Review
Biochemistry & Molecular Biology
Ruta Zulpaite, Povilas Miknevicius, Bettina Leber, Kestutis Strupas, Philipp Stiegler, Peter Schemmer
Summary: Solid organ transplantation faces challenges such as organ shortage, extended criteria donor organs, and immune regulation issues with a lack of accurate biomarkers for predicting dysfunction and rejection. Tryptophan and its metabolites are of interest in this field, offering therapeutic and prognostic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Nirmalya Pradhan, Nasim Akhtar, Barnali Nath, Jorge Pena-Garcia, Anjali Gupta, Horacio Perez-Sanchez, Sachin Kumar, Debasis Manna
Summary: Quinine derivatives effectively inhibit the activity of IDO1 by competing with heme, providing a potential avenue for immunotherapy-based drug discovery strategies.
CHEMICAL COMMUNICATIONS
(2021)
Review
Oncology
Yu Yao, Heng Liang, Xin Fang, Shengnan Zhang, Zikang Xing, Lei Shi, Chunxiang Kuang, Barbara Seliger, Qing Yang
Summary: IDO1, a heme-containing enzyme, plays a crucial role in the kynurenine pathway of tryptophan metabolism, with implications in immunity and neuronal function. Despite potential applications in cancer and neurodegenerative diseases, cautionary notes from clinical trials indicate a need for better understanding of IDO1 inhibition mechanisms.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Engineering, Multidisciplinary
Jan Lerut, Samuele Iesari
Summary: Perfect surgical techniques and adequate immunosuppression are crucial for graft and patient survival in liver transplantation. The current standard immunosuppression regimen is a triple-drug combination of a calcineurin inhibitor, antimetabolites, and short-term steroids. However, the optimal immunosuppression regimen is still unclear due to diverse study designs and changing definitions of rejection. Future trials should consider multiple endpoints and comprehensive evaluation of patient and graft survival, acute and chronic rejection, and long-term side effects.
Article
Engineering, Biomedical
Yang Lu, Feng Xu, Yang Wang, Chao Shi, Yuzhuo Sha, Guangli He, Qichao Yao, Kun Shao, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng
Summary: NBS-1MT, an organic photo-immune activator, effectively triggers pyroptosis and disrupts the suppressive tumor microenvironment, activating the immune response and inhibiting tumor growth.
Review
Biochemistry & Molecular Biology
Leila Sawada, Antonio Carlos Rosario Vallinoto, Igor Brasil-Costa
Summary: EBV is an oncovirus associated with various types of cancer, with the reason for cancer development in only some infected individuals still unknown. EBV-associated cancers are more aggressive and resistant to treatment compared to EBV-negative cancers, making monoclonal antibodies targeting immune checkpoints a potential therapy.
Review
Chemistry, Medicinal
Rahul Singh, Deepak B. Salunke
Summary: IDO1 enzyme catalyzes the initial step of kynurenine pathway and is implicated in immune modulation, antioxidation, and cancer progression. Overexpression of IDO1 plays a pivotal role in immune evasion and cancer development. Research and development of IDO1 inhibitors holds significant potential in immunotherapy and disease treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Ana Dolsak, Stanislav Gobec, Matej Sova
Summary: This review discusses the key step of tryptophan metabolism and the importance of relevant enzymes in pathological conditions. In recent years, many inhibitors targeting these enzymes have been developed, and these inhibitors have entered clinical trials.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Engineering, Biomedical
Yixuan Guo, Yu Liu, Wei Wu, Daishun Ling, Qiao Zhang, Peng Zhao, Xi Hu
Summary: This article will discuss different types of IDO inhibitors and relevant clinical trials, especially feasible combined therapeutic modalities. In addition, it will also review cutting-edge nanomedicines that combine IDO inhibitors with other therapeutic modalities to effectively enhance the effectiveness of cancer therapy. Finally, the prospects of IDO inhibitors in clinical application and potential breakthroughs will be briefly discussed.
Article
Oncology
Marie Solvay, Pauline Holfelder, Simon Klaessens, Luc Pilotte, Vincent Stroobant, Juliette Lamy, Stefan Naulaerts, Quentin Spillier, Raphael Frederick, Etienne De Plaen, Christine Sers, Christiane A. Opitz, Benoit J. van den Eynde, Jingjing Zhu
Summary: This study aimed to clarify the link between IDO1/TDO expression, AHR pathway activation, and immune suppression. The results showed that tryptophan deprivation sensitizes the AHR pathway, leading to increased Treg differentiation and immune suppression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Sara Assadiasl, Nuala Mooney, Mohammad Hossein Nicknam
Summary: Cytokines play crucial roles in autoimmune, allergic, and infectious diseases, as well as allograft rejection. Recent advances in novel anti-cytokine agents and gene therapy for immunomodulatory cytokines have shown significant improvements in managing dysregulated cytokine secretion and overexpression.
Article
Microbiology
Thiara Manuele Alves de Souza, Caroline Fernandes-Santos, Jessica Araujo da Paixao de Oliveira, Larissa Cristina Teixeira Tome, Victor Edgar Fiestas-Solorzano, Priscila Conrado Guerra Nunes, Gabriel Macedo Costa Guimaraes, Juan Camilo Sanchez-Arcila, Iury Amancio Paiva, Luis Jose de Souza, Paulo Vieira Damasco, Valber da Silva Frutuoso, Manoela Heringer, Luzia Maria De Oliveira-Pinto, Roberta Olmo Pinheiro, Flavia Barreto dos Santos, Elzinandes Leal de Azeredo
Summary: This study evaluated the activity of IDO-1 and the patterns of cytokines/chemokines in CHIKV patients. It was found that IDO-1 activity increased during the early acute phase of infection and decreased in the chronic phase. In the acute phase, concentrations of TNF-alpha, IL-6, IFN-gamma, CCL2/MCP-1, and CXCL10/IP-10 were increased. In the chronic phase, concentrations of CCL4/MIP-1 beta were increased, especially in patients with arthritis.
Article
Chemistry, Medicinal
Kai Tang, Bo Wang, Bin Yu, Hong-Min Liu
Summary: Indoleamine 2,3-dioxygenase 1 (IDO1) is an important immunosuppressive enzyme in cancer therapy. Multiple IDO1 inhibitors have entered clinical trials, and PROTAC-based degraders also show promise for cancer treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Daojing Yan, Jiakun Xu, Xiang Wang, Jiaxing Zhang, Gang Zhao, Yingwu Lin, Xiangshi Tan
Summary: This study systematically investigated the SAR405838 analogs as potential IDO inhibitors for cancer immunotherapy. The results showed that inhibitor 3 exhibited the highest IDO1 inhibitory activity among all inhibitors and demonstrated effective inhibition in MCF-7 cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Arina Kozlova, Leopold Thabault, Maxime Liberelle, Simon Klaessens, Julien R. C. Prevost, Caroline Mathieu, Luc Pilotte, Vincent Stroobant, Benoit Van den Eynde, Raphael Frederick
Summary: In this study, a new scaffold of TDO2 inhibitors, 6-(1H-indol-3-yl)-benzotriazole, was developed through rational design, leading to the synthesis of stable compounds with nanomolar cellular potency. The rigidification of the initial scaffold provided a better understanding of the structural modulations inside the active site of hTDO2.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ming-Shian Tsai, Hui-Ming Lee, Shih-Che Huang, Cheuk-Kwan Sun, Ting-Chia Chiu, Po-Han Chen, Yu-Chun Lin, Tzu-Min Hung, Po-Huang Lee, Ying-Hsien Kao
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2020)
Article
Biochemistry & Molecular Biology
Shang-Hung Lin, Ji-Chen Ho, Sung-Chou Li, Yu-Wen Cheng, Yi-Chien Yang, Jia-Feng Chen, Chung-Yuan Hsu, Toshiaki Nakano, Feng-Sheng Wang, Ming-Yu Yang, Chih-Hung Lee, Chang-Chun Hsiao
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, Research & Experimental
Cheng- Cheng, Huoy-Rou Chang, Ming-Hong Tai, Ming-Huei Chou, Guan-Ting Chen, Po-Han Chen, Ying-Hsien Kao
Article
Medicine, Research & Experimental
Yo-Chen Chang, Chia-Wei Lin, Yuh-Shin Chang, Po-Han Chen, Chia-Yang Li, Wen-Chuan Wu, Ying-Hsien Kao
Article
Biochemistry & Molecular Biology
Ming-Huei Chou, Hui-Ching Chuang, Yu-Tsai Lin, Ming-Hsien Tsai, Ying-Hsien Kao, I-Chun Lin, Tai-Lin Huang, Fu-Min Fang, Chih-Yen Chien
Summary: Advanced head and neck squamous cell carcinoma (HNSCC) patients have poor prognosis, but molecular targeted therapy, particularly targeting the mTOR pathway, shows promise as an effective treatment strategy. In this study, docetaxel was found to significantly inhibit HNSCC cell proliferation and migration via the PI3K/mTOR/CCL-20 signaling pathway. Additionally, mTOR inhibitors demonstrated dose-dependent inhibition of HNSCC cell growth and migration, showing synergistic effects when combined with docetaxel.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Po-Jung Chen, Toshiaki Nakano, Chia-Yun Lai, Kuei-Chen Chang, Chao-Long Chen, Shigeru Goto
Summary: The study reveals that daily full spectrum light exposure (phototherapy) has an impact on the pathogenesis of food allergies (FAs) by improving allergic diarrhea and low vitamin D-3 levels. Experiments involving fecal microbiota transplantation (FMT) show a correlation between microbiota composition and FAs. Phototherapy can prevent FAs-like allergic diarrhea by modulating vitamin D-3 status and microbiota composition.
NPJ BIOFILMS AND MICROBIOMES
(2021)
Article
Chemistry, Medicinal
Yuh-Shin Chang, Yo-Chen Chang, Po-Han Chen, Chia-Yang Li, Wen-Chuan Wu, Ying-Hsien Kao
Summary: This study investigates the role of miR-100 in H2O2-induced apoptosis of ARPE-19 cells, showing that PI3K, p38 MAPK, and NF-κB activities are involved in oxidative-stress-induced miR-100 upregulation. Blocking PI3K, JNK, and NF-κB signaling attenuates oxidative cell death. MiR-100 antagomir treatment exerts a cytoprotective effect by restoring cellular mTOR levels and upregulating heme oxygenase-1 expression.
Article
Cell Biology
Cheng- Cheng, Ming-Hong Tai, Huoy-Rou Chang, Ming-Huei Chou, Guan-Ting Chen, Po-Han Chen, Ying-Hsien Kao
Summary: This study characterized the role of hepatoma-derived growth factor (HDGF) in oxLDL-induced foam cell formation in vascular smooth muscle cells (SMCs), revealing that HDGF plays a role in the process by regulating the expression of LOX-1 and CD36.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2021)
Article
Oncology
Chih-Cheng Hsiao, Yo-Chen Chang, Yu-Ting Hsiao, Po-Han Chen, Ming-Chu Hsieh, Wen-Chuan Wu, Ying-Hsien Kao
Summary: The study suggests that triamcinolone acetonide (TA) can alter the biological effects of transforming growth factor-beta 2 (TGF-beta 2) on human retinal pigment epithelial cells, potentially by attenuating TGF-beta 2-induced cell apoptosis and collagen gel contraction through inhibition of Smad2, ERK, and p38 signaling pathways. Additionally, TA can reduce TGF-beta 2-induced VEGF expression and block MMP-9 gelatinolytic activity.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Environmental Sciences
Toshiaki Nakano, Kuei-Chen Chiang, Chien-Chih Chen, Po-Jung Chen, Chia-Yun Lai, Li-Wen Hsu, Naoya Ohmori, Takeshi Goto, Chao-Long Chen, Shigeru Goto
Summary: Sunlight exposure is essential for vitamin D-3 production, but excessive UV radiation may increase the risk of skin aging and wrinkles. While avoiding sunlight exposure can reduce the risk of skin cancer, it may also lead to vitamin D-3 deficiency.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Yueh-Hua Chung, Yuan-Tso Cheng, Ying-Hsien Kao, Wan-Chi Tsai, Gong-Kai Huang, Yen-Ta Chen, Yuan-Chi Shen, Ming-Hong Tai, Po-Hui Chiang
Summary: This study investigates the expression of miR-26a-5p in upper tract urothelial carcinoma (UTUC) and its associated signaling network. The results demonstrate significant down-regulation of miR-26a-5p in UTUC tumors and its ability to inhibit cell proliferation and migration by reversing epithelial-to-mesenchymal transition (EMT) process.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Shao-Wen Weng, Jian-Ching Wu, Feng-Chih Shen, Yen-Hsiang Chang, Yu-Jih Su, Wei-Shiung Lian, Ming-Hong Tai, Chia-Hao Su, Jiin-Haur Chuang, Tsu-Kung Lin, Chia-Wei Liou, Tian-Huei Chu, Ying-Hsien Kao, Feng-Sheng Wang, Pei-Wen Wang
Summary: This study investigates the role of mitochondrial chaperonin HSP60 in diet-induced non-alcoholic fatty liver disease (NAFLD). The findings suggest that HSP60 promotes fatty acid oxidation, reduces mitochondrial stress and inflammation, and shows hepatoprotective effects. These results indicate that HSP60 could be a potential target for therapeutics in NAFLD or type 2 diabetes.
Article
Biochemistry & Molecular Biology
Toshiaki Nakano, Chao-Long Chen, I-Hsuan Chen, Hui-Peng Tseng, Kuei-Chen Chiang, Chia-Yun Lai, Li-Wen Hsu, Shigeru Goto, Chih-Che Lin, Yu-Fan Cheng
Summary: Accumulating evidence suggests the involvement of tumor-derived exosomes in HCC development and recurrence. The study explores the impact of miR-4669 overexpression on HCC and its clinical value in predicting treatment response and HCC recurrence. Overexpression of miR-4669 enhances migration ability, leads to sorafenib resistance, and generates an immunosuppressive tumor microenvironment. Exosomal miR-4669 has clinical value in predicting treatment response and assessing the risk of HCC recurrence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yueh-Hua Chung, Gong-Kai Huang, Chih-Hsiung Kang, Yuan-Tso Cheng, Ying-Hsien Kao, Yu-Shu Chien
Summary: Renal fibrosis is a characteristic of chronic renal diseases, and the downregulation of miR-26a-5p plays an important role in this process. MiR-26a-5p restoration attenuates renal fibrosis by inhibiting TGF-beta and NF-kappa B signaling pathways, suggesting it as a potential therapeutic target for obstruction-induced renal fibrosis.
LABORATORY INVESTIGATION
(2023)
Article
Clinical Neurology
Chien-Chih Chen, Toshiaki Nakano, Li-Wen Hsu, Chia Yi Chu, Kuang-Tzu Huang
Summary: The effects of olanzapine treatment on hepatic lipid metabolism and its relationship with adipose tissue status are complex and may be related to metabolic disturbances induced by antipsychotic drugs.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)