期刊
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
卷 26, 期 4, 页码 639-648出版社
WILEY
DOI: 10.1111/j.1440-1746.2010.06602.x
关键词
Barrett's esophagus; esophageal adenocarcinoma; esophageal epithelium; intestinal metaplasia
资金
- Cancer Council of New South Wales
- National Health and Medical Research Council of Australia
- Australian Research Council
Barrett's esophagus is an acquired metaplastic abnormality in which the normal stratified squamous epithelium lining of the esophagus is replaced by an intestinal-like columnar epithelium. While in itself a benign and asymptomatic disorder, the clinical importance of this relatively common condition relates to its role as a precursor lesion to esophageal adenocarcinoma, the incidence of which has dramatically increased in Western populations in recent years. Although known to arise as a consequence of chronic gastroesophageal reflux, the cellular and molecular mechanisms underlying development Barrett's esophagus and its progression to cancer remain unclear.
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