Article
Biochemistry & Molecular Biology
Ziqiang Xia, Juzeng Zheng, Liang Zheng, Endian Zheng, Zhuolin Zou, Xiong Sheng, Jinming Wu
Summary: The prevalence of dyslipidemia in China is increasing annually, and research shows that dyslipidemia can impact HBeAg seroconversion in CHB patients receiving nucleoside analogues treatment, but does not affect virological response.
LIPIDS IN HEALTH AND DISEASE
(2021)
Review
Chemistry, Medicinal
Georgia-Myrto Prifti, Dimitrios Moianos, Erofili Giannakopoulou, Vasiliki Pardali, John E. Tavis, Grigoris Zoidis
Summary: Hepatitis B virus infection has a significant global impact, with limitations in current antiviral drugs. Recent research on the viral replication cycle has led to the development of novel therapeutic approaches, providing hope for achieving a functional cure of the infection in the future.
Article
Virology
Yuki Takamatsu, Sanae Hayashi, Hiroki Kumamoto, Shuhei Imoto, Yasuhito Tanaka, Hiroaki Mitsuya, Nobuyo Higashi-Kuwata
Summary: This study investigated the effects of chronic HBV infection on cellular senescence in human hepatocytes and humanized-liver chimeric mice. The results showed that HBV infection perturbed multiple senescence-associated markers in both human hepatocytes and humanized-mice liver, while treatment with the anti-HBV drug E-CFCP restored this phenomenon.
Article
Virology
Mengyang Zhang, Shuyan Chen, Xiaoning Wu, Jialing Zhou, Tailing Wang, Hui Liu, Xinyan Zhao, Bingqiong Wang, Xinyu Zhao, Yuanyuan Kong, Gwyneth Shook Ting Soon, Xiaojuan Ou, Jidong Jia, Wei Chen, Yameng Sun, Hong You
Summary: This study aimed to investigate the impact of antiviral therapy on steatosis and fibrosis in patients with chronic hepatitis B. The study found that persistent steatosis was associated with decreased fibrosis regression. Patients with persistent steatosis showed unique changes in serum proteomics and glycolipid metabolism.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Zhanqing Zhang, Wei Lu, Dong Zeng, Dan Huang, Weijia Lin, Li Yan, Yanling Feng
Summary: Quantitative HBsAg is more valuable than HBV DNA in predicting significant hepatitis activity of HBeAg-positive chronic HBV infection, with higher sensitivity and specificity levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Virology
Maryam Moini, Scott Fung
Summary: Despite the availability of vaccines and antiviral therapy, chronic hepatitis B remains a global health threat. The functional cure of HBV is rare and the current antiviral therapy has limited efficacy. Exciting developments in novel antiviral agents may improve the cure rate, but further research is needed. Improved detection methods and combination therapies are important for achieving a functional cure.
Article
Gastroenterology & Hepatology
Hye-Lin Kim, Gi-Ae Kim, Jae-A Park, Hye-Rim Kang, Eui-Kyung Lee, Young-Suk Lim
Summary: This study found that starting antiviral therapy in the immune-tolerant phase is more cost-effective compared with delaying treatment until the active hepatitis phase in CHB patients, especially with increasing hepatocellular carcinoma risk, decreasing drug costs, and consideration of productivity loss.
Article
Chemistry, Medicinal
Hyung Joon Yim, Ji Hoon Kim, Yong Kyun Cho, Young Oh Kweon, Hyun Chin Cho, Jae Seok Hwang, Changhyeong Lee, Moon Soo Koh, Yang-Hyun Baek, Young-Min Park, Jeong-Hoon Lee, Seung Up Kim, Min-Kyu Kang, Neung Hwa Park, June Sung Lee, Young Eun Chon, Gab Jin Cheon, Hee Bok Chae, Joo Hyun Sohn, Young-Suk Lim
Summary: The study evaluated the antiviral effects and safety of switching from TDF to TD treatment in patients with chronic hepatitis B. TD was non-inferior to TDF in maintaining viral suppression in CHB patients, with less impact on renal function.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Immunology
Jun Li, Xiao-Qin Dong, Li-Hua Cao, Zhan-Qing Zhang, Wei-Feng Zhao, Qing-Hua Shang, Da-Zhi Zhang, An-Lin Ma, Qing Xie, Hong-Lian Gui, Guo Zhang, Ying-Xia Liu, Jia Shang, Shi-Bin Xie, Yi-Qi Liu, Chi Zhang, Gui-Qiang Wang, Hong Zhao
Summary: This study investigated the factors associated with persistent viremia in patients with chronic hepatitis B receiving long-term antiviral therapy, and found that baseline HBV DNA level, Anti-HBc level, and HBeAg seropositivity were associated with persistent viremia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Lilian Yan Liang, Vincent Wai-Sun Wong, Grace Lai-Hung Wong, Terry Cheuk-Fung Yip
Summary: Functional cure of chronic hepatitis B virus (HBV) infection is the treatment goal of new HBV therapies, defined as clearance of hepatitis B surface antigen (HBsAg), with or without anti-HBs seroconversion, and undetectable serum HBV DNA. Studies have shown that achieving functional cure generally leads to a favorable clinical course, with reduced risk of hepatic events and hepatocellular carcinoma (HCC). However, there is still a low yet definite risk of HCC occurrence, especially in male patients who achieve functional cure after 50 years of age.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tao Li, Yan Liang, Meng Zhang, Feng Liu, Lixin Zhang, Baohua Yang, Lei Wang
Summary: The study aimed to evaluate the effects of consolidation therapy after discontinuation of nucleoside/nucleotide analogs (NAs) in HBeAg positive chronic hepatitis B (CHB) patients. Results showed that long-term consolidation therapy is generally safe and feasible in these patients, with a preference for a three-year consolidation period in clinical practice.
HEPATOLOGY RESEARCH
(2021)
Review
Immunology
Lu Zhang, Tingting Jiang, Ying Yang, Wen Deng, Huihui Lu, Shiyu Wang, Ruyu Liu, Min Chang, Shuling Wu, Yuanjiao Gao, Hongxiao Hao, Ge Shen, Mengjiao Xu, Xiaoxue Chen, Leiping Hu, Liu Yang, Xiaoyue Bi, Yanjie Lin, Yao Lu, Yuyong Jiang, Minghui Li, Yao Xie
Summary: In order to develop immune tolerance to the fetus, the maternal immune system undergoes modifications before and during pregnancy. Both innate and adaptive immunity play important roles in immune tolerance, with natural killer cells, macrophages, dendritic cells, and regulatory T cells being key players. Various factors such as trophoblast cells, indoleamine 2,3-dioxygenase, HLA-G, and cytokine shifting contribute to maternal fetal immune tolerance. Postpartum hepatitis in chronic HBV infection women is influenced by hormonal changes, immune dysregulation, and HBV-specific T cell responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Julien Marlet, Clement Lier, Emmanuelle Roch, Alain Moreau, Benjamin Combe, Lynda Handala, Sandrine Lefeuvre, Morgan Maugey, Laure Elkrief, Louis D'Alteroche, Pascal Potier, Denys Brand, Catherine Gaudy-Graffin
Summary: The study found that treatment failure with entecavir does not necessarily require resistance mutations in the entire HBV genome; certain mutations may also be selected before or during treatment and contribute to treatment failure through mechanisms other than increased resistance.
ANTIVIRAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Guang Huan Shen, Joon Hee Hong
Summary: This review focuses on the synthesis of cyclic 5'-deoxynucleoside phosphonate analogs, discussing various methods for the formation of different alkyl moieties and the coupling of nucleobases with cyclic moieties. The biological activity of these analogs is summarized.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Gastroenterology & Hepatology
Yang Wang, Qiqi Li, Cheng Li, Cong Wang, Shijie Wang, Wenjie Yuan, Demin Yu, Ke Zhang, Bisheng Shi, Xiaomei Chen, Tiantian Liu, Zhenghong Yuan, Shuping Tong, Michael Nassal, Yu-Mei Wen, Yong-Xiang Wang
Summary: We developed multiple CARs targeting HBV envelope proteins and investigated their effects on HBsAg secretion and HBV infection using various cell culture models and HBV mouse models. We found that these CARs could block HBV infection and virion secretion, and G12-CARs could also inhibit HBsAg secretion. In HBV mouse models, G12-CAR-Fc strongly suppressed serum HBsAg levels.
Article
Biochemistry & Molecular Biology
Lung-Yi Mak, Wai-Kay Seto, Ching-Lung Lai, Man-Fung Yuen
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2018)
Article
Gastroenterology & Hepatology
Wai-Kay Seto, Thomas Sau-Yan Chan, Yu-Yan Hwang, Danny Ka-Ho Wong, James Fung, Kevin Sze-Hang Liu, Harinder Gill, Yuk-Fai Lam, Eric H. Y. Lau, Ka-Shing Cheung, Albert K. W. Lie, Ching-Lung Lai, Yok-Lam Kwong, Man-Fung Yuen
Article
Gastroenterology & Hepatology
An-Ye Zhang, Ching-Lung Lai, Fung-Yu Huang, Wai-Kay Seto, James Fung, Danny Ka-Ho Wong, Man-Fung Yuen
JOURNAL OF GASTROENTEROLOGY
(2017)
Article
Gastroenterology & Hepatology
Henry Lik-Yuen Chan, Owen Tak-Yin Tsang, Yee-Tak Hui, James Fung, Grace Chung-Yan Lui, Ching-Lung Lai, Grace Lai-Hung Wong, Kam-Hon Chan, David Yiu-Kuen But, Moon-Sing Lai, Wai-Cheung Lao, Carmen Ka-Man Chan, Yip-Shun Lam, Wai-Kay Seto, Carlton Li, Man-Fung Yuen, Vincent Wai-Sun Wong
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2017)
Article
Gastroenterology & Hepatology
Ching-Lung Lai, Danny Wong, Philip Ip, Malgorzata Kopaniszen, Wai-Kay Seto, James Fung, Fung-Yu Huang, Brian Lee, Giuseppe Cullaro, Chun Kong Chong, Ringo Wu, Charles Cheng, John Yuen, Vincent Ngai, Man-Fung Yuen
JOURNAL OF HEPATOLOGY
(2017)
Article
Gastroenterology & Hepatology
R. W. H. Hui, W. -K. Seto, K. -S. Cheung, L. -Y. Mak, K. S. H. Liu, J. Fung, D. K. -H. Wong, C. -L. Lai, M. -F. Yuen
JOURNAL OF VIRAL HEPATITIS
(2018)
Article
Gastroenterology & Hepatology
Wai-Kay Seto, Rex W. H. Hui, Lung-Yi Mak, James Fung, Ka-Shing Cheung, Kevin S. H. Liu, Danny Ka-Ho Wong, Ching-Lung Lai, Man-Fung Yuen
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Lung-Yi Mak, Wai-Kay Seto, Ching-Lung Lai, Man-Fung Yuen
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2018)
Article
Gastroenterology & Hepatology
James Fung, Ka-Shing Cheung, Danny Ka-Ho Wong, Lung-Yi Mak, Wai-Pan To, Wai-Kay Seto, Ching-Lung Lai, Man-Fung Yuen
Article
Gastroenterology & Hepatology
Zobair M. Younossi, Maria Stepanova, Linda Henry, Kwang-Hyub Han, Sang Hoon Ahn, Young-Suk Lim, Wan-Long Chuang, Jia-Horng Kao, Kinh V. Nguyen, Ching Lung Lai, Henry Lik-Yuen Chan, Lai Wei
JOURNAL OF VIRAL HEPATITIS
(2018)
Article
Gastroenterology & Hepatology
Zobair M. Younossi, Maria Stepanova, Linda Henry, Kwang-Hyub Han, Sang Hoon Ahn, Young-Suk Lim, Wan-Long Chuang, Jia-Horng Kao, Nguyen Kinh, Ching Lung Lai, Man-Fung Yuen, Henry Lik-Yuen Chan, Wei Lai
LIVER INTERNATIONAL
(2018)
Article
Gastroenterology & Hepatology
Lung-Yi Mak, Danny Ka-Ho Wong, Ka-Shing Cheung, Wai-Kay Seto, Ching-Lung Lai, Man-Fung Yuen
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2018)
Article
Medicine, General & Internal
Man-Fung Yuen, Ding-Shinn Chen, Geoffrey M. Dusheiko, Harry L. A. Janssen, Daryl T. Y. Lau, Stephen A. Locarnini, Marion G. Peters, Ching-Lung Lai
NATURE REVIEWS DISEASE PRIMERS
(2018)
Article
Urology & Nephrology
Michel Jadoul, Marina C. Berenguer, Wahid Doss, Fabrizio Fabrizi, Jacques Izopet, Vivekanand Jha, Nassim Kamar, Bertram L. Kasiske, Ching-Lung Lai, Jose M. Morales, Priti R. Patel, Stanislas Po, Marcelo O. Silva, Ethan M. Balk, Craig E. Gordon, Amy Earley, Mengyang Di, Paul Martin
KIDNEY INTERNATIONAL
(2018)
Review
Gastroenterology & Hepatology
L. -Y. Mak, D. K. -H. Wong, K. -S. Cheung, W. -K. Seto, C. -L. Lai, M. -F. Yuen
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2018)