Article
Radiology, Nuclear Medicine & Medical Imaging
Jie Chen, Alina M. Allen, Terry M. Therneau, Jun Chen, Jiahui Li, Safa Hoodeshenas, Jingbiao Chen, Xin Lu, Zheng Zhu, Sudhakar K. Venkatesh, Bin Song, Richard L. Ehman, Meng Yin
Summary: A retrospective study on 256 patients with NAFLD showed that PDFF had high diagnostic accuracy in distinguishing hepatic steatosis grades, but there was no significant relationship between liver stiffness measurement and proton density fat fraction.
EUROPEAN RADIOLOGY
(2022)
Article
Biochemical Research Methods
Kyohei Okubo, Yuichi Kitagawa, Naoki Hosokawa, Masakazu Umezawa, Masao Kamimura, Tomonori Kamiya, Naoko Ohtani, Kohei Soga
Summary: The study demonstrated the use of near-infrared hyperspectral imaging for quantitatively visualizing lipid content in mouse liver, offering a non-invasive method for diagnosing fatty liver. The results show that support vector regression with standard normal variate pretreatment outperforms partial least squares regression in terms of accuracy and performance.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sangkeun Song, Hokun Kim, Joon-Il Choi, Dong Hwan Kim, Bohyun Kim, Hyunsoo Lee, Jiwon Lee
Summary: This retrospective study evaluated the validity of an automated screening Dixon (e-DIXON) technique for quantifying hepatic steatosis in living liver-donor patients. The results showed that the e-DIXON technique had good sensitivity and negative predictive value for diagnosing hepatic steatosis, but may not be accurate for detecting hepatic iron deposition.
ABDOMINAL RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Martin Burian, Milan Hajek, Petr Sedivy, Irena Mikova, Pavel Trunecka, Monika Dezortova
Summary: This study utilized H-1 MRS to measure hepatic fat content and fatty acid composition in liver transplant recipients, finding that HFC can effectively differentiate different types of fatty liver diseases. It was observed that relative hepatic lipid saturation increases with higher HFC, while unsaturation decreases.
Article
Cardiac & Cardiovascular Systems
Laura D'Erasmo, Michele Di Martino, Thomas Neufeld, Tyler J. Fraum, Chul Joo Kang, Kendall H. Burks, Alessia Di Costanzo, Ilenia Minicocci, Simone Bini, Marianna Maranghi, Giovanni Pigna, Giancarlo Labbadia, Jie Zheng, Davide Fierro, Anna Montali, Fabrizio Ceci, Carlo Catalano, Nicholas O. Davidson, Giuseppe Lucisano, Antonio Nicolucci, Marcello Arca, Nathan O. Stitziel
Summary: The study recruited participants with ANGPTL3 deficiency related to gene mutations as well as those with genetically determined reduction in plasma ANGPTL3 levels, showing that these conditions are not associated with increased risk of hepatic steatosis.
Article
Gastroenterology & Hepatology
Remi Collin, Benoit Magnin, Constance Gaillard, Carine Nicolas, Armand Abergel, Benjamin Buchard
Summary: This study evaluated new ultrasonographic tools for detecting and measuring hepatic steatosis. The results showed that HRI had the best performance and was also the simplest and most available method.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Young Choi, Seung Soo Lee, Na Young Kim, Hyo Jung Park, Yu Sub Sung, Yedaun Lee, Jee Seok Yoon, Heung-Il Suk
Summary: This study aimed to evaluate the impact of hepatic steatosis (HS) on liver volume and develop a formula to estimate lean liver volume after correcting for the effect of HS. The results showed that HS was positively associated with liver volume and a formula was proposed to estimate PDFF-adjusted lean liver volume, which can be used to account for the effect of HS on liver volume.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Lea Hitpass, Iakovos Amygdalos, Paul Sieben, Vanessa Raaff, Sven Lang, Philipp Bruners, Christiane K. Kuhl, Alexandra Barabasch
Summary: Elevated hepatic fat fraction (hFF) in pre-procedural MRI does not correlate with hypertrophy rate after portal vein embolization (PVE) in patients with colorectal cancer liver metastases (CRCLM) and should not be used as a contraindication to the procedure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeong Woo Kim, Chang Hee Lee, Zepa Yang, Baek-Hui Kim, Young-Sun Lee, Kyeong Ah Kim
Summary: This study compared the correlation between hepatic fat fraction measured by magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) with two different histopathologic methods. The results demonstrated a strong correlation between MRI-PDFF and MRS, as well as with the histopathologic measurements. The diagnostic performance of MRI-PDFF and MRS for grading hepatic steatosis was also evaluated, showing promising results.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yunjung Choi, Dong Kyun Kim, Seo Yeon Youn, Hokun Kim, Joon-Il Choi
Summary: This study aimed to determine the diagnostic performance and establish the reference range of low-kVp unenhanced CT for assessing hepatic steatosis in liver transplantation donors using MR spectroscopy as a reference standard. The results showed that low-kVp unenhanced CT was negatively correlated with the degree of hepatic steatosis, and it is an effective technique with reduced radiation exposure for diagnosing moderate to severe hepatic steatosis.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Review
Biochemistry & Molecular Biology
Ayhan Gursan, Jeanine J. Prompers
Summary: The liver is crucial for glucose homeostasis and MRI and MRS techniques provide unique insights into liver glucose metabolism in both healthy individuals and those with metabolic diseases such as diabetes.
Article
Nutrition & Dietetics
Jinwang Li, Siyu Xie, Wendi Teng
Summary: Sulforaphane (SFA) has the potential to improve lipid metabolism, inhibit lipid accumulation and apoptosis, making it a potential candidate for preventing and treating nonalcoholic fatty liver disease (NAFLD).
Article
Radiology, Nuclear Medicine & Medical Imaging
Riccardo De Robertis, Flavio Spoto, Daniele Autelitano, Daniela Guagenti, Antonia Olivieri, Piero Zanutto, Greta Incarbone, Mirko D'Onofrio
Summary: This study compared the efficacy of ultrasound (US) and US-derived fat fraction (UDFF) with magnetic resonance proton density fat fraction (MRI-PDFF) in detecting hepatic steatosis and quantifying liver fat content. The results showed that UDFF can reliably quantify liver fat content and improve the diagnostic value of US for detecting hepatic steatosis.
Article
Medicine, General & Internal
Li-Shan Shen, Quan-Xi Li, Xiao-Wen Luo, Hui-Jun Tang, You-Jie Tang, Wen-Jie Tang, Ruo-Mi Guo
Summary: Using magnetic resonance imaging-determined proton density fat fraction (PDFF), there is a high correlation between liver fat content and hepatic perfusion disorders (HPD) after radiofrequency ablation (RFA) for liver cancer. Higher liver fat content increases the risk of hyperperfusion abnormalities, but has little impact on hypoperfusion abnormalities.
Article
Radiology, Nuclear Medicine & Medical Imaging
Owen T. T. Carmichael, Maninder Singh, Adil Bashir, Anne M. M. Russell, Mark Bolding, David T. T. Redden, Judd Storrs, William R. R. Willoughby, Candace Howard-Claudio, Daniel S. S. Hsia, Robert P. P. Kimberly, Meagan E. E. Gray, Eric Ravussin, Thomas S. S. Denney
Summary: The goal of this study was to harmonize 3T magnetic resonance imaging measurements in obese individuals across different academic sites and MRI vendors. The results showed high repeatability of the measurements of liver fat and stiffness in both humans and phantoms. This study demonstrates that multisite MRI harmonization could improve the assessment of interventions and therapy for NAFLD in multisite clinical trials.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Gastroenterology & Hepatology
Hou-Ying Cheng, Cheng-Maw Ho, Chih-Yang Hsiao, Ming-Chih Ho, Yao-Ming Wu, Po-Huang Lee, Rey-Heng Hu
Summary: This study investigated the changes in transplantability between primary and recurrent Hepato-cellular carcinoma (HCC) after hepatic resection (HR) and identified risk factors for nontransplantable recurrence (NTR). The study found that tumor diameter, resection extent, pathological grade, microvascular invasion, and early recurrence were associated with NTR. The overall transplantable pool increased after HR, suggesting that liver transplantation may not be necessary for some patients.
Article
Gastroenterology & Hepatology
Ping-Jui Yu, Cheng-Maw Ho, Chih-Yang Hsiao, Yao-Ming Wu, Ming-Chih Ho, Po-Huang Lee, Rey-Heng Hu
Summary: Primary sclerosing cholangitis (PSC) is a rare disease in Asia and little research has been conducted on this ethnic group, especially in wait-listed patients for liver transplantation (LT). This study aimed to investigate the prognosis and outcomes of wait-listed patients with PSC in an Asian transplant center. The results showed that female PSC patients had higher AST to platelet ratio index scores and bilirubin levels compared to males, and were more likely to present with decompensating events. Female gender and LT were identified as protective factors for overall survival in multivariable analysis.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Yu-Chen Wang, Tiffany Ting -Fang Shih, Chih-Wei Yu, Yunn-Jy Chen
Summary: This study used kinematic magnetic resonance imaging to explore the mandibular condylar movements in patients with TMJ disorders. The results showed a significant correlation between condylar translation and rotation in all TMJs, regardless of the disc status.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Letter
Gastroenterology & Hepatology
Chien-Hui Wu, Kao-Lang Liu, Po-Chin Liang, Tzu-Pin Lu, Ting-Chun Kuo, Yu-Wen Tien
Review
Gastroenterology & Hepatology
Shiou-Hwei Yeh, Chiao-Ling Li, You-Yu Lin, Ming-Chih Ho, Ya-Chun Wang, Sheng-Tai Tseng, Pei-Jer Chen
Summary: Mechanistic studies of HBV integration-induced insertional mutagenesis have revealed the importance of monitoring residual HCC after therapy or the development of de novo recurrence. HBV integration provides valuable biomarkers for HCC diagnosis and treatment.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Surgery
Hao-Yun Liu, Tzu-Hsin Lin, Ke-Cheng Chen, Wei-Ling Hsiao, Rey-Heng Hu, Hsien-Chi Liao
Summary: This study aimed to evaluate the outcomes of non-surgical and surgical treatments in major trauma patients without brain injuries. The results showed that the surgical group had significantly improved pain scores and shorter hospital stays compared to the non-surgical group. Therefore, surgical management of rib fractures can have positive effects on pain and hospital stay in major trauma patients.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Hou-Ying Cheng, Rey-Heng Hu, Chih-Yang Hsiao, Ming-Chih Ho, Yao-Ming Wu, Po-Huang Lee, Cheng-Maw Ho
Summary: This retrospective study analyzed 726 patients who experienced intrahepatic recurrence after primary hepatectomy for hepatocellular carcinoma (HCC). The results showed that both radiofrequency ablation (RFA) and transarterial chemoembolization (TACE) were effective in improving long-term survival, particularly in patients with hepatitis B virus (HBV). Antiviral treatment complemented the survival of patients with hepatitis C virus (HCV) after RFA, especially in late first recurrence.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Po-Ting Chen, Tiffany Ting Fang Shih
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Medicine, General & Internal
Wen-Jie Liu, Wern-Cherng Cheng, Yun-Yuan Chen, Chun-Min Kang, Jen-Wei Chen, Ming-Chih Ho, Shyh-Chyi Lo
Summary: Perioperative fresh frozen plasma transfusion is associated with poorer short-term outcomes, including postoperative bacterial infection and extended length of stay, in hepatocellular carcinoma patients undergoing liver resection. Reducing perioperative fresh frozen plasma transfusions may improve postoperative outcomes.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Oncology
Chih-Horng Wu, Ming-Chih Ho, Chien-Hung Chen, Ja-Der Liang, Kai-Wen Huang, Mei-Fang Cheng, Chih-Kai Chang, Chia-Hung Chang, Po-Chin Liang
Summary: CT-assessed sarcopenia defined using the psoas muscle (PM) is an independent prognostic factor for the poorer prognosis of unresectable hepatocellular carcinoma (HCC) after radioembolization.
Article
Oncology
Chiao-Ling Li, Chia-Lang Hsu, You-Yu Lin, Ming-Chih Ho, Chi-Ling Chen, Tung-Ching Ho, Yung-Feng Lin, Shih-Feng Tsai, Sheng-Tai Tzeng, Chin-Fang Huang, Ya-Chun Wang, Shiou-Hwei Yeh, Pei-Jer Chen
Summary: This study developed a simple and robust genetic classification for HBV-HCC, which divided it into 4 groups: G1 with HBV-TERT integration (25.5%); G2 with HBV-MLL4 integration (10.5%); G3 with TERT promoter mutation (30.1%); and G4 without these three mutations (34.0%). G3 had the highest male-to-female ratio and cirrhosis rate, and was associated with higher early recurrence and mortality after resection, while G4 had the best outcome.
Article
Medical Informatics
Rakesh Kumar Patnaik, Yu-Chen Lin, Ming Chih Ho, J. Andrew Yeh
Summary: Breath profiling is a non-invasive technique to identify biomarkers for various diseases. This study aimed to identify potential stable biomarkers in exhaled breath during different physiological states, including rest and brief workouts, to develop a non-invasive diagnostic tool for detecting abnormal liver function. Gas chromatography and mass-spectrometer quantified dataset was used for analysis, and machine learning techniques were employed for feature selection and model training.
HEALTH AND TECHNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ling-Kai Chang, Shun-Mao Yang, Wen-Yuan Chung, Lun-Che Chen, Hao-Chun Chang, Ming-Chih Ho, Yeun-Chung Chang, Chong-Jen Yu
Summary: This study reviewed patients who underwent image-guided percutaneous MWA for lung nodules in the HOR. The workflow in the HOR, including pre-procedure preparation, anesthesia considerations, operation methods, and postoperative care, was clearly described.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bang-Bin Chen, Po-Chin Liang, Tiffany Ting-Fang Shih, Tsung-Hao Liu, Ying-Chun Shen, Li-Chun Lu, Zhong-Zhe Lin, Chiun Hsu, Chih-Hung Hsu, Ann-Lii Cheng, Yu-Yun Shao
Summary: Sarcopenia and myosteatosis are independent prognostic factors in patients who received immunotherapy for advanced HCC.
EUROPEAN RADIOLOGY
(2023)