期刊
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
卷 27, 期 7, 页码 1150-1158出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1440-1746.2012.07109.x
关键词
cholestatic; itch; liver; pruritus
资金
- Hellenic Association for the Study of the Liver
Patients with cholestatic liver diseases such as primary biliary cirrhosis, primary sclerosing cholangitis and intrahepatic cholestasis of pregnancy commonly complain of pruritus. The underlying pathogenesis remains obscure with several mediators possibly playing an important role; these include lysophosphatidic acid, bile salts, opioids, histamine and progesterone metabolites. We describe in this review novel insights into the pathogenesis and management of pruritus in patients with cholestasis.
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