Review
Nutrition & Dietetics
Bara Aljada, Ahmed Zohni, Wael El-Matary
Summary: The gluten-free diet is popular for treating immune-mediated disorders caused by gluten, but it has disadvantages like high costs, nutritional deficiencies, and social and psychological barriers. Close follow-up with patients following the diet is recommended, and more data is needed to assess its effectiveness in managing mental and cognitive disorders.
Review
Nutrition & Dietetics
Aner Cardo, Itziar Churruca, Arrate Lasa, Virginia Navarro, Maialen Vazquez-Polo, Gesala Perez-Junkera, Idoia Larretxi
Summary: Celiac disease (CD) is an autoimmune disorder of the small intestine that requires a gluten-free diet (GFD) for effective treatment. Nutritional imbalances may occur in adults with CD following GFD, but deficiencies can improve as intestinal mucosa recovers over time. Monitoring nutrient intake, especially plant proteins and essential nutrients, is important to prevent nutritional deficiencies in the long term.
Article
Nutrition & Dietetics
Alberto Raiteri, Alessandro Granito, Chiara Faggiano, Alice Giamperoli, Teresa Catenaro, Giulia Negrini, Francesco Tovoli
Summary: The dietary habits of celiac disease (CD) patients adhering to a gluten-free diet (GFD) are correlated with the risk of nonalcoholic fatty liver disease (NAFLD). A questionnaire-based study found that specific patterns of packaged gluten-free food consumption are significantly associated with NAFLD. The information obtained through this study can be used in clinical practice for personalized treatment and further research.
Article
Nutrition & Dietetics
Vincenza Lombardo, Alice Scricciolo, Andrea Costantino, Luca Elli, Giorgia Legnani, Angel Cebolla, Luisa Doneda, Federica Mascaretti, Maurizio Vecchi, Leda Roncoroni
Summary: The aim of this study was to evaluate the clinical efficacy of urinary gluten immunogenic peptides (uGIP) in the follow-up of celiac disease (CD). The results showed that uGIP test can accurately assess the adherence to gluten-free diet and correlated significantly with duodenal biopsy results.
Review
Nutrition & Dietetics
Veronica Segura, Angela Ruiz-Carnicer, Carolina Sousa, Maria de Lourdes Moreno
Summary: The only current treatment for celiac disease is a strict gluten-free diet, but there is a need for non-dietary alternatives to prevent damage from dietary transgressions. Recent therapies for CD focus on degrading gluten, regulating the immune response, and inducing immunological tolerance, with promising results seen in some phase III and II clinical trials.
Article
Gastroenterology & Hepatology
Antonio Francavilla, Giulio Ferrero, Barbara Pardini, Sonia Tarallo, Laura Zanatto, Gian Paolo Caviglia, Sabina Sieri, Sara Grioni, Giulia Francescato, Francesco Stalla, Cristina Guiotto, Lucia Crocella, Marco Astegiano, Mauro Bruno, Pier Luigi Calvo, Paolo Vineis, Davide Giuseppe Ribaldone, Alessio Naccarati
Summary: Current treatment for celiac disease is adhering to a gluten-free diet, but its long-term molecular effects are still unknown. This study explored fecal small non-coding RNAs and gut microbiome profiles in celiac disease subjects and found altered miRNA and microbial profiles in treated celiac disease subjects.
Review
Nutrition & Dietetics
Rafael Martin-Masot, Maria Jimenez-Munoz, Marta Herrador-Lopez, Victor Manuel Navas-Lopez, Elia Obis, Mariona Jove, Reinald Pamplona, Teresa Nestares
Summary: Celiac disease is a complex disease caused by the interaction of genetic and environmental factors, and currently there are no effective biomarkers for early diagnosis. The cellular effects of a gluten-free diet, the only treatment available, are not well understood. Metabolomics studies are significant in unraveling the complexities of multifactorial and multisystemic disorders, and can provide insights into disease occurrence and treatment impact.
Article
Nutrition & Dietetics
Rafael Martin-Masot, Maria Jimenez-Munoz, Marta Herrador-Lopez, Marta Flor-Alemany, Victor Manuel Navas-Lopez, Teresa Nestares
Summary: This study aims to assess the importance of early follow-up for celiac patients, identify the role of stool gluten immunogenic peptides (GIPs) in assessing diet adherence, and analyze nutritional imbalances or deficiencies in the gluten-free diet (GFD). The results highlight the importance of early follow-up for celiac patients and the potential use of stool GIPs in monitoring adherence to the GFD.
Review
Nutrition & Dietetics
Roxana Nemteanu, Andreea Clim, Corina Elena Hincu, Liliana Gheorghe, Irina Ciortescu, Anca Trifan, Alina Plesa
Summary: Potential celiac disease (PCD) is a condition where there is positive celiac serology and HLA DQ2 or DQ8 heterodimers, but no villous atrophy on duodenal biopsies. PCD accounts for one fifth of all celiac disease diagnoses. Adult patients with PCD generally have lower rates of nutrient deficiencies and extraintestinal symptoms compared to celiac disease patients. Recommending a gluten-free diet (GFD) to symptomatic PCD patients provides significant clinical improvement, but the implementation of GFD for asymptomatic PCD is still debated. Further research is needed to determine the potential progression of PCD to overt celiac disease and the benefits of early GFD implementation.
Article
Nutrition & Dietetics
Zsofia Vereczkei, Timea Dergez, Zsuzsanna Fodor, Zsolt Szakacs, Judit Bajor
Summary: This retrospective cohort study aimed to investigate factors associated with baseline and follow-up BMI in celiac disease (CD) patients. The study found that males had higher mean BMI compared to females at diagnosis and during follow-up, and non-classical CD patients had higher mean BMI at diagnosis and long-term follow-up than classical patients.
Article
Nutrition & Dietetics
Teresa Nestares, Rafael Martin-Masot, Carlos de Teresa, Rocio Bonillo, Jose Maldonado, Marta Flor-Alemany, Virginia A. Aparicio
Summary: The study found that adherence to the Mediterranean Diet has a positive impact on bone health in young patients with celiac disease, while physical activity is associated with lean mass and bone density. Therefore, correctly monitoring dietary habits and physical activity levels in children with CD is crucial for improving their lean mass and bone quality.
Article
Gastroenterology & Hepatology
Valeriia Dotsenko, Mikko Oittinen, Juha Taavela, Alina Popp, Markku Peraaho, Synnove Staff, Jani Sarin, Francisco Leon, Jorma Isola, Markku Maki, Keijo Viiri
Summary: Gluten challenge studies showed that even on a strict gluten-free diet, celiac disease patients exhibit patterns of ongoing disease, with changes in gene expression and mucosal morphology. A regression model using four gene transcripts described the extent of gluten-induced duodenal mucosal injury with high accuracy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Raphael Enaud, Candice Tetard, Raphael Dupuis, David Laharie, Thierry Lamireau, Frank Zerbib, Pauline Riviere, Sarah Shili-Mismoudi, Florian Poullenot
Summary: This study investigated the factors associated with better quality of life in a large cohort of CD patients, finding that long-term adherence to a gluten-free diet and regular follow-up visits were key factors for improved quality of life.
Article
Gastroenterology & Hepatology
Gopal Veeraraghavan, Amelie Therrien, Maya Degroote, Allison McKeown, Paul D. Mitchell, Jocelyn A. Silvester, Daniel A. Leffler, Alan M. Leichtner, Ciaran P. Kelly, Dascha C. Weir
Summary: This study found a high incidence of non-responsive celiac disease (NRCD) in children and adolescents, with most patients being female. Initial symptoms of constipation and/or abdominal pain may be predictors of NRCD. The main causes of NRCD after a gluten-free diet (GFD) were gluten exposure and constipation.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mariana Verdelho Machado
Summary: Celiac disease (CD) is a common autoimmune disease, affecting approximately 1% of the population. Regardless of symptoms, all CD patients must adhere to a lifelong gluten-free diet (GFD). However, this can be challenging due to a lack of gluten awareness in foods and the widespread use of gluten in processed foods. Research has been conducted to find pharmacological treatment for CD, but achieving full histological recovery on a GFD remains difficult.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Gastroenterology & Hepatology
Jonathan P. Segal, Benjamin H. Mullish, Mohammed Nabil Quraishi, Tariq H. Iqbal
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Gastroenterology & Hepatology
Jonathan M. Rhodes, Sreedhar Subramanian, Paul K. Flanagan, Graham W. Horgan, Kate Martin, John Mansfield, Miles Parkes, Ailsa Hart, Helen Dallal, Tariq Iqbal, Jeffrey Butterworth, Kate Culshaw, Christopher Probert
Summary: The study assessed the efficacy and safety of an antibiotic/hydroxychloroquine combination for Crohn's disease, finding overall results to be unimpressive but showing long-term remission in some patients, warranting further study.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Gianluca Ianiro, Benjamin H. Mullish, Colleen R. Kelly, Zain Kassam, Ed J. Kuijper, Siew C. Ng, Tariq H. Iqbal, Jessica R. Allegretti, Stefano Bibbo, Harry Sokol, Faming Zhang, Monika Fischer, Samuel Paul Costello, Josbert J. Keller, Luca Masucci, Joffrey van Prehn, Gianluca Quaranta, Mohammed Nabil Quraishi, Jonathan Segal, Dina Kao, Reetta Satokari, Maurizio Sanguinetti, Herbert Tilg, Antonio Gasbarrini, Giovanni Cammarota
Letter
Gastroenterology & Hepatology
Christopher A. Green, Mohammed N. Quraishi, Sahida Shabir, Naveen Sharma, Richard Hansen, Daniel R. Gaya, Ailsa L. Hart, Nicholas J. Loman, Tariq H. Iqbal
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2020)
Editorial Material
Gastroenterology & Hepatology
Mohammed Nabil Quraishi, Tariq H. Iqbal, Ailsa L. Hart
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Gastroenterology & Hepatology
James L. Alexander, Gordon W. Moran, Daniel R. Gaya, Tim Raine, Ailsa Hart, Nicholas A. Kennedy, James O. Lindsay, Jonathan MacDonald, Jonathan P. Segal, Shaji Sebastian, Christian P. Selinger, Miles Parkes, Philip J. Smith, Anjan Dhar, Sreedhar Subramanian, Ramesh Arasaradnam, Christopher A. Lamb, Tariq Ahmad, Charlie W. Lees, Liz Dobson, Ruth Wakeman, Tariq H. Iqbal, Ian Arnott, Nick Powell
Summary: SARS-CoV-2 vaccination in patients with IBD is supported due to anticipated low risks, despite some concerns that protective immune responses may be diminished in certain patients. Further research is needed to address vaccine hesitancy, the impact of immunosuppression, and the search for predictive biomarkers of vaccine success.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Letter
Pediatrics
Richard Hansen, Mona Bajaj-Elliott, Georgina L. Hold, Konstantinos Gerasimidis, Tariq H. Iqbal, Gregory Amos, Linda Thomas, Julian R. Marchesi
ARCHIVES OF DISEASE IN CHILDHOOD
(2021)
Article
Gastroenterology & Hepatology
Georgiana Emmanuela Gilca-Blanariu, Gabriela Stefanescu, Irina Girleanu, Tariq Iqbal, Jonathan Segal, Benjamin Mullish, Mohammed Nabil Quraishi, Josbert Keller, Tamas Molnar, Francis Megraud, Dan Dumitrascu, Mircea Manuc, Luminita Smaranda Iancu, Cristina Marica, Cristian Gheorghe, Susan Manzoor, Anca Trifan
Summary: Fecal microbiota transplantation involves transferring intestinal microorganisms from a healthy individual to a diseased individual in order to restore normal gut flora. Currently, the only well-supported indication for fecal transplants is for refractory recurrent Clostridioides difficile infection. Regulations regarding fecal transplants vary among different countries, and Romania lacks a national guideline, necessitating the development of a national guideline for fecal microbiota transplantation.
JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
(2021)
Article
Gastroenterology & Hepatology
Lucy Hocking, Gianluca Ianiro, Rupert W. Leong, Tariq Iqbal, Dina Kao, Mark Cabling, Stephanie Stockwell, Robert J. Romanelli, Sonja Marjanovic
Summary: This study explores the key components of faecal microbiota transplantation (FMT) provision for recurrent Clostridioides difficile infection (CDI) and highlights the challenges and improvement opportunities in healthcare capacity, donors and donations, patient access, regulation, costs, and reimbursement. The findings emphasize the importance of building appropriate FMT capacity to effectively bring FMT to patients in healthcare systems.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Gianluca Ianiro, Benjamin H. Mullish, Christian Lodberg Hvas, Jonathan P. Segal, Ed J. Kuijper, Samuel P. Costello, Colleen R. Kelly, Jessica R. Allegretti, Monika Fischer, Tariq H. Iqbal, Reetta Satokari, Dina Kao, Joffrey van Prehn, Siew C. Ng, Stefano Bibbo, Simon Mark Dahl Baunwall, Mohammed N. Quraishi, Harry Sokol, Faming Zhang, Josbert Keller, Luca Masucci, Gianluca Quaranta, Zain Kassam, Maurizio Sanguinetti, Herbert Tilg, Antonio Gasbarrini, Giovanni Cammarota
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Benjamin H. Mullish, Mohammed Nabil Quraishi, Jonathan P. Segal, Gianluca Ianiro, Tariq H. Iqbal
Summary: In recent years, there has been a rapid growth in interest in the gut microbiome, especially in its potential contribution to gastrointestinal and liver diseases. This field holds the potential for novel diagnostics and therapeutics, but there are still many uncertainties and areas of debate due to its nascent nature.
FRONTLINE GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Nicholas A. Kennedy, Richard Hansen, Lisa Younge, Joel Mawdsley, R. Mark Beattie, Shahida Din, Christopher A. Lamb, Philip J. Smith, Christian Selinger, Jimmy Limdi, Tariq H. Iqbal, Alan Lobo, Rachel Cooney, Oliver Brain, Daniel R. Gaya, Charles Murray, Richard Pollok, Alexandra Kent, Tim Raine, Neeraj Bhala, James O. Lindsay, Peter M. Irving, Charlie W. Lees, Shaji Sebastian
FRONTLINE GASTROENTEROLOGY
(2020)
Review
Gastroenterology & Hepatology
Jonathan P. Segal, Benjamin H. Mullish, Mohammed N. Quraishi, Tariq Iqbal, Julian R. Marchesi, Harry Sokol
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2020)
Review
Medicine, General & Internal
Morris Gordon, Vassiliki Sinopoulou, Zipporah Iheozor-Ejiofor, Tariq Iqbal, Patrick Allen, Sami Hoque, Jaina Engineer, Anthony K. Akobeng
Summary: Inflammatory bowel disease affects approximately seven million people globally, with up to 90% of patients experiencing iron deficiency anaemia. The optimal treatment for this common systemic manifestation remains unclear among physicians. Studies evaluating the efficacy and safety of different interventions have yielded conflicting results, indicating the need for further research in this area.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Medicine, General & Internal
V. L. McCune, M. N. Quraishi, S. Manzoor, C. E. Moran, K. Banavathi, H. Steed, D. C. O. Massey, G. R. Trafford, T. H. Iqbal, P. M. Hawkey