Article
Health Care Sciences & Services
Yuhan Fu, Michael Kurin, Marc Landsman, Ronnie Fass, Gengqing Song
Summary: The aim of the study was to determine whether IBS is an independent risk factor for developing opioid addiction and related gastrointestinal symptoms in patients with IBD. The results showed that patients with concomitant IBD and IBS were more likely to be prescribed oral opioids and develop opioid dependence or abuse.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Marilyn Hagan, Bu' Hussain Hayee, Ana Rodriguez-Mateos
Summary: Polyphenols (PPs) may have therapeutic benefits in gastrointestinal (GI) disorders like IBS or IBD, but the evidence base is inconsistent and further research is needed to clarify their effects.
Article
Dermatology
Khalaf Kridin, Ralf J. Ludwig
Summary: Isotretinoin does not increase the risk of Crohn's disease, but it may be associated with a slight and temporary increase in the risk of ulcerative colitis. However, it can lower the risk of irritable bowel syndrome.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Review
Medicine, General & Internal
Mihaela Fadgyas Stanculete, Abdulrahman Ismaiel, Stefan-Lucian Popa, Octavia Oana Capatina
Summary: Irritable bowel syndrome (IBS) is a disorder characterized by altered gut-brain interaction and dysfunction of the brain-gut-microbiota axis. Prior studies have shown significant impairments in the health-related quality of life of patients with IBS. Resilience, as a psychosocial ability, plays a crucial role in promoting health and enhancing stress response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Lena Schroder, Franziska Regnath, Stefan Glasauer, Anna Hackenberg, Juliane Hente, Sonja Weilenmann, Daniel Pohl, Roland von Kanel, Nadine Lehnen
Summary: This study investigates sensorimotor processing during eye-head gaze shifts in irritable bowel syndrome (IBS). The results show that IBS patients display increased head oscillations compared to healthy controls when the head moment of inertia is increased, indicating sensorimotor processing deficits in IBS. These findings suggest the presence of general transdiagnostic processing deficits in functional somatic disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Gastroenterology & Hepatology
Hana Cipcic Paljetak, Anja Baresic, Marina Panek, Mihaela Peric, Mario Matijasic, Ivana Lojkic, Ana Barisic, Darija Vranesic Bender, Dina Ljubas Kelecic, Marko Brinar, Mirjana Kalauz, Marija Milicevic, Dora Grgic, Niksa Turk, Irena Karas, Silvija Cukovic-Cavka, Zeljko Krznaric, Donatella Verbanac
Summary: This study compares the differences in gut microbiota between newly diagnosed, treatment-naive adult inflammatory bowel disease (IBD) patients (CD and UC) with irritable bowel syndrome (IBS) patients and healthy individuals. The results show that changes in gut microbiota are detectable at the onset of disease and may play a significant role in the development of IBD.
Review
Gastroenterology & Hepatology
Arjun Gandhi, Ayesha Shah, Michael P. Jones, Natasha Koloski, Nicholas J. Talley, Mark Morrison, Gerald Holtmann
Summary: The systematic review and meta-analysis indicated that methane-positive SIBO is more prevalent in IBS, particularly in IBS-C, compared to controls, while it is less common in patients with IBD. In patients with IBD, methane-positive SIBO was significantly lower in Crohn's disease compared to ulcerative colitis. More studies are needed to establish a causal relationship due to the low quality of evidence and clinical heterogeneity in the current studies.
Article
Gastroenterology & Hepatology
Tadayuki Oshima, Kewin Tien Ho Siah, Takanori Yoshimoto, Ko Miura, Toshihiko Tomita, Hirokazu Fukui, Hiroto Miwa
Summary: This study investigated the impact of the COVID-19 pandemic on gastrointestinal and psychological symptoms of functional dyspepsia (FD) and irritable bowel syndrome (IBS). Results showed that during the pandemic, respondents with FD-IBS overlap syndrome had the worst symptoms, followed by IBS-alone and FD-alone respondents. 11.9% reported deterioration and 2.8% reported improvement of gastrointestinal symptoms.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Psychology, Biological
Andre Schulz, Sina-Katharina Welsch, Sarah Etringer, Greta Hansen, Lea Milbert, Jochen Schneider, Gennaro Taddei, Raquel Gomez Bravo, Charilaos Lygidakis, Zoe van Dyck, Annika Lutz, Paul Wilmes, Claus Vogele
Summary: This study investigates whether IBD and IBS patients have altered perception of 'natural' gastric distensions. The results show that IBD patients drink significantly more water until satiation than IBS patients, suggesting relative gastric hypersensitivity in IBS and relative hyposensitivity in IBD patients.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Gastroenterology & Hepatology
Irina Midenfjord, Cecilia Grinsvall, Peter Koj, Ida Carnerup, Hans Tornblom, Magnus Simren
Summary: Central sensitization was common in IBS and associated with GI symptom severity, but with stronger associations in chronic pain disorders and IBD. This suggests that other mechanisms may play a significant role in determining GI symptom severity in IBS.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Medicine, General & Internal
Haoran Ke, Zitong Li, Qianyun Lin, Zefeng Shen, Ye Chen, Jinjun Chen
Summary: This study aimed to determine the causal association between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) using genetic associations and Mendelian randomization analyses. The results showed that genetically predicted IBD was associated with an increased risk of IBS, but no association between genetically influenced IBS and IBD was identified. This study confirms the causal relationship between IBD and IBS, which may impact the diagnosis and treatment of both diseases.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Alexandra Aupetit, Sebastien Grigioni, Horace Roman, Moise Coeffier, Amelie Breant, Clotilde Hennetier, Najate Achamrah
Summary: This study found a significant association between irritable bowel syndrome (IBS), eating disorders (ED), and endometriosis. The prevalence of IBS and ED in patients with endometriosis was higher than in the general population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Gastroenterology & Hepatology
Cong Dai, Yu-Hong Huang, Min Jiang
Summary: This article is connected to the papers of Marasco et al. To access these papers, visit and
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Kwangwoo Nam, Nayoung Kim, Hyun Joo Song, Gwang Ho Baik, Suck Chei Choi, Hyun Jin Kim, Ju Yup Lee, Kyung Sik Park, Sun-Young Park, Seun Ja Park
Summary: The overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS) is associated with more severe upper gastrointestinal symptoms and depression compared to non-overlap patients. Women with FD-IBS overlap experience more severe gastrointestinal and depression symptoms than men.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Nutrition & Dietetics
Marlijne C. G. de Graaf, Corinne E. G. M. Spooren, Evelien M. B. Hendrix, Martine A. M. Hesselink, Edith J. M. Feskens, Agnieszka Smolinska, Daniel Keszthelyi, Marieke J. Pierik, Zlatan Mujagic, Daisy M. A. E. Jonkers
Summary: The study found that diet quality was lower in patients with IBD and IBS, and was associated with intestinal inflammation and gastrointestinal symptoms to varying degrees.
Letter
Public, Environmental & Occupational Health
Jack E. Henningfield, Oliver Grundmann, Albert Garcia-Romeu, Marc T. Swogger
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Article
Psychology, Biological
Kirsten E. Smith, Kelly E. Dunn, Oliver Grundmann, Albert Garcia-Romeu, Jeffrey M. Rogers, Marc T. Swogger, David H. Epstein
Summary: This study found that adults with kratom use histories generally had poorer psychological health, greater chronic pain, and higher rates of substance use disorder and polysubstance use compared to those with no kratom use history. Kratom users were typically younger, male, unpartnered, without children, and had lower income compared to non-users.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2022)
Editorial Material
Pharmacology & Pharmacy
Mark Rogge, Parag Kumar, Oliver Grundmann
JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Oliver Grundmann, Parag Kumar, Mark Rogge
JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Substance Abuse
Oliver Grundmann, Charles A. Veltri, Diana Morcos, David Knightes, Kirsten E. Smith, Jeffery M. Rogers
Summary: Although the COVID-19 pandemic did not alter the patterns of kratom use, it raised concerns among consumers about product shortages and the quality of available kratom. Younger consumers reported difficulty in obtaining their desired products from their usual sources. Social media discussions focused on quitting kratom during COVID-19, misinformation about the effects of kratom on COVID-19, and concerns about product quality.
Article
Nutrition & Dietetics
Jennifer Marie Crook, Ann L. Horgas, Saunjoo L. Yoon, Oliver Grundmann, Versie Johnson-Mallard
Summary: This study investigates the association between plasma vitamin C levels and inflammation biomarkers. The findings suggest that insufficient levels of vitamin C may be associated with increased inflammation, highlighting the importance of further research and treatment for individuals at risk of inflammatory-driven diseases.
Review
Psychology, Clinical
Cornel Stanciu, Saeed Ahmed, Samantha Gnanasegaram, Stephen Gibson, Thomas Penders, Oliver Grundmann, Christopher McCurdy
Summary: This study systematically reviewed the literature on the impact of kratom and its alkaloids in paradigms involving opioids. The results showed that kratom alkaloids have the potential to mitigate opioid withdrawal in rodent models. Some alkaloids were found to have less reinforcing properties than morphine and possess tolerance-sparing properties when coadministered with morphine. However, other alkaloids were found to substitute for morphine and have potential for tolerance and dependence. Case reports highlighted various confounding toxicities, while user surveys reported high self-reported efficacy as an opioid substitute with minimal adverse effects. Overall, the lack of controlled human clinical trials limits the ability to draw conclusions.
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
(2022)
Article
Psychology, Biological
Oliver Grundmann, Charles A. Veltri, Sara Morcos, Kirsten E. Smith, Darshan Singh, Ornella Corazza, Eduardo Cinosi, Giovanni Martinotti, Zach Walsh, Marc T. Swogger
Summary: The use of Kratom has significantly increased, especially for self-treatment of psychiatric conditions, outside of its indigenous regions in the past decade. An anonymous online survey was conducted among 4,945 Kratom users between July 2019 and July 2020. Among the respondents, 2,296 completed an extended survey which included clinical scales for measuring ADHD, PTSD, depressive and anxiety disorders. The findings suggest a positive correlation between Kratom use and improved mood among individuals with psychiatric conditions, indicating the need for further observational and clinical studies on Kratom.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Jennifer M. Crook, Saun-Joo L. Yoon, Oliver Grundmann, Ann Horgas, Versie Johnson-Mallard
Summary: Vitamin C is an important component of a healthy immune system, but many people have insufficient levels. Recent research found that inadequate vitamin C levels are associated with coronary artery disease, but this association weakens after controlling for inflammation.
Review
Geriatrics & Gerontology
Lisa Bagnall, Oliver Grundmann, Marilyn G. Teolis, Saun-Joo L. Yoon
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Letter
Substance Abuse
Oliver Grundmann, Albert Garcia-Romeu, Christopher R. Mccurdy, Abhisheak Sharma, Kirsten E. Smith, Marc T. Swogger, Stephanie T. Weiss
Review
Nutrition & Dietetics
Saunjoo L. Yoon, Oliver Grundmann
Summary: Cancer cachexia is a syndrome characterized by unintentional weight loss, sarcopenia, and systemic inflammation. Gastrointestinal cancer patients are more prone to cachexia due to impaired nutrient absorption and digestion. This study assessed the effects of fish oil, melatonin, probiotics, and green tea in managing GI cancer cachexia. Among these supplements, fish oil showed benefits in reducing inflammation, while melatonin had inconsistent findings. Probiotics decreased inflammatory biomarkers and improved chemotherapy tolerability, while green tea had a decreased risk of developing cancers without affecting tumor growth.
Article
Plant Sciences
Oliver Grundmann, Katherine Hill, Everest Al Barzanji, Nilofar Ghulam Hazrat, Gurnoor Kaur, Ryan Einstein Negeve, Soren Shade, Sam Weber, Charles A. Veltri
Summary: This study analyzed a specific kratom tea bag product to determine its mitragynine content using tea infusion preparation and methanolic extraction. An online anonymous survey was also conducted to gather information on demographics, kratom use patterns, and self-reported effects from consumers of both the tea bag product and other kratom products. The results showed that the mitragynine levels were lower in tea infusion extracts compared to methanolic extracts, but kratom tea bag consumers reported similar beneficial effects to consumers of other kratom products, although often milder. Overall, tea bag consumers reported better self-reported health, but less improvement in diagnosed medical conditions compared to those using other kratom products.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)