Article
Gastroenterology & Hepatology
Amer Khan, Marcin Mostowy, Michael Owusu, Mercy Mutambanengwe, Sam Habimana, Somoskoi Bence, Antonio Facciorusso
Summary: A meta-analysis of randomized-controlled trials compared microwave ablation (MWA) and radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) treatment, finding similar outcomes in terms of complete response rate, survival rate, and disease-free survival rate. Adverse event rates were also comparable between the two treatments, with bleeding and hematoma as the most common complications.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Oncology
Antonio Facciorusso, Andrea Chierici, Ivan Cincione, Rodolfo Sacco, Daryl Ramai, Babu P. Mohan, Saurabh Chandan, Andrew Ofosu, Christian Cotsoglou
Summary: In HCC patients, SBRT extends recurrence-free survival compared to RFA, although no significant survival benefit was demonstrated.
EXPERT REVIEW OF ANTICANCER THERAPY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Adrian Kobe, Yanick Kindler, Ernst Klotz, Gilbert Puippe, Florian Messmer, Hatem Alkadhi, Thomas Pfammatter
Summary: This study aimed to evaluate the fusion of pre-RFA MR imaging with post-treatment P-CT for predicting local tumor recurrence after RFA of HCCs. The results showed that this method is highly accurate in determining treatment success by predicting local tumor recurrence.
INVESTIGATIVE RADIOLOGY
(2021)
Article
Oncology
Rui Chen, Beining Hou, Yanzhao Zhou, Tuo Zhang, Zhengzheng Wang, Xun Chen, Yingwei Zhang, Man Chen
Summary: This study aimed to observe the influencing factors of different recurrence patterns after radiofrequency ablation (RFA) for the treatment of hepatocellular carcinoma (HCC) recurrence. The medical records of HCC patients who underwent RFA were retrospectively reviewed. Each pattern of recurrence has different risk factors for recurrence, overall survival (OS), and disease-free survival (DFS).
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, General & Internal
Federica De Muzio, Carmen Cutolo, Federica Dell'Aversana, Francesca Grassi, Ludovica Ravo, Marilina Ferrante, Ginevra Danti, Federica Flammia, Igino Simonetti, Pierpaolo Palumbo, Federico Bruno, Luca Pierpaoli, Roberta Fusco, Andrea Giovagnoni, Vittorio Miele, Antonio Barile, Vincenza Granata
Summary: Tumour ablation is a treatment strategy for small hepatocellular carcinoma or patients who are not suitable for surgical resection. Radiofrequency ablation and microwave ablation are the most commonly used methods. However, these procedures may result in complications, including vascular and biliary complications. This review aims to summarize the ultrasound and CT findings after ablative treatment.
Review
Medicine, General & Internal
Vincenza Granata, Roberta Fusco, Federica De Muzio, Carmen Cutolo, Sergio Venanzio Setola, Igino Simonetti, Federica Dell'Aversana, Francesca Grassi, Federico Bruno, Andrea Belli, Renato Patrone, Vincenzo Pilone, Antonella Petrillo, Francesco Izzo
Summary: Liver tumors are one of the major applications of ablation treatment. Radiofrequency ablation (RFA) and microwave ablation (MWA) are the most commonly used techniques. It is important to carefully select patients and assess their risks to reduce the occurrence of complications. Radiologists should pay attention to various complications and evaluate their severity and timing according to well-defined classification systems.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Shoujin Cao, Tianshi Lyu, Zeyang Fan, Haitao Guan, Li Song, Xiaoqiang Tong, Jian Wang, Yinghua Zou
Summary: Recent studies have shown that percutaneous radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) in the periportal location is associated with a higher risk of local tumor progression (LTP). This study analyzed the long-term outcomes of RFA as the first-line therapy for single periportal HCC and compared them with nonperiportal HCC. The results demonstrated that the periportal group had higher rates of LTP and worse overall survival (OS) compared to the nonperiportal group. Periportal HCC was identified as an independent prognostic factor for tumor progression after RFA.
Article
Medicine, General & Internal
Joonho Jeong, Jung Gu Park, Kwang Ill Seo, Ji Hyun Ahn, Jae Chun Park, Byung Cheol Yun, Sang Uk Lee, Jin Wook Lee, Jong Hyouk Yun
Summary: This study aimed to investigate factors affecting tumor necrosis with TACE and evaluate factors associated with early hepatocellular carcinoma recurrence after curative hepatectomy. Microvascular invasion (MVI) was found to be the strongest factor influencing TACE-induced tumor necrosis and recurrence-free survival rate within 2 years. MVI could play a crucial role in determining TACE as an initial treatment for hepatocellular carcinoma and predicting recurrence after curative hepatic resection.
Article
Medicine, General & Internal
Leonardo Centonze, Riccardo De Carlis, Ivan Vella, Luca Carbonaro, Niccolo Incarbone, Livia Palmieri, Cristiano Sgrazzutti, Alberto Ficarelli, Maria Grazia Valsecchi, Umberto Dello Iacono, Andrea Lauterio, Davide Bernasconi, Angelo Vanzulli, Luciano De Carlis
Summary: This study investigates the correlation between LI-RADS classification and pathological characteristics of HCC, as well as the prognostic implications on patient survival. The results suggest that LR-5 class is associated with unfavorable pathological features, while other factors such as patient age, performance status, and liver disease severity also play significant roles in postoperative outcomes.
Article
Oncology
Eleonora Terzi, Alice Giamperoli, Massimo Iavarone, Simona Leoni, Ludovico De Bonis, Alessandro Granito, Antonella Forgione, Francesco Tovoli, Fabio Piscaglia
Summary: The European and American guidelines for the management of hepatocellular carcinoma (HCC) provide different recommendations for the management of nodules with indeterminate imaging. This study shows that HCC classified as LR-3 and LR-4 by the CEUS LI-RADS algorithm have no better clinical outcome than typical HCC. These findings support the EASL policy of conclusive diagnostic investigations to avoid leaving aggressive HCC untreated.
Article
Cardiac & Cardiovascular Systems
Sae-Jin Park, Dong Ho Lee, Joon Koo Han
Summary: The study found that using AA infusion can effectively reduce pain during RFA treatment for subcapsular hepatocellular carcinoma (HCC) patients. Especially for patients with HCC adjacent to the parietal peritoneum, AA infusion can significantly reduce the dose of opioid used for pain control.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Medicine, General & Internal
Lea Penzkofer, Jens Mittler, Stefan Heinrich, Nicolas Wachter, Beate K. Straub, Roman Kloeckner, Fabian Stoehr, Simon Johannes Gairing, Fabian Bartsch, Hauke Lang
Summary: Liver cirrhosis is a common risk factor for hepatocellular carcinoma (HCC), but a small percentage of HCC cases occur in non-cirrhotic livers. This study found that liver resection for non-cirrhotic HCC is an acceptable treatment approach with relatively good outcomes, even for extensive tumors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Xin-Fei Xu, Han Wu, Ju-Dong Li, Lan-Qing Yao, Bin Huang, Yong-Kang Diao, Ting-Hao Chen, Wei-Min Gu, Zhong Chen, Jie Li, Yao-Ming Zhang, Hong Wang, Ying-Jian Liang, Ya-Hao Zhou, Chao Li, Ming-Da Wang, Cheng-Wu Zhang, Timothy M. Pawlik, Wan Yee Lau, Feng Shen, Tian Yang
Summary: This study found that the prognosis of solitary huge hepatocellular carcinoma (HCC) is associated with tumor morphology, with patients having balloon-shaped HCC (BS-HCC) showing better long-term survival after liver resection. This finding helps guide the treatment strategy for patients with solitary huge HCC.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Article
Oncology
Cyprien Toubert, Boris Guiu, Bader Al Taweel, Eric Assenat, Fabrizio Panaro, Francois-Regis Souche, Jose Ursic-Bedoya, Francis Navarro, Astrid Herrero
Summary: Surgical resection is the optimal treatment for hepatocellular carcinoma (HCC), but recurrence is common. This retrospective study analyzed survival after HCC recurrence following liver resection. The time and type of recurrence treatment were found to be major prognostic factors. However, overall survival did not significantly differ between patients who experienced recurrence and those who did not after receiving curative treatment.
Review
Oncology
Antonio Facciorusso, Nicola Tartaglia, Rosanna Villani, Gaetano Serviddio, Daryl Ramai, Babu P. Mohan, Saurabh Chandan, Mohamed A. Abd El Aziz, Jessica Evangelista, Christian Cotsoglou, Antonio Ambrosi
Summary: In comparing lenvatinib and sorafenib as first-line treatments for advanced hepatocellular carcinoma patients, lenvatinib showed a significant improvement in progression-free survival, objective response rate, and disease control rate. However, there was no significant difference in overall survival between the two treatments and the rate of severe adverse events was similar.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Review
Oncology
Burcu Sengez, Brian Carr, Hani Alotaibi
Summary: This article focuses on the association between EMT and inflammation in the context of HCC progression. EMT and inflammation are closely correlated with tumor aggressiveness and poor outcomes, and cellular heterogeneity is a common result. Identifying EMT-related biomarkers and understanding EMT regulatory molecules will contribute to promising developments in clinical practice and can be used for predicting metastasis.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Article
Surgery
Veysel Ersan, Sertac Usta, Cemalettin Aydin, Brian Carr, Sinan Karatoprak, Sezai Yilmaz
Summary: This study retrospectively examined the outcomes of non-transplant surgical approaches in patients with Bismuth-Corlette (BC) type IV perihilar cholangiocarcinoma (pCCA). The results showed that patients who underwent hepatectomy and had negative lymph nodes achieved the best survival rates. However, achieving high survival rates remains challenging in this patient population.
ACTA CHIRURGICA BELGICA
(2023)
Review
Nutrition & Dietetics
Michele Barone, Andrea Iannone, Fernanda Cristofori, Vanessa Nadia Dargenio, Flavia Indrio, Elvira Verduci, Alfredo Di Leo, Ruggiero Francavilla
Summary: Most celiac patients have a normal BMI at presentation, and a gluten-free diet does not increase the risk of overweight or obesity, especially in children.
Review
Nutrition & Dietetics
Michele Barone, Alfredo Di Leo, Marian A. E. de van der Schueren
Summary: Malnutrition is an important prognostic factor for survival in ALS patients. The GLIM criteria are used to define malnutrition and include parameters such as unintentional weight loss, low BMI, reduced muscle mass, decreased food intake, and inflammation. However, the reliability of muscle mass assessment is affected by muscle atrophy, and hypermetabolism in some patients can complicate energy requirement calculation.
Article
Medicine, General & Internal
Giuseppe Losurdo, Natale Lino Bruno Caccavo, Giuseppe Indellicati, Francesca Celiberto, Enzo Ierardi, Michele Barone, Alfredo Di Leo
Summary: Long-term use of proton pump inhibitors (PPIs) may affect the absorption of micronutrients, particularly vitamin B12, calcium, and vitamin D. A study found that long-term use of pantoprazole, a PPI, was associated with lower red blood cell count but similar hemoglobin levels. There were no significant differences in blood iron, ferritin, vitamin B12, and folate levels; however, vitamin D deficiency was more common in PPI users, with lower blood levels of vitamin D. Furthermore, PPI users had lower phosphate levels and a non-significant trend for zinc deficiency.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Oncology
Luca Giacomelli, Rodolfo Sacco, Simonetta Papa, Brian I. Carr
Review
Biochemistry & Molecular Biology
Giuseppe Losurdo, Daniele Angelillo, Nicolas Favia, Maria Chiara Sergi, Alfredo Di Leo, Giacomo Triggiano, Marco Tucci
Summary: Immunotherapy with immune checkpoint inhibitors (ICIs) is effective for solid tumors, but can cause side effects such as colitis. The severity of ICI enterocolitis is graded using the CTCAE system. Treatment for mild cases includes supportive therapy and for low-grade diarrhea includes symptomatic treatment and dietary changes. Severe cases may require corticosteroid treatment, and refractory cases may benefit from biological therapies.
Article
Nutrition & Dietetics
Rossella Donghia, Pasqua Letizia Pesole, Antonino Castellaneta, Sergio Coletta, Francesco Squeo, Caterina Bonfiglio, Giovanni De Pergola, Roberta Rinaldi, Sara De Nucci, Gianluigi Giannelli, Alfredo Di Leo, Rossella Tatoli
Summary: This study aimed to investigate the association between food intake and liver disease, and evaluate the differences in blood parameters among different age groups and steatosic condition. The results showed significant variations in both dietary habits and blood parameters between adult and elderly groups.
Article
Nutrition & Dietetics
Calogero Claudio Tedesco, Caterina Bonfiglio, Maria Notarnicola, Maria Rendina, Antonino Castellaneta, Alfredo Di Leo, Gianluigi Giannelli, Luigi Fontana
Summary: The study suggests that high consumption of extra virgin olive oil (EVOO) is associated with a reduced risk of non-alcoholic fatty liver disease (NAFLD). This effect is amplified in overweight and obese individuals.
Article
Nutrition & Dietetics
Michele Linsalata, Giuseppe Riezzo, Antonella Orlando, Benedetta D'Attoma, Laura Prospero, Antonia Ignazzi, Giuseppe Losurdo, Alfredo Di Leo, Gianluigi Giannelli, Francesco Russo
Summary: The relationship between overweight/obesity and irritable bowel syndrome (IBS) is unclear, but a modified intestinal barrier may play a significant role in the development of both conditions. Dietary interventions, such as a Low FODMAP Diet, are essential for managing overweight IBS-D.
Article
Microbiology
Michele Barone, Andrea Iannone, Martino Mezzapesa, Michele Milella, Francesco Di Gennaro, Grazia Niro, Rosa Cotugno, Raffaele Cozzolongo, Giuseppe Mennea, Maria Rendina, Alfredo Di Leo
Summary: This study evaluated spontaneous HBsAg seroclearance and its associated factors and disease progression in HBeAg-negative patients with inactive infection in South Italy for the first time. The study found that patients with HBsAg levels <100 IU/mL had the highest probability of HBsAg seroclearance.
Article
Oncology
Brian I. I. Carr, Vito Guerra
Summary: Multiple serum parameters were evaluated to determine their relationship with survival in patients with hepatocellular carcinoma. The combination of serum albumin plus GGT levels was found to be the most prognostically useful among the inflammation parameters that were tested.
Article
Medicine, General & Internal
Fatih Ozdemir, Volkan Ince, Sertac Usta, Brian I. I. Carr, Harika G. G. Bag, Ayse Nur Akatli, Aysegul Sagir Kahraman, Sezai Yilmaz
Summary: This study reviewed and compared the prognostic impact and clinicopathologic features of incidental hepatocellular carcinoma (iHCC) patients and hepatocellular carcinoma diagnosed before liver transplantation (pdHCC) patients. The results showed that iHCC patients had better histopathologic features and survival rates with lower tumor recurrence compared to pdHCC patients.
MEDICINA-LITHUANIA
(2023)