Article
Agriculture, Dairy & Animal Science
Wan Xie, Yang Xue, Xiaokun Song, Hongzhu Zhang, Guangjun Chang, Xiangzhen Shen
Summary: This study found that LPS activates TLR4 and inhibits FOXA2 expression, leading to NF-kappa B-mediated inflammation, ER stress, autophagy, and apoptosis. Inhibiting TLR4 and increasing FOXA2 expression can alleviate LPS-induced inflammation, ER stress, autophagy, and apoptosis, maintaining cellular homeostasis.
JOURNAL OF DAIRY SCIENCE
(2023)
Review
Oncology
Tania Ray, Terry Ryusaki, Partha S. Ray
Summary: Metastasis is a major cause of cancer-related mortality, highlighting the need for early prediction and targeted therapeutic strategies. Prognostic biomarkers and underlying molecular mechanisms play a crucial role in predicting cancer recurrence and metastasis, emphasizing the importance of identifying novel biomarkers for personalized treatment approaches.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Yanina Bogliotti, Mark Vander Roest, Aras N. Mattis, Robert G. Gish, Gary Peltz, Robin Anwyl, Salah Kivlighn, Eric R. Schuur
Summary: Liver disease is a major cause of global mortality, with late-stage liver disease being characterized by hepatocyte injury, inflammation, and aberrant tissue healing. Treatment options for liver disease are limited, but cell replacement therapy using hepatocyte-like cells shows promise as a safe and effective treatment option.
Article
Dentistry, Oral Surgery & Medicine
A. Jin, Y. Hong, Y. Yang, H. Xu, X. Huang, X. Gao, X. Gong, Q. Dai, L. Jiang
Summary: The high prevalence of malocclusion and dentofacial malformations has led to an increasing demand for orthodontic treatments. The mechanism of mechanical force-induced alveolar bone remodeling during orthodontic tooth movement (OTM) is critical, with bone mesenchymal stem cells (BMSCs) playing a crucial role in bone remodeling. FOXO3 has been identified as a key factor in mediating mechanical force-induced osteogenesis during OTM, promoting osteoblastic differentiation and enhancing osteogenesis. Inhibiting FOXO3 delays OTM by impairing bone formation, while knockdown of FOXO3 inhibits the mechanical force-induced osteoblastic differentiation of BMSCs.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Arezou Khosrojerdi, Sara Soudi, Ahmad Zavaran Hosseini, Sahar Ghaffari Khaligh, Seyed Mahmoud Hashemi
Summary: This study investigated the effect of different treatments on systemic and local inflammation in a mouse model of sepsis. MSC-derived exosomes combined with imipenem controlled inflammation and increased TCD4+ and Treg cell populations. Hepatocyte-derived exosomes combined with imipenem reduced liver inflammation and increased TCD8+ and Treg cell populations. The mixture of exosomes combined with imipenem showed the best function in reducing inflammation, maintaining all T lymphocyte populations, reducing liver damage, and increasing survival rate.
Review
Oncology
Shaojie Yang, Liwei Pang, Wanlin Dai, Shuodong Wu, Tengqi Ren, Yunlong Duan, Yuting Zheng, Shiyuan Bi, Xiaolin Zhang, Jing Kong
Summary: Hepatocellular carcinoma (HCC) is associated with high morbidity and mortality, with surgical resection being the main treatment. Foxo proteins play crucial roles in HCC and are considered multifunctional targets for cancer treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aysegul Ors, Alex Daniel Chitsazan, Aaron Reid Doe, Ryan M. Mulqueen, Cigdem Ak, Yahong Wen, Syber Haverlack, Mithila Handu, Spandana Naldiga, Joshua C. Saldivar, Hisham Mohammed
Summary: This study systematically tracked the response of breast cancer cells to estrogen at a single-cell level and uncovered the non-uniform nature of gene expression response. Different cell groups were found to express distinct transcriptional networks and have different chromatin accessibility states.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Medicine, Research & Experimental
Xiao-Fei Zhang, Ting Wang, Zi-Xuan Wang, Kun-Peng Huang, Yun-Wei Zhang, Guo-Liang Wang, Hong-Ji Zhang, Zi-Han Chen, Chang-Yan Wang, Jin-Xiang Zhang, Hui Wang
Summary: In a hypoxic microenvironment, ucMSCs enhance endothelial cell proliferation and migration through exosome-mediated paracrine function, accelerating wound healing. miR-125b in hypoxic exosomes targets and suppresses TP53INP1, alleviating hypoxia-induced cell apoptosis and promoting cutaneous repair.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Laetitia Herman, Berangere Legois, Anne-Laure Todeschini, Reiner A. Veitia
Summary: FOXL2 and ESR2 play key transcriptional roles in ovarian granulosa cells, with FOXL2 activating genes enriched in H3K27ac marks and capable of activating transcription through binding to enhancer sites. Depletion of either Foxl2 or Esr2 in granulosa cells leads to decreased migration, invasion, and adhesion, potentially through modulation of common targets involved in cell motility.
Review
Oncology
Peyman Tabnak, Aysa Hasanzade Bashkandi, Mohammad Ebrahimnezhad, Mahdieh Soleimani
Summary: This review discusses the roles of transcription factors FOXOs and FOXM1 in gliomas, including their interactions with other proteins and microRNAs in regulatory networks, as well as their significance in glioma progression.
CANCER CELL INTERNATIONAL
(2023)
Article
Engineering, Biomedical
Kevin Collon, Jennifer A. Bell, Stephanie W. Chang, Matthew C. Gallo, Osamu Sugiyama, Carolyn Marks, Jay R. Lieberman
Summary: This study compared different cell seeding techniques in transduced cell-based gene therapy. Static and negative pressure seeding techniques showed the highest seeding efficiency, while orbital shaking resulted in the greatest increase in BMP-2 production per cell. Low density cell suspensions were associated with the highest seeding efficiency, cell distribution uniformity, and the greatest increase in BMP-2 production after seeding.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Cell & Tissue Engineering
Hiroyuki Suzuki, Takayasu Ohtake, Toshitaka Tsukiyama, Marie Morota, Kunihiro Ishioka, Hidekazu Moriya, Yasuhiro Mochida, Sumi Hidaka, Tsutomu Sato, Takayuki Asahara, Shuzo Kobayashi
Summary: This case involved a 36-year-old male patient with severe AKI who underwent autologous granulocyte colony-stimulating factor-mobilized peripheral blood CD34-positive cell transplantation. After the intervention, the patient's serum creatinine levels improved significantly and no major adverse events were observed, making it the first case in a phase I/II clinical trial with a dose-escalating protocol.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Lucia Pena-Perez, Shabnam Kharazi, Nicolai Frengen, Aleksandra Krstic, Thibault Bouderlique, Julia Hauenstein, Minghui He, Ece Somuncular, Xiaoze Li Wang, Carin Dahlberg, Charlotte Gustafsson, Ann-Sofie Johansson, Julian Walfridsson, Nadir Kadri, Petter Woll, Marcin Kierczak, Hong Qian, Lisa Westerberg, Sidinh Luc, Robert Mansson
Summary: The study reveals the crucial roles of FOXO3 and FOXO1 in B cell development. Loss of FOXO3 impairs B cell development, while loss of FOXO1 hinders B cell commitment. Simultaneous loss of FOXO1 and FOXO3 results in the complete loss of the B cell lineage.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Hayeong Jeong, Chanbin Lee, Min Jae Lee, Youngmi Jung
Summary: Chronic liver disease is a common global disease, particularly prevalent among adults aged 40-60. Liver transplantation, while considered effective, is limited by donor availability and potential side effects. Impaired liver regeneration can also lead to liver failure. Further research on liver regeneration and therapeutic strategies is needed.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Mousaei Ghasroldasht, Jin Seok, Hang-Soo Park, Farzana Begum Liakath Ali, Ayman Al-Hendy
Summary: Regenerative medicine is a promising therapeutic mode using stem cells for the treatment of challenging human diseases. Stem cells have pleotropic therapeutic potential through inflammation or apoptosis inhibition, cell recruitment, angiogenesis stimulation, and differentiation. This review provides an overview of the translation process from idea to clinical practice, including guidelines for clinical trial approval and a review of regenerative medicine clinical trials registered on the Clinicaltrials.gov website.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Hyang Heun Lee, Hee Jun Lee, Hak Jun Kim, Jun Hyuck Lee, Yong Ko, Sun Mie Kim, Jung Ryeol Lee, Chang Suk Suh, Seok Hyun Kim
HUMAN REPRODUCTION
(2015)
Article
Engineering, Biomedical
Min Ho Kim, Wen Hao Wu, Jee Hyun Choi, Ji Hyun Kim, Seok-Ho Hong, Jin Hyun Jun, Yong Ko, Jong Hun Lee
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2018)
Article
Cell Biology
Min Ho Kim, Wen Hao Wu, Jee Hyun Choi, Jihyun Kim, Jin Hyun Jun, Yong Ko, Jong Hun Lee
WOUND REPAIR AND REGENERATION
(2018)
Article
Cell & Tissue Engineering
Hong J. Lee, In J. Lim, Seung W. Park, Yun B. Kim, Yong Ko, Seung U. Kim
CELL TRANSPLANTATION
(2012)
Article
Biochemistry & Molecular Biology
Won Kon Kim, Hye-Ryung Choi, Sung Goo Park, Yong Ko, Kwang-Hee Bae, Sang Chul Lee
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2012)
Article
Genetics & Heredity
Jeong Yoon, Kyoung-Mi Juhn, Jin-Kyung Ko, San-Hyun Yoon, Yong Ko, Chul-Young Lee, Jin-Ho Lim
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2013)
Article
Biochemistry & Molecular Biology
Young Sun Jeong, Jung Sun Park, Yong Ko, Yong-Kook Kang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Andrology
Seong-Ho Yang, San-Hyun Yoon, Jae-Noon Jung, Jin-Ho Lim, Yong Ko
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2019)
Article
Cell Biology
Jeong Yoon, Kyoung-Mi Juhn, Eun-Hye Jung, Hye-Jeong Park, San-Hyun Yoon, Yong Ko, Chang-Young Hur, Jin-Ho Lim
Article
Obstetrics & Gynecology
Seong-Ho Yang, Yong-Soo Hur, San-Hyun Yoon, Jae-Hoon Jung, Jin-Ho Lim, Yong Ko
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2020)
Article
Surgery
Min Ho Kim, Changho Chung, Mun Ho Oh, Jin Hyun Jun, Yong Ko, Jong Hun Lee
Summary: PVC-3D-EV significantly improved wound contraction, myofibroblast activation, collagen deposition, and angiogenesis, indicating its pivotal role in regulating granulation tissue formation, angiogenesis, and wound contraction in healing of a rat skin wound. The 3D-culture system using a polystyrene scaffold is shown to provide better physiological conditions than the 2D-culture system, and EVs from PVC cultured in 3D could be a promising option for healing skin wounds.
AESTHETIC PLASTIC SURGERY
(2021)
Article
Chemistry, Multidisciplinary
DongHyun Shon, SeJun Park, SukJun Yoon, Yong Ko
Summary: This study investigated the developmental characteristics and classification of adipocytes using Fourier transform infrared (FTIR) spectroscopy. The results showed differences in secretory protein profiles and lipid amounts between white and brown adipocytes. Additionally, the study explored the possibility of using FTIR spectroscopy as a non-tagging cell sorting system.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Se-Jun Park, Dong-Hyun Shon, Jae-Hyun Kim, Yang-Hwan Ryu, Yong Ko
Summary: SAMM50 plays a key role in regulating thermogenesis of brown/beige adipocytes by modulating mitochondrial dynamics. Inhibition of SAMM50 suppresses the expression of thermogenic genes, while overexpression promotes their expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Jeong Yoon, Kyoung-Mi Juhn, San-Hyun Yoon, Yong Ko, Jin-Ho Lim
CLINICAL AND EXPERIMENTAL REPRODUCTIVE MEDICINE-CERM
(2017)