase the total surgical process costs.
JOURNAL OF CLINICAL MEDICINE
(2023)