Review
Virology
Giacomo Emanuele Maria Rizzo, Giuseppe Cabibbo, Antonio Craxi
Summary: Hepatitis B virus (HBV) infection is associated with the risk of developing hepatocellular carcinoma (HCC), with or without liver cirrhosis, through various mechanisms. The molecular profile of HBV-HCC is constantly being studied, and it is the result of altered molecular pathways, changes in the microenvironment, and DNA damage. Proper management of HBV-related liver disease is crucial for prevention and treatment of HCC.
Article
Oncology
Meng Xue, Xiaona Lin, Qiu-Xiong Lin, Xiaoyong Pu, Jiumin Liu, Xing-Fang Li, Jun Hou, Xudong Liu, Ren Chen
Summary: This study found that HBV infection was associated with an increased risk of HCC compared to HEV infection, and that HEV infection may mitigate the promoting impact of HBV on HCC development.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Nicholas Noverati, Rukaiya Bashir-Hamidu, Dina Halegoua-DeMarzio, Hie-Won Hann
Summary: Hepatitis B virus is a significant cause of hepatocellular carcinoma globally. The complex mechanisms of this virus include interactions with the host's immune system. Factors such as stress can amplify these mechanisms. Chronic stress, harmful to health, can suppress or activate the host's defense system, leading to tumor initiation and progression in liver cancer. Chronic stress, often overlooked, should be recognized as a potential risk factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Mirjam B. Zeisel, Francesca Guerrieri, Massimo Levrero
Summary: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is largely caused by chronic hepatitis B virus (HBV) infection. While antiviral therapies can suppress viral replication, there is currently no cure for chronic HBV infection. HBV contributes to liver carcinogenesis through direct and indirect effects on host epigenetic alterations, modulating gene expression.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Sheng-Han Wang, Shiou-Hwei Yeh, Pei-Jer Chen
Summary: HBV infection is a major risk factor for HCC globally, with chronic hepatitis B generating an inflammatory microenvironment that leads to genetic mutations in hepatocytes predisposing them to cancer. Male dominance in HBV-related HCC highlights the interplay between sex hormones and viral factors influencing carcinogenesis.
Article
Gastroenterology & Hepatology
Hyun-seok Kim, Xian Yu, Jennifer Kramer, Aaron P. Thrift, Pete Richardson, Yao-Chun Hsu, Avegail Flores, Hashem B. El-Serag, Fasiha Kanwal
Summary: This study evaluated the performance of 10 HCC risk prediction models in patients with HBV, showing that most models performed well in predicting HCC risk and identified low-risk subsets for exclusion from HCC surveillance. Further research is needed to validate these findings.
JOURNAL OF HEPATOLOGY
(2022)
Review
Oncology
Xinhe Zhang, Lin Guan, Haoyu Tian, Zilu Zeng, Jiayu Chen, Die Huang, Ji Sun, Jiaqi Guo, Huipeng Cui, Yiling Li
Summary: HCC is a common cancer with increasing incidence caused by HBV and HCV infections, liver cirrhosis, and metabolic risk factors. Predictive factors can assess the risk of HCC, and prevention strategies include vaccination, antiviral treatment, and HCC management to reduce recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Zhiwei Liu, Chih-Jen Huang, Yu-Han Huang, Mei-Hung Pan, Mei-Hsuan Lee, Kelly J. Yu, Ruth M. Pfeiffer, Mathias Viard, Yuko Yuki, Xiaojiang Gao, Mary Carrington, Chien-Jen Chen, Allan Hildesheim, Hwai- Yang
Summary: The study found that an increase in the number of homozygous HLA class II loci is associated with an increased risk of chronic HBV infection and HBV-associated HCC. Specifically, HLA-DQB1 homozygosity is significantly associated with HCC risk.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Peng Lin, Dong-Yue Wen, Jin-Shu Pang, Wei Liao, Yu-Ji Chen, Yun He, Hong Yang
Summary: This study developed an overall survival prediction model based on protein expression profiles in HBV-infected nontumor liver tissues, demonstrating the feasibility of using protein expression profiles in nontumor liver tissues for survival prediction.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Oncology
Jian-Lv Huang, Xiang-Kun Wang, Xi-Wen Liao, Chuang-Ye Han, Ting-Dong Yu, Ke-Tuan Huang, Cheng-Kun Yang, Xiao-Guang Liu, Long Yu, Guang-Zhi Zhu, Hao Su, Wei Qin, Quan-Fa Han, Zheng-Qian Liu, Xin Zhou, Jun-Qi Liu, Xin-Ping Ye, Tao Peng
Summary: This study demonstrated that differential SOX4 expression is significantly upregulated in tumor tissue, and SOX4 is closely associated with overall survival and recurrence-free survival in HBV-associated HCC. SOX4 may impact TP53 metabolic processes, lymphocyte differentiation, and the insulin signaling pathway in HCC. The diagnostic and prognostic potential of SOX4 in HCC was also highlighted in this research.
Article
Pharmacology & Pharmacy
Xiaomi Li, Jingyan Wang, Xiaoyan Ding, Yawen Xu, Minghua Yu, Hongxiao Wu, Na Deng, Wei Li, Jinglong Chen
Summary: The clinical efficacy of lenvatinib was compared between hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and hepatitis C virus (HCV)-related HCC. The study found that patients with HBV-HCC had higher objective response rate and disease control rate compared to HCV-HCC, but there were no significant differences in progression-free survival and overall survival between the two groups. Multivariate regression analysis identified HBV infection and antiviral time > 5 years as independent favorable factors for progression-free survival. Overall, lenvatinib seemed to be more effective in HBV-related HCC compared to HCV-related HCC.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Jie Li, Hwai- Yang, Ming-Lun Yeh, Michael H. Le, An K. Le, Yee Hui Yeo, Chia-Yen Dai, Scott Barnett, Jian Q. Zhang, Jee-Fu Huang, Huy N. Trinh, Christopher Wong, Clifford Wong, Joseph K. Hoang, Ramsey Cheung, Ming-Lung Yu, Mindie H. Nguyen
Summary: This study found that concurrent FL in patients with CHB significantly reduces the risk of cirrhosis and HCC, as well as increases the rate of HBsAg seroclearance. Further research is needed to confirm these findings and investigate the underlying mechanisms of FL on CHB.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Oncology
Marco Y. W. Zaki, Ahmed M. Fathi, Samara Samir, Nardeen Eldafashi, Kerolis Y. William, Maiiada Hassan Nazmy, Moustafa Fathy, Upkar S. Gill, Shishir Shetty
Summary: HBV and HCV infections are the most common risk factors for hepatocellular carcinoma (HCC), and their distribution affects the global prevalence of this type of liver cancer. Hepatitis infections elicit immune responses within the liver microenvironment, and persistent viral infection leads to chronic liver inflammation and carcinogenesis.
Article
Immunology
Ruonan Sun, Jiawei Li, Xianyi Lin, Yidong Yang, Bing Liu, Tianbi Lan, Shuang Xiao, Anyi Deng, Zhinan Yin, Yan Xu, Zheng Xiang, Bin Wu
Summary: This study aimed to explore the changes in peripheral immunity in patients with HBV-related hepatocellular carcinoma (HBV-HCC). The results showed that circulating lymphocytes in HBV-HCC patients exhibited features of immune exhaustion, especially in patients with persistent viral replication and in those with intermediate and advanced HBV-HCC. The combination of CD3(+) T cells and CD8(+)HLADR(+)CD38(+) T cells may serve as a potential diagnostic indicator for HBV-HCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Jer-Wei Wu, Jia-Horng Kao, Tai-Chung Tseng
Summary: HBcrAg, as a marker of HBV replication, is associated with HCC risk in treatment-naive patients, but its value in treated patients needs further validation. The next challenge is to combine HBcrAg with other viral markers to construct a better HCC prediction model.
CLINICAL AND MOLECULAR HEPATOLOGY
(2021)
Article
Genetics & Heredity
Diptika Tiwari, Chandana Ray Das, Purabi Deka Bose, Sujoy Bose
Article
Genetics & Heredity
S. Das, C. Baruah, A. K. Saikia, S. Bose
INTERNATIONAL JOURNAL OF IMMUNOGENETICS
(2018)
Article
Immunology
Chandana Ray Das, Diptika Tiwari, Anita Dongre, Mohammad Aasif Khan, Syed Akhtar Husain, Anirudha Sarma, Sujoy Bose, Purabi Deka Bose
Article
Immunology
Alex J. Freemerman, Liyang Zhao, Ajeeth K. Pingili, Bin Teng, Alyssa J. Cozzo, Ashley M. Fuller, Amy R. Johnson, J. Justin Milner, Maili F. Lim, Joseph A. Galanko, Melinda A. Beck, James E. Bear, Jeremy D. Rotty, Lavanya Bezavada, Heather S. Smallwood, Michelle A. Puchowicz, Juan Liu, Jason W. Locasale, Douglas P. Lee, Brian J. Bennett, E. Dale Abel, Jeff C. Rathmell, Liza Makowski
JOURNAL OF IMMUNOLOGY
(2019)
Article
Oncology
Raktim Borkotoky, Biswajit Malakar, Anjan Kr Saikia, Shambhu N. Mukherjee, Sujoy Bose
CURRENT PROBLEMS IN CANCER
(2020)
Article
Genetics & Heredity
Somdatta Das, Chitralekha Baruah, Anjan Kumar Saikia, Diptika Tiwari, Sujoy Bose
JOURNAL OF GENETICS
(2019)
Article
Virology
Vargab Baruah, Sujoy Bose
JOURNAL OF MEDICAL VIROLOGY
(2019)
Article
Biochemistry & Molecular Biology
Nidhi Singh, Syed Naqui Kazim, Rizwana Sultana, Diptika Tiwari, Raktim Borkotoky, Shantipriya Kakati, Nrityendra Nath Das, Anjan Kumar Saikia, Sujoy Bose
FREE RADICAL RESEARCH
(2019)
Article
Virology
Mafidul Islam, Trishna Kalita, Anjan K. Saikia, Anjuma Begum, Vargab Baruah, Nidhi Singh, Raktim Borkotoky, Sujoy Bose
JOURNAL OF MEDICAL VIROLOGY
(2019)
Article
Biochemistry & Molecular Biology
Diptika Tiwari, Chandana Ray Das, Rizwana Sultana, Shantipriya Kakoti, Mohammad Aasif Khan, Anita Dongre, Syed Akhtar Husain, Purabi Deka Bose, Sujoy Bose
JOURNAL OF CELLULAR BIOCHEMISTRY
(2020)
Article
Oncology
Rizwana Sultana, Amal Ch Kataki, Bibhuti Bhusan Barthakur, Anupam Sarma, Sujoy Bose
CURRENT PROBLEMS IN CANCER
(2020)
Article
Virology
Vargab Baruah, Sujoy Bose
JOURNAL OF MEDICAL VIROLOGY
(2020)
Article
Genetics & Heredity
Rizwana Sultana, Saswati Sanyal Choudhury, Sujoy Bose, Diptika Tiwari, Abhijit Bharali, Swapna D. Kakoty
Article
Medicine, General & Internal
Manash P. Kalita, Subhash Medhi, Sujoy Bose, Dipankar Bujarbaruah, Tarun K. Basumatary, Ramie H. Begum
JOURNAL OF KRISHNA INSTITUTE OF MEDICAL SCIENCES UNIVERSITY
(2018)
Article
Medicine, General & Internal
Tarun K. Basumatary, Ramie H. Begum, Moumita Bose, Manash P. Kalita, Anjan K. Saikia, Sujoy Bose
JOURNAL OF KRISHNA INSTITUTE OF MEDICAL SCIENCES UNIVERSITY
(2017)