Editorial Material
Biochemistry & Molecular Biology
Gautham Yepuri, Alexander Shekhtman, Ann Marie Schmidt, Ravichandran Ramasamy
Summary: Excessive accumulation of heme in the bloodstream can lead to vascular dysfunction, inflammation, and thrombosis. Studies have found that heme is a ligand for RAGE, playing a crucial role in RAGE activation and leading to pro-inflammatory and procoagulant effects in the lungs. This discovery sheds light on the potential pathogenic role of heme-RAGE interaction in hemolytic diseases.
Article
Medicine, Research & Experimental
Katherine D. Wick, Lianne Siegel, James D. Neaton, Cathryn Oldmixon, Jens Lundgren, Robin L. Dewar, H. Clifford Lane, B. Taylor Thompson, Michael A. Matthay
Summary: Elevated plasma sRAGE in hospitalized, nonventilated patients with COVID-19 was associated with both clinical illness severity and plasma viral load. The highest quartile of plasma sRAGE was associated with a lower likelihood of sustained recovery and a higher unadjusted risk of death.
Article
Biochemistry & Molecular Biology
D. Recabarren-Leiva, C. F. Burgos, B. Hernandez, F. J. Garcia-Garcia, R. Castro, L. Guzman, E. Fuentes, I Palomo, M. Alarcon
Summary: The study revealed that RAGE expression is higher and more inducible in platelets from elderly individuals, indicating its potential significance in cardiovascular disease treatment for the elderly.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Immunology
Olga Tatsiy, Vanessa de Carvalho Oliveira, Hugo Tshivuadi Mosha, Patrick P. McDonald
Summary: Neutrophil extracellular trap (NET) formation is important in response against pathogens, with early events regulated by different signaling pathways and late events including chromatin decondensation. Factors like elastase and RAGE have varying effects on NET formation, and conditions like unstimulated neutrophils being poised for rapid NET induction are discovered. Understanding these cellular processes can offer new therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Minkyung Kim, Youngki Lee, Minhyung Lee
Summary: Ischemic stroke is caused by reduced blood flow to the brain. RAGE is overexpressed in hypoxic cells of the ischemic brain. RBP-Exo was developed as a carrier for delivering anti-microRNA oligonucleotide to the brain and showed neuroprotective effects in an ischemic stroke model.
Review
Biochemistry & Molecular Biology
Matthew Snelson, Elisa Lucut, Melinda T. Coughlan
Summary: There is increasing evidence for the role of intestinal permeability in the pathogenesis of diabetes, and the binding of advanced glycation endproducts to RAGE receptor may trigger proinflammatory signaling cascade, leading to intestinal inflammation and increased permeability, thus contributing to the development of diabetes complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Rufaida Wasim, Tarique Mahmood, Mohd Haris Siddiqui, Farogh Ahsan, Arshiya Shamim, Aditya Singh, Mohammad Shariq, Saba Parveen
Summary: Among various pathophysiological cascades, Advanced Glycation End products (AGEs) play a crucial role in the pathogenesis and progression of cardiovascular disorders, causing oxidative stress and inflammation in myocardial and vascular tissues. Nutrition is a major exogenous source of AGEs, while their accumulation affects the structure and function of cardiac cells, leading to microvascular and macrovascular issues in the heart.
Review
Medicine, General & Internal
Niki L. Reynaert, Lowie E. G. W. Vanfleteren, Timothy N. Perkins
Summary: Chronic obstructive pulmonary disease (COPD) is a disease of the airways and lungs caused by enhanced inflammatory response and commonly associated with smoking. Patients with COPD often have multiple chronic inflammatory conditions, which increases disease burden and complicates management. The receptor for advanced glycation end products (RAGE) drives chronic inflammation, while advanced glycation end products (AGEs) contribute to further inflammation and oxidative stress in COPD and comorbidities. Understanding the mechanisms of RAGE signaling and AGE accumulation is crucial in studying the pathophysiology of these diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Kensei Taguchi, Kei Fukami
Summary: Diabetes, a leading cause of death worldwide, is expected to affect 642 million people by 2040. The concept of diabetic kidney disease (DKD) is widely accepted due to the increasing number of diabetes patients with multiple underlying diseases. Receptor for advanced glycation endproducts (RAGE), a multiligand receptor, is upregulated in patients with diabetes, hypertension, obesity, and chronic inflammation, and can be a therapeutic target for inhibiting the progression of DKD and its complications.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Samiya Al-Robaiy, Alexander Navarrete Santos, Andreas Simm
Summary: Methylglyoxal (MG) is a reactive compound associated with aging and degenerative diseases. The effect of long-term oral administration of MG on lung function was studied in mice. MG was taken up in the circulation and efficiently excreted, but had little effect on lung function in the short term. Only after long-term treatment, MG secretion was reduced, leading to tissue impairment.
Review
Neurosciences
Judyta Juranek, Konark Mukherjee, Bernard Kordas, Michal Zalecki, Agnieszka Korytko, Kamila Zglejc-Waszak, Jaroslaw Szuszkiewicz, Marta Banach
Summary: This review discusses the role of RAGE in the nervous system and highlights the incomplete understanding of this signaling pathway. While some clinical trials have not shown the expected therapeutic efficacy, there is still hope for treating nervous system diseases through the use of different blocking agents.
NEUROSCIENCE BULLETIN
(2022)
Article
Endocrinology & Metabolism
Sherman S. Leung, Danielle J. Borg, Domenica A. McCarthy, Tamar E. Boursalian, Justen Cracraft, Aowen Zhuang, Amelia K. Fotheringham, Nicole Flemming, Thomas Watkins, John J. Miles, Per-Henrik Groop, Jean L. Scheijen, Casper G. Schalkwijk, Raymond J. Steptoe, Kristen J. Radford, Mikael Knip, Josephine M. Forbes
Summary: This study highlights the potential of sRAGE as an attractive treatment for preventing diabetes. The research showed efficacy and reproducibility of sRAGE at multiple research centers and in human T cells. The study found that sRAGE increased regulatory T cells and improved pancreatic islet function, providing protection against diabetes.
Article
Immunology
Katherine N. Killian, Jessica L. Kosanovich, Madeline A. Lipp, Kerry M. Empey, Tim D. Oury, Timothy N. Perkins
Summary: This study evaluated the effects of genetic ablation of RAGE and pharmacological inhibition of the NLRP3 inflammasome on neutrophilic airway inflammation using a mouse model. The results showed that both RAGE ablation and NLRP3 inhibition significantly reduced neutrophilic airway inflammation. The study also found that RAGE expression promoted sustained neutrophil accumulation in response to AA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Forrest Jessop, Benjamin Schwarz, Dana Scott, Lydia M. Roberts, Eric Bohrnsen, John R. Hoidal, Catharine M. Bosio
Summary: The study defines the cellular and molecular events leading to lung injury following SARS-CoV-2 infection and identifies the receptor for advanced glycation end products (RAGE) as a therapeutic target for improving outcomes. Targeting RAGE with the antagonist FPS-ZM1 improves survival, reduces inflammation, and mitigates associated vascular pathology.
Article
Food Science & Technology
Hee-Weon Lee, Min Ji Gu, Jee-Young Lee, Seungju Lee, Yoonsook Kim, Sang Keun Ha
Summary: The study found that MOLD significantly increases RAGE expression in mouse mesangial cells, leading to ROS production and mitochondrial dysfunction. MOLD activates PI3KB and NF-kappa B signaling pathways, triggering inflammatory responses.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)