Article
Surgery
Incheon Kang, Mi Jang, Jae Geun Lee, Dai Hoon Han, Dong Jin Joo, Kyung Sik Kim, Myoung Soo Kim, Jin Sub Choi, Soon Il Kim, Young Nyun Park, Gi Hong Choi
Summary: Subclassification of MiVI in HCC showed that MPVI was associated with more aggressive tumor characteristics and poorer survival compared to MI only. The original MiVI classification should be divided into MI and MPVI for better prognostic assessment.
Review
Immunology
Zunyi Zhang, Erlei Zhang
Summary: Hepatocellular carcinoma (HCC) is a common type of liver cancer with high mortality rate. A significant percentage of HCC patients have vascular invasion at initial diagnosis. Traditional guidelines classify HCC with vascular invasion as advanced stage, limiting surgical options. However, recent advancements in systemic and locoregional treatments have shown promising responses, leading to the proposal of a conversion therapy strategy to eventually enable surgical resection. This review summarizes the clinical experience and evidence of conversion treatment in HCC patients with vascular invasion.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Oncology
Norihiro Kokudo, Takashi Kokudo, Kiyoshi Hasegawa
Summary: The study suggests that surgical resection may be superior to other treatments for HCC patients with macrovascular invasion, with some surgical centers reporting acceptable outcomes. This provides a new approach for hepatologists in Western countries to improve survival rates for such patients through a combination of systemic therapy and surgery.
Article
Biochemistry & Molecular Biology
Liangliang Xu, Peng Wang, Li Li, Lian Li, Yang Huang, Yanfang Zhang, Xiaobo Zheng, Pengsheng Yi, Ming Zhang, Mingqing Xu
Summary: This study reveals that circPSD3 plays a critical role in the vascular invasion and metastasis of HCC and may serve as a prognostic biomarker and therapeutic target.
Article
Oncology
Yuan Chen, Hao Xu, Hao Tang, Hongyuan Li, Chi Zhang, Shengjie Jin, Dousheng Bai
Summary: This study found that miR-9-5p can predict vascular invasion and prognosis in hepatocellular carcinoma (HCC) patients. Experimental results showed that downregulation of miR-9-5p inhibits migration, invasion, and angiogenesis of HCC cells. MiR-9-5p is an independent risk factor for HCC, and the nomogram based on miR-9-5p has a good predictive value for HCC survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Z-Y Guo, Z-T Zhu
Summary: NCAPG upregulation is associated with poor prognosis in hepatocellular carcinoma patients with vascular invasion, and serves as an independent predictor of patient survival outcomes. NCAPG expression levels are related to DNA hypomethylation status, tumor immune cell infiltration, and immune cell-related biomarker expression.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Oncology
Rajalakshmi Govalan, Marie Lauzon, Michael Luu, Joseph C. Ahn, Kambiz Kosari, Tsuyoshi Todo, Irene K. Kim, Mazen Noureddin, Alexander Kuo, Ayoub S. Walid, Vinay Sundaram, Shelly C. Lu, Lewis R. Roberts, Amit G. Singal, Julie K. Heimbach, Vatche G. Agopian, Nicholas Nissen, Ju Dong Yang
Summary: The study suggests that surgical resection may provide better outcomes compared to systemic therapy for HCC patients with vascular invasion. Factors such as ethnicity, clinical characteristics, and treating facility type and region were associated with the likelihood of receiving surgical resection.
Article
Oncology
Jinhong Jung, Ji Hyeon Joo, So Yeon Kim, Jin Hyoung Kim, Jonggi Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Jin-hong Park, Sang Min Yoon
Summary: The study evaluated the radiologic response rate of combined TACE plus RT in patients with liver-confined HCC with MVI, and found that radiologic response was an independent prognostic factor for overall survival.
Article
Biology
Gun Ha Kim, Sang Lim Choi, Jin Hyoung Kim, Ju Hyun Shim, Meshari Alali, Nayoung Kim
Summary: This study aimed to compare the efficacy and safety of TACE plus sorafenib with TACE alone in patients with locally advanced HCC. The results showed that TACE plus sorafenib had better outcomes in terms of PFS and OS, indicating a potential benefit of combination therapy in this patient population.
Article
Oncology
Michael Krasovitsky, Yeh Chen Lee, Hao-Wen Sim, Tanya Chawla, Helen Moore, Daniel Moses, Luke Baker, Catherine Mandel, Ania Kielar, Angus Hartery, Martin O'Malley, Michael Friedlander, Amit M. Oza, Lisa Wang, Stephanie Lheureux, Michelle Wilson
Summary: This study assessed the variability of target lesion selection and measurement according to RECIST version 1.1 in patients with ovarian cancer. The results showed significant variability among different observers and within the same observer in both selection and measurement. The factors with the lowest reproducibility were peritoneal lesions in selection and lymph node lesions in measurement.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Gastroenterology & Hepatology
Xiang-Pan Meng, Tian-Yu Tang, Yongping Zhou, Cong Xia, Tianyi Xia, Yibing Shi, Xueying Long, Yun Liang, Wenbo Xiao, Yuan-Cheng Wang, Xiangming Fang, Shenghong Ju
Summary: A prognostic model integrating imaging-based surrogates of distinct vascular patterns was developed to predict postoperative recurrence-free survival (RFS) in patients with hepatocellular carcinoma (HCC). The model can potentially assist in selecting the appropriate type of surgical resection and predict patients' RFS.
Article
Gastroenterology & Hepatology
Lan-Qing Yao, Chao Li, Yong-Kang Diao, Lei Liang, Hang-Dong Jia, Shi-Chuan Tang, Yong-Yi Zeng, Han Wu, Ming-Da Wang, Li-Hui Gu, Timothy M. Pawlik, Wan Yee Lau, Cheng-Wu Zhang, Feng Shen, Kui Wang, Tian Yang
Summary: This study aimed to determine whether the grading severity of microscopic vascular invasion (MVI) was associated with recurrence and survival in patients with solitary hepatocellular carcinoma (HCC). The results showed that the severity of MVI was independently associated with recurrence-free survival (RFS) and overall survival (OS) after hepatectomy for solitary HCC, with more severe MVI grading (M2) being particularly important.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Article
Cell Biology
Yi-Chieh Yang, Ming-Hsien Chien, Tsung-Ching Lai, Min-Che Tung, Yi-Hua Jan, Wei-Ming Chang, Shih-Ming Jung, Ming-Huang Chen, Chun-Nan Yeh, Michael Hsiao
Summary: The study identified elevated expression of TMED9 in HCC tissues, which was significantly associated with disease progression and poor prognosis. TMED9 was found to have an oncogenic role in HCC cells, suggesting it could serve as a novel predictor of clinical outcomes and a potential therapeutic target.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Cell Biology
Xiaobo Zheng, Peng Wang, Li Li, Jing Yu, Chune Yu, Liangliang Xu, Lian Li, Fuzhen Dai, Lei Feng, Hong Zou, Xiaobo Chen, Ming Zhang, Mingqing Xu
Summary: The study revealed that the cancer-associated fibroblast-secreted decorin plays a crucial role in the vascular invasion of hepatocellular carcinoma, with low-level expression being associated with a poor prognosis. Decorin inhibited HCC cell invasion and migration by downregulating integrin beta 1, and its synergistic effect with integrin beta 1 knockdown enhanced the anti-metastatic effects. The direct interaction of decorin with integrin beta 1 was confirmed, suggesting that targeting decorin may provide a promising strategy for inhibiting HCC vascular invasion and metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Zhijun Liu, Yuyu You, Qiyi Chen, Guobang Li, Wenfeng Pan, Qing Yang, Jiajun Dong, Yi Wu, Jin-Xin Bei, Chaoyun Pan, Fuming Li, Bo Li
Summary: Hepatocellular carcinoma (HCC) is characterized by metabolic and immune remodeling in the tumor microenvironment. Liver-specific deletion of fructose-1, 6-bisphosphatase 1 (FBP1) promotes liver tumorigenesis, partly due to the suppression of natural killer (NK) cells. Mechanistically, FBP1 attenuation in hepatocytes inhibits PKLR expression and reduces the activity of NK cells by transferring PKLR-attenuated extracellular vesicles (EVs) from hepatocytes.