Article
Gastroenterology & Hepatology
V. J. Kroon, L. A. Daamen, D. S. J. Tseng, A. Roele-de Vreugd, L. J. H. Brada, O. R. Busch, T. C. Derksen, A. Gerritsen, S. J. E. Rombouts, F. J. Smits, M. S. Walma, R. A. W. Wennink, M. G. Besselink, H. C. van Santvoort, I. Q. Molenaar
Summary: This study found a high incidence of pancreatic exocrine insufficiency (PEI) following pancreatoduodenectomy (PD), with the majority of patients developing PEI within a few months after surgery. Only 35%-70% of patients experienced symptom resolution during follow-up. Additionally, deficiencies in vitamin D and vitamin K were commonly observed.
Article
Oncology
S. Powell-Brett, N. de Liguori Carino, K. Roberts
Summary: Pancreatic exocrine insufficiency (PEI) is prevalent in pancreatic cancer patients, and treatment with pancreatic enzyme replacement therapy (PERT) can improve quality of life and survival. However, many patients do not currently receive PERT. The nutritional consequences of PEI are extensive, especially in the elderly due to age-related gastrointestinal and pancreatic changes.
Article
Oncology
Deepika Satish, I-Hsin Lin, James Flory, Hans Gerdes, Michael A. Postow, David M. Faleck
Summary: This study describes the incidence, risk factors, and clinical characteristics of immune checkpoint inhibitor-related exocrine pancreatic insufficiency (EPI). It found that immune checkpoint inhibitor-related EPI is a rare but clinically significant event, which should be considered in patients with late onset diarrhea after immune checkpoint inhibitor treatment and often is associated with the development of hyperglycemia and diabetes.
Article
Gastroenterology & Hepatology
Anam Khan, Santhi Swaroop Vege, Vikas Dudeja, Suresh T. Chari
Summary: Exocrine pancreatic insufficiency (EPI) is a condition of insufficient digestive capacity caused by severe loss of pancreatic exocrine function. By measuring parameters such as fecal elastase 1 (FE1), EPI can be classified into different stages, guiding the selection of appropriate treatments.
Review
Oncology
G. Roeyen, F. Berrevoet, I Borbath, K. Geboes, M. Peeters, B. Topal, E. Van Cutsem, J-L Van Laethem
Summary: Pancreatic exocrine insufficiency (PEI) is a common condition in patients with pancreatic cancer (PC). PERT treatment is widely used, but there is limited clinical evidence supporting its effectiveness. More research is needed to evaluate the efficacy of PERT in PC patients.
Article
Surgery
Maimoena S. S. Guman, Nienke van Olst, Zehra G. Yaman, Rogier P. Voermans, Maurits L. de Brauw, Max Nieuwdorp, Victor E. A. Gerdes
Summary: This study aimed to evaluate the clinical value of the Pancreatic Exocrine Insufficiency Questionnaire (PEI-Q) as a screening tool for PEI. The study found that PEI-Q cannot be used as a screening tool for PEI, and the specificity of the fecalelastase (FE) test seems to be reduced after surgery.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Gastroenterology & Hepatology
V. Hartman, E. Roeyen, B. Bracke, F. Huysentruyt, S. De Gendt, T. Chapelle, D. Ysebaert, B. Hendrikx, G. Roeyen
Summary: Background: Patients undergoing pancreatic surgery are at risk of pancreatic exocrine insufficiency (PEI) and needing pancreatic enzyme replacement therapy (PERT). This study aimed to evaluate the exocrine function and the need for PERT in patients undergoing pancreatic surgery for oncologic indications. The majority of patients undergoing pancreaticoduodenectomy for oncologic indications experience a significant drop in exocrine function and are at high risk of developing pancreatic exocrine insufficiency, necessitating treatment with pancreatic enzyme replacement therapy.
Article
Oncology
Caitlin Sok, Sameer Sandhu, Hardik Shah, Pranay S. Ajay, Maria C. Russell, Kenneth Cardona, Felipe Maegawa, Shishir K. Maithel, Juan Sarmiento, Subir Goyal, David A. Kooby, Mihir M. Shah
Summary: The study aimed to identify features on preoperative CT imaging that correlate with an increased risk of postoperative pancreatic fistula (POPF). The results showed that patients with a thick pancreatic neck and increased intra-abdominal girth have a heightened risk of CR-POPF after pancreatoduodenectomy, and they experience more serious postoperative complications.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Pediatrics
Isabelle Scheers, Silvia Berardis
Summary: Congenital exocrine pancreatic insufficiency is a rare condition often associated with cystic fibrosis and Shwachman-Bodian-Diamond syndrome. Treatment mainly involves pancreatic enzyme replacement and liposoluble vitamins supplementation.
FRONTIERS IN PEDIATRICS
(2022)
Review
Gastroenterology & Hepatology
Amanda Landers, Francis Donaldson, Helen Brown, Clare McKenzie, Sayali Pendharkar
Summary: This systematic literature review explores the impact of pancreatic enzyme replacement therapy (PERT) on patients with advanced pancreatic cancer. The study found that PERT has the potential to improve symptoms, nutrition, weight loss, and survival, but high-quality studies with standardized outcomes are lacking. Patient and health professional education is needed to increase awareness about the use of PERT in pancreatic cancer.
Review
Pediatrics
Yuhua Zheng, Shikib Mostamand
Summary: Exocrine pancreatic insufficiency (EPI) is characterized by pancreatic loss of exocrine function, leading to maldigestion and malabsorption of nutrients. If left undiagnosed, EPI can result in poor digestion, chronic diarrhea, severe malnutrition, and related complications. Early diagnosis of EPI is crucial for appropriate nutritional support and initiation of pancreatic enzyme replacement therapy (PERT) to improve patient outcomes. In this review, the evaluation of nutritional status and unique management in children with EPI will be discussed.
FRONTIERS IN PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Kota Uetsuki, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Tadashi Iida, Kenta Yamamoto, Kazuhiro Furukawa, Masanao Nakamura, Takashi Honda, Masatoshi Ishigami, Yoshiki Hirooka, Mitsuhiro Fujishiro
Summary: This study evaluated the potential of fasting breath hydrogen concentration (FBHC) measurement for the diagnosis of pancreatic exocrine insufficiency (PEI), and found a significant correlation between FBHC levels and PEI diagnosis. The cutoff value of FBHC was determined to be 10.7 ppm, showing sensitivity and specificity for PEI diagnosis.
BMC GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Daniel Vasile Balaban, Iulia Enache, Marina Ciochina, Alina Popp, Mariana Jinga
Summary: Celiac disease is a chronic autoimmune disease that primarily affects the intestines but can also impact the pancreas. While the endocrine changes in the pancreas, such as type 1 diabetes, have been extensively studied in relation to celiac disease, there has been less focus on the exocrine alterations. This review examines the available evidence on the risk of pancreatitis, autoimmune pancreatitis, prevalence and outcomes of exocrine insufficiency, and the link with cystic fibrosis in celiac disease patients. The mechanisms behind the associated exocrine impairment in celiac disease are also discussed, along with recommendations for clinical practice.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hong-Yuan Shi, Zi-Peng Lu, Ming-Na Li, Ying-Qian Ge, Kui-Rong Jiang, Qing Xu
Summary: Dual-energy CT-derived pancreatic parenchymal-to-portal venous phase IC ratio is an independent predictor for postoperative pancreatic fistula (POPF) and has a higher predictive performance compared with CT value ratio in the same phases. In addition, the IC ratio is associated with pancreatic fibrosis.
Article
Oncology
Darko Siuka, Kristina Kumer, Borut Stabuc, David Stubljar, David Drobne, Rado Jansa
Summary: This study found that abbreviating the C-13-MTGT test from 5 to 2.5 hours does not decrease its diagnostic accuracy for detecting pancreatic exocrine insufficiency in patients who have undergone subtotal or total gastrectomy for gastric cancer. This allows for significant time savings in diagnosing PEI in this subgroup of patients.
RADIOLOGY AND ONCOLOGY
(2022)
Article
Respiratory System
Takahiko Otsuki, Taku Nakashima, Hironobu Hamada, Yusuke Takayama, Shin Akita, Takeshi Masuda, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Yoshihiro Miyata, Masayuki Miyake, Nobuoki Kohno, Morihito Okada, Noboru Hattori
EUROPEAN RESPIRATORY JOURNAL
(2018)
Article
Cardiac & Cardiovascular Systems
Atsuhiro Senoo, Toshiro Kitagawa, Shinya Torimaki, Hideya Yamamoto, Kazuhiro Sentani, Shinya Takahashi, Yumiko Kubo, Wataru Yasui, Taijiro Sueda, Yasuki Kihara
Article
Peripheral Vascular Disease
Toshiro Kitagawa, Hideya Yamamoto, Takuya Hattori, Kazuhiro Sentani, Shinya Takahashi, Atsuhiro Senoo, Yumiko Kubo, Wataru Yasui, Taijiro Sueda, Yasuki Kihara
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2018)
Article
Chemistry, Analytical
Ahmed Ali, Yasmine Abouleila, Yoshihiro Shimizu, Eiso Hiyama, Tomonobu M. Watanabe, Toshio Yanagida, Arno Germond
ANALYTICAL CHEMISTRY
(2019)
Article
Oncology
Yasmine Abouleila, Kaoru Onidani, Ahmed Ali, Hirokazu Shoji, Takayuki Kawai, Chwee Teck Lim, Vipin Kumar, Shinobu Okaya, Ken Kato, Eiso Hiyama, Toshio Yanagida, Tsutomu Masujima, Yoshihiro Shimizu, Kazufumi Honda
Review
Pediatrics
Tomoro Hishiki, Shohei Honda, Yuichi Takama, Yukihiro Inomata, Hideaki Okajima, Ken Hoshino, Tatsuya Suzuki, Ryota Souzaki, Motoshi Wada, Mureo Kasahara, Koichi Mizuta, Takaharu Oue, Akiko Yokoi, Takuro Kazama, Shugo Komatsu, Isamu Saeki, Osamu Miyazaki, Tetsuya Takimoto, Kohmei Ida, Kenichiro Watanabe, Eiso Hiyama
Summary: The study involved using a real-time central surgical reviewing system to facilitate early referral of liver transplantation candidates, leading to prompt surgical decisions and procedures.
Article
Oncology
Takahiro Fukazawa, Keiji Tanimoto, Emi Yamaoka, Masato Kojima, Masami Kanawa, Nobuyuki Hirohashi, Eiso Hiyama
Summary: Hepatoblastoma (HBL) is a rare liver malignancy that occurs mainly in early childhood. Although treatment regimens have improved the prognosis, there are still refractory cases and the current treatment often leads to severe side effects. This study demonstrates that ADAM32, a protein involved in various cancer types, is highly expressed in HBL and is associated with poor prognosis. ADAM32 plays a role in cancer cell proliferation, stemness, migration, invasion, and chemotherapy resistance. This suggests that ADAM32 could be a promising target for therapy and provides insights into the molecular mechanisms of HBL carcinogenesis.
Article
Cell Biology
Yoko Hiyama, Emi Yamaoka, Takahiro Fukazawa, Masato Kojima, Yusuke Sotomaru, Eiso Hiyama
Summary: In this study, we investigated the association between the expression of DHRS3, NROB1, and CYP26A1 genes and the suppression of neuroblastoma cell growth. The overexpression of these genes led to a reduction in cell growth and induced morphological senescence, mainly through pathways related to cellular senescence and cell adhesion. DHRS3 and NROB1 also arrested the cell cycle and induced differentiation and senescence. These findings suggest that the induction of these genes could be a potential therapeutic strategy for suppressing high-risk neuroblastoma growth.
Article
Oncology
Angela D. Trobaugh-Lotrario, Rudolf Maibach, Daniel C. Aronson, Arun Rangaswami, Beate Haeberle, Allison F. O'Neill, Irene Schmid, Marc Ansari, Tomoro Hishiki, Sarangarajan Ranganathan, Rita Alaggio, Ronald R. de Krijger, Yukichi Tanaka, Soo-Jin Cho, Christian Vokuhl, Rebecca Maxwell, Mark Krailo, Eiso Hiyama, Piotr Czauderna, Milton Finegold, James H. Feusner, Marcio H. Malogolowkin, Rebecka L. Meyers, Dolores Lopez-Terrada
Summary: Hepatoblastoma is the most common malignant liver tumor in children, and small cell undifferentiated histology and low alpha-fetoprotein levels have been associated with poor prognosis. It is important to differentiate rhabdoid tumors from hepatoblastoma with small cell undifferentiated component or low alpha-fetoprotein levels, as the treatment differs significantly. When rhabdoid tumors are correctly diagnosed, neither the presence of small cell undifferentiated component nor low alpha-fetoprotein levels are associated with poor prognosis.
Article
Biology
Sungmin Yang, Kyungsik Ha, Woojeung Song, Masashi Fujita, Kirsten Kuebler, Paz Polak, Eiso Hiyama, Hidewaki Nakagawa, Hong-Gee Kim, Hwajin Lee
Summary: We have developed COOBoostR, a computational method that can predict the tissue or cell of origin for various types of cancer. COOBoostR uses regional somatic mutation density information and chromatin mark features in an extreme gradient boosting-based machine-learning algorithm. By ranking chromatin marks from different tissue and cell types, COOBoostR can determine the most likely tissue or cell of origin based on the somatic mutation density landscape of a sample.
Article
Pediatrics
Masumi Kawashima, Yuka Ueda, Sho Kurihara, Noriyuki Shiroma, Eiso Hiyama
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2019)
Meeting Abstract
Oncology
Hana K. P. Faisal, Emi Yamaoka, Yasushi Horimasu, Noboru Hattori, Eiso Hiyama
Meeting Abstract
Oncology
Ahmad Arfan, Hana K. P. Faisal, Emi Yamaoka, Eiso Hiyama
Meeting Abstract
Oncology
Hiroyuki Aburatani, Hidewaki Nakagawa, Eiso Hiyama
Meeting Abstract
Oncology
Shogo Yamamoto, Kenji Tatsuno, Genta Nagae, Masashi Fujita, Hidewaki Nakagawa, Eiso Hiyama, Hiroyuki Aburatani